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김범준,장기육,오용석,승기배,백상홍,신우승,임상현,김재형,홍순조,최규보 대한심장학회 2005 Korean Circulation Journal Vol.35 No.2
Background and Objectives :Matrix metalloproteinase-9 (MMP-9) plays an important role in the genesis of atherosclerotic plaque rupture and acute coronary syndrome (ACS), including an acute myocardial infarction (AMI). A single nucleotide polymorphism (SNP) in the MMP-9 promoter (- 1562C>T) has recently been identified. This study investigated whether the SNP of the MMP-9 promoter is a significant risk factor for an AMI due to plaque rupture and if SNPs afect the transcription of the gene that elevates the MMP-9 expresion level. Subjects and Methods :A polymerase chain reaction, followed by a restriction fragment length poly-morphism analysis, was performed in 173 control participants and 206 AMI patients. The serum levels of MMP-9 in the groups with or without the SNP were measured, using ELISA, and compared. Results:There was a significantly higher incidence of the -1562C> (27.6% vs. 17.9%, p=0.04). A multiple logistic regresion analysis of the risk factors for coronary artery disease and the MMP-9 polymorphism showed the MMP-9 polymorphism to be an important factor in the prediction of an AMI (odds ratio 1.67, 95% confidence interval 1.02-2.67, p=0.04). Conclusion :The -1562C>T polymorphism in the MMP-9 promoter is a definite risk factor for an AMI, and is associated with elevated MMP-9 expression. These results sugest that a SNP in the MMP-9 promoter is strongly associated with an Acute Myocardial Infarction.
서백종,장기육,박용근,채현석,한석원,이창돈,정인식,차상복,박두호 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 만성췌장염환자에서 지속적인 오심과 구토를 주소로 내원하여 십이지장협착으로 진단된 1예를 경험하였기에 보고하는 바이다. Duodenal stenosis resulting from fibroinflammatory process is a rare complication of chronic pancreatitis. The mechanism of duodenal stenosis seems to be related to ischemia and edema caused by persistent inflammation, which results in irreversible change of duodenal wall structure. We experienced a chronic alcoholic male patient with duodenal stenosis who had a history of choledochojejunostomy to relieve distal bile duct stenosis several years ago. He had suffered persistent postprandial nausea and vomiting for several months. Barium study of upper gastrointestinal tract and repeated endoscopy show narrowing lumen of duodenum with coarse nodular surface due to reactive inflammatory change.