전기자극이 성견 골결손부에 매식된 임플란트 주위조직의 치유에 미치는 영향

심재창,김영준,김옥수,정현주 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

Several experimental studies showed that the application of small amounts of electric current to bone stimulated osteogenesis at the site of the cathode and suggested that electrical currents promote osseointegration around dental implants. The purpose of this study was to determine the effect of direct microcurrent to endosseous titanium implants placed in bone defects. The right and left 2nd, 3rd and 4th mandibular premolars in ten mongrel dogs (15kg of weight) were extracted. One month later, Ti-machined screw type implants(3.8 mm diameter×8.5 mm length, AVANA�, Ostem) were placed in surgically created circumferential defect area(width 5mm, depth 4mm). The implants were divided into three groups according to the treatment modalities: Control group- implants without electrical stimulation; Experimental group I- implants with allogenic demineralized freeze dried bone grafting and Experimental group Ⅱ- implants allogenic demineralized freeze dried bone grafting and electric stimulation. The animals were sacrificed in the 4th and 8th week after implant placement and un-decalcified specimens were prepared for histological and histometrical evaluation of bone-implant contact ratio (BIC) and bone formation area ratio (BFA) in defect area. Some specimens at 8 weeks after implantation were used for removal torque testing. Histologically, there were connective tissue infiltration in the coronal part of defect area in control and the experimental group I. whereas direct bone contact was found in the experimental group Ⅱ without connective tissue invasion. Average BIC ratios at 4 weeks of healing were 60.1% in the experimental group Ⅱ, 47.4% in the experimental group I and 42.7% in the control. Average BIC ratios at 8 weeks after implantation were 67.6% in the experimental group Ⅱ, 55.9% in the experimental group I and 54,6% in the control. The average BFA ratio was 84.0% in the experimental group Ⅱ, 71.8% in the experimental group I and 58.8% in the control at 4 weeks, and the BFA ratios were 89.6% in the experimental group Ⅱ, 81.4% in the experimental group I and 70.5% in the control at 8 weeks after implantation. The experimental group Ⅱ showed also significantly greater BIC and BFA ratios compared to the control and the experimental group I (p<0.05). The removal torque values at 8 weeks after implantation were 56 Ncm in the experimental group Ⅱ, 49 Ncm in the experimental group I and 43 Ncm in the control. There was a statistically significant difference among 3 groups(p<0.05) . These results suggest that electrical stimulation improve and accelerate bone healing around endosseous titanium implants in bone defect.

가상현실 기법의 활용이 지식 성취도 향상에 미치는 효과 : 눈의 구조와 기능 내용을 중심으로 The Structure and Function of Eye

심규철,류수정,김현섭,김희수,박영철 한국과학교육학회 2003 한국과학교육학회지 Vol.23 No.1

The purpose of present study was to develop teaching-learning materials based virtual reality technology(VRT), and to examine the effect of it on the knowledge achievement of biology. Authoring tool of virtual reality(VR) was 3D Webmaster made in Superscape Ltd., United Kingdom. Educational materials was developed for the structure and function of eye of life field in the 10th science. It was learner-directed and interactive educational material using the Web-based and desktop VR. The result showed a meaningful improvement on the achievement. Using 3D VR shows the potential of available education media in the next generation as science teaching-aided material, which especially was efficient in the understanding and perception of abstract or difficult to direct experience learning contents.

고량강의 항염증 작용에 대한 연구

박히준,이제현,김수영,심범상,구헌종,강전모,최일환,이재동,김남재,이지숙,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The use of herbal therapy is becoming an increasingly attractive approach for the treatment of various inflammatory disorders. The Alpiniae officinari Rhizoma is popular in Aisa as a traditional herbal medicine. Alpiniae officinari Rhizoma is a species of the ginger family(Zingiberacease). Method : This study was performed to investigate the anti-inflammatory effect of Alpiniae officinari Rhizoma extract by the methods of "carrageenan induced paw edema" and "Lipopolysaccharide-induced inflammatory mediators in mouse macrophage RAW 264.7 cells". Result : We suggest that Alpiniae officinari Rhizoma extract decreased paw volume induced by plantar injection of carrageenan. Also Alpiniae officinari Rhizoma extract inhibited nitric oxide, prostaglandin E₂production and induced nitric oxide synthase, cyclooxygenase-2 protein expression in Mouse macrophage RAW 264.7 cells stimulated with lipopolysaccharide. Conclusion : This study shows that Alpiniae officinari Rhizoma extract seems to have anti-inflammatory effect by inhibition of nitric oxide, prostaglandin E_(2) production and nitric oxide synthase, cyclooxygenase-2 protein expression.

계지의 항염 효과에 관한 연구

박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.

CORRELATION BETWEEN FARMING ENVIRONMENT AND PACIFIC OYSTER, Crassostrea gigas BIOMARKER IN WESTERN SEA OF KOREA

Hyun Jeong Lim,Haeng Woon Kim,Won Young Lee,Ju Hyun Yoon,Ji Hyun Lee,Eun Hee Choi,Na Young Shim,Su Kyoung Kim,Seung Yoon Park,Seung Min Lee 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5

Treatment of Self-Injurious Oral Trauma in Patient with Cerebral Palsy: A Case Report

Su-Hyun Shim,Geum-Sun Ahn 대한예방치과학회 2017 International Journal of Clinical Preventive Denti Vol.13 No.3

Self-injurious behavior can be defined as deliberated harm to one’s own body without conscious suicidal intent. It frequently involves oral tissues. In pediatric patients, self-injurious behavior usually is reported as lip, cheek and tongue biting. The case presented in this report discuss oral self-injurious behavior (SIB) in hospitalized patient who had cerebral palsy. Clinicians should be well aware of the possibility of oral self-injurious behavior in various mental disorders, comatose status, poisoning, or character disorders. Moreover, dentists are able to manage those patients with several treatment modalities and to prevent SIB according to the causative disorders.

Improving combinatorial ambiguities oftt¯events using neural networks

Shim, Ji Hyun,Lee, Hyun Su American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.11

We present a method for resolving the combinatorial issues in the t(t) over bar lepton + jets events occurring at the Tevatron collider. By incorporating multiple information into an artificial neural network, we introduce a novel event reconstruction method for such events. We find that this method significantly reduces the number of combinatorial ambiguities. Compared to the classical reconstruction method, our method provides significantly higher purity with the same efficiency. We illustrate the reconstructed observables for the realistic top-quark mass and the forward-backward asymmetry measurements. A Monte Carlo study shows that our method provides meaningful improvements in the top-quark measurements using the same amount of data as other methods.

Risk Factors of Postpartum Depression Among Korean Women: An Analysis Based on the Korean Pregnancy Outcome Study (KPOS)

Shim So Hyun,Lee Su Young,Jung Inkyung,Heo Seok-Jae,Han You Jung,Kwak Dong Wook,Kim Min Hyoung,Park Hee Jin,Chung Jin Hoon,Lim Ji Hyae,Kim Moon Young,Cha Dong Hyun,Shim Sung Shin,Cho Hee Young,Ryu Hyu 대한의학회 2024 Journal of Korean medical science Vol.39 No.3

Background: Postpartum depression (PPD) can negatively affect infant well-being and child development. Although the frequency and risk factors of PPD symptoms might vary depending on the country and culture, there is limited research on these risk factors among Korean women. This study aimed to elucidate the potential risk factors of PPD throughout pregnancy to help improve PPD screening and prevention in Korean women. Methods: The pregnant women at 12 gestational weeks (GW) were enrolled from two obstetric specialized hospitals from March 2013 to November 2017. A questionnaire survey was administered at 12 GW, 24 GW, 36 GW, and 4 weeks postpartum. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale, and PPD was defined as a score of ≥ 10. Results: PPD was prevalent in 16.3% (410/2,512) of the participants. Depressive feeling at 12 GW and postpartum factors of stress, relationship with children, depressive feeling, fear, sadness, and neonatal intensive care unit admission of baby were significantly associated with a higher risk of PPD. Meanwhile, high postpartum quality of life and marital satisfaction at postpartum period were significantly associated with a lower risk of PPD. We developed a model for predicting PPD using factors as mentioned above and it had an area under the curve of 0.871. Conclusion: Depressive feeling at 12 GW and postpartum stress, fear, sadness, relationship with children, low quality of life, and low marital satisfaction increased the risk of PPD. A risk model that comprises significant factors can effectively predict PPD and can be helpful for its prevention and appropriate treatment.

Diet Control Program through the Cariogenic Potentiality Index for Adult

Su-Hyun Shim 대한예방치과학회 2016 International Journal of Clinical Preventive Denti Vol.12 No.3

Objective: Caries prevention through the diet control can be achieved clinically by use of the computer program. This program analyzes the nutrient and cariogenic potentiality for a range of food commonly eaten by the average Korean adult. Methods: Seventy volunteers between the age of 20 and 30 years participated in the clinical experiment. Participants were asked to record 5 consecutive days of dietary intake. Using the diet control program established by the cariogenic potentiality indices, we were able to determine an individual participants’ average nutritional intake over the course of five days (calory, basic nutrient, cariogenic potentiality, sodium intake for a day, individually, were revealed from the computer program). In addition to such average data, we also know whether excess or deficiency for each item. And the correlation between the intake of foods and the oral status for caries experience in subjects, were revealed. Results: The average calory of the subjects was revealed as 2,082.52±657.87 kcal/day as included in the recommendation level for Korean adults. But the average intake of sodium was 4,618.02±1,384.65 mg/day, it was significantly higher than the recommended daily requirements (1,500-2,000 mg) in Korean adults. Basic nutrient amounts for carbohydrate, protein, fat were within the recommendation level, as well as the clean food. The average cariogenic potentiality index was estimated as 127.26±47.49 minutes. Conclusion: Computer program for analysis of each nutrient using the cariogenic potentiality index was considered as useful tool for diet therapy in clinical preventive dentistry.

Oral Manifestation and the Treatment of Self-Injurious Behaviors Associated with a Preterm Infant: A Case Report

Su-Hyun Shim,Byeng-Ken Cho,Ja-Won Cho 대한예방치과학회 2015 International Journal of Clinical Preventive Denti Vol.11 No.1

Behavioral problems could be easily observed in patients with various mental disorders. Self-injurious behavior (SIB) can be defined as deliberated harm to one’s own body without conscious suicidal intent. It usually occurs as head banging or hitting, body hitting, skin cutting, or finger biting. Also it frequently involves oral tissue’s damage in pediatric patients, such as lip, cheek and tongue biting. Various articles have described prostheses used to prevent SIB-related injuries to the oral tissues of patients who have developmental or medical problems, such as psychological problems, congenital syndromes or mental retardation. But reports of oral SIB in individuals unaffected by the above conditions are scarce. The case presented in this report discusses oral SIB in a premature baby. We found an optimal way that would prevent SIB-related injuries and also protect the causative teeth. These days, dentists should be able to manage those patients with several treatment modalities, furthermore, to prevent SIB according to the causative disorders