이식형 제세동기를 위한 Flyback Converter의 출력보상

卞咭浩,劉永善,李祥準,李鐘雨,金正國,許雄 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

On the occasion of sudden cardiac fibrillation, it is critical to use the defibrillator which delivers electrical energy across the patient's chest, in short time. Since the capacitor and battery inside 1CD(implantable cardioverter/defibrillator) degrade according to the increase of usage and time, the charging time of capacitor becomes prolonged, in order to compensate the prolonged charging time, we propose an algorithm which controls the charging time by changing frequency and duty cycle of feeding pulses to the input of flyback converter.

각종 소화장애 및 식욕부진에서의 Gaspylor^(�)의 임상적 효과

변상현,정상덕,이건수,이재호,정용헌 최신의학사 1993 最新醫學 Vol.36 No.5

호산구증가증을 동반한 혈관임파양 증식증

변영남,정필훈,윤영호,김종철 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Angiolymphoid hyperplasia with eosinophilia(ALHE) is benign subcutaneous lesion that primarily affects head and neck region. It is characterized by single or multiple nodules in the subcutaneous tissue associated with eosinophilia in the peripheral blood. Kimura's disease, originally reported by Kimura et al., is similar lesion with ALHE in the clinical and histopathological aspects. There has been considerable controversy about the relation between Kimura's disease and ALHE. IN Korea, 26 cases of Kimura's disease and ALHE have been reported since 1975. We present a case of recurred ALHE occurring on the left cheek in a 58-year-old woman. Including this case, we summarized all cases that were reported as Kimura's disease or ALHE in Korea through literature review. We also give an outline of clinical and histopathological characteristics of cases reported in Korea.

광범위 외측 접근법으로 수술한 종골 골절의 술 후 조기 합병증

변영수,조영호,박준우,이진석,김지환 대한골절학회 2004 대한골절학회지 Vol.17 No.4

목적 : 광범위 외측 접근법으로 수술한 종골 골절에서 술 후 조기 합병증들을 분석하고 창상 합병증에 대한 위험 요인들을 알아보았다. 대상 및 방법 : 1990년 7월부터 2003년 2월까지 광범위 외측 접근법으로 수술한 종골 골절 104명, 116예를 대상으로 하였다. 환자들의 병록지에서 술 후 조기에 발생한 합병증들을 조사하여 분석하였으며, 창상 합병증의 위험을 증가시키는 요인들을 알아보기 위해 예견되는 변수들에 대하여 통계학적 분석을 하였다. 결과 : 감염이 14예 (12.0%)에서 발생하였으며, 10예 (8.6%)는 표재 감염이었고 4예 (3.4%)는 삼부 감염으로 수술적 치료가 필요하였다. 피부 괴사가 8예 (6.9%)에서 발생하였으며, 6예 (5.2%)는 수술창 변역부의 피부 괴사였고 2예 (1.7%)는 피판 괴사로 수술적 치료가 필요하였다. 비복신경 손상이 7예 (6.0%)에서 발생하였으나 부가적인 치료 없이 회복되었다. 통계학적 분석 결과 개방성 골절 군(p=0.003)과 수술시간이 90분 이상 연장된 군 (p=0.049)에서 창상 합병증의 발생률이 유의하게 높았다. 결론 : 광범위 외측 접근법으로 수술한 종골 골절에서 술 후 조기 합병증의 발생률이 높으므로 개방성 골절에서는 개방창을 철저하게 치료하고, 술 전 계획과 계획된 술기를 통하여 수술 시간을 90분 이내로 단축하고, 비복신경의 해부학적 위치를 고려하여 절개함으로 술 후 조기 합병증의 발생률을 감소시킬 수 있을 것으로 사료된다. Purpose : To analyze early postoperative complications of calcaneal fractures operated by a lateral extensile approach and to identify risk factors for would complications. Materials and Methods : From July 1990 to February 2003, 116 calcaneal fractures in 104 patients were treated by open reduction and internal fixation through a lateral extensile approach. The patient's records were reviewed for early postoperative complications. Statistical analysis was performed to determine significant relationships between predicted variables and the development of would complications. Results: Fourteen fractures (12.0%) developed infection. Ten of them were superficial infection and four were deep infection that required surgical treatment. Eight fractures (6.9%) developed skin necrosis. Six of them were marginal skin necrosis and two were flap necrosis that required surgical treatment. Seven fractures (6.0%) developed sural nerve injury, but their symptoms were improved without additional treatment. Open fracture (p=0.003) and prolonged operating time (p=0.049) increased significantly the rate of wound complications. Conclusion: The rate of early postoperative complications of calcaneal fractures operated by a lateral extensile approach is high. These complications can be reduced by meticulous treatment of an open wound, reduced operating time within 90minutes through preoperative planning and skillful technique, and correct incision to avoid damage of the sural nerve.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

치근단 및 치수병변 환자에서의 TNF-α와 β, IL-1β및 TGF-β1 의 수준과 근관내 특정 black pigmented bacteria와의 연관성에 관한 연구

변호영,임성삼,박동성 大韓齒科保存學會 1999 Restorative Dentistry & Endodontics Vol.24 No.1

난소제거된 백서에서 호르몬제 투여가 대퇴골 경부의 강도에 미치는 영향에 관한 실험적 연구

박정호,변영수 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.1

Aging is characterized by an age-dependent reduction in bone density. Pronounced bone loss by postmenopausal estrogen deficiency induces a bad effect on dynamic balance of bone metabolism. When the bone density is reduced to the level below the fracture threshold. the risk for fracture is greatly increased. Osteoporosis-induced fractures as a result, especially around hip joint, inevitably need the operative treatment. Thus, in order to decrease the occurrence of new fractures, a corrective therapy is needed to stimulate bone formation. Antiresorptive agents such as estrogen and calcitonin inhibit bone resorption at early period of menopause, but are not effective for established osteoporosis. However. parathyroid hormone is approved a s an effective agent available for the treatment of osteoporosis such as an anabolic effect on bone density and a positive effect on the rate of osteoporosis-induced fractures. The aim of present study is to elucidate the effects of estrogen, calcitonin, parathyroid hormone alone or combination therapy of parathyroid hormone with estrogen or calcitonin on the strength of the femur neck and the amount of bone mineral density of the proximal tibia in ovariectomized rats. Sixty-four female rats(Sprague-Dawley rat). of three months old and weighing in 250gm~300gm. were used for the experiment. Fifty-five rats were ovariectomized and divided into six groups and remaining nine rats were subjected to sham-operation. All groups were untreated for eight weeks to induce significant bone loss. Then they were administrated of hormone for four weeks according to protocols except control and sham-operation group. They consisted of group Ⅰ (n=10) for control. group Ⅱ (n=9) for sham-operation. group Ⅲ (n=9) for administration of estrogen, group Ⅳ(n=l0) for parathyroid hormone, group Ⅴ (n=8) for calcitonin, group Ⅵ(n=9) for parathyroid hormone with calcitonin and group Ⅶ (n=9) for parathyroid hormone with estrogen. The retrieved femurs were harvested to biomechanical testing using universal testing machine (Instron-4467) and ipsilateral proximal tibias were assessed for bone mineral density with dual energy x-ray absorptiometry (Hologic QDR 2000). These results were statistically analyzed by unpaired student t-test. The results obtained were as follows : 1. The mean mechanical strength of femur neck was 182.98±33.25 MPa in control group(group Ⅰ), 220.53±34.61 MPa in group Ⅱ, 233.90±56.64 MPa in group Ⅲ, 217.08±l7.73 MPa in group Ⅳ and 190.61±42.74 MPa in group Ⅴ, 198.84±26.29 MPa in group Ⅵ and 213.80±19.88 MPa in group Ⅶ. As compared with the result of control group, the results of group Ⅱ, Ⅲ, Ⅳ, Ⅶwere statistically significant (P<0.05), however, of group Ⅴ and Ⅵ were statistically insignificant (P>0.05). 2. The mean bone mineral density of the proximal tibia were 0.066±0.0095 gm/㎠ in control group(group Ⅰ), 0.088±0.0084 gm/㎠ in group Ⅱ , 0.081±0.0094 gm/㎠ in group Ⅲ, 0.085±0.0093 gm/㎠ in group Ⅳ and 0.069±0.0112 gm/㎠ in group Ⅴ , 0.079±0.0111 gm/㎠ in group Ⅵ and 0.079±0.0117 gm/㎠ in group Ⅶ. As compared with the result of control group, the results of group Ⅱ, Ⅲ, Ⅳ, Ⅵ, Ⅶ was statistically significant (P<0.05), however, of group Ⅴ was insignificant (P>0.05). Thus, these findings provide asupport for using estrogen or parathyroid hormone in the treatment of postmenopausal osteoporosis. The combination treatment of the parathyroid hormone with estrogen or calcitonin is shown no outstanding advantage over the treatment with estrogen or parathyroid hormone alone. The treatment of calcitonin does not promise any potential of its use in the postmenopausal osteoporosis.

비침습적 검사를 이용한 수술후 하지 심부 정맥 혈전증의 감시

김영욱,정한준,윤봉호,김신윤,이상국,변경환,김태헌 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

Deep vein thrombosis is recognized as a common complication in surgical patients in western countries especially in patients with high risk factors. The purposes of this study were to detect leg DVTs in early postoperative period by non-invasive surveillance and to analyze the risk factors of DVT. One hundred seventy one patients who underwent major operations(67 curative resection of colorectal cancer, 64 total hip replacement, 38 femur operation for fracture, and 2 colon resections for benign colon disease) were included for the prospective surveillance of leg DVT within 2 weeks after the operations. For the surveillance of leg DVT, strain gauge plethysmography(SPG) and Duplex scanning of both legs were completed for all patients except 10 patients. These 10 patients were examined in only one leg. The patients with past history of leg DVT or under prophylactic anticoagulant therapy were excluded from this study. To determine the risk factors related with leg DVT formation, age and sex of the patients, indication of surgery or surgical procedures, duration of operation, position during the operation, duration of postoperative immobilization, and preoperative serum level of antithrombin III (AT- III) were analyzed using Chi-square test. After performing SPG of 342 legs, 38 legs, showed abnormal on venous outflow/venous capacitance discriminant line chart, and 13 legs of 12 patients showed the finding(s) suggesting DVT on duplex scanning. Among the patients with abnormal duplex findings, 7 limbs(53.8%) were symptomatic, but the remaining 6 legs were silent. In 6 (15.8%) patients of 36 femur operations, 3(4.7%) of 64 total hip replacements and 3(4.5%) of 67 curative resections of colorectal cancer developed DVT by duplex scanning in the iliac(5), femoral-popliteal(6), and isolated calf(2) veins. After analyzing the risk factors, we could not find any statistically significant(p<0.05) factor related with leg DVT.

이차성 구순열 비변형의 교정술 : 증례보고

여환호,변웅래,김영균 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.2

A wide variety of deformities can occur following repair of the cleft lip. Especially, cleft lip nasal deformities offer the severe psychologic, esthetic, and functional impairment. We must restore the deformities of alar cartilge, nasal tip, septum, columella, or pyriform aperture. The authors reconstructed the cleft lip nasal deformities using with the alar cartilage rearrangement, postauricular cartilage graft, and/or columellar lengthening. The 3 case reports are presented.

수종 한약재가 백혈병 세포에 미치는 영향에 대한 연구

崔湖榮,金澤,柳志昌,卞德市,盧昇鉉 대한본초학회 1999 大韓本草學會誌 Vol.14 No.1

I am reporting here a syntematic in vitro examination for specificity of anti-cancer effect of several oriental herbs, which have been used frequently for cancer pateints(therapy), on Molt-4 LCL(Lymphoblastoid Cell Line) Leukemic cells in relation to its density and time of incubation. 1. ErOH extract of Jujubae Fructus reduced Molt-4 cell's survival rate effectively after 48 hours' treatment at 1000㎍/㎖'s density and it reduced survival rate of LCL effectively after 12 hours' treatment at 1000㎍/㎖'s density. 2. EtOH extract of Cordyceps reduced LCL's survival rate effectively after 36 hour's treatment at 1000㎍/㎖'s density. 2. EtOH extract of Fici Fructus reduced LCL's survival rate effectively after 36 hours' treatment at 1000㎍/㎖'s density. 4. EtOH extract of Trionycis reduced Molt-4 cell's survival rate even at 500㎍/㎖ density and further effective at 1000㎍/㎖ density after 24 hours treatment and it killed the cells completely at 1000㎍/㎖ density after 48 hours treatment, It also Killed LCL completely after 12 hours and 36 hours' treatment at 1000㎍/㎖'s density. 5. EtOH extract of Biotae Cacumen reduced LCL's survival rate effectively after 12 hours' treatment at 1000㎍/㎖'s density, and after 36 hours treatment it reduced LCL's survival time very effectively. 6. EtOH extract of Psoraleae Fructus reduced Molt-4 cell's survival rate very effectively after 24 hours' treatment at 500㎍/㎖ and 1000㎍/㎖'s density, and after 48 hours' treatment at 250㎍/㎖'s density it reduced effectively and it killed the cell completely at 500㎍/㎖ and 1000㎍/㎖'s density. It also killed LCL completely after 12 hours and 36 hours' treatment at 1000㎍/㎖'s density. I hope to proceed with more advanced experiment in vivo and clinically as for the two kinds of oriental herbs and another herbs effective for leukemia.