우리나라 성인 2형 당뇨환자에서의 외래 투약 순응도와 관련요인 분석

홍재석,강희정 한국보건행정학회 2010 보건행정학회지 Vol.20 No.2

Objectives : This study aims to estimate the oral antihyperglycemic medications adherence among ambulatory care with adult type 2 diabetes patients and to identify factors affecting the medication adherence in Korea. Methods : This study used the Korean National Health Insurance Database. Study population was 40,082 patients who were 20 years of age or older and first diagnosed with type 2 diabetes (ICD-10: E11) in 2004. The patients were followed up for two years in order to measure adherence with oral antihyperglycemic medications. The level of medication adherence was measured by the medication possession ratio (MPR). Results : The average MPR in the study population was 49.5%. The appropriate adherence rate (MPR 80%) was 29.4% and showed variation ≥ according to the characteristics of individual patients. Multiple logistic regression analysis revealed that the odds of appropriate adherence increased with female (OR:1.21,CI:1.14-1.27), older age, increasing ambulatory care visits, health insurance (OR:1.53, CI:1.33-1.76), decreasing ambulatory care providers, using a specialized general hospital as their main attending medical institution (OR:10.08,CI:8.96-11.33), having co-morbidity, using polytherapy (OR:1.07, CI:1.01-1.13). Conclusions : The medications adherence for patient with type 2 diabetes is low in Korea, and shows variation according to the characteristics of patients. For proper management of diabetes, health care policy is expected to be enacted to improve medications adherence continuously. In particular, more intensive management is needed for patients with low medications adherence. Also, health care policy makers need to develop the program to induce health care utilization by a patient to be more concentrated with the same provider.

Long-Term Trend in the Incidence of Acute Myocardial Infarction in Korea: 1997-2007

홍재석,강희정,이선희,김재용 대한심장학회 2009 Korean Circulation Journal Vol.39 No.11

Background and Objectives: Information about disease incidence is indispensable for the active prevention and control of acute myocardial infarction (AMI). The purpose of this study was to provide basic information for the establishment of policy related to AMI by examining the long-term trends in incidence of AMI. Subjects and Methods: This study identified the trend in disease incidence during between 1997 and 2007 using the Korean National Health Insurance Database that includes AMI {the 10th International Classification of Disease (ICD- 10) code: I21, I22, I23, I250, I251} as a primary or secondary disease. Results: The attack and incidence rates for AMI in 2007 were 118.4 and 91.8 per 100,000 persons, respectively, and the rates more than doubled for the 11 years. Both rates were higher among males than females and increased more in the older age groups. Incidence cases accounted for most of the total attack cases every year; however, in recent years the proportion of relapse cases was on the rise. The case fatality rate was highest (14.5%) in 2000, and declined rapidly to 9.8% in 2007. The case fatality rate was higher among females than males and the older age groups; in particular, female patients ≥65 years of age had the highest fatality rate. Conclusion: This study showed that AMI has been on the rise in Korea for 11 years. Therefore, the establishment of policy for intensive control of the incidence of AMI is necessary by building a continuous monitoring and surveillance system. Background and Objectives: Information about disease incidence is indispensable for the active prevention and control of acute myocardial infarction (AMI). The purpose of this study was to provide basic information for the establishment of policy related to AMI by examining the long-term trends in incidence of AMI. Subjects and Methods: This study identified the trend in disease incidence during between 1997 and 2007 using the Korean National Health Insurance Database that includes AMI {the 10th International Classification of Disease (ICD- 10) code: I21, I22, I23, I250, I251} as a primary or secondary disease. Results: The attack and incidence rates for AMI in 2007 were 118.4 and 91.8 per 100,000 persons, respectively, and the rates more than doubled for the 11 years. Both rates were higher among males than females and increased more in the older age groups. Incidence cases accounted for most of the total attack cases every year; however, in recent years the proportion of relapse cases was on the rise. The case fatality rate was highest (14.5%) in 2000, and declined rapidly to 9.8% in 2007. The case fatality rate was higher among females than males and the older age groups; in particular, female patients ≥65 years of age had the highest fatality rate. Conclusion: This study showed that AMI has been on the rise in Korea for 11 years. Therefore, the establishment of policy for intensive control of the incidence of AMI is necessary by building a continuous monitoring and surveillance system.

우리나라 병상자원 분포 및 운영 현황

홍재석 건강보험심사평가원 심사평가연구소 2012 HIRA 정책동향 Vol.6 No.6

폐경 연령과 사망력과의 관계에 대한 코호트 연구 - 강화 코호트 연구 -

홍재석,이상욱,지선하,손태용,오희철,Hong, Jae-Seok,Yi, Sang-Wook,Jee, Sun-Ha,Sohn, Tae-Yong,Ohrr, Hee-Choul 대한예방의학회 2001 예방의학회지 Vol.34 No.4

Objective : To examine the association between age at menopause and mortality in a population-based sample of women in Kangwha, Korea. Methods : From the Kangwha Cohort, followed-up from 1985 to 1999, the data of the over 55 year old female group(n=3,596) was used in this study to examine the association between age at menopause and mortality. We calculated the all causes mortality risk ratio and the cancer mortality risk ratio by age at menopause grouping using the Cox Proportional Hazards Model with adjustments for age, BMI, smoking, education, chronic disease, self-rated health status, alcohol consumption and age at first birth. Result and conclusion : Compared to women who had menopause at 45-49 years, the all causes mortality risk ratio was 1.24 for women with menopause at less than 40 years(95% CI=1.01-1.53) and 1.05 for women with menopause at over 50 years(95% CI=0.92-1.20). Also, compared to women who had menopause at 45-49 years, the cancer mortality risk ratio was 1.53 for women with menopause at less than 40 years(95% CI=0.78-2.98) and 1.17 for women with menopause at over 50 years(95% CI=0.77-1.80).

출산아 사망의 계절적 차이에 관한 연구

홍재석 청주대학교 보건의료과학연구소 2017 보건의료과학연구 Vol.5 No.2

The purpose of this study was to examine the seasonal variation in neonatal mortality in Korea. Data of Korean vital statistics linked National Infant Mortality Survey conducted on births in 1999 were used in this study(n=617,867). When neonatal mortality was compared by season and month, neonatal mortality was highest in summer(2.14/1,000 births) and July(2.37/1,000 births). However, after adjusting for gender, plurality, birth order, maternal age, and low birth weight, the probability of neonatal death did not differ by season and month(Spring, odds ratio[OR], 1.03, 95% confidence interval[CI], 0.88 1.22; Summer, OR, 1.07, 95% CI, 0.91 1.26; Autumn, OR, 1.13, 95% CI, 0.96 1.33). Seasonal variations in neonatal mortality seems to be attributed to differences in neonatal characteristics according to seasons rather than the climatological characteristics of the seasons.

일차의료서비스 이용의 지속성 측정 지표

홍재석,김재용 건강보험심사평가원 심사평가연구소 2008 HIRA 정책동향 Vol.2 No.6

중고 · 노후 특수의료장비의 설치 및 사용 현황

홍재석 건강보험심사평가원 심사평가연구소 2011 HIRA 정책동향 Vol.5 No.3

산모 연령과 영아 사망과의 관련성 연구

홍재석 한국디지털정책학회 2016 디지털융복합연구 Vol.14 No.9

본 연구는 우리나라 출생아 전수(n=617,867)를 대상으로 산모 연령과 영아 사망과의 관련성을 파악하고자 시행하였다. 연구자료는 인구동태통계자료와 영아사망조사자료를 연계하여 사용하였고, 산모 연령에 따른 영아 사망 위험을 파악해 보기 위해 출생아의 성별과 다태 여부, 출생순위, 저체중아 여부, 선천성기형 여부를 보정한 다중 로지스틱 회귀분석을 시행하였다. 여러 혼란요인을 보정한 분석 결과, 25-29세 산모에 비해 20세 미만 산모(Odds ratio [OR], 5.29, 95% confidence interval [CI], 3.51-7.98)와 20-24세 산모(OR, 1.44, 95% CI, 1.23-1.69), 35-39세 산모(OR, 1.28, 95% CI, 1.11-1.46), 40세 이상 산모(OR, 1.94, 95% CI, 1.53-2.45)에서 영아 사망 오즈가 통계적으로 유의하게 높았다. 결론적으로, 이번 연구를 통해 35세 이상 고 연령 산모와 25세 미만의 저 연령 산모에서 영아 사망 위험이 높은 것을 확인할 수 있었고, 이들에서 영아 사망 위험이 높은 이유는 저체중아나 미숙아의 출산이 많기 때문으로 보인다. 산전관리 시 고령 산모의 경우 생물학적인 문제를 극복할 수 있는 관리정책이 만들어져야 할 것으로 보이고, 저 연령 산모의 경우 사회경제적인 부분과 사회적 편견 문제를 해결할 수 있는 관리정책이 만들어져야 할 것으로 보인다. The purpose of this study was to examine the relationship between maternal age and infant mortality in Korea(n=617,867). Data of Korean vital statistics linked National Infant Mortality Survey conducted on births in 1999 were used in this study. The odds ratios (ORs) of infant death by maternal age were estimated with the multiple logistic regression model, adjusting for gender, plurality, birth order, low birth weight, and congenital malformation. After adjusting for the relevant variables, the odds of infant death in the group of maternal age with less than 20 years(Odds ratio [OR], 5.29, 95% confidence interval [CI], 3.51-7.98), 20-24 years(OR, 1.44, 95% CI, 1.23-1.69), 35-39 years(OR, 1.28, 95% CI, 1.11-1.46), and more than 40 years(OR, 1.94, 95% CI, 1.53-2.45) was higher than that of reference group(25-29 years). In conclusion, the higher infant mortality in the group of maternal age with less than 25 years and more than 35 years in Korea appears to be due to higher proportion of low birth weight and pre-term birth. Prenatal care intervention programs which tackle biological factors for advanced maternal age and address socio-economic problems and social stigma for early maternal age should be devised.

전자선 증착 기술레 의해 성막된 IZO 박막의 특성 연구

홍재석,김화민,김종재,박승환,윤재경,이병로 한국물리학회 2004 새물리 Vol.48 No.4

In2O3-ZnO (IZO) thin films with a Zn content of 33 at.%. were prepared by using an electron- beam evaporation technique. The films deposited in vacuum were opaque and poorly conductive due to an oxygen deffciency. To compensate for the oxygen defficiency, we annealed the opaque films in air. During the heat treatment, the opaque films had their best conductivity after transitioning to a new stabile state, simultaneously, they become transparent. The new stabile state was reached after a very short annealing time and was caused by a structural change due to the oxygen defficiency being compensated for. If the lm is, however, annealed for a long time, excessive oxygens are adsorbed into the films and seriously aect the electrical and the optical properties.

RF-Magnetron Sputtering 으로 제작된 Nd₂O₃박막의 광학적 특성

홍재석,김화민,안정선,제구출 한국물리학회 2002 새물리 Vol.44 No.5

For application as a band rejection color filter to improve the primary purity of a plasma display panel (PDP), Nd$_{2}$O$_{3}$ films have been fabricated using the RF-magnetron sputtering method and their optical properties have been investigated as functions of the oxygen concentration, the RF-power and the thickness of film. Absorption of the Nd$_{2}$O$_{3}$ thin films in the visible range appears for films with thicknesses over 1.9 $\mu$m and becomes larger with increasing film thickness. It originates from intra-transitions within the 4f shell of the Nd$^{+3}$ ion. In particular, for the 17.7$\mu$m thick Nd$_2$O$_3$ film fabricaited in a pure Ar atmosphere, the transmittance at wavelengths near 590 nm was reduced by about 60 \% suggest compared with the values (over 80 \%) at wavelengths near 460, 550 and 620 nm. These results that PDP devices using Nd$_{2}$O$_{3}$ films as band rejection color filters can sufficiently bleach the orange light (585.2 nm) induced by the neon gas discharge and the sidebands of phosphors. PDP의 색순도를 개선하기 위한 밴드 차단 칼라필타(band rejection color filter)의 응용성을 조사하기 위하여 RF 마그네트론 스퍼터링 방법을 사용하여 Nd$_{2}$O$_{3}$ 박막을 제작하여, 이들의 광학적 특성을 박막 두께, 산소농도 그리고 인가전압의 함수로 조사하였다. Nd$_{2}$O$_{3}$ 박막의 가시광 영역에서의 흡수는 Nd$^{+3}$ 이온의 4f shell 내의 전이 (transition)에 의한 것으로서, 박막의 두께가 증가할수록 커진다. 이와 같은 흡수는 1.9 $\mu$m 이상의 두께를 갖는 박막에서부터 관측되기 시작하였다. 순수한 Ar 분위기에서 제작된 Nd$_{2}$O$_{3}$ 박막의 경우 두께가 17.7 $\mu$m 일 때, 590 nm 근방의 파장 영역에서 광 투과율은 460 nm, 550 nm 및 620 nm 파장에서의 광 투과율 (80 \% 이상)보다 약 60 \% 정도 감소하는 것이 관측되었다. 이 결과는 Nd$_{2}$O$_{3}$ 박막을 PDP 소자의 칼라필터로 응용할 경우, Ne 가스 방전시 방출되는 오렌지 광(585.2 nm) 및 side band 효과를 충분히 차단할 수 있음을 제시한다.