감모후유증(感冒後遺症)으로 기허형(氣虛型)호흡기 질환을 호소하는 환자의 한약치료에 관한 임상연구

김현진,한효정,장정아,박은영,안태한,서호석,김진원,Kim, Hyun-Jin,Han, Hyo-Jung,Jang, Jeong-A,Park, Eun-Young,An, Tae-Han,Seo, Ho-Seok,Kim, Jin-Won 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.1

Objectives : In order to confirm a remedial effect and related influence of the clinic treatment by prescribing Samchuljojung-tang(蔘朮調中湯), Bojungikqi-tang(補中益氣湯) and Samso-um(蔘蘇飮) to patients who suffering from a chronic cough and rhinorrhea. Methods : 1. In a clinical observation and analysis method, we have selected the 23 patients who have visited National Oriental Medical Center, date from 2007.8.21 to 2008.7.31 and suffering from a chronic cough and rhinorrhea caused by the common cold sequelae. 2. Separated them into three types(I: cough type, II: rhinorrhea type, III: cough & rhinorrhea type). 3. Observed thoroughly the level of symptom and recorded it for each type with questionnaire survey at the beginning set 4. Prescribed Samchuljojung-tang, Bojungikqi-tang and Samso-um for type I, II, III respectively. 5. Observed the level of symptom and treatment afterwards affect, and recorded movements of intensity level for 3 types with same questionnaires. Results : 1. Type I : The survey turned out to be from 9 patients, initial level recorded 31.89 at the entry diagnosis, and next level that means changing of symptoms, recorded to 12.67 after prescribing herb medication. 2. Type II : From 11 patients, initial level was 32.82 and next level was 13.45. 3. Type III : From 3 patients, initial level was 37.67 and next one was 16.00. Conclusions : It is concluded that there is a significant remedial effect and related influence of the clinic treatment for each type of patients who suffering from a chronic cough and rhinorrhea caused by the common cold sequelae.

Burden of Disease Due to Outdoor Air Pollution in Korea: Based on PM₁₀

김현진,윤석준,김형수,이건세,김은정,조민우,오인환,Kim, Hyun-Jin,Yoon, Seok-Jun,Kim, Hyeong-Su,Lee, Kun-Sei,Kim, Eun-Jung,Jo, Min-Woo,Oh, In-Hwan Korean Society of Environmental Health 2011 한국환경보건학회지 Vol.37 No.5

Purpose: This study measured the burden of disease in Korea related to outdoor air pollution using disability-adjusted life year (DALY). Materials and Methods: As a risk factor of outdoor air pollution, particulate matter with a diameter less than 10 ${\mu}m$($PM_{10}$) was used. First, $PM_{10}$-related diseases and their relative risk (RR) were selected by means of a literature review. Second, population attributable fractions were computed by using formulae including RR and population exposure to $PM_{10}$. Third, DALYs of $PM_{10}$-related diseases in Korea were estimated. Finally, the attributable burden of disease due to $PM_{10}$ was measured as the sum of the products that multiplied the DALYs of $PM_{10}$-related diseases by their population attributable fractions. Results: The disease burden of PM10 was 6.9 DALY per 1,000 persons in 2007. The attributable burden of $PM_{10}$ was 2.68 for lung cancer, 2.41 for COPD, 0.62 for ischemic heart disease, 0.61 for pneumonia, 0.55 for asthma, and 0.03 for preterm. Conclusions: This study showed the environmental burden of disease of $PM_{10}$ and burden of $PM_{10}$-related disease through objective data. It also suggested that active efforts are needed to continuously measure and reduce the burden of environmental diseases in Korea.

Saccharomyces cerevisiae에서 Cycloinulooligosaccharide Fructanotransferase 유전자의 표층 발현

김현진,이재형,김현철,김연희,권현주,남수완,Kim, Hyun-Jin,Lee, Jae-Hyung,Kim, Hyun-Chul,Kim, Yeon-Hee,Kwon, Hyun-Ju,Nam, Soo-Wan 한국생명과학회 2007 생명과학회지 Vol.17 No.2

Paenibacillus macerans 유래의 cycloinulooligosaccharide fructanotransferase (CFTase) 유전자(cft, 2832 bp, 103.8 kDa)를 효모 표층발현 vector인 pCTcon (GAL1 promoter)에 subcloning 하였다. 구축된 pCTECFTN (9.0 kb)를 숙주세포인 s. cerevisiae EBY100에 형질전환한 후, uracil이 결핍된 배지와 inulin 함유배지에서 선별하였다. cft 유전자는 GAL1 promoter에 의해 효모 형질전환체에서 성공적으로 발현되었다. inulin으로부터 cyclofructans (CFs)로 생산하는 효소적 능력으로부터 표층발현 유무를 확인하였다. YPDG배지에서 48시간 배양 후 분획한 균체는 5.52 unit/ l 의 활성을 보였다. CF 생산을 위한 효소의 최적 반응 조건으로 pH 8.0, 반응온도 $50^{\circ}C$, 기질농도 5%, 기질은 Jerusalem artichoke 등의 inulin과 표층 발현 CFTase 효소반응 결과, cycloinulohexaose (CF6), cycloinuloheptaose (CF7), 그리고 cycloinulooctaose (CF8)이 생성되었고, 이 중에서 CF6가 주 생성물이었다. The cycloinulooligosaccharide fructanotransferase (CFTase) gene (cft) from Paenibacillus macerans was subcloned into the surface display vector, pCTcon (GAL1 promoter). The constructed plasmid, pCTECFTN (9.0 kb) was introduced to S. cerevisiae EBY100 cell and then east transformants were selected on the synthetic defined medium lacking uracil and on the inulin containing medium. The surface display of CFTase was confirmed by immunofluorescence microscopy and its enzymatic ability to form cycloinulooligosaccharides(cyclofructans, CFs) from inulin. The total activity of the CFTase was reached about 5.52 unit/1 by cultivation of yeast transformant on YPDG medium. The optimized conditions determined were as follows; pH, 8.0; temperature, $50^{\circ}C$ ; substrate concentration, 5%; inulin source, Jerusalem artichoke. By the reaction with inulin, CFs consisting of cycloinulohexaose (CF6), cycloinuloheptaose (CF7), and cycloinulooctaose (CF8) were produced and CF6 was the major product.

스트레스 완화 목적의 아로마 요법에 관한 문헌고찰

김현진,정수현,정혜인,김경한,Kim, Hyeon-Jin,Jeong, Soo-Hyun,Jeong, Hye-In,Kim, Kyeong Han 대한예방한의학회 2021 대한예방한의학회지 Vol.25 No.2

Objective : This study was aimed to review randomized controlled trials (RCTs) about whether aromatherapy relieves stress. Method : We searched document about criteria to use words like 'Aroma', 'Oil' and 'Stress'. The study included 24 RCTs which were selected by total 167 studies searched in Korean Journal by searching OASIS, ScienceON, KISS, RISS. Cases that cannot be performed alone are excluded. Results : We got 24 domestic standard documents. Of the 24 studies, 14 were for students, and 6 were for patients receiving hospital treatment. Among the 7 treatments, dry-inhalation was used 13 times, and necklace-inhalation was used 9 times. Of the 24 Studies, lavender oil was used 19 times and sweet orange was used 4 times. Among the 28 types of measuring instruments used, 10 related to the autonomic nervous system and 8 STAIs and VASs were used respectively. Conclusion : It was possible to conclude that aromatherapy was effective in relieving stress. Through further research, it is necessary to study effective oil mixing methods, methods for measuring subjective stress, multimodal intervention, and effective intervention periods.

내경계막 제거술 후 광간섭단층촬영에서 나타난 황반부 형태의 변형에 대한 분석

김현진,이정희,Hyun-Jin Kim,Jeong-Hee Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.2

`Purpose: To analyse the postoperative anatomical changes of maculae using optical coherent tomography after internal limiting membrane peeling during vitrectomy. Methods: A retrospective review of 22 patients (22 eyes) who underwent vitrectomy with internal limiting membrane peeling was performed. Age, sex, fundus findings, BCVA, operation methods, complications, and postoperative OCT findings were recorded. Results: Of 22 eyes, 12 eyes had epiretinal membranes, 5 eyes had macular holes, and 5 eyes had diffuse diabetic macular edemas. Eighteen of 22 eyes underwent internal limiting membrane peeling using ICG, with 1 eye treated with triamcinolone and 3 eyes treated with nothing. The postoperative improvement of BCVA was statistically significant in epiretinal membrane and diffuse macular edema patients (p<0.05), but insignificant in macular hole patients (p>0.05). Postoperative OCT findings of 17 eyes showed that they had returned to normal shape and thickness. However, among the 18 eyes that underwent ICG dye-assisted ILM, 3 eyes showed irregular macular thinning and 1 eye showed macular cystic changes. One eye treated with triamcinolone presented with a recurrent cytoid macular edema. No postoperative complications or recurrences were reported by epiretinal membrane patients. Conclusions: Changes to macular shape did not significantly affect the final BCVA after internal limiting membrane peeling, but they can cause changes to the microstructure of maculae. Therefore, caution during surgery and close follow-up are necessary.`

Ultrastructural Charateristics of a Human Sialolith

김현진,이수근,서봉직,Kim, Hyun-Jin,Lee, Soo-Guen,Suh, Bong-Jik The Korean Academy of Orofacial Pain and Oral Medi 1999 Journal of Oral Medicine and Pain Vol.24 No.4

타석에 관한 연구는 타석증을 보이는 환자에 대한 임상적 특징, 진단 및 치료에서부터 타석의 성분 및 구조 등에 이르기까지 다양한 범위에 걸쳐 이루어지고 있다. 타석의 미세구조에 관한 연구는 타석의 미세구조가 다양한 형태인 것으로 보고되고 있으며, 특히 최근 타석증의 치료에 새롭게 소개되고 있는 체외충격파쇄석술은 타석의 구조에 따라 그 효과가 영향을 받을 수 있을 것으로 사료된다. 이에 저자는 인간 타석의 미세구조에 관한 기본 자료가 필요할 것으로 사료되어 한국인 중년 여성으로부터 적출된 악하선 타석을 광학현미경 및 주사전자현미경을 이용하여 미세구조적 특징을 관찰한 결과, 다음과 같은 결론을 얻었다. 1. 타석은 중심부의 핵, 핵 주변의 층상구조 및 외피막으로 이루어져 있었다. 2. 핵은 비정형의 중심과 상대적으로 균질의 외곽부위로 구성되어 있었다. 3. 핵 주변은 대부분 동심원적인 층상구조를 보였지만 일부분에서는 균질의 구조를 보였다. 4. 타석 단면의 전체직경과 중심부 핵의 직경은 각각 $3,500{\mu}m$와 $1,500{\mu}m$였고, 층상구조를 이루는 각 층의 두께는 위치에 따라 약 $10{\sim}40{\mu}m$ 이내였다.

식품분야에서 Systems Biology 기술의 응용

김현진,Kim, Hyun-Jin 한국식품연구원 2011 食品技術 Vol.24 No.2

가와사끼병에서 면역글로불린 조기치료의 안전성과 효과

김현진,염혜원,김혜순,손세정,Kim, Hyun Jin,Yom, Hae Won,Kim, Hae Soon,Sohn, Sejung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.10

Purpose : To determine the differences in clinical characteristics, blood chemistry and coronary artery complications between patients with Kawasaki disease who received intravenous immunoglobulin (IVIG) within the fourth day of illness and after the fifth day of illness. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to Ewha Mokdong Hospital between January 2001 and June 2002. The early treatment group received IVIG within the fourth day of illness(n=34) and the control group received IVIG after the fifth day of illness(n=53). Clinical manifestations, fever duration, hospitalization days, CBC, blood chemistry and coronary artery complications were compared between two groups. Results : No demographic differences were noted between the two groups(P>0.05). Total duration of fever was significantly shorter in the early treatment group than the control group($4.8{\pm}2.5days$ vs $7.4{\pm}3.0days$, P<0.05), but there were no differences in fever duration after IVIG treatment and hospitalization days between two groups(P>0.05). No significant differences were noted in the level of hemoglobin, WBC, ESR, CRP, AST, ALT and albumin between two groups(P>0.05). No significant differences in the incidence of IVIG retreatment were noted between the two groups(11.8% vs 5.7%, P>0.05). No significant differences in the incidence of coronary artery complications were noted between the two groups(11.7% vs 18.9%, P>0.05). No significant differences in the recurrence rate were noted between the two groups(3% vs 2%, P>0.05). Conclusion : Early IVIG treatment in patients with Kawasaki disease reduces the total fever duration. Coronary artery complications were not increased in patients with early IVIG treatment. 목 적 : 가와사끼병 환아에서 면역글로불린을 조기 투여하였을 때 치료 실패의 빈도와 관상 동맥의 합병증이 증가하는 지를 알아보고자 본 연구를 시행하였다. 방 법 : 2001년 1월부터 2002년 6월 사이에 이화의대 목동병원 소아과에서 가와사끼병으로 치료받은 환아 87명의 입원 및 외래 기록을 후향적으로 조사하였다. 면역글로불린을 발열 4일 이전에 투여받은 환아를 조기투여군(34명), 발열 5일 이후에 투여 받은 환아를 대조군(53명)으로 하였다. 두 군간의 임상양상, 혈액 검사, 발열기간, 치료 및 관상 동맥 합병증을 비교 조사하였다. 결 과 : 1) 두 군간의 인구학적 특징의 차이는 없었다(P>0.05). 2) 총 발열기간은 조기 투여군과 대조군이 각각 $4.8{\pm}2.5$일과 $7.4{\pm}3.0$일로 조기 투여군에서 유의하게 짧았다(P<0.05). 면역글로불린 투여 후 발열 기간과 입원기간은 두 군에서 유의한 차이를 보이지 않았다(P>0.05). 3) 혈색소, 백혈구수, 혈소판수, 혈침속도, CRP, AST, ALT, 알부민은 두 군간에 유의한 차이가 없었다(P>0.05). 4) 면역글로불린 재투여 빈도는 조기 투여군과 대조군에서 각각 11.8%와 5.7%로 유의한 차이를 보이지 않았다(P>0.05). 5) 관상 동맥 합병증은 조기 투여군에서 11.7%와 대조군에서 18.9%로 유의한 차이가 없었다(P>0.05). 6) 가와사끼병의 재발은 각각 3%와 2%로 두 군간에 유의한 차이가 없었다(P>0.05). 결 론 : 가와사끼병에서 면역글로불린 조기투여는 총 발열기간을 감소시키고, 면역글로불린 치료 실패율과 관상 동맥류 발생을 증가시키지 않았다.

다중 주사 경로 회로 기판을 위한 내장된 자체 테스트 기법의 연구

김현진,신종철,임용태,강성호,Kim, Hyun-Jin,Shin, Jong-Chul,Yim, Yong-Tae,Kang, Sung-Ho 대한전자공학회 1999 電子工學會論文誌, C Vol.c36 No.2

The IEEE standard 1149.1, which was proposed to increase the observability and the controllability in I/O pins, makes it possible the board level testing. In the boundary-scan environments, many shift operations are required due to their serial nature. This increases the test application time and the test application costs. To reduce the test application time, the method based on the parallel opereational multiple scan paths was proposed, but this requires the additional I/O pins and the internal wires. Moreover, it is difficult to make the designs in conformity to the IEEE standard 1149.1 since the standard does not support the parallel operation of data shifts on the scan paths. In this paper, the multiple scan path access algorithm which controls two scan paths simultaneously with one test bus is proposed. Based on the new algorithm, the new algorithm, the new board level BIST architecture which has a relatively small area overhead is developed. The new BIST architecture can reduce the test application time since it can shift the test patterns and the test responses of two scan paths at a time. In addition, it can reduce the costs for the test pattern generation and the test response analysis. 인쇄 회로 보드 수준의 테스팅을 위해 제안된 IEEE 표준 1149.1은 보드상의 테스트 지점에 대한 제어용이도와 관측용이도를 향상시켜 보드의 테스트를 용이하게 해준다. 그러나, 경계 주사 환경에서는 테스트 입력과 테스트 결과에 따른 데이터가 하나의 주사 연결에 의해서 직렬로 이동된다. 이는 테스트 적용시간을 증가시키고 따라서 테스트에 드는 비용을 증가시킨다. 테스트에 소모되는 시간을 줄이기 위해 병렬로 다중주사 경로를 구성하는 방법이 제안되었다. 하지만 이는 여분의 입출력 핀과 내선을 필요로 한다. 더구나 IEEE 표준 1149.1은 주사 경로 상에 있는 IC들의 병렬 동작을 지원하지 않기 때문에 표준에 맞게 설계하기가 어렵다. 본 논문에서는 하나의 테스트 버스로 두 개의 주사 경로를 동시에 제안하는 다중 주사 경로 접근 알고리즘에 기초하여 적은 면적 오버헤드를 가지고 빠른 시간 내에 보드를 테스트할 수 있는 새로운 보드수준의 내장된 자체 테스트 구조를 구현하였다. 제안된 내장된 자체 테스트 구조는 두 개의 주사 경로에 대한 테스트 입력과 테스트 결과를 이동시킬 수 있으므로 테스트에 소모되는 시간을 줄일 수 있고 또한 테스트 입력의 생성과 테스트 결과의 분석에 소모되는 비용을 줄일 수 있다.

혼합용매 내에서 단분산 Al2O3 미립자의 합성에 대한 전해질 첨가효과

김현진,김희택,배성렬,류경옥 ( Hyun Jin Kim,Hee Taik Kim,Seong Youl Bae,Kyong Ok Yoo ) 한국화학공학회 1995 화학공학의이론과응용 Vol.1 No.2