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ICR 마우스를 이용한 팔물탕 및 발효팔물탕의 급성독성 연구
정기연,황윤환,장두례,하정호,마진열,Jung, Kiyoun,Hwang, Youn-Hwan,Jang, Doorye,Ha, Jeong-Ho,Ma, Jin Yeul 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.1
Objectives : This study was carried out to investigate the acute toxicity and safety of Palmultang and Fermented Palmultang Extract in Mice. Methods : To evaluate their acute toxicity and safety, 0 (control group), 2000 mg/kg of Palmultang and Fermented Palmultang Extracts were orally administered to 15 male and 15 female ICR mice. After a single administration, we observed survival rates, behavioral pattern, clinical sign, body weight. The results of biochemical analysis and hematological analysis were no any significant change. Results : Compared with the control group, we could not find any toxic alteration in all treated mice. Conclusions : Overall, the results suggest that, the oral administration of Palmultang and Fermented Palmultang extracts did not produce significant toxic effect in mice. Hence, the fermented extract can be utilized for herbal therapy.
박화용,황윤환,하정호,정기연,마진열,Park, Hwayong,Hwang, Youn-Hwan,Ha, Jeong-Ho,Jung, Kiyoun,Ma, Jin Yeul 대한한의학방제학회 2013 大韓韓醫學方劑學會誌 Vol.21 No.1
Objectives : Traditional medicine Oryeong-san (ORS) has been prescribed for a long time to treat light fever, thirst, dysuria, and accompanying edema. However, the acute toxicity and safety were not reported. In this study, we evaluated the potent acute toxicity and safety of ORS. Methods : ICR mice were used to evaluate acute toxicity and safety by oral administration of 0, 500, 1,000, 2,000mg/kg of ORS. Mortality, body weight, and clinical symptoms were observed, and organ weight and blood biochemical parameters were analyzed after necropsy. Results : We found no mortality and no toxic or abnormal clinical symptoms by administration of ORS. Comparing with control group, no significant alterations in organ weight and blood biochemical parameters were observed. Conclusions : ORS recognized as safe and non-toxic medicinal material, and median lethal dose considered to be over 2,000 mg/kg in both male and female ICR mice.
박화용,황윤환,장두례,하정호,정기연,마진열,Park, Hwayong,Hwang, Youn-Hwan,Jang, Doorye,Ha, Jeong-Ho,Jung, Kiyoun,Ma, Jin Yeul 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.2
Objectives : Traditional medicine Gumiganghwal-tang (GT) has been used in Asia to treat inflammatory diseases including common cold, pain, fever, and algor. In this study we investigated the acute toxicity and safety of GT and fermented GT (FGT). Methods : Acute toxicity and safety were evaluated in male and female ICR mice orally administered 0 (control) and 2,000 mg/kg of GT and FGT. After the administration of GT and FGT, we observed mortality, body weight, clinical symptoms. After necropsy, organ weights were measured and blood analysis was performed. Results : There was no mortality and clinical symptoms according to the administration of GT and FGT. Comparing with control group, there were no significant alterations on the organ weight, complete blood cell count and biochemical parameters. Conclusions : Median lethal dose of GT and FGT considered to be over 2,000 mg/kg in both male and female mice, and recognized as safe with no toxicity.
ICR 마우스를 이용한 삼소음 및 발효삼소음의 급성독성 연구
이주혜,황윤환,이지혜,임남희,조원경,마진열,Lee, Ju-Hye,Hwang, Youn-Hwan,Lee, Ji-Hye,Yim, Nam-Hui,Cho, Won-Kyung,Ma, Jin-Yeul 대한한의학방제학회 2011 大韓韓醫學方劑學會誌 Vol.19 No.2
Objectives : This study aims to investigate the acute oral toxicity and safety of Samsoeum (Shensuyin) extracts and fermented Samsoeum extracts. Methods : For that objective, we used ICR mice. ICR mice were administerd orally with dosage of 1250mg/kg, 2500mg/kg and 5000mg/kg of Samsoeum extracts and fermented Samsoeum extracts. Results : We daily examined number of deaths, clinical signs, body weights and gross findings for 2 weeks. 1. The results of acute oral toxicity using ICR mice showed that LD50 of value over 5000 mg/kg. 2. Samsoeum extracts and fermented Samsoeum extracts not affect on bodyweight gross findings of ICR mice. 3. The results of Serum chemistry analysis and Complete Blood Count(CBC) through the autopsy were showed normal range values. Conclusions : Samsoeum extracts and fermented Samsoeum extracts did not show any toxic effects in ICR mice. And oral LD50 value was over 5000mg/kg in ICR mice and it is very safe for ICR mice.
소청룡탕 및 발효 소청룡탕 추출물의 단회투여 독성에 관한 연구
이지선 ( Ji Seon Lee ),황윤환 ( Youn Hwan Hwang ),이지혜 ( Ji Hye Lee ),오수영 ( Su Young Oh ),김태수 ( Tae Soo Kim ),마진열 ( Jin Yeul Ma ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.4
Objectives: Socheongryong-Tang (小靑龍湯, SCRT) has been widely used to treat respiratory disease. In this study, we investigate the acute toxicity and safety of fermented Socheongryong-Tang extract. Methods: To evaluate the acute toxicity and safety, 0 (control group), 1250, 2500 and 5000 mg/kg of Socheongryong-Tang and fermented Socheongryong-Tang extracts were orally administered to male and female ICR mice. After single administration, we observed survival rates, general toxicity, changes of body weight for the 14 days and autopsy. Results: Compared with the control group, we could not find any toxic alteration in all treated group (1250, 2500 and 5000 mg/kg). Conclusions: LD50 of Socheongryong-Tang and fermented Socheongryong-Tang extracts might be over 5000 mg/kg and it is safe to ICR mice.
ICR 마우스를 이용한 평위산과 발효평위산 급성독성 연구
장두례 ( Doo Rye Jang ),황윤환 ( Youn Hwan Hwang ),정기연 ( Ki Youn Jung ),하정호 ( Jeong Ho Ha ),박화용 ( Hwa Yong Park ),마진열 ( Jin Yeul Ma ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.1
Objectives: This study was conducted to investigate the acute toxicity of Pyungwi-san (Pingwei-san in Chinese) in ICR mice, according to KFDA and OECD guideline. Methods: In the present study, 15 male and female ICR mice administrated singly by gavage at dose levels of 0 and 2000 mg/kg of Pyungwi-san. During the experimental period, no treatment-related death was observed. There were no adverse effects on clinical signs, body weight, and gross findings at all treatment groups. Results: These results showed that the single oral adminstration of Pyungwi-san (Pingwei-san) did not cause any toxic effect at the dose levels of 2000 mg/kg in rats. Conclusions: Taken together, the median lethal dose (LD50) of Pyungwi-san (Pingwei-san) was considered to be over 2000 mg/kg body for both sexes.
박병권(Byung-Kwon Park),임종환(Jong-Hwan Lim),황윤환(Youn-Hwan Hwang),김명석(Myung-Seok Kim),송인배(In-Bae Song),이홍기(Hong-Gee Lee),한성진(Sung-Jin Han),황미현(Mi-Hyun Hwang),김종우(Jong-Woo Kim),이만휘(Man-Hee Rhee),박승춘(Seong-C 한국독성학회 2006 Toxicological Research Vol.22 No.4
This study was carried out to investigate the acute toxicity of surfactin C in mice. Surfactin C was administered orally at does of 0, 381, 610, 977, 1562 and 2500 ㎎/㎏. Number of deaths, clinical signs, body weights, feed and water consumptions, and biochemical examinations were investigated for 14 days after single oral administration of surfactin C. LD?? value was over 2500 ㎎/㎏ in mice. In addition, no differences were found between control and treated groups in clinical signs, body weight gains, hematology, serum chemistry, feed and water consumptions. The results indicate that surfactin C did not show any toxic effects at 2500 ㎎/㎏ in mice.