Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm

Ying Zou,Shi-Xue Dai,Hong-Gang Chi,Tao Li,Zhi-Wei He,Jian Wang,Cai-Guo Ye,Guo-Liang Huang,Bing Zhao,Wen-Yang Li,Zheng Wan,Jin-Shan Feng,Xue-Bao Zheng 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10

Baicalin, a flavonoid, has a wide range ofpharmacological properties, including immunomodulation. The objective of this study was to investigate the effect ofbaicalin on the balance of T helper 17 (Th17) and regulatoryT (Treg) cells in a colitis model. The rat colitis modelwas induced by 2,4,6-trinitrobenzene sulfonic acid(TNBS). Baicalin (10 ml/kg, each) or mesalazine (positivecontrol) was then administered orally for 7 days. Inflammatoryand immunological responses were evaluated bypathology, enzyme-linked immunosorbent assay, real-timepolymerase chain reaction, western blot analysis, and flowcytometry. Our study showed that baicalin not only significantlyattenuated TNBS-induced colitis by reducing thedisease activity index as well as macroscopic and microscopicscores, but it also improved the weight loss andshortening of the colon. Baicalin treatment also induced asignificant decrease in the levels of inflammatory mediators,including the myeloperoxidase activity, the levels oftumor necrosis factor a, IL-1b, and Th1-related cytokinesIL-12 and IFN-c. Furthermore, the beneficial effects ofbaicalin seem to be associated with regulation of the Th17and Treg paradigm. We found that administration ofbaicalin significantly downregulated the number of Th17cells and the levels of Th17-related cytokines (IL-17 andIL-6) and retinoic acid receptor-related orphan receptor ct. In contrast, there was an increase in Treg cells numbers,Treg-related cytokines transforming growth factor-b andIL-10, and forkhead box P3. Our results suggest that theanti-inflammatory effect of baicalin may be linked tomodulation of the balance between Th17 and Treg cells inTNBS-induced ulcerative colitis.

Codelivery of hydrophilic and hydrophobic drugs in a microneedle patch for the treatment of skin pigmentation

Li Qin Zhang,Xiao Peng Zhang,Yu Ying Hao,Bao Li Zhang,Xin Dong Guo 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.88 No.-

When overexposed to ultraviolet B (UVB) irradiation, skin can cause a series of abnormal reactions, suchas excessive pigmentation and solar elastosis. In order to better treat the skin after overexposed to UVB,we designed a dissolving microneedles (MNs) loading hydrophilic ascorbic acid and hydrophobic vitaminA palmitate to achieve codelivery. Here, we confirmed that MNs had enough mechanical strength toinsert the skin and two drugs were delivered subcutaneously in sequence in vitro. In white guinea pigs,surface observation and histological observation results confirmed that two drugs by MNs transdermaldelivery were better than topical administration in the treatment of UVB-damaged skin. The MNs providea method of loading different drugs into the needles and advance the development of transdermal drugdelivery.

Acupuncture for Treatment of Erectile Dysfunction: A Systematic Review and Meta-Analysis

Bao-yong Lai,Hui-juan Cao,Guo-yan Yang,Li-yan Jia,Suzanne Grant,Yu-tong Fei,Emma Wong,Xin-lin Li,Xiao-ying Yang,Jian-ping Liu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.3

ChinaPurpose: To assess the effectiveness and safety of acupuncture for erectile dysfunction (ED).Materials and Methods: We searched six major English and Chinese databases included randomized controlled trials (RCTs) testing acupuncture alone or in combination for ED. Dichotomous data were presented as risk ratio (RR) and continuous data were presented as mean difference (MD) both with 95% confidence interval (CI). The Revman (v.5.3) was used for data analyses. Quality of evidence across studies was assessed by the online GRADEpro tool.Results: We identified 22 RCTs, fourteen of them involving psychogenic ED. Most of the included RCTs had high or unclear risk of bias. There was no difference between electro-acupuncture and sham acupuncture with electrical stimulation on the rate of satisfaction and self-assessment (RR, 1.50; 95% CI, 0.71–3.16; 1 trial). Acupuncture combined with tadalafil appeared to have better effect on increasing cure rate (RR, 1.31; 95% CI, 1.00–1.71; 2 trials), and International Index of Erectile Function-5 scores (MD, 5.38; 95% CI, 4.46–6.29; 2 trials). When acupuncture plus herbal medicine compared with herbal medicine alone, the combination therapy showed significant better improvement in erectile function (RR, 1.68; 95% CI, 1.31–2.15; 7 trials). Only two trials reported facial red and dizziness cases, and needle sticking and pruritus cases in acupuncture group. Conclusions: Low quality evidence shows beneficial effect of acupuncture as adjunctive treatment for people mainly with psychogenic ED. Safety of acupuncture was insufficiently reported. The findings should be confirmed in large, rigorously designed and well-reported trials.

Partnership Between Families of Children with Muscular Dystrophy and Health-care Professionals: From Parents' Perspective

Bao-Huan Yang,Chia-Ying Chung,Yuh-Shiow Li 한국간호과학회 2018 Asian Nursing Research Vol.12 No.2

Purpose: At present, there is still controversy between parents of children with muscular dystrophy (MD) and health-care professionals on care issues. Partnerships can connect the affected children and their families to appropriate health-care services, to jointly face the care environment together and thereby improve the quality of life of children with MD. Therefore, the objective of this study is to explore partnerships between families and health-care professionals from the perspectives of parents of children with MD. Methods: Husserl's phenomenological research was applied to explore the basic structures of parents' descriptions of MD. Through purposive sampling, we conducted in-depth interviews with parents, and analyzed the data according to the theory of Giorgi. Nineteen parents (10 mothers, 9 fathers) participated in this study. The precision of the research results was tested by applying the four standards of Lincoln and Guba. Results: This study identified five constituents: feasible resources and detailed care information; the provision of an integrated medical care across systems; family and home as key elements in critical care; respect and care for family care demands; and finally, feedback and support from families. Conclusion: This study demonstrated that partnerships were established by health-care professionals, enhancing the care capacity of the families, developing the preventive medicine of MD, and enhancing children's potential for self-care within the families. Hospital policies should include the promotion of family partnership care. The findings can help health-care professionals recognize the life experiences of children with MD when providing medical care.

Self-care Experiences of Adolescents with Spinal Muscular Atrophy

Bao-Huan Yang,Chia-Ying Chung,Wen-Chin Weng,Kao-Wen Lo,Yuh-Shiow Li 한국간호과학회 2021 Asian Nursing Research Vol.15 No.4

Purpose: We examined the self-care experiences of adolescents with spinal muscle atrophy (SMA) and their perceptions of the interactions between their body and the environment. Methods: We interviewed ten adolescents with SMA aged 13-18 years regarding personal care practices. Purposive sampling was conducted in two medical centers in northern Taiwan. Data were analyzed using the Giorgi analysis method. Results: Four constitutions were identified: (1) limited space for independent development, (2) multiple reconstructions of self-image to improve physical ability, (3) self-care of disease, and (4) developing activity styles to accommodate social culture. Conclusion: The self-care lived experiences of patients reflect dynamic changes in the body and environment. Self-existence was exhibited by adjustment, practice, and creativity of physical activity to integrate into society. Nursing staff should understand the self-care experiences and needs of adolescents with SMA to develop a database of self-care skills. This study recommended that nursing staff improve their ability to guide patients in taking care of themselves by developing body awareness self-care courses and individual care plans in response to various stages of disability to help patients delay deterioration, realize their physical potential, and promote independence and social development.

Mycena subpiligera sp. nov., a Symbiotic Species from China Associated with the Seed Germination of Gastrodia elata

Li-na Liu,Guo-ying Zhou,Ai-rong Shen,Bao-ming Shen,Yun Tan,Zhu-ming Tan 한국균학회 2022 Mycobiology Vol.50 No.5

Mycena subpiligera, a new taxon in sect. Fragilipedes that can strongly enhance the germin- ation efficiency of Gastrodia elata seeds, was discovered in subtropical areas of China. As revealed by a morphological comparison with related Mycena species as well as maximum likelihood (ML) and Bayesian phylogenetic analyses based on sequences of the internal tran- scribed spacer (ITS) and the large subunit (LSU) regions of nuclear ribosomal RNA, the new taxon can be distinguished from phenotypically similar and phylogenetically related species. Optimal cultural conditions for M. subpiligera basidiomata are reported, and the germination rate of the new species is compared with that of M. citrinomarginata.

PARALLEL IMAGE RECONSTRUCTION FOR NEW VACUUM SOLAR TELESCOPE

Xue-Bao Li,Feng Wang,Yong Yuan Xiang,Yan-Fang Zheng,Ying Bo Liu,Hui Deng,Kai-fan Ji 한국천문학회 2014 Journal of The Korean Astronomical Society Vol.47 No.2

Many advanced ground-based solar telescopes improve the spatial resolution of observation images using an adaptive optics (AO) system. As any AO correction remains only partial, it is necessary to use post-processing image reconstruction techniques such as speckle masking or shift-and-add (SAA) to reconstruct a high-spatial-resolution image from atmospherically degraded solar images. In the New Vacuum Solar Telescope (NVST), the spatial resolution in solar images is improved by frame selection and SAA. In order to overcome the burden of massive speckle data processing, we investigate the possibility of using the speckle reconstruction program in a real-time application at the telescope site. The code has been written in the C programming language and optimized for parallel processing in a multi-processor environment. We analyze the scalability of the code to identify possible bottlenecks, and we conclude that the presented code is capable of being run in real-time reconstruction applications at NVST and future large aperture solar telescopes if care is taken that the multi-processor environment has low latencies between the computation nodes.

H∞ Control with Multiple Packets Compensation Scheme for T-S Fuzzy Systems Subject to Cyber Attacks

Xiu-Ying Li,Bao-Jun Wang,Lei Zhang,Xiang-Hua Ma 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1

This paper is concerned with the H∞ controller design problem for a class of network-based nonlinearsystems (NCSs) represented by the Takagi-Sugeno (T-S) fuzzy model. A multiple packets compensation schemeis developed which uses all the data stored in a finite memory buffer to compensate the negative effects of packetdropouts. This model contains the medium access constraint problem as a special case. The time-multiplexingmechanism may be used for such a case so that there are multiple packets arrive at the receiver side. By taking thestochastic cyber attacks into account, the desired controller in terms of linear matrix inequalities (LMIs) is designedby using fuzzy-rule-dependent Lyapunov method. The sufficient condition is obtained which makes the closed-loopsystem be asymptotically mean-square stable and achieve the prescribed H∞ disturbance-rejection-attenuation level. Finally, a mass-spring-damping system is given to show the effectiveness of the algorithm.

Influence of Vanadium Substitution on Phase Structure, Magnetic and Dielectric Properties of BiFeO₃ Ceramics

Qiang Li,Shengxiang Bao,Tao Hong,Libo Ai,Yingli Liu,Yulan Jing,Jie Li 한국자기학회 2018 Journal of Magnetics Vol.23 No.1

BiFe1-xVxO₃ (x = 0.00, 0.03, 0.05, 0.07, 0.09) ceramics were prepared by solid-sate reaction method. The effect of V<SUP>5+</SUP> substitution on phase structure, morphology, magnetic and dielectric properties had been investigated. The Rietveld refinement of the X-Ray diffraction data from the BiFe1-xVxO₃ (BFVO) ceramics showed samples with rhombohedral structure (R3c) for x = 0.00-0.07. When x = 0.09, partial phase structural be translated to orthorhombic phase (Pnma). Morphology showed two kinds of crystal and proved the phase to be transition. Magnetic measurements exhibited weak ferromagnetic behavior of sample. BiFe0.93V0.07O₃ ceramic exhibited the highest value of saturation magnetization. Due to V<SUP>5+</SUP> substitution, maybe BFVO attributed weak ferromagnetism to structure distortion and phase transition. Dielectric constant kept a stable value in a wide range frequency of 1 MHz to 1 GHz. With V<SUP>5+</SUP> ions increasing, dielectric constant increased significantly, while dielectric loss kept a low value. These results indicated that BFVO may be promising for application in magneto-electric devices.

Model Predictive Current Control for Dual Three-Phase Permanent Magnet Synchronous Motor Based on Active Disturbance Rejection

Zhao Li-Ping,Ge Bao-Jun,Gao Han-Ying,Tao Da-Jun 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5

In order to improve the dynamic performance of dual three-phase permanent magnet synchronous motor (DTP-PMSM) and the problems of large current ripples, an improved model predictive current control (MPCC) method of DTP-PMSM combined with linear active disturbance rejection control (ADRC) is proposed. An improved MPCC strategy for the purpose of reducing voltage vector control error is proposed, based on the largest and second largest voltage vector control sets. The cost function of restraining harmonic plane current is established, and the three-step model predictive current control is carried out. Aiming at the problems of steady-state error and low prediction accuracy caused by motor parameters and external disturbance, the linear ADRC is adopted. The second-order linear extended state observer is introduced to improve the difficult problem of multi parameter tuning of nonlinear extended state observer. Through simulation and experiment of the proposed method for DTP-PMSM, the results verify the effectiveness and feasibility of the method.