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Junko Ogawa(Junko Ogawa ),Seiko Mochida(Seiko Mochida ),Haruo Kimura(Haruo Kimura ),Aiping Liu(Aiping Liu ),Yoichi Sakakihara(Yoichi Sakakihara ) The Pacific Early Childhood Education Research Ass 2024 Asia-Pacific journal of research in early childhoo Vol.18 No.1
This study aimed to obtain implications on childrearing and childcare practices for achieving children's well-being through analyzing factors predicting children's well-being during the COVID-19 pandemic in eight Asian countries. We primarily focused on “resilience,” the ability to cope with and recover from difficult situations, which had been confirmed from previous studies as a positive factor towards children’s development in the context of hardships. We also chose other potential predictors referring to Bronfenbrenner’s ecological systems theory, including mothers’ concerns about COVID-19, household income, number of playmates, support from childcare facilities/schools, family environments, and children’s lifestyles, and examined how these predictor variables predict children’s well-being. We found that children’s resilience strongly predicted their well-being, which was common in all eight countries. Family factors and children's daily life factors were also associated with children's well-being. The country-specific analysis also indicated the importance of support from childcare facilities/schools on well-being. Well-being and resilience are both psychological constructs and often studied as important indicators of child health. Resilience has been spot-lighted as an effective protective factor for children experiencing adversities such as the COVID-19 pandemic. We have found that resilience was the strongest predictor of well-being among other factors even during the COVID-19 pandemic.
Cao Aiping,Gao Ling,Wang Fei,Tong Xuechen,Xie Shuangquan,Chen Xifeng,Lu Tianxin,Shen Haitao,Liu Hailiang,Jin Xiang,Li Hongbin 한국유전학회 2022 Genes & Genomics Vol.44 No.7
Background: Mitogen-activated protein kinases (MPKs) play important role in response to environmental stress as crucial signal receptors or sensors. Our previous study indicated that salt stress acts as a positive factor to stimulate the production of pharmacodynamic metabolites in the medicinal plant Glycyrrhiza uralensis. Currently, little is known about the MPK gene family and their functions in the medicinal plant G. uralensis. Objective: Identification, comprehensive bioinformatic analysis, expression profiling, and response pattern under salt stress of the G. uralensis GuMPK gene family. Methods: Genome-wide investigation and expression profiling of the MPK gene family in G. uralensis, and their phylogenetic relationships, evolutionary characteristics, gene structure, motif distribution, promoter cis-acting element, and expression pattern under salt stress in two different salt-tolerant Glycyrrhiza species were performed. Results: A total of 20 G. uralensis GuMPK genes were identified and categorized into five groups, and had conserved gene structure and motif distribution. Expression profiling of GuMPK genes suggested their potentially diverse functions in plant growth and in response to phytohormones and environmental stress, particularly GuMPK1, 2, 5, and 10 as key components for G. uralensis in response to abiotic stress. Further expression analysis under NaCl treatment in two different salt-tolerant Glycyrrhiza species displayed the MPKs' different response patterns, emphasizing the role of MPK2, 5, 7, and 16 as potentially crucial genes for Glycyrrhiza to respond to salt stress. Conclusion: Our results provide a genome-wide identification and expression profiling of MPK gene family in G. uralensis, and establish the foundation for screening key responsive genes and understanding the potential function and regulatory mechanism of GuMPKs in salt responsiveness.
Improved design method for line gear pair based on screw theory
Jiang Ding,Liwei Liu,Yuting Wei,Aiping Deng 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.4
The line gear (LG) is a novel gear mechanism based on conjugate space curve meshing theory. It is suitable for micro-mechanical systems due to its small size, light weight, and large transmission ratio. Since its invention, the LG pair has been studied from the perspective of differential geometry. To simplify the design process of the LG pair, we studied the LG pair from the innovative perspective of screw algebra. A unified screw coordinate was created for the LG pair, and velocity screws were established to derive its meshing equations. Moreover, the design equations of the center curves and contact curves were calculated for the driving line teeth and the driven line teeth, respectively. Finally, examples of LG pairs were fabricated for the kinematic performance tests, which indicated that the LG pairs designed according to screw theory were capable of performing a stable transmission.
Luo, Dandan,Ruan, Shichao,Liu, Aiping,Kong, Xiangdong,Lee, In-Seop,Chen, Cen Dove Medical Press 2018 International journal of nanomedicine Vol.13 No.-
<P><B>Background</B></P><P>Functionalizing biomaterial substrates with biological signals shows promise in regulating neural stem cell (NSC) behaviors through mimicking cellular microenvironment. However, diverse methods for immobilizing biological molecules yields promising results but with many problems. Biomimetic apatite is an excellent carrier due to its non-toxicity, good biocompatibility, biodegradability, and favorable affinity to plenty of molecules. Therefore, it may provide a promising alternative in regulating NSC behaviors.</P><P><B>Methods</B></P><P>Biomimetic apatite immobilized with the extracellular protein – laminin (LN) was prepared through coprecipitation process in modified Dulbecco’s phosphate-buffered saline (DPBS) containing LN. The amount of coprecipitated LN and their release kinetics were examined. The adhesion and proliferation behaviors of NSC on biomimetic apatite immobilized with LN were investigated.</P><P><B>Results</B></P><P>The coprecipitation approach provided well retention of LN within biomimetic apatite up to 28 days, and supported the adhesion and proliferation of NSCs without cytotoxicity. For long-term cultivation, NSCs formed neurosphere-like aggregates on non-functionalized biomimetic apatite. A monolayer of proliferated NSCs on biomimetic apatite with coprecipitated LN was observed and even more stable than the positive control of LN coated tissue-culture treated polystyrene (TCP).</P><P><B>Conclusion</B></P><P>The simple and reproducible method of coprecipitation suggests that biomimetic apatite is an ideal carrier to functionalize materials with biological molecules for neural-related applications.</P>
Cloning and Characterization of the IgA Fc Receptor from Swine
( Yumei Chen ),( Yunchao Liu ),( Gaiping Zhang ),( Hua Feng ),( Pengchao Ji ),( Guoqiang Wang ),( Chang Liu ),( Yapeng Song ),( Yunfang Su ),( Songlin Qiao ),( Aiping Wang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.12
The myeloid-specific IgA Fc receptor (FcαR) is a cell surface molecule on immunocytes that provides a fundamental connection between humoral and cellular immunity. In this study, the full-length cDNA sequence of swine FcαRI (swFcαRI) was isolated and characterized and found to contain a 792-base-pair open reading frame, encoding a 264-amino-acid transmembrane glycoprotein with a predicted molecular mass of 29.4 kDa. The swFcαRI shares high amino acid sequence homology (>50%) with its counterparts from cattle, seal, and horse. Rosetting analysis confirmed that COS-7 cells transfected with an swFcαRI expression plasmid was able to combine with chicken erythrocytes sensitized with porcine IgA, but not IgG.
Research on Laser Thread Form Bending of Stainless Steel Tube
Fuqiang Li,Shourong Liu,Aiping Shi,Qiulu Chu,Qiang Shi,Yuxiang Li 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.6
Compared to traditional bending methods, laser bending can yield products with better shapes and higher quality using the simpler equipment. In this paper, the mechanism of Laser-assisted tube bending is elaborated, and then the influence of processing parameters (including laser power, scanning speed, spot diameter, and scanning times) on the bending angle is studied with both the finite element method and experiments. The bending angle increases with an increase of laser power and spot diameter and with a decrease in the scanning speed. Three-dimensional (3D) thread form bending can be achieved by planning the optimal route, scanning parameters, and the number of laser scans. In contrast to the desired thread diameter of 20 mm and thread pitch of 180 mm, the resulting thread of the stainless steel tube is close to the target shape with errors of 3% for thread diameter and 2.5% for thread pitch, which are both in an acceptable range and thus verify the validity of the parameters selection and route planning method.
Hao Zhang,Jing Sun,Xianting Liu,Chuan Hong,Yuanbo Zhu,Aiping Liu,Siqi Li,Huiyuan Guo,Fazheng Ren 한국미생물학회 2013 The journal of microbiology Vol.51 No.6
Lactobacillus paracasei subsp. paracasei LC01 (LC01) can tolerate intestinal stresses and has antioxidant activity. To evaluate the effect of the bacterium on human intestinal microflora,a randomized, double-blind, placebo-controlled human trial was carried out. Fifty-two healthy adult volunteers were randomized equally to two groups. One group consumed 12% (wt/vol) skimmed milk supplemented with 1010 CFU of LC01 each day for the 4-week treatment period,and then consumed placebo in the next treatment period,separated by a 2-week washout. The other group followed the reverse order. Group-specific real-time PCR and biochemical analyses was used to determine the intestinal bacterial composition of fecal samples collected at the end of every period, and the concentration of short-chain fatty acids and ammonia. A significant inhibition in fecal Escherichia coli and increase in Lactobacillus, Bifidobacterium, and Roseburia intestinalis were observed after consumption of LC01. Acetic acid and butyric acid were significantly higher in the probiotic stage and fecal ammonia was significantly lower. The results indicated a modulation effect of LC01 on the intestinal microflora of young adults, suggesting a beneficial effect on bowel health. LC01 may have potential value as a probiotic.
( Jianhua Liang ),( Hui Qu ),( Xiaowen Wang ),( Aiping Wang ),( Lingling Liu ),( Ping Tu ),( Ruoyu Li ),( Mingyue Wang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of herpes family viruses has been observed in some DRESS patients, and activated CD8+ T lymphocytes are largely directed against Epstein-Barr virus. Here, we report two cases complicated with this infection. Both patients received antibiotics and non-steroidal anti-inflammatory drugs. These patients manifested clinically with high fever, facial edema, diffuse pruritic erythroderma and maculopapules over the entire body, purpuric rashes in both lower limbs and lymphadenopathy of cervical and inguinal nodes. Laboratory tests revealed abnormal liver function, blood eosinophils, and ferritin levels. The patients recovered completely; however, the female patient developed hemophagocytic syndrome on the 15th day of illness. She developed new itchy rash, and laboratory tests rapidly worsened with fibrinogen levels dramatically reduced to 0.61 g/L. Bone marrow aspiration revealed an increased number of macrophages with hemophagocytosis and a reversed CD4/CD8 ratio of 0.45. These cases suggest that human herpes virus and coagulation function evaluations are necessary in DRESS patients. (Ann Dermatol 30(1) 71∼74, 2018)
Identification of a mimotope of an infectious bronchitis virus S1 protein
Jingming Zhou,Jianan Li,Yanghui Li,Hongliang Liu,Yanhua Qi,Aiping Wang 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.4
The S1 protein of the infectious bronchitis virus (IBV) is a major structural protein that induces the production of the virus-neutralization antibodies. The monoclonal antibody against the IBV M41 S1 protein was used as a target for biopanning. After three rounds of biopanning, randomly selected phages bound to the monoclonal antibody. Sequence analysis showed that the dominant sequence was SFYDFEMQGFFI. Indirect competitive enzyme-linked immunosorbent assay showed that SFYDFEMQGFFI is a mimotope of the S1 protein that was predicted by PepSurf. The mimotope may provide information for further structural and functional analyses of the S1 protein.