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한국 중년 및 노년 여성에서 복압성 요실금과 대사증후군 (Metabolic syndrome)과의 상관관계에 대한 연구
박한뫼 ( Han Moie Park ),이상수 ( Sang Soo Lee ),박창면 ( Chang Myeon Park ),박선민 ( Sun Min Park ),박정원 ( Jung Won Park ),이상욱 ( Sang Wook Yi ),손우석 ( Woo Seok Sohn ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.2
목적: 본 연구에서는 복압성 요실금과 대사증후군의 지표인자와의 상관관계를 분석함으로써 복압성 요실금과 대사증후군과의 관련성을 알아보고자 하였다. 연구방법: 2004년부터 2006년까지 복압성 요실금을 진단받고 수술 및 약물치료를 시행한 208명의 환자와 같은 기간 부인과 양성질환을 본원 산부인과에 내원한 대조군 154명을 대상으로 하여 대사증후군과 복압성 요실금의 상관관계를 분석하였다. 대사증후군의 지표인자는 NCEP ; ATP III 진단지침에 따른 중성지방, 고밀도 콜레스테롤, 고혈압 그리고 인슐린 저항성의 기준으로 하였으며 단 복부비만에 대한 지표를 허리둘레가 아닌 BMI로 대체하였다. 따라서 지표인자 중 3가지 이상 해당되는 환자를 대사증후군의 위험군으로 분류하였다. 결과: 대사증후군의 위험군은 복압성 요실금과 유의한 상관관계를 보였으며, 대사증후군의 위험군에서 복압성 요실금의 위험도는 2.503 (95% CI 1.28-4.87, p=0.004)이었다. 다변량 분석을 통해 인슐린 저항성 (OR 2.563; 95% CI 0.04-0.31, p<0.001) 및 BMI (OR 3.574; 95% CI 0.09-0.31, p=0.011)는 복압성 요실금에 대한 독립적인 위험인자임을 알 수 있었다. 결론: 인슐린 저항성을 포함하는 대사증후군은 요실금과 상관관계가 있을 것으로 생각된다. Objective: The purpose of this study was to identify the relationship between metabolic syndrome and stress urinary incontinence. Methods: Based form 362 case, the risk factors including the parameters of metabolic syndrome for stress urinary incontinence (SUI) were analyzed retrospectively: body mass index (BMI), hypertension, insulin resistance, triglyceride, HDL-cholesterol. Results: The risk for metabolic syndrome were associated positively with SUI. Women with the risks for metabolic syndrome had 2.503 times of the odds for SUI compared without the risks for metabolic syndrome (95% CI 1.28-4.87, p<0.001). The independent risk factors for SUI were BMI (OR 3.574 ; 95% CI 0.09-0.31, p<0.001) and insulin resistance (OR 2.563 ; 95% CI 0.04-0.31, p=0.011) by multivariate analysis. Conclusion: Our results suggested that metabolic syndrome was the important factor of the stress urnary incontinence. And we confirmed the need for the treatment of metabolic disturbance and the prevention of metabolic syndrome aimed at correcting hormonal-metabolic disturbance in middle-aged and older women with SUI.
침윤성 자궁경부암에서 Vascular Endothelial Growth Factor와 Angiopoietin-1 & -2 mRNA의 발현에 관한 연구
박한뫼 ( Han Moie Park ),정혜원 ( Hye Won Chung ),안정자 ( Jung Ja Ahn ),김승철 ( Seung Cheol Kim ),문혜성 ( Hye Sung Moon ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
목적 : 본 연구에서는 자궁경부암과 정상 자궁경부조직에서의 VEGF mRNA와 Ang-1 & -2 mRNA 발현을 연구함으로서, 자궁경부암의 암화과정에 관여하는지를 알아보고자 하였으며 VEGF mRNA와 Ang-1 & -2 mRNA발현의 차이를 알아보고 자궁경부암 예후 인자와의 관련성을 알아보고자 하였다. 연구 방법: 34예의 자궁경부암 환자와 14예의 정상자궁경부 조직에서 RT-PCR과 QC-PCR을 이용하여 VEGF mRNA와 Ang-1 & -2 m Objective: This study was aimed to investigate the vascular endothelial growth factor (VEGF) mRNA and angiopoietin (Ang) -1 & -2 mRNA expressions between cervical cancer and normal cervix, and to assess the relationships among their expression and other p
폐경 여성에서의 호르몬 대체요법에 따른 유방 음영과의 연관성에 대한 연구
박한뫼(Han Moie Park),문혜성(Hye Sung Moon),정혜원(Hye Won Jung),류호선(Ho Sun Lyoo),김무희(Moo Hee Kim),최혜영(Hye Young Choi),황아실이(A Sil Ee Hwaung),안정자(Jung Ja Ahn) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : To determine the frequency and degree on change in mammographic densities, and calcification in the breast tissue, during different types of hormone replacement therapy and to evaluate the factors that play a role on the breast cancer. Method : A retrospective review of 268 cases menopausal women for HRT group and 52 cases menopausal women for unmatched control group. Mammographic evaluations for the distribution of breast densities and calcification, new solid mass and cyst in four different type of HRT were performed each every year during 5 years. The significant increase of breast densities and calcifications and new formation of neoplasm were taken with breast sonogram. 10 cases were biopsied for the confirmation of maliganancy. Result : Compared with the conrol groups, the hormone user group have a significant increase in the breast densitiy for 5 years (p<0.05), and the addition of progesterone in HRT showed a significant increase in the breast densities during 5 years (p<0.05), but we cannot find the correlation for new formation of solid mass and cyst and HRT (p>0.05). Among 10 cases in suspicious malignancy, 9 cases were confirmed to the malignancy by biopsy. Conclusion : The results of this study revealed that not only progesterone combined HRT but also estrogen only HRT significantly increased mammographic density. There is no relationship on the calcification and HRT in this study. The annual checking of mammography is necessary to HRT.
한국여성의 질에서 분리된 유산간균총의 미생물학적, 분자유전학적 분석 및 우량간균 KLB46을 이용한 질염 치료의 예비적 임상실험 결과
박미영 ( Mi Young Park ),박한뫼 ( Han Moie Park ),소재성 ( Jae Seong So ),김승철 ( Seung Cheol Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.6
목적 : 한국 여성의 질에서 유산간균총을 분리하여 그 중 probiotics로서 사용될 수 있는 유력한 유산간균주를 선정하여 질염의 치료효과를 확인하고자 하였다. 연구 방법 : 205명의 건강한 여자의 질 분비물로부터 분리된 유산균주들을 catalase test, 세포 표면 소수성검사, 항균 활성도 측정, Restriction fragment length polymorphism (RFLP)을 이용한 분자 유전학적 분석 등을 시행하여 그 종류와 분포 및 항생제 감수성을 분석하였다. 또한 L. crispatus KMB 46 균주를 이용하여 세균성 질증 및 위축성 질염 환자를 대상으로 예비적 임상실험을 시행하였다. 결과 : 분리된 유산간균주는 105종으로 대부분 항균활성을 보였다. 가장 많이 분포하는 우점균주는 L. crispatus와 L. acidophilus (51%)였고, 우량균주 KLB 46은 L. crispatus 였다. L.crispatus KLB 46을 질 내에 접종한 후 세균성 질증 환자와 위축성 질염 환자에서 우수한 치료효과를 보였다. 결론 : 한국 여성의 질에서 분리된 유산간균총의 우점균주는 성장속도, 생존력, 항균활성에서 모두 좋은 결과를 보이며, L. crispatus KLB 46은 세균성 질증의 예비적 임상실험에서 우수한 치료결과를 보여 향후 probiotics로서 유망한 균주로 사료된다. Objective : The aim of this study was to analize the biologic and molecular genetic characteristics of Lactobacillus spp. isolated from vagina of Korean healthy women and to perform a pilot clinical study on the treatment of vaginitis using the best Lactobacillus strain KLB 46. Methods : Vaginal specimens were obtained from 205 Korean women with healthy vaginal ecosystems. 155 lactobacillus strains were used for catalase test, cell surface hydrophobicity (SCH) test and antimicrobial activity test. Also we identified the species prevalence by PCR-RFLP analysis of 16S rDNA gene and performed the minimal inhibitory concentrationtest using14 antibiotics to determine their patterns of antibiotic susceptibility. A pilot clinical trial of 8 bacterial vagionsis, 1 trichomonas vaginitis and 6 atrophic vaginitis using Lactobacillus crispatus KLB 46 was done by maginal instillation (10^10-10^11 cells/mL). Results : 155 lactobacilli strains were isolated and all isolates showed high CSH and 61% of the isolates had higher CSH. L. acidophilus and L. criopatus were the most prevalent species by PCR-RELP analysis of their 16S rDNA gene. And PCR-RFLP analysis suggested that KLB 46 was L. crispatus. The clinical study showed that the vaginal epithelial adherence rate was high as 77% for bacterial vaginosis and 33.3% for atrophic vaginitis. Conclusion : The predominating lactobacilli were L. crispatus and L. acidophilus in Korean women`s vaginas. Although further study would be needed, L. crispatus KLB 46 is a good candidate of suitable probiotics for bacterial vaginosis.
김윤수 ( Yoon Soo Kim ),이선옥 ( Sun Ok Lee ),이영경 ( Young Kyoung Lee ),박한뫼 ( Han Moie Park ),정경아 ( Kyung Ah Jung ),전선희 ( Sun Hee Chun ),안정자 ( Jung Ja Ahn ),김종일 ( Chong Il Kim ),한운섭 ( Woon Sub Han ),김승철 ( Se 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
Multiple primary malignant neoplasm means that more than 2 cancers are independently developed in one individual. In general, the neoplasms are diagnosed simultaneously or within 6 month interval. Simultaneous presentation of carcinomas involving ovary an
이상욱 ( Sang Wook Yi ),손우석 ( Woo Seok Sohn ),박한뫼 ( Han Moie Park ),이상수 ( Sang Soo Lee ),임명철 ( Myoung Cheol Lim ),엄대운 ( Dae Woon Eom ),강길현 ( Gil Hyun Kang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
Small cell carcinoma of ovary is extremely rare. This neoplasms compose predominantly or exclusively of small round cells with scant cytoplasm. There are two types of primary small cell carcinoma of ovary described in the literature : the hypercalcemic type and the pulmonary type. The first 11 patients with a primary ovarian small cell carcinoma of the pulmonary type were described by Eichorn et al. in 1992. The prognosis of this tumor is very poor and only limited data on the treatment of this tumor type are available. In the present case report, we describe a patient with the pulmonary type of small cell carcinoma associated with huge mucinous cystadenocarcinoma with a brief review of the concerned literatures.
자궁내막증과 자궁선근증에서 금속단백효소 및 금속단백효소 저해자의 발현 - 에스트로겐 수용체 및 프로게스테론 수용체 발현과의 비교
엄대운 ( Dae Woon Eom ),강길현 ( Gil Hyun Kang ),박한뫼 ( Han Moie Park ),이상수 ( Sang Su Lee ),손우석 ( U Seog Son ),이옥준 ( Ok Jun Lee ),김정란 ( Jung Ran Kim ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 자궁내막증과 자궁선근증에서 월경주기에 따른 금속단백효소-2 (matrix metalloproteinase 2, MMP-2)와 금속단백효소 저해자 (inhibitor of metalloproteinase 2, TIMP-2)의 발현양상을 에스트로겐 수용체 (estrogen receptor, ER), 프로게스테론 수용체 (progesterone receptor, PR)의 발현양상과 비교함으로써 두 질환의 발생기전에 있어서 MMP-2와 TIMP-2의 Objective : This study was aimed to investigate the role of matrix metalloproteinase-2 (MMP-2) and inhibitor of metalloproteinase-2 (TIMP-2) for pathogenesis of endometriosis and adeonomyosis by the comparison of their expressions with those of ER (nuclea
김수희 ( Soo Hee Kim ),문혜성 ( Hye Sung Moon ),박한뫼 ( Han Moie Park ),김승철 ( Seung Cheol Kim ),한운섭 ( Woon Sup Han ),안정자 ( Jung Ja Ahn ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.2
Primitive neuroectodermal tumor (PNET) is a rare tumor derived from fetal neuroectodermal cells. These tumors occur in the central nervous system and peripheral locations, but the occurrence of primitive neuroectodermal tumors located in the uterus is ext