Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Haplogroup Classification of Korean Cattle Breeds Based on Sequence Variations of mtDNA Control Region

Kim, Jae-Hwan,Lee, Seong-Su,Kim, Seung Chang,Choi, Seong-Bok,Kim, Su-Hyun,Lee, Chang Woo,Jung, Kyoung-Sub,Kim, Eun Sung,Choi, Young-Sun,Kim, Sung-Bok,Kim, Woo Hyun,Cho, Chang-Yeon Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.5

Many studies have reported the frequency and distribution of haplogroups among various cattle breeds for verification of their origins and genetic diversity. In this study, 318 complete sequences of the mtDNA control region from four Korean cattle breeds were used for haplogroup classification. 71 polymorphic sites and 66 haplotypes were found in these sequences. Consistent with the genetic patterns in previous reports, four haplogroups (T1, T2, T3, and T4) were identified in Korean cattle breeds. In addition, T1a, T3a, and T3b sub-haplogroups were classified. In the phylogenetic tree, each haplogroup formed an independent cluster. The frequencies of T3, T4, T1 (containing T1a), and T2 were 66%, 16%, 10%, and 8%, respectively. Especially, the T1 haplogroup contained only one haplotype and a sample. All four haplogroups were found in Chikso, Jeju black and Hanwoo. However, only the T3 and T4 haplogroups appeared in Heugu, and most Chikso populations showed a partial of four haplogroups. These results will be useful for stable conservation and efficient management of Korean cattle breeds.

맞벌이 여부에 따른 직장-가정간 갈등과 직무만족도

최수찬,우종민,박웅섭,김상아 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 본 연구에서는 기혼의 직장인들을 대상으로 직장 역할에 참여함으로서 가정역할 수행이 어려운 경우와 반대로 가정역할에 참여함으로서 직장 역할 수행이 어려운 경우에 발생하는 직장-가정 간 갈등과 같은 스트레스가 직무태도에 미치는 영향에 있어 맞벌이 여부에 따른 차별적 영향의 가능성을 고찰해보고자 하였다 방법 서울과 수도권에 거주하고 있는 직장인 1,000명을 대상으로 우편설문을 실시하여 44.0%의 회수율을 보였으며 본 연구의 주제인 맞벌이 여부에 맞도록 기혼상태로 보고한 236부의 설문지만을 최종 자료로 사용하였다 수집된 자료는 전산입력 후 SAS 10.0 프로그램을 사용하여 통계처리 하였다 결과 직무만족도를 종속변수로 이변량분석에서 유의한 변수들을 독립변수로 한 다중희귀분석수행결과 홑벌이에 있어서는 직장이 가정에 끼치는 갈등이 감소할수록 직무만족도가 유의하게 높았고(p<0.05) 맞벌이에서는 가정이 직장에 끼치는 갈등이 감소할수록 직무만족도가 유의하게 높았다(p<0.05) 결론 맞벌이 여부에 따라 경험하는 직장-가정과 관련된 스트레스의 내용에 차이가 있으므로 추후 기업 내에서 근로자들의 직무만족도를 향상시키기 위해서는 홑벌이와 맞벌이와 같은 가족형태에 따른 차별적 서비스를 제공할 필요가 있다 Objectives Work family conflict can arise from two opposite directions the experiences at work interfere with family life and the experiences in the family interfere with work life This study explored the effects of the presence of two income sources on the association between work-family conflict and Job attitude Methods Responses to structured survey questionnaires were received from 236 two-income families living in the Seoul Metropolitan Area Results A differential effect was observed between single income families and two-income families Higher job satisfaction was related with lower work interference with family (WIF) among single-income families and with lower family interference with work (FIW) among two-income families Conclusions Employee welfare programs need to be expanded to enhance job satisfaction for the increasing number of two-income families

정신 장애자의 병실 이탈에 관한 연구

최상섭 大韓神經精神醫學會 1978 신경정신의학 Vol.17 No.3

One hundred and five attempted escapes made by 44 mental patients from Neuro-Psychiatric ward of E-Wha University Hospital during the period from 1973, Apr. 1 to 1978 Mar. 31 with available chart records were reviewed. The ward has 20 beds. The personnels were 2 board specialists, 4 residents, 5 nurses, 3male aides, one clinical psychologist and 8 to 12 students of medical and nursing schools and social work department. There was no sex difference. About 80% of the escapees were those in second and third decades of age. Seventy five % of them had had educational background of high school and college. Schizophrenia was the most frequent diagnosis, comprising 59.1% of the total subjects. Seventy five % of then had been admitted involuntarily, and for 84.1% of them the admission had been the first. Most of them had been placed on psychotherapy and drug therapy. About 89% of them had been visited and met during their hospitalization by their families reqularly or irregularly. Average length of their hospitalization was 43.5 days. Choice of time for their escapes was most frequently during the first week comprising 31.7% of the total attempts. It was mostly in the evening or in day time. Weekends and days of family visits; were frequently chosen. They usually escaped on foot in hospital gowns. Only 17% of them succeeded in going out of the hospital compound, and about one quarter of the total attempted escapes were successful. Most of the escapes were detected by ward personnels; about 81% was detected within 15 minutes but about 10% was detected over one hour after the attempt. Most of them returned to the hospital but 6.7% of them failed to return. About 59% of the families were cooperative in returning the patients to hospital but 9% of them were overtly reluctant to return the patients. Two escape attempters were physically injured during the escapes. On returning to the ward, 87.6% of them resumed stability by interview alone without resort to physical restraint or additional emergency medication. Seventy five % of them were followed up at this O.P.D.

스테로이드로 유발된 쥐의 근골격계 변화에대한 성장호르몬의 치료 효과

최기섭,박창일,정우성,이상건,박용욱 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.5

植物凝集素 Agastache rugosa O.Kuntze 및 닭 赤血球에 의한 사람 血淸型에 關한 硏究

崔相燮,文國鎭 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.3

Since the discovery that certain seeds contain agglutinins specific for some human blood group antigens at the end of 1940's by the respective studies of Renkonen and Boyd, et al., many blood group specific phytagglutinins were reported and some of them are being used for the classification of human blood groups. Recently, with the increasing requirement of individual identification in medicolegal field, various panphytagglutinins have been also investigated for the new classification of human sera by their inhibition properties to agglutination reaction of panphytagglutinin with human or aminal red blood cells. Agastache rugosa extract used in this study reacts as panphytagglutinin on chicken red blood cells. Agglutination inhibition test was performed with 556 cases of fresh human sera. 100 cases of each human serum stain and whole blood stain, and compared them with other known blood groups and serum types statistically. The results obtained could be summarized as follows: 1. Human sera could be classified into two groups. One group inhibited agglutination activities of Agastache rugosa agglutinin to chicken red blood cells and the other did not. 2. Among the investigated 556 human sera, the frequency of the former was 34% and the latter was 66%. 3. The agglutination inhibition phenomena of human sera to agglutination reaction of Agastache rugosa extract with chicken red blood cells showed no constant relation with other known blood groups and serum types, such as ABO, Cl, H, MN, Vp, WVp, Cea, WCea, ab.C, CCI, CCN, PVI and PVN, and Hp respectively. 4. This new classification of human serum type may be applicable for the classification of blood stains.

충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996

최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).

Resistive switching characteristic of Ce0.9Y0.1O2/ TiO2 bi‑layer structure by photochemical metal‑organic deposition

Sung‑Eun Kim,Jin-Gyu Lee,In-Young Choi,Ha-Eun Kim,Hong-Sub Lee 한국세라믹학회 2020 한국세라믹학회지 Vol.57 No.1

Sneak current is one of the main bottlenecks for dense crossbar array resistive random access memory. This study reports highly non-linear resistive switching characteristic from Ce0.9Y0.1O2/ TiO2 bi-layer (1S/1R device) structure, fabricated by photochemical metal-organic deposition, as a solution for sneak current issue. Ce0.9Y0.1O2 material, possessing oxygen vacancies, was used as a potential barrier as well as oxygen reservoir which rectified the current of low resistance state without an electrical breakdown in 1S/1R device. TiO2 was adopted for resistive switching property, and TiO2 layer having mixed phase (anatase and brookite) showed typical diode switching behavior. The photochemical reaction of photochemical metal-organic deposition process and phase formation were monitored and established using by Fourier-transform infrared spectroscopy and X-ray diffraction, respectively. The 1S/1R device showed highly non-linear resistive switching characteristic, large on/ off ratio of above three orders of magnitude with low operating current.

서울시 사회복지시설 근무 사회복지사들의 직무스트레스 수준

최수찬,김상아,이정은,박웅섭 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 사회복지사의 직무스트레스 실태를 알아보고,복지시설 유형과 직업조건에 따른 직무스트레스의 차이를 조사하고자 하였다. 방법: 서울시 소재 681개 사회복지시설에 근무 중인 사회복지사를 대상으로 우편설문을 시행하였으며 ,최종 분석 사용된 설문지는 총 432부였다. 한국인 직무스트레스 측정도구(KOSS)의 단축형을 사용하여 직무스트레스를 측정하였고,빈도분석,t-test,ANOVA 분석을 실시하였다. 결과: 노인복지시설의 경우 타 기관에 비해 직무요구,직무자율성결여,보상부적절로 인한 스트레스 수준이 모두 높게 나타났다. 작업조건별로는 업무형태,근무시간, 정규휴식시간,직위에 따라 직무스트레스 수준에 차이가 있었다. 서비스와 행정을 둘 다 수행하는 경우에 직무스트레스총점,직무요구,관계갈등,직무불안정,조직체계,보상부적절, 직장문화 영역의 직무스트레스 수준이 높았고,근무시간이 10시간 이상인 경우에 직무요구 영역에서 ,일선 및 선엄사회복지사가 직무자율성결여 및 보상부 적절로 인한 직무스트레스 수준이 높게 나타났다,또한 정규휴식시간 유무에 따라서는 직무스트레스 총점 및 직무스트레스의 7개 하위 영역 모두에서 유의한 차이가 있었다. 결론: 사회복지사의 직무스트레스를 적절한 관리하기 위해서는 서비스와 행정업무 병행에 대한 조치 및 정규휴식시간 확보가 필요하고,특히 노인복지시설 사회복지사의 직무스트레스에 대한 적절한 관리가 필요하다. Objectives: To investigate the level and variation of job stress according to social welfare organizations and work conditions among social workers in Seoul. Methods: For this survey, a self-reported questionnaire was administrated to 1,000 social workers working in organizations for social welfare practice in Seoul. A total of 432 completed questionnaires were received (43.2% response rate). Results: Social workers working in welfare organizations for the aged had higher job stress in the areas of job demand, insufficient job control and lack of reward than those in other welfare organizations. In addition, higher job stress was found in those in charge of both service and administrational work, without regular time for rest, working over 10 hours, in the frontline and senior grade. Conclusions: This study confirms the importance of guaranteeing regular time for breaks in the work schedule and of considering the service and administrational work ratio in job arrangement in order to alleviate stress of social workers.