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        Stabilization of Benchmark Under-actuated Systems via Saturated Controls

        Jun Liu,Huawen Ye,Xianting Qi 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.11

        In this paper, we present controllers to stabilize benchmark under-actuated systems such as inertia wheel pendulum (IWP), cart-pole, cart-pendulum, overhead crane, VTOL aircraft, ball-and-beam, translational oscillations with a rotational actuator (TORA), and active magnetic bearing (AMB). The mentioned systems are transformed into the feedforward systems subject to uncertain gains, the nested-saturation controllers in an almost unified form are then designed. Due to the analysis mechanism of saturation reduction (checking the time-derivatives of boundary surfaces), the bounds of uncertain gains can always be determined in small domains. In turn, there is no need to treat in advance certain subsystems, and the fully-saturated controllers (rather than partially-saturated ones) can be taken as global stabilizers. Moreover, the explicit inequality conditions can always be summarized. In addition, for the relatively complicated systems such as the overhead crane system, a non-strict upper-triangular subsystem of the ball-and-beam system as well as the TORA system, special technical strategies are developed to treat the linear perturbation, the non-strict upper-triangular structure and an oscillator.

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        Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults

        Hao Zhang,Jing Sun,Xianting Liu,Chuan Hong,Yuanbo Zhu,Aiping Liu,Siqi Li,Huiyuan Guo,Fazheng Ren 한국미생물학회 2013 The journal of microbiology Vol.51 No.6

        Lactobacillus paracasei subsp. paracasei LC01 (LC01) can tolerate intestinal stresses and has antioxidant activity. To evaluate the effect of the bacterium on human intestinal microflora,a randomized, double-blind, placebo-controlled human trial was carried out. Fifty-two healthy adult volunteers were randomized equally to two groups. One group consumed 12% (wt/vol) skimmed milk supplemented with 1010 CFU of LC01 each day for the 4-week treatment period,and then consumed placebo in the next treatment period,separated by a 2-week washout. The other group followed the reverse order. Group-specific real-time PCR and biochemical analyses was used to determine the intestinal bacterial composition of fecal samples collected at the end of every period, and the concentration of short-chain fatty acids and ammonia. A significant inhibition in fecal Escherichia coli and increase in Lactobacillus, Bifidobacterium, and Roseburia intestinalis were observed after consumption of LC01. Acetic acid and butyric acid were significantly higher in the probiotic stage and fecal ammonia was significantly lower. The results indicated a modulation effect of LC01 on the intestinal microflora of young adults, suggesting a beneficial effect on bowel health. LC01 may have potential value as a probiotic.

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        Analysis of Peripheral B Cell Subsets in Patients With Allergic Rhinitis

        Jing Luo,Huanhuan Guo,Zhuofu Liu,Tao Peng,Xianting Hu,Miaomiao Han,Xiangping Yang,Xuhong Zhou,Huabin Li 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.3

        Purpose: Recent evidence suggests that B cells can both promote and inhibit the development and progression of allergic disease. However, the characteristics of B cell subsets in patients with allergic rhinitis (AR) have not been well documented. This study aimed to analyze the characteristics of B cell subsets in the peripheral blood of AR patients. Methods: Forty-seven AR patients and 54 healthy controls were enrolled in this study, and the B cell subsets in peripheral blood of all subjects were analyzed by flow cytometry. Moreover, the serum total immunoglobulin E (IgE) and IgE concentrations secreted into the cultured peripheral blood mononuclear cells (PBMCs) were measured by using enzyme-linked immunosorbent assay. Results: We found the peripheral blood of AR patients contained higher percentages of memory B cells, plasma cells, and CD19+CD24hiCD27+ regulatory B cells (Bregs) than those of age-matched healthy controls (P<0.05), while the percentages of naïve B cells and CD19+CD24hiCD38hi Bregs were significantly lower in AR patients than in healthy individuals (P<0.05). In addition, the serum total IgE and IgE concentrations secreted into the cultured PBMCs were elevated in AR patients than in the healthy controls (P<0.05). Conclusions: Our findings indicate that AR patients were characterized by increase in terminally differentiated memory B cells or plasma cells and decreases in CD19+CD24hiCD38hi Breg cells in the peripheral blood.

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