고혈압과 비만증이 심초음파도상 좌심실기능에 미치는 영향에 관한 연구

유창범,김성구,권영주 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

비만증은 관상동맥질환의 위험인자로 작용함과 동시에 고혈압과 밀접한 관계가 있다. 비만증은 심장에 구조적변화와 기능적 장애를 유발하며 이에 대한 임상적, 혈역학적, 생화학적 방법에 의한 연구는 많이 있었으나 심초음파도 및 도플러(Doppler) 혈류검사를 이용한 연구는 많지 않다. 대상 및 방법 : 고혈압과 비만증이 있는 군(Ⅰ군, 13명)과 혈압은 정상이나 비만증이 있는 군(Ⅱ군, 21명), 혈압이 정상이고 비만증도 없는 군(Ⅲ군, 14명)을 대상으로 비만도, 혈압측정, 생화학적 검사, 심전도, 심초음파도 및 도플러 혈류검사를 시행하였다. 결과 : 1. 초음파 검사에서 Ⅰ군의 심실중격 및 후벽의 두께, 좌심방내경, 좌심실질량이 Ⅲ군보다 유의하게 컸으며, Ⅱ군에서는 좌심방내경이 Ⅲ군 보다 유의하게 컸다. 2. 승모판 도플러 검사에서 Ⅰ군의 A파 최대속도와 A-TVI는 Ⅲ군 보다 유의하게 컸으며, Ⅱ군의 A파 최대속도와 A-TVI는 Ⅲ군 보다 큰 경향이 있었다.(P〈0.06) 3. 비만증에서 체지방 비율과 비만도는 심실중격 및 좌심실후벽의 두께, 좌심방내경, 좌심실질량, 승모판혈류의 A파 최대속도 및 A-TVI와는 유의한 상관관계가 있었다. 결론 : 비만증환자의 심초음파도 및 도플러 혈류 검사에서 좌심실과 좌심방의 구조적 변화 및 기능장애가 관찰되었고 이는 비만정도와 상관관계가 있었다. Background : Obesity is a risk factor for coronary artery disease and is associated hypertension. Obesity increases the cardiac dimension and functional abnormality and many studies on clinical, hemodynamic and biochemical method have been done but few studies on echocrdiographic and doppler flow method have been done. Methods: We performed obesity measurement, measurement of blood pressure, biochemical labs, electrocardiogram, echocardiogram and doppler flow echocardiogram in obese patients with hypertension (Group I, 13cases), obese normotensive (Group Ⅱ, 21 cases) and lean normoterive patient(Group III, 14 cases) and used to compare with the characteristics of these groups and their relation to obesity. Results: 1. In echocardiogram, interventricular septal thickness, left ventricular posterior wall thickness, left atrial dimension, and left ventricular mass were greater in group I than group III. Group II had greater left atrial dimension than group III. Left ventricular dimension showed tendency to more increasing in group I and II than group III. 2. In doppler mitral flow, A peak velocity and A-TVI were greater in group I than group III. A peak velocity and A-TVI showed tendency to more increasing in group II than in group III(P<0.06). 3. Total body fat and obesity index in obese patients correlated with the interventricular septal thickness, left ventricular posterior wall thickness, left atrial dimension, left ventricular mass index and A peak velocity and A-TVI in doppler mitral flow. Conclusion: The present study demonstrates that obese patients have left ventricular and left atrial structural and functional abnormality in echocardiogram and doppler mitral flow and it correlates with degree of obesity. Obese patients with hypertension had greater degree of abnormalities.

대절토 암반사면의 안정화 검토 및 현장계측 분석

박범준,류권일,고영헌,김팔규 忠南大學校 産業技術硏究所 2003 산업기술연구논문집 Vol.18 No.2

We investigated the stability of rock slope caused by large-scale cutting on construction of rapid-transit railway. Applying anchor method in order to build the up, we analyzed the stability using long-term measurement. Slope stability analysis is established by STABL 5M and DIPS as basic programs. Field measurement is required to prove the stability of rock slope which results from the reinforcement corresponding to slope stability analysis. Thus, we used one ground inclinometer and 8 load-cells for the measurement system.

한의과대학 부속 한방병원 한방응급실 내원환자에 대한 임상적 분석

소형진,류재환,김영철,이범준 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : By recording basic data of patients visiting the emergency room of the oriental medicine center, we can understand their characteristics and gain better insight about them. Methods : We performed a retrospective study of 2,674 patients who visited the emergency room of Kyunghee Oriental Medical Center, from June 1, 2006 to May 31, 2007. Results : 1. Of 2,674 total patients, the male to female ratio was 0.94:1 and the 6th decade of life was the peak age group. 2. The majorit of patients visited our emergency room between 06:00 and 24:00(midnight). 3. Most patients visited on a Saturday or Sunday. 4. By monthly distribution, the patients incrcased slightly during June, July, August and October. 5. The majority of patients visited the emergency room within 24 hours of onset. 6. The patients were categorized as follows : neurological diseases 71.15%, musculoskeletal diseases 16.02%, internal medical discase 9.04% psychiatric and related disease 3.79%. 7. The average transit time waS about 1 hour 30 minutes. 8. Admission rate was 48% and the rate of admission to the intensive care unit (ICU) was 5% of total visiting patients. Conclusion : Assuming that this research will continue adding patien's data continuously, this work will help us to understand the features of patients who visiting the emergency room of the oriental medical center.

곁사슬을 갖는 새로운 액정중합체의 합성 및 특성

전옥철,김윤준,류범영,최재곤,조병욱,홍진후 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.1

A series of wholly aromatic polyesters with side chains were synthesized by solution polycondensation from 2,5-dialkoxyterephthaloyl chlorides with the corresponding diol. The polymers showed the schlieren textures which is indicative of a nematic phase above their melting temperature. The inherent viscosities (η_(inh)) measured at 35℃ in phenol/p-chlorophenol/1,1,2,2-tetrachloroethane were 0.56-0.98 dℓ/g. The glass transition temperature (T_(g)) and melting temperature (T_(m)) decreased with increasing the length of the alkoxy side chain. Initial decomposition temperatures in TGA occurred at 338 ~ 363℃ in N₂ gas and thermal stability of polymers decreased with increasing the length of the side chain.

A New Single Cross Maize Hybrid for Silage "Pungmiok"

Beom Young Son,Hyeon Gui Moon,Tae Wook Jung,Seon Woo Cha,Sung Kook Kim,Nam Kyu Park,Yong Hwan Ryu,Jong Ho Seo,Keun Jin Choi,Byung Ryul Sung,Chang Suk Huh,Si Hwan Ryu 한국육종학회 2003 한국육종학회지 Vol.35 No.4

A single cross, Pungmiok is yellow dent hybrid maize (Zea mays L.) developed by the corn breeding team at the National Crop Experiment Station (NCES), RDA in 2002. This hybrid, which has a high yield of dry matter, total digestible nutrients (TDN), is mad

Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles

Ryu, Sunhyo,Lee, Yonghee,Hyun, Moo Yeol,Choi, Sun Young,Jeong, Kwan Ho,Park, Young Min,Kang, Hoon,Park, Kui Young,Armstrong, Cheryl A.,Johnson, Andrew,Song, Peter I.,Kim, Beom Joon MDPI 2014 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.15 No.9

<P>Recently, various immunosuppressant drugs have been shown to induce hair growth in normal hair as well as in alopecia areata and androgenic alopecia; however, the responsible mechanism has not yet been fully elucidated. In this study, we investigate the influence of mycophenolate (MPA), an immunosuppressant, on the proliferation of human dermal papilla cells (hDPCs) and on the growth of human hair follicles following catagen induction with interferon (IFN)-γ. IFN-γ was found to reduce β-catenin, an activator of hair follicle growth, and activate glycogen synthase kinase (GSK)-3β, and enhance expression of the Wnt inhibitor DKK-1 and catagen inducer transforming growth factor (TGF)-β2. IFN-γ inhibited expression of ALP and other dermal papillar cells (DPCs) markers such as Axin2, IGF-1, and FGF 7 and 10. MPA increased β-catenin in IFN-γ-treated hDPCs leading to its nuclear accumulation via inhibition of GSK3β and reduction of DKK-1. Furthermore, MPA significantly increased expression of ALP and other DPC marker genes but inhibited expression of TGF-β2. Therefore, we demonstrate for the first time that IFN-γ induces catagen-like changes in hDPCs and in hair follicles via inhibition of Wnt/β-catenin signaling, and that MPA stabilizes β-catenin by inhibiting GSK3β leading to increased β-catenin target gene and DP signature gene expression, which may, in part, counteract IFN-γ-induced catagen in hDPCs.</P>

A New Single Cross Maize Hybrid Cultivar, "Jangdaok" for Grain and Silage

Beom Young Son,Hyeon Gui Moon,Tae Wook Jung,Nam Kyu Park,Sung Kook Kim,Seon Woo Cha,Yong Hwan Ryu,Byung Ryul Sung,Chang Suk Huh,Si Hwan Ryu 한국육종학회 2004 한국육종학회지 Vol.36 No.3

A single cross, Jangdaok, is an yellow dent maize hybrid (Zea mays L.) developed by the maize breeding team at the National Institute of Crop Science (NICS), RDA in 2003. This hybrid, which has a high yield of dry matter, total digestible nutrients (TDN)

Clinical course in children with equivocal appendicitis on computed tomography: a retrospective cohort study

Hee-Beom Yang*,Han-Byol Song*,Ji-Won Han,Joong Kee Youn,Dayoung Ko,Young Jin Ryu,Ji Young Kim,Hyun-Young Kim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.104 No.1

Purpose: Appendectomy is one of the most common surgeries in children. Although various radiological examinations are performed, they do not always reveal a definitive diagnosis of appendicitis. This study aimed to investigate the clinical course of equivocal appendicitis, identify the factors associated with appendectomy, and suggest appropriate management for these patients. Methods: Patients younger than 19 years who visited Seoul National University Bundang Hospital with a differential diagnosis of appendicitis from January 2013 to December 2017 were included. All participants conducted ‘appendiceal CT’ with a scoring scale of 1–5. The higher the score, the higher the likelihood of a radiologic diagnosis of appendicitis. We defined the appendicitis CT score of 2–4 as equivocal appendicitis (n = 143). Medical records were reviewed retrospectively for demographics, further examination as abdominal ultrasonography, and appendectomy status (yes or no). The mean follow-up period was 15.6 ± 71 days. Results: Equivocal appendicitis accounted for 16.7%. Additional ultrasonography test was performed in 24.5% (35 of 143). In total, 34 patients (23.8%) underwent appendectomy. Among the patients with appendiceal CT scores 2, 3, and 4, 4.9%, 50.0%, and 87.5% underwent appendectomy, respectively. Higher WBC count, higher appendicitis CT score, and readmission were significantly associated with appendectomy in patients with equivocal appendicitis. Conclusion: Higher appendicitis CT score and WBC level were positively associated with appendectomy. Careful observation can be a treatment option in appendicitis CT score 2 or 3 groups. Appendectomy is the first-line treatment for patients with appendicitis score 4. Additional ultrasonography test is advisable to determine treatment modality for equivocal appendicitis.

Original article : Simultaneous analysis and monitoring of thirteen preservatives in cosmetics by liquid chromatography

( Yong Jae Ryu ),( Gun Mook Yoon ),( Bang Han Yun ),( Bo Young Lee ),( Pil Ki Min ),( Ji Young Yun ),( Sang Yoon Nam ),( Beom Jun Lee ),( Young Won Yoon ) 한국예방수의학회 2013 예방수의학회지 Vol.37 No.2

The content of 13 preservatives was investigated for 107 sold in retail markets. A simultaneously analytical method of liquid chromatography, LC, for the preservatives in cosmetics was developed using an AvQuityTM Ultra performance LC System, Waters, BEH C18 column, 150mmx2.1mm,1.7 ㎛, and photo Diode Array, PDA, detector λ;220 nm for quantitative analysis, λ;190∼400nm for qualitative analysis. The developed instrumental method was validated using limit of detection, LOD, limit of quantification, LOQ, precision, accuracy, and linearity of standard curves. LOD and LOQ wre lower than 0.23mg/l and 0.75mg/l, respectively. When standard compounds were analyzed seven times consecutively at the LOQ level, precision and accuracy were lower than 2.49% and, 2.04%, respectively. Good linear relationships, R2 ⊇0.9998, were obtained for all compounds. Recoveries ranged between 96.03% and 102.61%and the overall variability was below 3%, RSD, The type of cosmetics showing the lowest detection rate of target compounds was sunscreen lotion, with a detection rate of 42.9%, followed by baby lotions and mask packs with the same detection rate at 69.2% At least one of the target preservatives was detected in 82.4% of creams, 93.3% of skin toners, 95.2% of lotions, and 92.9% of body lotions. Overall 79.4% of all samples contained at least one of the target compounds. The most frequently detected compound was phenoxyethanol. Methyl and propyl paraben also had a higher detection rate than the others, except, phenoxyethanol. Although the target preservatives in cosmetics sold in retail markets were detected by the simultaneous analysis of LC, the content of the detected preservatives was within the maximum allowed amount established by the Korean FDA.

악성 위출구 협착에서의 경구적 자가확작형 금속제 인공관 유치의 유용성 : 경내시경적 인공관을 중심으로

조주영,김영석,김진오,이문성,고봉민,심찬섭,조영덕,문종호,유창범,천영국,이준성 대한소화기내시경학회 2000 Clinical Endoscopy Vol.21 No.1

Background/Aims : Placement of stents in cases of inoperable malignant gastric outlet obstruction is difficult due to anatomical and technical problems. The aim of this study was to assess the feasibility, effectiveness, safety, and long-term outcome of a self-expandable metal stent (SEMS) as a means of providing palliative care for patients with an inoperable malignant gastric outlet obstruction, Methods : Fifty-one consecutive patients (53 cases of stent insertion) with onoperable gastric outlet obstruction were treated palliatively with EsophaCoil, Choo's stent, or through-the-scope (TTS) stent. Results : Technical Success was achieved in 46 cases (86.8%). Six cases of stent insertion failure were caused by acute angulation of the stenotic area and sereve distal luminal narrowing. The other failed case was due to the inappropriate location of the stent. In 41 cases, the patients (89.1%) could ingest soft or solid foods after successful insertion of the stents. All the remaining 16 cases of TTS SEMS had technical and clinical successes. During the follow-up (mean; 3.3±1.1 months, range; 1∼11 months), there was 1case of aspiration pneumonia, 1 case of bowel perforation, 2 cases of stent migration, and 2 cases of stent occlusion by tumor ingrowth. Conclusions ; Placement of a SEMS, especially TTS SEMS in patients with malignant gastric outlet obstruction is a feasible, effective, and safe palliative therapy.