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Bei Jiang,Ling Guo,Bao-Ying Li,Jun-Hui Zhen,Jian Song,Tao Peng,Xiang-Dong Yang,Zhao Hu,Hai-Qing Gao 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.6
Diabetic nephropathy (DN) is the major cause of end-stage renal disease. Resveratrol has been shown to ameliorate hyperglycemia in diabetic rats. However, the effects of resveratrol on DN remain unknown. The aim of the present study is to investigate the effects of resveratrol on early-stage DN. Diabetes was induced by streptozotocin injection in male Wistar rats. The diabetic rats were treated with resveratrol at a dose of 20 mg/kg body weight for 8 weeks. Plasma glucose, creatinine, kidney/body weight ratio, and 24-h urinary protein were determined. The renal pathological changes were examined with periodic acid Schiff staining, and renal mesangial cells were cultured in high glucose concentrations with indicated concentrations of resveratrol (2.5, 5.0, and 10.0 lmol/L). The proliferation of mesangial cells was evaluated by methylthiazoletetrazolium assay. Expressions of glutathione S-transferases Mu (GSTM) and nuclear factor erythroid 2-related factor 2 (Nrf2) were detected by western blot, and apoptosis was analyzed using a flow cytometer. Resveratrol reduced plasma glucose, creatinine, and urinary protein excretion, and attenuated renal hypertrophy. Moreover, resveratrol also reduced the expression of GSTM in diabetic rats. In vitro, resveratrol inhibited the proliferation of mesangial cells caused by high glucose and down-regulated GSTM and Nrf2 expressions in a dose-dependent manner. These findings suggest that resveratrol help prevent the progression of DN. The renoprotection by resveratrol is in part mediated through the inhibition of high glucoseinduced rat mesangial cell proliferation and downregulation of GSTM expression.
Bei Jiang,Zhiying Wang,Chuxuan Xu,Weijia Liu,Donghua Jiang 한국미생물학회 2019 The journal of microbiology Vol.57 No.7
To screen for Aspergillus activity against Xanthomonas oryzae pv. oryzae and analyse the antimicrobial components involved, 60 Aspergillus spp. were isolated and purified from fruits, soil and other habitats. As-75, an Aspergillus strain that can antagonize Xanthomonas oryzae pv. oryzae, was identified based on the zone of inhibition formed during co-culture. According to morphological, ITS rDNA gene sequencing and phylogenetic tree results, the strain showed close homology to Aspergillus sclerotiorum. The biochemical characterization tests showed that the fermentation broth of strain As-75 exhibited a high capacity for environmental adaptation. The results of the antimicrobial spectrum experiments demonstrated that As-75 exhibited fairly strong antagonistic activity against five plant pathogenic fungi and six plant pathogenic bacteria in vitro. The fermentation broth of strain As-75 displayed maximum stability under fluorescent illumination at temperatures below 60°C at pH 6.5. A substance with antagonistic activity was obtained from strain As-75 via fractional extraction, silica gel column chromatography and thinlayer chromatography. Through mass spectrometry, nuclear magnetic resonance and electrospray ionization mass spectrometry (ESI-MS) analyses, the target compound was identified as (2Z)-2-butenedioic acid-2-(1-methylethenyl)-4-methyl ester; its molecular weight of 170.06 daltons and formula of C8H10O4 identify it as a novel compound. Trials of the preventative and curative effects demonstrated that compound S1 exhibited a better control efficiency than the control against rice bacterial blight. Additionally, the M1 processing method was better, and the efficiency of compound S1 in preventing rice bacterial blight in six rice varieties, TN1, IR24, ZF802, Zhonghua 11, Wuyunjing 21, and Nipponbare, was 78.3%, 77.5%, 74.2%, 75.3%, 70.9%, and 72.1%, respectively.
Bei Wang,Xuefeng Yan,Qingchao Jiang 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.6
Considering the huge number of variables in plant-wide process monitoring and complex relationships(linear, nonlinear, partial correlation, or independence) among these variables, multivariate statistical process monitoring(MSPM) performance may be deteriorated especially by the independent variables. Meanwhile, whether related variableskeep high concordance during the variation process is still a question. Under this circumstance, a multi-block technologybased on mathematical statistics method, Kullback-Leibler Divergence, is proposed to put the variables having similarstatistical characteristics into the same block, and then build principal component analysis (PCA) models in each lowdimensionalsubspace. Bayesian inference is also employed to combine the monitoring results from each sub-blockinto the final monitoring statistics. Additionally, a novel fault diagnosis approach is developed for fault identification. The superiority of the proposed method is demonstrated by applications on a simple simulated multivariate processand the Tennessee Eastman benchmark process.
Jiang, Chang,Liao, Fang-Xin,Rong, Yu-Ming,Yang, Qiong,Yin, Chen-Xi,He, Wen-Zhuo,Cai, Xiu-Yu,Guo, Gui-Fang,Qiu, Hui-Juan,Chen, Xu-Xian,Zhang, Bei,Xia, Liang-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Objective: To compare the efficacy of taxane-based regimens in the first line setting retrospectively in Chinese patients with recurrent and/or metastatic esophageal cancer. Methods: We analyzed 102 recurrent and/or metastatic esophageal cancer patients who received taxanes-based regimens in a first-line setting from January 2009 to December 2013. Sixteen (15.7%) patients were administered Nab-PTX based chemotherapy and 86 patients (84.3%) received paclitaxel (PTX) or docetaxel (DTX) based chemotherapy. Patients in the PTX/DTX group could be further divided into TP (71 patients) and TPF (15 patients) groups. Results: The objective response rate (ORR) of all patients was 20.6%, and the disease control rate (DCR) was 67.6%. The median overall survival (OS) was 10.5 months (95% CI 10.1-16.4) and the median progression-free survival (PFS) was 6.04 months (95% CI 5.09-7.91). The DCR was higher in the TPF group than the TP group (93.3% vs. 59.1%; p = 0.015 ). There were no significant differences in ORR, OS, and PFS among Nab-PTX, TPF and TP groups. Conclusions: The three regimens of Nab-PTX based, TP and TPF proved active in a first line setting of Chinese patients with recurrent and/or metastatic esophageal cancer, and should thus be regarded as alternative treatments.
A Novel Three-Phase Four-Wire Grid-Connected Synchronverter that Mimics Synchronous Generators
Qian Tan,Zhipeng Lv,Bei Xu,Wenqian Jiang,Xin Ai,Qingchang Zhong 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6
Voltage and frequency stability issues occur in existing centralized power system due to the high penetration of renewable energy sources, which decrease grid absorptive capacity of them. The grid-connected inverter that mimics synchronous generator characteristics with inertia characteristic is beneficial to electric power system stability. This paper proposed a novel three-phase four-wire grid-connected inverter with an independent neutral line module that mimics synchronous generators. A mathematical model of the synchronous generator and operation principles of the synchronverter are introduced. The main circuit and control parameters design procedures are also provided in detail. A 10 ㎾ prototype is built and tested for further verification. The primary frequency modulation and primary voltage regulation characteristics of the synchronous generator are emulated and automatically adjusted by the proposed circuit, which helps to supports the grid.
Prognostic Model Built on Blood-based Biomarkers in Patients with Metastatic Colorectal Cancer
He, Wen-Zhuo,Jiang, Chang,Yin, Chen-Xi,Guo, Gui-Fang,Rong, Ru-Ming,Qiu, Hui-Juan,Chen, Xu-Xian,Zhang, Bei,Xia, Liang-Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: We had previously showed that the neutrophil lymphocyte ratio (NLR), ${\gamma}$-glutamyl transpeptidase (GGT) and carcinoembryonic antigen (CEA) are prognostic factors for metastatic colorectal cancer (mCRC) patients. In this study we developed a prognostic model based on these three indices. Materials and Methods: A total of 243 patients who were initially diagnosed as mCRC between 2005 and 2010 in the Sun Yat-sen University Cancer Center were studied. The endpoint was overall survival (OS). Results: NLR>3, elevated GGT and elevated CEA were confirmed as independent risk factors which could predict poor prognosis. Patients could be divided into three groups according to the number of risk factors they had. Those with two or three were defined as the high risk group, individuals with one risk factor as the modest risk group and patients without risk factor as the low risk group. The OS values for these three groups were 16.2 months (2.80~68.8), 24.2 months (4.07~79.0), and 37.2 months (12.6~87.8), respectively (p<0.001). Conclusions: We developed a simple but useful model based on NLR, GGT and CEA to provide prognostic information to clinical practice in highly selected mCRC patients. Further prospective and multi-center studies are warranted to test our model.
Xiaofeng Zhu,Jiaguo Yu,Chuanjia Jiang,Bei Cheng 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-
Formaldehyde (HCHO) catalytic decomposition at room temperature is an important method for HCHOremoval in indoor environment. Herein,flower-like g-Al2O3 microspheres with high specific surface area,special textural structure, and abundant surface defects were prepared through a one-pot hydrothermalmethod by using aluminum foil as Al source. And it was used as oxide support to prepare highly-dispersed Pt catalyst (Pt/Al2O3). Compared with Pt supported on commercial g-Al2O3, the as-prepared Pt/Al2O3 showed enhanced catalytic activity for HCHO decomposition at room temperature. This workprovides new insights into designing and fabricating highly-dispersed Pt catalysts for efficient indoor airpurification.
Jing Li,Li Zhu,Xiao-Bei Zhan,Min Xu,Chi Chung Lin,Zhiyong Zheng,Wei-Jiang Li 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.3
Endo-β-1,3-glucanase (Endo23) was purifiedfrom a Trichoderma reesei GIMCC 3.498 fermentationbroth using anion exchange and 2-stage size exclusionchromatography. Purification of 44.5× and a 12% recoveryyield of enzyme activity were achieved. The Mw andisoelectric point were estimated to be 24 kDa and 3.85using SDS-PAGE and IEF, respectively. The highestsubstrate specificity was observed for water-insoluble curdlan. The optimal conditions for hydrolyzing curdlan were pH5.0 and 50oC. The main hydrolytic products were glucobioseand glucotriose. Minor amounts of glucose and glucotetraosewere detected. Hg2+, Fe2+, Fe3+, and Sn2+ inhibited thehydrolysis activity of Endo23 at 5 and 50 mM. K+ slightlypromoted Endo23 activity. Endo23 belongs to the categoryEC3.2.1.39. The peptide sequences of Endo23 showedidentity with conserved sequences that typically exist in β-1,3-glucanases of the glycoside hydrolase family. TheEndo23 sequence was partially similar to a hypotheticallignocellulase from Penicillium oxalicum 114-2.