Anti-HIV agent VP-0501의 생체이용성 향상을 위한 아미노산 프로드럭 개발 및 약물동태연구

조희정,채경애,성지민,정상민,한진수,김진석,신호철,Cho, Hee-Jeong,Choi, Kyung-Ae,Sung, Ji-Min,Jeong, Sang-Min,Han, Jin-Soo,Kim, Jin-Suk,Shin, Ho-Chul 대한수의학회 2006 大韓獸醫學會誌 Vol.46 No.1

We have studied pharmacokinetics of a new anti-human immunodeficiency virus (HIV) agent VP-0501 and its amino acid prodrug VP-0501AL which is designed to improve oral bioavailability. After oral administration at 100 mg/kg dose in rats (n = 4), VP-0501 was not detectable in plasma (<50 ng/ml), while after the administration of VP-0501AL, VP-0501 was quantitatively detected, at least for 8 hrs, with Cmax of ca. $2.5{\mu}g/ml$ and AUC of $8hr^{\ast}{\mu}g/ml$. When VP-0501 was intravenously administered at 50mg/kg, this compound appeared at a marginal level in plasma with AUC of $2hr^{\ast}{\mu}g/ml$, $t_{1/2}$ of 2 hr, $C_0$ of $0.7{\mu}g/ml$, and MRT of 3 hr. On the other hand, with intravenous VP-0501AL at the same dose, both the prodrug VP-0501AL and its metabolite VP-0501 appeared comparatively at higher level in the plasma: pharmacokinetic parameters of VP-0501AL including $Vd_{\beta}$, AUC, $t_{1/2,{\beta}}$, $C_0$, $CL_{tot}$, and MRT were ca. 2 L/kg, $70hr^{\ast}{\mu}g/ml$, 2 hr, $180{\mu}g/ml$, 0.7 L/hr/kg, and 1 hr, respectively. These results demonstrate that attachment of amino acid alanine to VP-0501 is an effective approach for improvement of its oral bioavailability. Therefore, VP-0501AL is expected to become a new highly bioavailable and potent anti-AIDS drug candidate/lead compound.

한국산 고등 균류의 성분 연구 ( 제57보 ) 구름버섯 항암성분의 비교

조희정,심미자,최응칠,김병각 ( Hee Jeong Cho,Mi Ja Shim,Eung Chil Choi,Byong Kak Kim ) 한국균학회 1988 韓國菌學會誌 Vol.16 No.3

Rethinking Wordsworth`s "Twaddling Stuff": Sympathy and Narrative in Eliot`s Adam Bede

조희정 ( Hee Jeong Cho ) 근대 영미소설 학회 2004 근대 영미소설 Vol.11 No.2

Although George Eliot acknowledges Wordsworth`s influence by quoting his poetry for the epigraph of Adam Bede, Eliot`s response to Wordsworth in the novel is not a straightforward celebration. The efficacy of Wordsworthian rhetoric, which aims at the education of sympathy, is questioned in Arthur`s dismissal of Wordsworth`s Lyrical Ballads and his later victimization of Hetty. By reproducing the narrative of "The Thorn" through the action of Arthur, one of Wordsworth`s readers, Eliot connotes the limits of Wordsworthian sympathy and her subsequent departure from it. Wordsworth`s poems in the Lyrical Ballads center on the problematization of sympathy. The poems explore the possibility of an imaginary exchange between human beings`s sensations and feelings by having the narrator examine his own ways of perceiving and conceiving others. As a result, many of the poems expose the distance between the narrator`s projection and the actual circumstances of his subject-matter. Interestingly, Dinah in Adam Beck is a character who repeats the Wordsworthian narrator`s problem in establishing sympathetic connection with others. In her attempts to understand Hetty, Dinah gets absorbed in her own ego and thus fails to sympathize with Hetty. Yet, unlike Wordsworth`s poems, Eliot`s ensuing narrative in Adam Bede shows that such a failure of sympathy leads to certain consequences. While Wordsworth`s poetry usually foregrounds the narrator`s consciousness and thereby puts a stop to the narrative progress in the temporal plane, Eliot ruthlessly narrativizes the consequences of an individual`s misrepresentation. The problem of misrepresentation also burdens Eliot as a storyteller. Dinah, who is first introduced as a narrator figure in the novel, delivers spectacular sermons, but her mode of narration fails to create a lasting sense of presence for her audiences. Eliot attempts to distance her own narrative from Dinah`s by resorting to the metaphor of "Dutch Paintings," which stand for a faithful representation of reality. However, her other metaphor, the "defective mirror," points to the problem of self-projection and undermines the model of narrative embodied in the metaphor of "Dutch Paintings." Trapped in between the desire for truthful narration and the realization that any narrative is partially the reflection of subjectivity, Eliot`s narrative experiments in Adam Bede foreshadow the dilemma of the "modem" storyteller.

논문 : 코울리지와 워즈워드의 대화, 그리고 근대적 서정시의 (재)탄생

조희정 ( Hee Jeong Cho ) 한국영어영문학회 2008 영어 영문학 Vol.54 No.5

예이츠 시에서 흰 새의 이미지: 현실과 이상의 통합을 향한 비전

조희정 ( Hee Jeong Cho ),유미란 ( Mi Ran Yoo ) 21세기영어영문학회 2008 영어영문학21 Vol.21 No.1

N3WS : 키워드 및 요약문장 추출을 이용한 인터랙티브 신문기사 탐색

조희정 ( Hee-jeong Cho ),손지연 ( Ji-youn Son ),윤별이 ( Byeol-yi Yoon ),조아현 ( A-hyun Cho ),김명 ( Myung Kim ),박은정 ( Eun-jeong Park ) 한국정보처리학회 2017 한국정보처리학회 학술대회논문집 Vol.24 No.2

최근 인터넷 기사 중에는 부정확한 제목이나 자극적인 단어를 사용하는 경우가 많아 구독자에게 불편함을 준다. 본 논문에서는 이러한 기사들의 헤드라인을 삭제하고, 기사의 내용을 3 문장으로 요약해 주어, 구독자가 원하는 기사를 효율적으로 파악할 수 있게 하는 시스템을 제안한다. 제안하는 본 시스템은 파이썬 언어의 KoNLPy 패키지를 사용하여 기사의 단어들을 형태소 단위로 분석하며, 추출된 키워드를 토대로 워드 클라우드를 생성한다. 사용자가 클라우드의 특정 단어를 선택하면, 해당 신문기사들의 본문을 분석하여 각 신문 기사만의 핵심적인 문장을 3 문장으로 출력해준다.

대화시에서 극적 독백으로 : 브라우닝의 『폴린』

조희정 ( Cho¸ Hee Jeong ) 동국대학교 영어권문화연구소 2018 영어권문화연구 Vol.11 No.1

This paper aims to investigate Browning's generic experimentation taking place in Pauline. Although the poem has been entertaining relatively low critical attention due to its incoherence, it merits close analysis in the context of the generic development that transforms a conversation poem into a dramatic monologue. Browning’s Pauline resembles the conversation poem in that its speaker focuses on his own mental movement and invokes a female auditor in order to confess his feelings and thoughts. Yet, the speaker, who clearly shows the tendency toward self-supremacy in the beginning, increasingly realizes his own limit in connecting with the outer world. The speaker’s clear self-consciousness inserted later into the text renders the poem “double-voiced.” In addition, through the footnote added by Pauline in the middle of the text, the poem reveals a striking discrepancy between the speaker’s utterance and the female auditor’s reaction. Pauline in this poem does not function merely as a silent, passive recipient of the speaker’s monologue; rather, she becomes a reader and a critic, who possesses the potential to dialogize the poetic text. Pauline displays its author’s ambivalent view of Romanic poethood as well as the inherited poetic form. Diverging from the generic features of the conversation poem, it foreshadows the emergence of the dramatic monologue in Browning's later poetry.

두 편의 낭만주의 소네트에 나타난 고대의 "폐허"

조희정 ( Hee Jeong Cho ),김종경 ( Jong Keyong Kim ) 한국영미문화학회 2011 영미문화 Vol.11 No.3

This paper aims at examining the image of ancient ruins in Romantic poetry by investigating two sonnets that contain self-conscious reflections on "fragments." John Keats`s "On seeing the Elgin Marbles for the first time" and Percy Bysshe Shelley`s "Ozymandias" both convey romantic ideas about the past and the present, the part and the whole, and mortality and immortality. In both poems, the Elgin Marbles and the sculpture of Ozymandias are presented as artworks embodying perfection in their own days, but they only remain in fractured ruins at the time when the poets compose these sonnets. The poetic speakers in both sonnets attempt to reconstruct the meaning of these ruins through communicative interactions with the shattered artworks transferred from the past. In "On seeing the Elgin Marbles for the first time," the speaker initially experiences highly melancholy feelings upon his encounter with the gigantic ruins. Yet, his painful meditations on mortality and human imperfection presented in the octave turns into an aesthetic experience of "the sublime" in the sestet. By exemplifying a successful way of coming to terms with the fragmented artwork of the past, Keats expresses his own longing for an ideal reader who can ultimately complete unfinished poetic texts. In the octave of "Ozymandias," Shelley deploys multiple speakers who read and interpret the historical figure of Ozymandias in their own ways. Then, these conflicting comments on the central figure of this poem open for the reader a new way of perceiving Ozymandias in her own terms. In the sestet, where the speaker`s presence is largely missing, the reader directly hears Ozymandias`s commanding voices, which are set in sharp contrast to the "lone and level sands" that deconstruct the emperor`s self-aggrandizing words. These two poems tactfully utilize the sonnet form in converting the "ruins" from the past into the "fragments" for the future. Through the invocation of future readers who can participate in the meaning process, these sonnets display the romantic aspiration toward open-ended vision and unrestrained imagination.

만성 림프구성 백혈병에 대한 최신 지견

조희정 ( Hee Jeong Cho ),손상균 ( Sang Kyun Sohn ) 대한내과학회 2021 대한내과학회지 Vol.96 No.3

Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with early stage CLL can be followed up without treatment; however, those with active or advanced disease require treatment immediately after diagnosis, for symptom alleviation and prolonging survival. Previously, chemotherapy using cytotoxic agents was the only therapeutic option available for patients with CLL. Research has provided a deeper understanding of the pathophysiology of the disease, and novel agents such as monoclonal antibodies and small-molecule inhibitors that target specific sites on leukemic cells have been introduced. The advent of these new drugs has led to improved clinical outcomes in patients with CLL. Currently, Bruton’s tyrosine kinase inhibitors or B-cell lymphoma-2 inhibitors are recommended as frontline therapy, prior to the administration of cytotoxic agents or combination therapy with monoclonal antibodies. In this article, we review the diagnosis and prognosis of CLL, in addition to the clinical implications of the various therapeutic options. (Korean J Med 2021;96:195-208)

유아교육적 적용을 위한 ASSURE 모형 탐색

조희정 ( Cho Hee-jeong ) 한국실천유아교육학회 2014 실천유아교육 Vol.19 No.-

본 연구는 체계적인 수업의 전문성 향상을 위한 방안으로 ASSURE 모형의 유아교육적 적용을 이론적으로 탐색하였다. 이론적 탐색을 통해, ASSURE 모형의 적용 가능성을 알 수 있었다. ASSURE 모형은 교수ㆍ학습과정에서 효과적 적용을 통해 수업목적을 성취하도록 하며, 수업 설계 시 유용한 구조와 단계를 안내하는 모형이다. ASSURE는 6단계 교수절차로 수업설계를 할 때 유용한 구조와 단계적 안내를 하며, 매체 사용에 대한 적합한 방법을 구체적으로 제시해 준다. ASSURE 모형은 학습자의 특성을 충분히 파악하고 이해하게 하며, 기대되는 학습결과 즉 학습목표를 명백하게 제시하고, 적절한 교수전략과 자료를 선택하게 한다. 그리고 최적의 학습 제공을 위해 가장 유용한 공학과 매체를 적절히 사용하며, 적절한 연습과 피드백을 제공하여 학습자를 적극적으로 학습에 참여시킨다. 교수ㆍ학습 전 과정에서 학습자의 학습을 측정하고, 각 요소는 물론 수업 경험을 평가하여 필요한 경우 수정, 보완하게 한다. 따라서 ASSURE 모형에 기초한 수업모형의 적용은 유아교사들이 수업목표를 인지하면서 수업을 계획, 진행, 평가할 수 있도록 하여 효율적이고 체계적인 수업경험을 할 수 있을 것으로 기대된다. The purpose of this study was to investigate application of early childhood education using ASSURE model. ASSURE model that Heinich et al (1996) have developed makes achieve the purpose of the lesson in the process of teaching and learning through the effective application of instructional media, and provides guidance of useful structure and phase when the instructional design. Especially, ASSURE model facilitate writing lesson plan to use the instructional media and model that teacher can easily practice in the field of education. Whin the model, will allow you to make a advanced lesson plan by providing opportunity to think for teaching evaluation and improvement.