대동맥 협착증과 동반된 출혈성 위장관 동정맥 기형에서 Estrogen-Progesterone 치료 1예

김도연,김화정,김효정,남준식,박수영,박영미,신정은,주미순,황민규,정혜경,손혜영,이선영,이한주 大韓消化器內視鏡學會 1999 Clinical Endoscopy Vol.19 No.부록2

IgA 신병증의 임상 및 병리학적 고찰

이강욱,최영환,신영태,노흥규,서광선 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Twenty eight cases of primary IgA nephropathy were diagnosed and studied in the Department of Internal Medicine, Chungnam National University Hospital over a period of 49 months from June 1981 to July 1985. The results were summerized as follows: 1. These cases represented 45.2% of patients with primary glomerular diseases undergoing renal biopsy and immunofluorescent studies during the same period. 2. There were 20 males and 8 females. They were 15 to 54 years old and the average age was 29.1. 3. The main symptoms were loin pain, gross hematuria, myalgia, fatigability and generalized edema in 18, 15, 12, 12, and 4 cases, respectively. Upper respiratory tract infection symptoms were presented in 50% of the cases of all patient just before and during the course of disease. 4. Proteinuria was observed in 27 cases and hematuria was seen in 23 cases, Among hematuria, the gross hematuria was observed in 15 cases. Hypoalbuminemia and hypercholesterolemia was presented in 4 cases with generalized edema. Serum BUN and creatinine were elevated in 3 cases with marked decreased Creatinine Clearence in 3 cases (Ccr<50ml/min). 5. The light microscopic findings showed mainly mesangial proliferative glomerulonephritis and focal and segmental glomerular sclerosis in 11 and 7 cases, respectively. Immunofluorescent microscopic findings disclosed diffuse mesangial deposit of IgA in all cases. IgG, igM, C3 and fibrinogen deposits were observed in mesangium in 5, 4, 20, and 7 cases, respectively.

ERCP후 발생되는 췌장염의 예방적 치료의 평가

이선영,이경은 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : Pancreatitis is the most common and serious complication of diagnostic and the-rapeutic ERCP. On the basis of several reports, corticostroid or octreotide might be effective in this regard. The aim of this study was to determine whether the pharmacologic agents(stroid and octreotide) prevent post-ERCP pancreatitis. Methods : Patients received an intravenous infusion of hydrcortisone(100㎎) and octreotide (0.2㎎ bolus) in treated group Tmmediately before endoscopy. A total of 140 patients(73men and 67 women, with an average age of 61.5 yr) who were scheduled to undergo diagnostic or therapeutic ERCP. Nine patients were excluded from the final evaluation for incomplete records. The remaining 131 patients, 61 in the treated group and 70 in the control group, were analyzed. Results : The overall frequency of hyperamylasmia and pancreatitis were 33.6%(44/131) and 7.6%(10/131), respectively. The all pancreatitis were mild. There was no difference between the groups with the incidence and severity of pancreatitis. The procedure-induced pancreatitis oc-cured in 5 of 61(8.2%) patients treated with hydrocortisone and octreotide and 5 of 70(7.2%) patients in the control group(p=ns). the groups were similar with regard to desmographic cha-racteristics, type of procedure performed(diagnostic or therapeutic), the presence of diverticulum, visualization of pancreatic duct. The only risk factor of ERCP- pancreatitis is the visualization of pancreatic duct in both groups. Conclusion : Prophylactic administered corticosteroid and octreotide did not prevent of post-ERCP pancreatitis. Pancreatic injury may be only related to maneuver of pancreatic duct. 목적: 진단적 또는 치료적 ERCP 후에 발생되는 췌장염은 가장 흔하기도 하지만 심각한 합병증이 될 수 있다. 몇몇의 보고에 의하면 스테로이드나 octreotide가 효과적이라는 보고가 있었다. 본 연구의 목적은 ERCP후 발생하는 췌장염을 시술 전 약물의 투여로 예방할 수 있는 가를 알아보는 연구이다. 방법: 치료군은 스테로이드(hydrocortisone 100㎎)과 oct-reotide(0.2㎎)을 시술 바로 전 정맥투여하였다. 전체 환자는 140예였고 남자 73예, 여자 67예였으며 평균 연령 61.5세였다. 모두 ERCP를 시행한 환자로 이중 9예는 기록의 미비로 제외되었다. 따라서 분석한 환자는 치료군은 61예였고 대조군은 70예였다. 결과: 전체 환자 131명에서 ERCP 시행후 발생된 고아밀라제 혈증은 33.6%(44/131)에서 발생하였고 췌장염은 7.6%(10/131)에서 발생하였다. 고아밀라제혈증은 대조군과 치료군에서 각각30% (21예), 37.7%(23예)였으며(p=ns)췌장염은 모두 경증의 췌장염이었고 각 군에서 5예씩(7.2% 대조군 ; 8.2% 치료군, p=ns)발생하였다. 췌장염의 발생 위험인자인 주 췌관의 조영여부, ERCP의 종류(진단적 또는 치료적), 담즙 배액술 여부, 그리고 십이지장게실의 유무 등을 분석하였는데 대조군(p=0.023) 과 치료군(p=0.01) 모두에서 주췌관 조영이 된 경우만이 통계적으로 유의한 위험인자로 나타났다. 결론: ERCP전에 췌장염의 발생을 줄이기 위해 전 처치로서 스테로이드나 octreotide는 췌장염 예방에 효과가 없으며 진단을 위해나 치료를 목적으로 숙련된 내시경 의사가 ERCP를 시도한다면 중증의 췌장염 빈도는 거의 발생하는 일이 드물다. 또한 췌관의 십관과 조영을 조심스럽게 시도한다면 고아밀라제혈증 또한 예방할 수 있을 것으로 생각한다.

교통사고 후 신체 손상 환자의 외상후 스트레스장애에 대한 연구

강영수,김동인,이선미,김 임,김태형,은헌정 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

연구 목적 : 임상가를 위한 외상후스트레스장애 척도를 이용하여 교통 사고 후 신체 손상 환자의 외상후스트레스장애의 발병률을 알아보고, 사회인구학적 변인들, 손상 심각도, 불안, 우울과 외상후스트레스장애와의 상호관련성을 고찰하고자 하였다. 방 법 : 104명의 교통사고 환자들을 대상으로 , 자기 보고형인 사고 후 정신 건강에 관한 설문지와 외상후스트레스장애를 진단하기 위해서 임상가를 위한 외상후스트레스장애 척도를 이용하여 면담을 실시하였으며, 손상 심각도 척도를 이용하여 신체 손상의 정도를 측정하였다. 결 과 : 외상후스트레스장애의 발병률은 61.5%이었으며, 사회인구학적 변인들과 손상 심각도 점수에서는 외상후스트레스장애군과 비 외상후스트레스장애군이 유의한 차이를 나타내지 않았다. 그러나 외상후스트레스장애 군에 속한 사람들이 사고 당시에 사망자나 부상자를 목격한 경우가 의미있게 많았고(χ²=8.48, p<0.05). Beck의 우울점수가 외상후스트레스장애군에서 유의한 증가를 보였다.(t=5.03, p<0.05). 결 론 : 교통사고 후 외상후스트레스장애의 발병률은 매우 높았고, 두 집단 모두가 정상인 보다 훨씬 더 높은 불안과 우울을 보고하고 있다. 이와 함께 연구 결과는 상황에서 사망자와 부상자의 목격시 외상후스트레스장애로 발병하게 하는 위험 요인 중 하나 일 수 있다. Objectives : the authors attempted to estimate the incidence of posttraumatic stress disorder (PTSD) and the differences of sociodemographical feature, injury severity, depression and anxiety between PTSD and non-PTSD groups after motor vehicle accident. Methods : The subjects were 104 patients who had undergone motor vehicle accidents, and been hospitalized to orthopedic surgery hospitals. We administered them clinician-administered PTSD scale(CAPS) for diagnosing PTSD, injury severity scale(ISS) for identifying their physical injury, self-reported questionnaire made to identify socioepidemographic data, Beck Depression Inventory(BDI) for measuring depression, and State Trait Anxiety Inventory Ⅰ,Ⅱ(STAI-Ⅰ,Ⅱ) for measuring anxiety. Results : The incidence of PTSD in subjects was 61.5%. Most of sociodemographic factors were not different between PTSD and non-PTSD groups. Only there were significant differences between PTSD group and non-PTSD group on the cases that observed the dead or the wounded at the scene of motor vehicle accident(χ²=8.478, p<0.05) and BDI(t=5.03, p<0.05). Conclusion : These results indicate that prevalence of PTSD is higher after motor vehicle accident and both of the two groups report much higher depression and anxiety than normal population. In addition, the results of this study show that the observation of dead or wounded at accident situation can be one of risk factors to precipitate PTSD.

인지심리학의 이해와 응용 : 교육과 신경인지 Education and Neurocognition

진영선,이준석 경북대학교 사회과학연구소 1991 社會科學硏究 Vol.7 No.-

Cognitive psychology is a discipline which tries to delineate and to understand fundamental mechanisms of human thinking. The mechanisms that have been found by cognitive psychologists have such meaningful implications to other areas of social research that they now serve as important frameworks for research of a variety of social phenomena. In the first part of the paper, brief history of how cognitive psychology has evolved is presented in a very schcematic style for who dont have any background in psychology. Secondly, main part of the paper will be devoted to introduce a few basic topics in cognitive field, including attention, memory, schema and metacognition and discuss their implications in a couple of related fields. Finally, current interests both by novice people and experts on neurocognitive approach to human thinking and education is briefly highlighted, although the topics presented are far from exhaustive.

고등학교 체육특기·적성 교육활동에 관한 운영 분석

김평석,김이수,최현영,노덕선 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2

The objective of this research is a place where it examines the participation actual condition regarding the physical training specialty-an aptitude education activity of the high school students and a satisfactory degree. In the research object currently the high school south which are to Seoul - Inch'on - Kyonggi-Do. about it set at the royal tomb which points out specifically the students and u, the ticket house method the house Rag radio ticket house law (cluster random sampling) with total 405 people was ticket collected goods. In order to analyze the data of the research which it sees it uses a SPSS 11.0 for windows statistical program with the statistical technique which it uses ! and frequency analysis (frequency analysis), x²verification, and independent group t- verification (independent group t-test) it is a back. With above same research method and process it leads and it gets and the position conclusion with afterwords is same. First, participation objective the south student the motion technology advancement and health and the physical strength increase showed a high ratio, the schoolgirl in order with the friends together description below, the and hold was doing the motion technology advancement, the person who gives the place effect which selects from a physical training department south. about as the student all friend the student answer back appeared highly. physical training relation station the map the physical training teacher the other side which is visible a most high ratio it wants the coaching staff with the fact that it prefers the leader which equips a specialty map ability. Second, physical training specialty- aptitude education activity problem point, the diversification and the schoolgirl of program the map method south student of the coaching staff was investigated recognition of physical training pure with. third, physical training activity which participates with the fact that it will receive a many help in study it led and motor function and physical strength increase and health and. Function improvement and physical strength increase, against a study help the south student, the schoolgirl appeared in small quantity highly from healthy help. physical training activity which participates it led and school life it was it is joyful. satisfactory in intimate feeling and friend relationship of stress solution and the teacher and became the many help, it will appear, that even after words it will be active from the physical training relation station, the student answer back highly was investigated and even from multi problem point inside satisfactory boat song it was investigated with the high thing.

Variation of seed germiability in diverse rice genetic resources

Gi-An Lee,Young-Ah Jeon,Ho-Sun Lee,Young-Yi Lee,Jung-Sook Sung,Jung-Yoon Yi,Jong-Wook Chung,Myung-Chul Lee,Sok-Young Lee,Yeon-Gyu Kim 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

Rice (Oryza sativa L.) is important crop as a staple carbohydrate sources and was regarded as domesticated in Asia region. The seed dormancy is one of the domesticated traits, and this character allows that plants survive in various environment. The degree of dormancy have been targeted for controling in breeding program while weak dormancy cause pre-harvest sprouting contrary to the nonuniform seed germination by strong dormancy. In this study, we surveyed the variation of germiability in diverse rice genetic resources including japonica and indica ecotype. Overall, the degree of seed dormancy of rice germplasm was distinguished into four groups and admixed types; first group(G-1) included accessions revealing high germiability, the accessions of second group(G-2) acquired the high germiability by after-ripening process, third group(G-3)’s accessions showed high germiability after dormancy breaking process and the accessions of last group(G-4) maintained the low germiability in spite of the dormancy breaking process. Among the 51 japonica accessions G-1, G-2, G-3 and G-4 included 15, 15, 11 and 10 accessions, respectively, and among 40 indica accessions, G-1, G-2, G-3 and G-4 groups included 15, 15, 9 and 1 accessions, respectively. Based on these primary test, we plan to detail examine the seed germiability and survey the genetic factors affecting the degree of germiability in representative accessions of each group

A case of erythema elevatum diutinum in the patient with systemic lupus erythematosus

( Young Min Cho ),( Hyun Yi Lee ),( Yu Jin Jeon ),( Dae Young Oh ),( Joong Sun Lee ),( Dae Won Koo ),( Kyung Eun Jung ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Erythema elevatum diutinum (EED) is a rare type of leukocytoclastic vasculitis characterized by red, purple, brown, or yellow papules, plaques, or nodules. These lesions are usually distributed on the extensor surfaces of the body. Men with EED are usually older (Hutchinson type), and women are usually younger (Bury type). Briefly, the Bury type consists of confluent nodules, which occurred over the joint of young females, while the Hutchinson type occurred in elderly males and had no predilection for the joints. The cause of EED has not yet been definitively established. Disorders that have been associated with EED include recurrent bacterial infections, viral infections and rheumatologic disease (in the Bury type). A 17-year-old girl presented with mild pruritic erythematous to skin colored multiple papules on the extensor surface of both extremities 3 days ago. She was diagnosed with Systemic Lupus Erythematosus three years ago and was on medication at rheumatology. Histopathologic exam showed vessel wall thickening, perivascular leukocytoclasis in dermis without abnormal finding in epidermis. The patient was diagnosed with EED and skin lesion improved after topical and systemic steroid treatment. We repot this case because it is rare and the patient's age, clinical features, and underlying disease were very typical, so it was considered appropriate for educational purposes.

Sequence Analysis and Expression of ORF5 in Korean Isolate of Porcine Reproductive and Respiratory Syndrome Virus

Sun Shin Yi,Ji-Sun Sun,Hyun-Soo Kim,Shien-Young Kang,Tae-Wook Hahn 대한미생물학회 2011 Journal of Bacteriology and Virology Vol.41 No.3

Sequence Analysis and Expression of ORF5 in Korean Isolate of Porcine Reproductive and Respiratory Syndrome Virus

Yi, Sun-Shin,Sun, Ji-Sun,Kim, Hyun-Soo,Kang, Shien-Young,Hahn, Tae-Wook The Korean Society for Microbiology 2011 Journal of Bacteriology and Virology Vol.41 No.3

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of reproductive failure and respiratory disorders in pigs. The viral genome consists of eight overlapping open reading frames (ORFs). ORF5 encodes one of the major glycoproteins and is known as an immunologically important structural protein associated with virus neutralization. The ORF5 gene of the Korean PRRSV isolate, CNV-1, was amplified by reverse transcription-polymerase chain reaction (RT-PCR), cloned and sequenced. The nucleotide and amino acid sequences of CNV-1 ORF5 shared 91% and 83% identity, respectively, with the American isolate (VR2332 strain) and 57% and 49% identity with the European isolate. For the expression and easy purification of ORF5, the cDNA containing the complete ORF5 sequence fused in-frame with sequence encoding glutathione S-transferase (GST) was cloned into a baculovirus transfer vector and transfected into Sf9 cells. The GST-ORF5 fusion protein produced in Sf9 cells was detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. Sequencing results confirmed that the recombinant baculovirus from Sf9 cells contains the complete ORF5 gene. Further studies in this direction will address whether ORF5 can be a good candidate for a subunit vaccine against PRRSV in Korea.