두경부 편평상피세포암종에서 $^{18}FDG-PET$을 이용한 방사선치료 반응평가

이상욱,류진숙,이병용,김종훈,안승도,신성수,김상윤,남순열,송시열,윤상민,박진홍,김성배,김재승,Lee Sang-Wook,Ryu Jin-Sook,Yi Byong-Yong,Kim Jong-Hoon,Ahn Seung-Do,Shin Seong-Soo,Kim Sang-Yoon,Nam Soon-Yuhl,Song Si-Yeol,Yoon Sang-Min,Park Jin-H 대한두경부종양학회 2003 대한두경부 종양학회지 Vol.19 No.1

Purpose: To evaluate the efficacy of positron emission tomography with 2-[F-18] fluoro-2-deoxy-D-glucose in discrimination of response in the nasopharyngeal carcinoma patients who treated with radiotherapy. Methods and Materials: Twenty-four patients who underwent FDG-PET scan before and after radiotherapy for no disseminated head and neck carcinoma at the Asan Medical Center between August 2001 and September 2002 were evaluate by prospective analysis. First FDG-PET scan performed before radiotherapy within 1 month, and second FDG-PET scan performed 1 month after radiotherapy. FDG-PET images were analyzed by standard uptake value (SUV). Follow-up period was more than 6 months. Results: The pretreatment SUV was 3.4-14.0 (median: 6.0) and posttreatment SUV was ground level-7.7 (median: 2.0). The overall sensitivity and specicity of FDG-PET to evaluate residual tumors in the nasopharyngeal carcinoma patients were 94% and 94%. Conclusion: FDG-PET is effective in evaluation of radiation response in the nasopharyngeal carcinoma. We think that the timing of one month after finished radiotherapy FDG-PET scan was not too fast to evaluation of radiation response.

강화지역 암의 유병률

이상욱,이강희,김석일,강형곤,지선하,오희철,Yi, Sang-Wook,Lee, Kang-Hee,Kim, Suk-Il,Kang, Hyung-Gon,Jee, Sun-Ha,Ohrr, Hee-Choul 대한예방의학회 1999 예방의학회지 Vol.32 No.3

Objectives: Most descriptive studies of cancer have focused either or cancer incidence or mortality. Cancer prevalence has rarely been estimated. Cancer prevalence data can be used as a measure of the economic and social burden of cancer and are also useful for health care planning. This study attempts to estimate cancer prevalence in Kangwha county. Methods: This investigation is based on data of Kangwha cancer registry. The data include all cases of cancer diagnosed from 1983 through 1992. We define 'prevalent cases' as cancer patients who is alive as of January 1, 1993. For each five-year age group, the number of 'known prevalent cases' is added to the number of 'estimated prevalent cases'. Prevalence is calculated by dividing these sums by the populations of Kangwha County on December 31, 1992(derived from Kangwha Statistics Annual). Results: Crude prevalence of cancel among males and females are 536.7 and 601.1 per 100,000 respectively. Gastric cancer is the most common malignant neoplasm(213.2 per 100,000, crude prevalence) among males. It is followed by lung cancer(45.1 per 100,000), liver cancer(32.8 per 100,000), rectal cancer(25.4 per 100,000) and colon cancer(25.4 per 100,000). Cervical cancer is the most common cancer(201.9 per 100,000, crude prevalence) and is fellowed by gastric cancer(91.5 per 100,000), thyroid cancer(64.8 per 100,000), breast cancer(57.2 per 100,000) and rectal cancer(32.7 per 100,000) among females. Conclusions: We tried to estimate cancer prevalence based on the Kangwha cancer registry for the first time in Korea. The estimation of cancer prevalence based on a population-based cancer registry will be more correct and useful as the data accumulate. We will make another estimation in the near future. 유병률은 암의 발생과 생존, 사망을 한눈에 파악할 수 있으며, 지역사회에서 암의 영향을 살펴보는데 좋은 지표가 된다. 이 연구에서는 강화암등록사업 자료중 1983-1992년의 10년간의 자료를 이용하여 강화지역 암의 유병률을 추정하였다. 그 연구결과를 요약하면 다음과 같다. 1. 1993년 1월 1일 현재 강화지역에서 전체암의 보통유병률은 남자에서 인구 10만명에 536.7명, 여자에서 10만명에 601.1명이었고, 세계표준인구 연령표준화 유병률은 남자에서 인구 10만명에 436.5명, 여자에서 10만명에 462.1명 이었다. 2. 1993년 1월 1일 현재 남자에서 유병률이 가장 높은 암은 위암으로 보통유병률은 10만명당 213.2명이고, 그 다음이 폐암(10만명당 45.1명), 간암 (10만명당 32.8명), 직장암(10만명당 25.4명), 대장암(10만명당 25.4명)의 순이었다. 3. 1993년 1월 1일 현재 여자에서 유병률이 가장 높은 암은 자궁경부암으로 보통유병률은 10만명 당 201.9명이었고, 위암(10만명당 91.5명), 갑상샘암 (10만명당 64.8명), 유방암(10만명당 57.2명), 직장암(10만명당 32.7명)의 순이었다. 4. 전체암의 발생률은 남자가 여자보다 높았으나, 유병률은 오히려 여자가 남자보다 높았다. 5. 이 연구는 일부 제한점이 있으나 우리나라에서 장기간 지속된 지역사회 암등록 사업에 기초하여 암유병률을 추정한 최초의 연구로서 큰 의의가 있다고 생각한다.

한국인에서 고엽제 관련 노출과 건강영향 및 보상정책

이상욱,오희철,임현술,Yi, Sang-Wook,Ohrr, Heechoul,Lim, Hyun-Sul 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.3

Several US veterans stationed in Korea have told the press that around 250 fifty-five gallon drums of herbicides, including Agent Orange, were buried at Camp Carroll in 1978. Joint Korean-US Agent Orange investigation and environmental and health studies were started in July 2011. Korean soldiers and military personnel who served in Vietnam during 1964-1973 or near the demilitarized zone in Korea during 1967-1970 were exposed to dioxincontaminated Agent Orange. The joint Korean-US Agent Orange investigation team found that herbicides, pesticides, solvents and other chemicals -not Agent Orange- were buried at Camp Carroll. However, there remains the possibility that Agent Orange was stored and buried at Camp Carroll or other military camps in Korea. Adverse health effects have not been clearly explained despite a number of health studies among veterans in Korea with potential Agent Orange exposure. Although the Korean government has been compensating veterans and military personnel with 18 presumptive-service-connected-diseases and their offspring with three diseases, there are many veterans, military personnel and civilians who require the government°Øs support. The environmental study on contaminated sites and health studies among veterans and civilians were initiated three or four decades after possible Agent Orange contamination and exposure. Several toxic chemicals, including dioxin-contaminated Agent Orange, could remain in the environment and could have hazardous effects on the health of exposed people for more than several decades. Further environmental investigations and health studies are needed to ensure public safety and health, and government support should be guaranteed for people potentially exposed to these toxic chemicals.

베트남 참전군인에서 우편으로 검진대상자를 모집하기 위한 예비조사

이상욱,홍재석,오희철,Yi, Sang-Wook,Hong, Jae-Seok,Ohrr, Hee-Choul 대한예방의학회 2003 Journal of Preventive Medicine and Public Health Vol.36 No.2

Objective : The aim of this study was to identify the validity of recruiting medical checkup participants of Vietnam veterans using a mail survey, and to identify the 'Vietnam service related characteristics' and 'general characteristics' of Vietnam veterans groups, Method : In this study, a total 900 veterans were randomly selected from the list of Vietnam veterans from f964 to 1973. The veterans were classified into 5 groups, taking into consideration their registered status in the Ministry of Patriots and Veterans Affairs: the VRD (veterans who have agent orange-related diseases), VSD (veterans who have agent orange-suspected disease), VM (veterans who peformed meritorious deeds during the war), VR (veterans who were registered with the Ministry of Patriots and Veterans Affair) and OV (other veterans) groups. By means of postal surveys, the veterans' intention to participate in the medical checkup for our research, and their socioeconomic and general characteristics were investigated. 52 surveys were returned due to the subjects not residing at the listed address, and were excluded from the analysis. Result : 699 of the 848 veterans (82.4%) responded to the survey, of which 619 (88.6%) intended to participate in the medical checkup for our research. The S veterans groups all had similar ages, Vietnam service period, Agent Orange exposure, troop characteristic and wartime class, with the exception of VM, who were older, and with a greater number of officers than the other 4 groups, There was a big difference in the health statius among the Vietnam veterans group. The VM and OV were much healthier than VRD, VSD and VR groups, The socioeconomic stati of the VRD, VSD and VR groups were lower than those of the VM and OV groups. Conclusion : Although there were some limitations, the recruitment, by mail, of medical checkup participants from Vietnam veterans is a valid and feasible method. The VM and OV groups were much healthier, and with higher socioeconomic stati, than the VRD, VSD, and VR groups.

Risk and Risk Perception of Nanotechnology

이상욱,Yi, Sang-Wook The Korean Vacuum Society 2010 Applied Science and Convergence Technology Vol.19 No.6

나노기술은 현재 대부분의 연구 및 산업 선진국에서 미래의 가장 영향력 있는 기술로 간주되고 있다. 이런 이유로 여러 나라의 정부는 미래의 기술경쟁에서 앞서 나가기 위해 나노기술 연구에 상당한 인적, 물적, 자원을 투여하고 있다. 그러므로 나노기술 연구는 다른 곳에 쓰일 수도 있었을 공적자원의 사용과 관련된 책무성을 요구받는 분야가 된다. 저자는 나노기술 연구의 책무성을 적절하게 지켜내기 위해서는 위험만이 아니라 시민의 위험인지도 반드시 고려해야 한다고 주장한다. 흔히 위험인지는 객관적 확률로 주어지는 위험에 비해 사람에 따라 달라지고, 시간에 따라 변화하고 극단적으로 양분되는 경향을 보인다는 근거에서 기술연구 정책에서 정당한 고려사항이 될 수 없다고 여겨진다. 하지만 저자는 위험인지가 대중이 특정 방향으로 행동하게 만들 수 있다는 의미에서 유효하고, 많은 사람이 공유한다는 의미에서 상호주관적이며, 민주주의 사회에서 필수적으로 반영되어야 한다는 점에서 고려대상으로서의 정당성을 획득한다고 주장한다. Nanotechnology is now widely believed to be one of the most influential techno-sciences of the future. Or at least it is believed that way in most of industrial countries including South Korea. Naturally, the governments of these industrial countries are currently investing a sizable portion of their human and material resources in order to go ahead in this prominent area of research. Consequently, nanotechnology in these countries has become one of the social sectors where reasonable accountability is normally called for. I claim that reasonable accountability of nanotechnology should take into account the risk-perception of citizens as regards nanotechnology as well as its risk itself. Risk-perception could be variable, changeable, and prone to be polarized; still we should pay more attention to public risk-perception because it is clearly effective in mobilizing public movements, objective in the intersubjective way, and legitimate in a democratic society.

고엽제의 건강위해성 평가를 위한 연구설계와 방법 제안

이상욱,원종욱,홍재석,오희철,Yi, Sang-Wook,Won, Jong-Uk,Hong, Jae-Seok,Ohrr, Hee-Choul 대한예방의학회 2001 Journal of Preventive Medicine and Public Health Vol.34 No.3

Objectives : To propose a feasible, valid and appropriate study designs and epidemiologic methods for evaluating the adverse health effects of Agent Orange-chemical defoliants used in Vietnam- in Korea. Methods : A literature study was peformed on Agent Orange, herbicides, pesticides and dioxins. The study subjects, study design, exposure assessment and health outcomes assessment were examined in each study. The potential data sources for the study subjects, study design, exposure assessment and health outcomes assessment in Korea were investigated. Results and Conclusion : In earlier Korean studies, research subjects for studying the effects of Agent Orange were identified from the patients or persons who claimed to have Agent Orange-related diseases due to the difficulties in identifying the entire population of Vietnam veterans in Korea. In this study, an attempt was made to identify the total number of Vietnam veterans in Korea. As a result, the addresses of 20,000 Vietnam veterans were obtained. It is proposed that a retrospective cohort design on a sample of the total number of Vietnam veterans is a feasible and appropriate study design. Self report questionnaires and military records were proposed to assess the exposure level. It is believed that measuring the plasma or tissue TCDD should be used only for a validation study assessing the level of exposure. For the health outcomes assessment, it is possible to obtain the mortality, cancer frequency, physical examination, screening and medical insurance record data.

음주와 순환기계질환 사망 및 전체사망과의 관련성

이상욱,유상현,설재웅,오희철,Yi, Sang-Wook,Yoo, Sang-Hyun,Sull, Jae-Woong,Ohrr, Hee-Choul 대한예방의학회 2004 예방의학회지 Vol.37 No.2

Objectives : This study sought to examine relationships between alcohol drinking and cardiovascular disease mortality and all-cause mortality. Methods : From March 1985 through December 1999, 2,696 males and 3,595 females aged 55 or over as of 1985 were followed up for their mortality until 31 December 1999. We calculated the mortality risk ratios by level of alcohol consumption. Among the drinker, the level of alcohol consumption was calculated by the frequency of alcohol comsumption and the type of alcohol. Cox proportional hazard model was used to adjust for confounding factors. Results : Among males, compared to abstainer, heavy drinker had significantly higher mortality in all cause(Risk ratio=1.35), cardiovascular disease(Risk ratio=1.52) and cerebrovascular disease(Risk ratio =1.66). Although not significant, moderate drinker had lower ischemic heart disease mortality(Risk ratio =0.38). Among females, there was no statistically significant association between alcohol comsumption and mortality. Conclusion : The results of this study suggest that alcohol drinking has harmful effect on all-cause mortality, cardiovascular disease mortality and cerebrovascular disease mortality among males, especially in heavy drinker among males. Minimal evidence on protective effect for cardiovascular disease mortality in low or moderate drinker is observed.

학제간 과학철학 연구의 두 방향

이상욱(Yi Sang Wook) 한국과학기술학회 2005 과학기술학연구 Vol.5 No.2

‘과학기술학’과 ‘과학, 기술, 사회’의 두 가지로 번역되는 STS는 최근 국내외에서 과학기술철학, 과학기술역사학, 과학기술사회학, 과학기술정책학 등의 여러 분과 학문의 연합체로서가 아니라 나름대로의 학문적 정체성을 가진 독자적인 연구분야로 자리잡아 가고 있다. 본 논문은 이런 상황에서 과학철학이 과학기술학으로 이해된 STS에서 이루어지는 다양한 형태의 학제간 연구에 기여할 수 있는 방식을 모색한다. 이를 위해 우선 과학기술학 연구는 학제간 연구가 이루어지는 구체적인 양식에 따라 분과통합적 지적 협력인 간학문적 연구와 주제중심적 지적 협력인 다학문적 연구로 나뉘어 질 수 있음을 지적한다. 그 후 구체적인 예를 통해 과학철학이 이 두 분야 모두에 생산적으로 참여할 수 있음을 보인다. It has been a point of dispute how to define the disciplinary identity of STS; science and technology studies or science, technology and society? Still, STS is now emerging as an autonomous research discipline with its own agendas and styles of reasoning from a mere collections of various meta disciplines such as philosophy of science, history of science and sociology of science. The paper discusses how philosophy of science in its cross-disciplineary mode can contribute to STS (understood as science and technology studies) research given these recent academic trends. We can start from the observation that there are two distinctive ways of doing cross-disciplinary research: inter-disciplinary and multi-disciplinary. Then it is shown with concrete examples how philosophy of science can productively participate in both ways of cross-disciplinary researches in STS.

중신관 기원 추정의 여성부속기 종양

이상욱 ( Sang Wook Yi ),박한뫼 ( Han Moie Park ),손우석 ( Woo Seok Sohn ),강길현 ( Gil Hyun Kang ),엄대운 ( Dae Woon Eom ),이상수 ( Sang Soo Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.2

성분업의 모형기반 이해와 방법론적 다원주의

이상욱 ( Sang Wook Yi ) 한국과학철학회 2010 과학철학 Vol.13 No.2

Scientists tend to seek unified explanations. The tendency is understandable under the standard epistemic, social, cultural environments of scientific research. Still I argue that the tendency is methodologically unjustifiable by analyzing competing models of sexual division of labor in evolutionary anthropology. In most cases, what we can achieve from scientific research is not a dramatically inclusive and exactly valid universal-theory-based understanding, perhaps exemplified by Newtonian explanation of gravitation. Rather we normally get a model-based understanding which allows us to capture the core of a phenomena and to causally intervene in it, while not entirely covering its every aspect. I also claim that pursuing model-based understanding need not be regarded as ``lazy`` as long as some reasonable ontological conditions are met for the success of methodological pluralism.