날개-몸체 접합부의 난류유동에 관한 수치계산

신승주(Seung-Joo Shin),이덕주(Duck-Joo Lee),박승오(Seuong O Park) 한국항공우주학회 1990 韓國航空宇宙學會誌 Vol.18 No.1

무색 인공수정체렌즈안과 광변색 인공수정체안에서의 수술 전후 스트레이라이트의 비교

김인혁,황형빈,신승주,정성근,In Hyuk Kim,MD,Hyung Bin Hwang,MD,Seung Joo Shin,MD,Sung Kun Chung,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.2

Purpose: To compare visual acuity and intraocular straylight after implantation of clear and photochromic intraocular lenses (IOLs) in a mesopic lighting condition. Methods: Clear IOLs were implanted in 95 eyes of 72 patients (clear IOL group), and photochromic IOLs were implanted in 22 eyes of 16 patients (photochromic IOL group). Best-corrected visual acuity (BCVA) was measured indoors before surgery and 1 month after surgery. Straylight values were measured indoors before surgery and 1 and 2 months after surgery using the C-quant straylight meter (Oculus GmbH, Wetzlar, Germany). Results: There were no significant differences between the 2 groups in BCVA at 1 month postoperatively (p = 0.587). Mean straylight values of clear and photochromic IOL groups were 2.76 ± 1.89 log (s) and 2.88 ± 2.04 log (s) preoperatively, 1.39 ± 0.84 log (s) and 1.32 ± 0.26 log (s) at 1 month postoperatively, and 1.43 ± 0.92 log (s) and 1.45 ± 0.50 log (s) at 2 months postoperatively. There were no significant differences between the 2 groups in indoor straylight values (p = 0.778, 0.709, 0.929, before surgery, 1 and 2 months after surgery respectively). Repeated-measure analysis of straylight values also showed no significant difference between the 2 groups (p > 0.05). Conclusions: There were no significant differences in BCVA and straylight values between clear and photochromic IOL groups under a mesopic light condition. Therefore, photochromic IOL could be suitable choice for cataract patients who spend significant time under mesopic conditions. J Korean Ophthalmol Soc 2014;55(2):190-195

Methylenetetrahydrofolate Reductase(MTHFR) 유전자다형과 자연 유산아 발생의 관련성에 관한 연구

전익범,지승일,신승주,차선희,최동희,임동진,박상희,이수만,이상화,고정재,김남근,Jeon, Nick-Beom,Ji, Seung Il,Shin, Seung Joo,Cha, Sun Hee,Choi, Dong Hee,Yim, Dong Jin,Park, Sang Hee,Lee, Suman,Lee, Sang Hwa,Ko, Jung Jae,Kim, Nam Keun 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.1

목 적: 본 연구는 methylenetetrahydrofolate reductase (MTHFR C677T와 A1298C) 유전자 돌연변이형이 자연유산아 발생의 원인 유전자로 작용하는지에 대해 알아보고자 시도하였다. 연구방법: 95명의 자연유산아 조직과 대조군으로 100명의 정상 소아의 혈액 그리고 449명의 정상 성인의 혈액을 채취하여 DNA를 분리하여 사용하였다. 유전자형은 분리된 DNA를 이용하여 중합효소 연쇄반응과 제한효소 절편다형 분석방법으로 결정하였다. 결 과: 자연유산아 그룹은 소아대조군에서 보다 MTHFR 677CC 형 (p=0.014)은 높게, 677CT형 (p=0.063)은 낮게 나타났다. 성인대조군과의 비교에서도 MTHFR 677CT 형의 빈도는 현저히 낮게 나타났다 (p=0.032). 그리고 MTHFR 677CC/1298AC 조합형 유전자의 경우 소아대조군 (p=0.034)과의 비교에서는 현저히 높은 빈도를 나타냈으나, 성인대조군 (p=0.063)과의 비교에서는 높은 경향성은 있었으나 통계학적으로 유의한 차이는 없었다. 결 론: MTHFR 677CC와 MTHFR 677CC/1298AC 유전자형은 자연유산아 발생의 위험인자일 가능성이 높으며, 지속적인 연구가 요구된다. Objectives : This study was performed to understand the influence of the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) genotypes on the spontaneously aborted embryos. Methods : DNA was extracted from tissue samples of 95 spontaneously aborted embryos and 100 samples of normal children randomly and 449 samples of normal adults were selected as the controls. MTHFR genotypes were determined by a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results : The aborted embryo group had higher frequency of MTHFR 677CC type (p=0.014) and lower 677CT type (p=0.063) than the controlled child group. The frequency of MTHFR 677CT type was drastically lower than that of controlled adult group (p=0.032). In the MTHFR C677T/A1298C combination, 677CC/1298AC genotype of the aborted embryo was significantly higher (p=0.034) than that of controlled child group, but it was not statistically significant in controlled adult group (p=0.063). Conclusion : MTHFR 677CC and MTHFR 677CC/1298AC genotypes may represent genetic markers for the risk of spontaneously aborted embryos at least in Koreans.

체외수정시술을 받은 산모와 자연 임신된 산모에서의 임신 중반기 산모혈청 삼중식별검사결과 비교에 관한 연구

이상걸(Sang Geol Lee),신승주(Seung Joo Shin) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8

목적: 체외수정시술을 받은 산모와 자연 임신된 산모와의 Down 증후군 및 개방성 신경관 결손증에 대한 산모 혈청 검사상의 선별 양성율에 차이가 있는지를 알아보아서 IVF 태아에서도 triple test가 잘 적용되는지를 연구하였다. 연구방법: 1995년 1월부터 1998년 4월까지 각각 200 명씩의 단태아 임신 산모를 대상으로 하여 임신 15주에서 20주사이에 산모 혈청 삼중식별검사를 시행하였다. 결과: 인공수정시술 군에서 선별 양성율은 0.5%이고 자연 임신군 에서는 1%이었다. AFP, unconjugated-E3, hCG의 평균치는 인공수정시술 군에서 각각 0.92 MoM, 1.44 MoM, 0.87 MoM 이었고 자연임신 군에서 각각 0.86 MoM, 1.28 MoM, 0.83 MoM 이었다. 통계학적 분석은 student t-test, chi-square test 등을 이용하였으며 P-value 〈0.05 인 경우 통계학적 유의성이 있는 것으로 분석하였다. 결론: 본 연구결과 두 집단간의 Down 증후군에 대한 산모 혈청선별검사상 양성일 확률에는 차이가 없는 것으로 밝혀졌고 향후 많은 환자 분석을 하여 좀더 정확한 비교치를 구할 필요가 있고 앞으로 인공수정시술을 받은 산모의 혈청선별검사에 도움이 되면 한다. Objective : To evaluate the results of second-trimester maternal serum triple-marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived from in vitro fertilization, the screen positive rates and triple-marker level of patients conceiving singleton pregnancies by IVF were compared to those of pregnancies conceived naturally. Methods : Two hundred singleton pregnancies conceived by IVF and naturally conceived pregnancies who had done maternal serum screening test during the second trimester were analyzed from January 1995 to April 1998. Results : One (0.5%) of the 200 cases of IVF singleton pregnancies had a positive result for Down syndrome compared with 1% of screen positive rate in the 200 cases of naturally conceived pregnancies. The median level of the triple markers were 0.92 multiples of the median(MoM) for alpha-fetoprotein(AFP), 1.44 MoM for unconjugated estriol(E3) and 0.87 MoM for human chorionic gonadotropin(hCG) respectively. Conclusion : The positive rate of triple test for Down syndrome and open neural tube defect in the two groups were significantly not different. As additional data are collected, corrected standards should be determined.

단순화된 자동차 형상주위의 유동장에 관한 수치적 연구

서정수(Jung-Soo Suh),신승주(Seung-Joo Shin),이기석(Ki-Seok Lee) 한국전산유체공학회 1997 한국전산유체공학회 학술대회논문집 Vol.1997 No.-

Three dimensional flows around a vechicle-like bluff body (Ahmed's body) in ground proximity were computed by using structured finite volume solver FLUENT, and unstructured finite volume solver FLUENT/UNS. The numerical computations were performed for various afterbody upper-surface slant angles at a constant Renolds number of 4.3 x lO^6 based on the body length. The results are compared with Ahmed's experimental data and the results by Taeyoung Han. Most of the essential features of the flowfield around Ahmed's vehicle-like body in ground approximity, such as the formation of trailing vortices, were well predicted.

5,10-Methylenetetrahydrofolate Reductase (MTHFR C677T와 A1298C) 유전자 돌연변이의 반복자연유산 관련성 연구

김남근,남윤성,이수만,김선희,신승주,장성운,김세현,차광렬,오도연,Kim, Nam-Keun,Nam, Yoon-Sung,Lee, Su-Man,Kim, Sun-Hee,Shin, Seung-Joo,Chang, Sung-Woon,Kim, Se-Hyun,Cha, Kwang-Yul,Oh, Do-Yeun 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.3

Objective : Previous studies have suggested that hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR C677T) mutations are associated with increased risk of recurrent spontaneous abortion (RSA). Recently, a second site polymorphism in MTHFR, 1298A-->C, which changes a glutamic acid into an alanine residue, was shown to be associated with a decreased enzyme activity. We tested whether the variant alleles of MTHFR C677T and A1298C are risk factor (biomarker) for RSA. Materials and Methods: We analyzed DNA from a case-control study in the Korean DNA was extracted from blood samples of 118 patients with RSA and 123 healthy fertile patients as the controls. MTHFR variant alleles were determined by a PCR-restriction fragment length polymorphism assay. Results: We found no evidence for an association between 677TT genotype and risk of RSA (OR=1.95, 95% CI=$0.84{\sim}4.50$, p=0.12). However, the MTHFR 1298AC (OR=0.36, 95% CI=$0.20{\sim}0.63$, p=0.0004) and 1298AC+CC (OR=0.35, 95% CI=$0.20{\sim}0.61$, p=0.0002) genotypes were lower among 118 RSA cases compared with 123 controls, conferring a 2.8-fold decrease in risk of RSA, respectively. Moreover, the combined genotypes of MTHFR 677CC/1298AC (OR=0.30, 95% CI=$0.10{\sim}0.88$, p=0.029) and 677CT/1298AC (OR=0.77, 95% CI=$0.60{\sim}0.99$, p=0.043) also showed significantly lower risk than those with MTHFR 677CC/1298AA type. Conclusion: MTHFR 1298AC, MTHFR 677CC/1298AC and 677CT/1298AC genotypes may represent genetic markers for the protection of RSA at least in Korean women.

열 잉크젯 프린트 헤드 내 열-유동의 Lumped 모델링

이유섭(You-Seop Lee),신수호(Suho Shin),김민수(Min Soo Kim),신승주(Seung-Joo Shin),오용수(Yong Soo Oh) 대한기계학회 2002 대한기계학회 기타 간행물 Vol.2002 No.11

잉크젯 작동 상태 진단 및 모니터링

권계시(Kye-Si Kwon),김병헌(Byung-Hun Kim),김상일(Sang-Il Kim),신승주(Seung-Joo Shin),김성진(Seongjin Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5

A self-sensing circuit for piezo inkjet has been designed in order to monitor the operating condition during printing. In order to verify the circuit, both ink droplet images from strobe LED and vibration signals from the laser vibrometer were measured and compared with self-sensing signal. Experimental results show that selfsensing signal was effective in detecting the pressure wave change due to the bubble trapped in inkjet printhead.

유도분만과 자궁경관 숙화에 있어 Misoprostol과 Dinoprostone 의 비교

이현행(Hyun Haing Lee),박원식(Won Sik Park),신승주(Seung Joo Shin) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.11

목적: 자궁경관 숙화와 분만유도에서 자궁경관내 dinorprostone (PGE2 겔)과 질내 misoprostole 의 안정성 및 효과를 비교분석하고자 하였다. 연구방법: 유도분만의 적응증과 비숙화된 자궁경부를 갖는 총 60명의 임산부를 대상으로 임의로 misoprostol 과 dinorprostone 사용군으로 나누었다. misoprostol 사용군은 50 ug 을 4시간 간격으로 최고 3회까지 질후원개 부위에 삽입였고 dinorprostone은 0.5mg을 6시간 간격으로 2회까지 자궁경부내에 삽입하였다. 양막파수나 활성분만진통기가 시작되면 더 이상의 약물투여는 중지하였다. 결과: 60명의 임산부중 30명은 misoprostol 을 그리고 나머지 30명은 dinorprostone을 각각 투여하였다. 유도분만후 활성분만 진통기에 걸린 평균시간이 misoprostol 사용군(6.5±3.2시간)이 dinorprostone 사용군 (10.7±7.3시간)에 비해 짧았으며 (P<0.05), 옥시토신의 사용은 dinorprostone 사용군(36.7%)에서 misoprstol 사용군(10%)보다 빈발하였다. 반면 태아곤란증(23.3% 대 3.3%) 및 tachysystole(16.6% 대 6.6%) misoprostol 사용군에서 현저히 많았다(p<0.05). 결론: misoprostol은 자궁경관 숙화와 유도분만에 있어 효과적이고 가격면에서 misoprostol 200㎍ 1정이 360원으로 dinorprostone (42,000원/0.5mg)보다 훨씬 저렴하다. 그러므로 misoprostol 투여는 특히 포괄수가제의 적용을 받는 병원에서 유리하다. 하지만 본연구에서 적용된 misoprostol의 용량은 dinorprostone에 비해 태아가사와 tachysystole의 빈도가 유의하게 높았으므로 misoprostol 의 안정성과 적절한 용량을 위한 더 많은 연구가 필요하다고 사료된다. Objective: To compare the safety and efficacy of intravaginal misoprostol versus intracervical dinoprostone (prostaglandin E2 gel) for cervical ripening and labor induction. Methods: 60 patients with indication for labor induction and unfavorable cervices were randomly assigned to receive either intravaginal misoprostol or intracervical dinoprostone. 50 ㎍ tablets of misoprostol were placed in the posterior vaginal fornix every 4 hours for a maximum of 3 doses or dinoprostone 0.5mg was placed into the endocervix every 6 hours for a maximum of 2doses. No more medication was given after either spontaneous rupture of membranes or beginning of active labor. Results: Among 60 patients enrolled, 30 received misoprostol and 30 received dinoprostone. The average interval from start of induction to active labor was shorter in misoprostol group (6.5±3.2 hours) than in the dinoprostone group (10.7±7.3 hours) (p<0.05). Oxytocin augmentation of labor occurred more often in the dinoprostone group (36.7%) than in the misoprostol group (10.0%) (p<0.05). There was a higher prevalence of fetal distress (23.3% versus 3.3%) and tachysystole (16.6% versus 6.6%) in the misorprostol group than in the dinoprostone group(p<0.05). Conclusions: Vaginally administered misoprostol is an effective agent for cervical ripening and induction of labor. Furthermore, the cost of misoprostol ( 360/200㎍) is much less than that of dinoprostone ( 42,000/0.5mg). Cost benefits from administration of misoprostol are evident, especially in clinics under system of diagnosis-related group (DRG) : however when given at this dosage, it is associated with a higher prevalence of fetal distress and tachysystole than dinoprostone. Further studies to compare the safety of misoprostole to that of dinoprostone and to delineate an optimal dosing regimen for misoprostol are needed.

피에조 잉크젯의 셀프 센싱 검출 및 응용

권계시(Kye-Si Kwon),김우식(Wousik Kim),김상일(Sang-Il Kim),신승주(Seung-Joo Shin),김성진(Seongjin Kim) 한국소음진동공학회 2007 한국소음진동공학회 학술대회논문집 Vol.2007 No.3