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Lack of Association Between CYP1A1 Polymorphisms and Risk of Bladder Cancer: a Meta-analysis
Lu, Yu,Zhang, Xiao-Lian,Xie, Li,Li, Tai-Jie,He, Yu,Peng, Qi-Liu,Deng, Yan,Wang, Jian,Qin, Xue,Li, Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.9
Background: The effects of CYP1A1 gene polymorphisms on the risk of bladder cancer (BC) remain controversial. We carried out a meta-analysis to clarify the role of CYP1A1 gene polymorphisms in BC. Material and Methods: A comprehensive literature search was conducted up to November 20, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of the association. Meta-regression, subgroup analysis, sensitivity analysis and publication bias were also performed. Results: Eight studies involving 1,059 BC cases and 1,061 controls were included. The meta-analysis showed that there was no significant association between the two common mutations of CYP1A1 and BC risk. For the I1e462Val A/G polymorphism with GG vs. AA the OR was 1.47 (95 % CI= 0.70-3.07, P =0.308). For the MspI T/C polymorphism, though a slight trend was found this was not statistically nonsignificant (CC vs.TT, OR = 1.24, 95 % CI= 0.98-1.58, P =0.078). Subgroup analyses by ethnicity also found no obvious association between CYP1A1 and BC risk. Conclusion: The present meta-analysis suggests that CYP1A1 polymorphism is not associated with bladder cancer risk.
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Zhang, Xiao-Lian,Lu, Yu,Yang, Shi,Peng, Qi-Liu,Wang, Jian,Xie, Li,Deng, Yan,He, Yu,Li, Tai-Jie,Qin, Xue,Li, Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. The purpose of this updated meta-analysis was to examine whether XRCC1 Arg399Gln polymorphism confers susceptibility to HCC. Methods: Eligible studies extracted from PubMed, Embase, Cochrane Library, VIP (chinese) and CNKI (chinese) up to November 2013 were included in the study. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk. Results: Finally, 21 studies with 4,170 cases and 5,030 controls were involved in our meta-analysis. The results demonstrated that there was significant association between Arg399Gln polymorphism and HCC risk under two contrast models in overall populations (AG vs GG: OR=1.265, 95%CI=1.036-1.545, p=0.021; AA+AG vs GG: OR=1.240, 95%CI=1.021-1.506, p=0.030). In subgroup analyses, significant association was found in Asians (A vs G: OR=1.175, 95%CI=1.013-1.362, p=0.033; AG vs GG: OR=1.317, 95%CI=1.070-1.622, p=0.009; AA+AG vs GG: OR=1.289, 95%CI=1.055-1.575, p=0.013) and Caucasians (A vs G: OR=0.591, 95%CI=0.361-0.966, p=0.036; AA+AG vs GG: OR=0.468, 95%CI=0.234-0.934, p=0.031). Conclusions: The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians. However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.
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Haroon,Li Yu‐Xin,Ye Chen‐Xu,Ma Xiao‐Qin,Su Jian,Su Xiao‐Hong,Xing Lian‐Xi 한국곤충학회 2021 Entomological Research Vol.51 No.9
Aging and longevity is a dynamic, chronological process assumed to originate from several hallmarks causing archetypal and beguiling cycles with incredible natural diversity. This phenomenon is widely observed in different animals, and the estimated age of Drosophila melanogaster, Caenorhabditis elegans, Daphnia longispina are a few days to weeks. Reproductive termites live for 30 years, although the root cause of longevity in termite castes is still debated for molecular and cellular changes. Insulin and insulin signaling pathway-related (IIS) genes are important metabolic factors (glucose) highly conserved in lower to higher organisms. Therefore, in this study, we pooled Reticulitermes chinensis castes as primary king (PK), primary queen (PQ), ergatoid king “SWRK” and queen “SWRQ”,male (WM), and female (WF) workers. We determined transcriptome sequencing of R. chinensis castes as a model organism for longevity to investigate the insulin signaling pathway and longevity genes. Through RNA-sequencing, we identified 35 IIS- pathway-related genes out of 343 to the KEGG pathway in ergatoid king and queen, PK, PQ, WM, and WF. Among these genes, Ts c 2 , akt2-a, mTOR, EIF4E, Pdk1,and RPS expressed highly in ergatoid king and queen, PK, and PQ. However, a significant cornerstone tradeoff between reproductive and non-reproductive efforts for early life is essential for evolutionary longevity. The present study concludes that a highly conserved IIS-pathway is evidence for the prolonged termite reproductive life span. We recommended devoting insulin signaling pathway genes to their biological function for termite survival and new insights into the maintenance and relationships between biomolecular homeostasis and remarkable longevity.
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