http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국 프로야구 선수들이 지각한 감독의 리더십과 선수들의 스트레스 및 생활 만족도에 관한 연구
이상호,이계윤,김갑룡,원유병,이해권 창원대학교 체육과학연구소 2002 경남 체육연구 Vol.7 No.1
현장에 적용하여, 한국 프로야구 감독자들의 리더 역할이 효율적 또는 비효율적 프로파일 중에서 어느 프로파일에 해당하는지 알아보고, 그리고 감독자들의 6개 리더 역할과 선수들의 스트레스 및 생활만족도 간에 상관 관계를 분석하였다. 조사대상은 해태 야구 선수를 포함하여 해태 야구 선수들과 시합을 하기 위해 어웨이 경기차 광주를 방문한 7개 구단 선수들을 본 연구자가 직접 숙소로 찾아가 조사 목적과 설문 내용을 설명하고, 본 설문지에 응답토록 하였다. 조사된 설문지 중에서 성의없이 응답했거나, 전체 문항중 10%이상 응답을 하지 않은 자료에 대해서는 연구 대상에서 제외한 결과 최종 145명을 연구자료로 확정하였다. 측정도구는 하형주(1996)가 개발한 스포츠 지도자의 대응가치 리더십 검사지(CVLQS:Competing V alues Leadership Questionnaire for Scale)를 사용하였다. 스트레스를 알아보기 위해 첫째, 한국 스트레스 매니지먼트 연구소에서 개발한 심리적, 신체적 스트레스 척도(1990)를 사용하였고, 둘째, 운동 스트레스는 이계윤(1997)이 개발한 프로야구 선수들의 스트레스 척도를 사용하였다. 자료분석은 먼저 선행 연구에서 밝힌 스포츠 지도자의 효율적인 리더십 프로파일을 제시한 후, 각 구단별 프로야구 감독들의 리더 역할에 대해 Z점수를 구하고, Quinn(1988)이제안한 리더십 프로파일에 적용하여 비교 분석하였다. 마지막으로 한국 프로야구 감독들의 6개 리더 역할과 선수들의 스트레스, 생활 만족도 간에 상관 분석을 하였다. 이상과 같은 연구과정을 통해 도출된 결론은 다음과 같다. 첫째, 효율적인 리더역할 프로파일에 해당한 감독은 8개 구단 감독 중 감독 2, 3, 4, 7, 8로 나타났고, 비효율적인 리더역할 프로파일에 해당한 감독은 감독 1, 5, 6으로 나타났다. 둘째, 한국 프로야구 감독들의 리더역할과 운동선수들의 스트레스, 생활만족도 간의 상관분석은 감독의 리더역할과 운동선수들의 신체적 스트레스, 운동 스트레스, 생활만족도 간에 유의한 상관으로 나타났다.
아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성
조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.
니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 엘카틴 정의 생물학적 동등성
조혜영,윤지훈,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-
Acetyl-L-camitine (ALC), an endogenous component of the L-carnitine family, is a naturally existing molecule synthesized from L-carnitine (LC) by carmtine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^TM (Dong-A Pharmaceutical Co.) and L-Cartin^TM (Kuhn Il Pharmaceutical Co.), according to the guidelines of Korea Food and Drug Administration (KFDA). The ALC release from the two ALC tablets in vitro was tested using KP Ⅶ Apparatus Ⅱ method in various dissolution media (pH 1.2, 6.0 and 6.8). Twenty six normal male volunteers, 24.46±3.67 years in age and 64.45±5.54 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. The dissolution profiles of the two ALC tablets were similar in all the dissolution media. The pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 0.35%, 0.93% and 2.34%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 98.72% and 85.48%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 13.21% and 18.42% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -7.38~8.09 and -9.86~11.72 for AUC_t and C_max, respectively). These two parameters met the criteria of KFDA for bioequivalence, indicating that L-Cartin^TM tablet is bioequivalent to Nicetile^TM tablet.
Overview of the status of the development of antiviral drugs for COVID-19
Seung Yun Lee(Seung Yun Lee),Ji Hyeop Kang(Ji Hyeop Kang),Hea Jin Kang(Hea Jin Kang),Sun Jin Hur(Sun Jin Hur) 한국축산식품학회 2020 Food and Life Vol.2020 No.2
In this study, we surveyed worldwide media reports and research papers on the development of vaccines and antiviral drugs for COVID-19 treatment published over the past few months. We found that more studies were being conducted on the use of already approved drugs (remdesivir, lopinavir/ritonavir, chloroquine, niclosamide, and ivermectin) as new COVID-19 treatments, than on the development of new antiviral drugs. This could be due to the urgent need for drug development. We found that till date, there seem to be no results on current or future COVID-19 vaccine development. However, media reports showed that numerous companies have invested in vaccine development and some clinical trials are already underway (mostly in phase I–II). According to the results of our survey, the drugs that have been previously approved to treat other diseases have not yet been found to be very effective in treating COVID-19 patients; however, remdesivir is the most promising drug. Due to the pandemic situation, the number of patients participating in these clinical trials, compared to that in other previous clinical studies, is small. Therefore, due to the low reliability of the findings, additional experiments must be continued.
Overview of energy intake, physical activity, and neuronal substances on obesity
Seung Yun Lee(Seung Yun Lee),Hea Jin Kang(Hea Jin Kang),Sun Jin Hur(Sun Jin Hur) 한국축산식품학회 2020 Food and Life Vol.2020 No.1
This study provides an overview of the effects that energy sources, physical activity, endocrine substances and meat consumption have on the prevention and treatment of obesity. We found that many factors are considered to be involved in the occurrence of obesity, and that controversies exist over the mechanisms underlying, and solutions for, obesity. Several endocrines, including dopamine, insulin, leptin, and adiponectin, are implicated in body weight gain or obesity. The accumulation of body fat may vary depending on the percentage of carbohydrate and fat intake, but the results of several studies regarding this aspect are inconsistent. Information regarding the effects of the extreme restriction of carbohydrate intake or fat intake on the reduction of body weight gain is also insufficient. Furthermore, the relationship between eating habits, physical activity and meat consumption in obesity remains controversial. While the influence of leptin and adiponectin on food intake and obesity has been widely studied, the development of drugs that use these substances to treat obesity is difficult. Based on the findings of this study, the authors believe that further research is needed to determine how to control body weight gain and to address the various controversies regarding diet or obesity.
( Kyung Hea Park ),( Seok Jong Lee ),( Moon Bum Kim ),( Il Hwan Kim ),( Sook Jung Yun ),( Dong Youn Lee ),( Mi Woo Lee ),( Kee Yang Chung ),( Kwang Hyun Cho ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Cutaneous melanoma in Korean is as rare as approximately 2,085 new patients in South Korea from 2006 to 2010 therefore little data are available in Korea. Objectives: The Purpose of our study is to investigate the current status of clinico-pathological diagnosis and management of melanoma in Korea. Methods: We surveyed melanoma patients from 8 hospitals with questionnaire including overall clinical characteristics, evaluation tool, behavior of pathologic diagnosis and management. Results: Data revealed that 905 new melanoma cases (43.4% from total 2,085 patients) were enrolled from 8 hospitals during past 5 years (2006~2010). Half of them operate the multidisciplinary meeting. Seven performed a sentinel lymph node biopsy, the percentage ranged from 4.1% to 83.5% (average 29.5%). Information routinely included in pathological report is various; Breslow thickness (7 hospitals), ulceration (7), mitotic rate (7), Clark level (5) and etc. There was a diagnostic mismatch (0~5.3%) between pathologist and dermatologist and it was developed mostly due to differentiation between malignancy and benignancy. Strategy for surgery including surgical margin was almost similar. However interferon for stage 3 was employed from 0% to 62.2% and dacarbazine was used variably (6.0% ~ 54.5%) for stage 4 melanoma. Conclusion: Korean standard for melanoma has to be established due to considerable discrepancy in terms of pathological diagnosis and clinical management of melanoma from hospital to hospital.