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( Ryeon Jin Cho ),( You Sun Kim ),( Ji Young Kim ),( Sei Won Lee ),( Sang Do Lee ),( Yeon Mok Oh ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Stem cell treatments via intra-venous route were reported to restore emphysema in mice model. In these mice model, a serious adverse event, sudden death was recognized immediately after the infusion of stem cells. So we tried a different route of stem cell infusion via intra-pleural route and evaluated the effect of adipose-derived stem cells via intra-pleural infusion in elastase- induced emphysema mice. Methods: Mouse emphysema model was developed in C57BL/6 mice with the intra-tracheal injection of elastase(0.4 units/mice). 1×105 of ASCs were infused via intra-pleural route at 1week after elastase injection in C57BL/6 mice. Histological analysis of lung tissue was performed with the measurement of mean linear intercept (MLI) at 1week after ASCs intra-pleural infusion. Results: Elastase induced emphysema in these mice model (mean standard deviation of MLI: 122μm ± 17 μm, n=4 for elastase-injected mice, n=4 vs. 57μm ± 1 μm, n=2 for control mice, n=2 ) We observed the restoration of alveolar destruction by the infusion of adipose-derived stem cells via intra-pleural route in elastase-induced emphysema mice (MLI for ASCs-treated mice via intra- pleural route, 89μm ± 4 μm, n=4 vs. only elastase-injected mice 122μm ± 17 μm, n=4; p=0.0286). Conclusions: Intra-pleural route may be a candidate route of the stem cell treatment for lung diseases.
( Ryeon Jin Cho ),( You-sun Kim ),( Ji-young Kim ),( Yeon-mok Oh ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2
Emphysema, a pathologic component of the chronic obstructive pulmonary disease, causes irreversible destruction of lung. Many researchers have reported that mesenchymal stem cells can regenerate lung tissue after emphysema. We evaluated if spheroid human adipose-derived mesenchymal stem cells (ASCs) showed greater regenerative effects than dissociated ASCs in mice with elastase-induced emphysema. ASCs were administered via an intrapleural route. Mice injected with spheroid ASCs showed improved regeneration of lung tissues, increased expression of growth factors such as fibroblast growth factor-2 (FGF2) and hepatocyte growth factor (HGF), and a reduction in proteases with an induction of protease inhibitors when compared with mice injected with dissociated ASCs. Our findings indicate that spheroid ASCs show better regeneration of lung tissues than dissociated ACSs in mice with elastase-induced emphysema. [BMB Reports 2017; 50(2): 79-84]
( Ryeon Jin Cho ),( You Sun Kim ),( Ji Young Kim ),( Seiwon Lee ),( Sang Do Lee ),( Yeon Mok Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Stem cell treatments via intra-venous route were reported to restore emphysema in mice model. In these mice model, a serious adverse event, sudden death was recognized immediately after the infusion of stem cells. So we tried a different route of stem cell infusion via intra-pleural route and evaluated the effect of adipose-derived stem cells via intra-pleural infusion in elastase-induced emphysema mice. Methods: Mouse emphysema model was developed in C57BL/6 mice with the intra- tracheal injection of elastase(0.4 units/mice). 1x10<sup>5</sup> of ASCs were infused via intra-pleural route at 1week after elastase injection in C57BL/6 mice. Histological analysis of lung tissue was performed with the measurement of mean linear intercept (MLI) at 1week after ASCs intra-pleural infusion. Results: Elastase induced emphysema in these mice model (mean standard deviation of MLI: 122μm ± 17 μm, n=4 for elastase-injected mice, n=4 vs. 57μm ± 1 μm, n=2 for control mice, n=2 ) We observed the restoration of alveolar destruction by the infusion of adipose-derived stem cells via intra-pleural route in elastase-induced emphysema mice (MLI for ASCs-treated mice via intra-pleural route, 89μm ± 4 μm, n=4 vs. only elastase-injected mice 122μm ± 17 μm, n=4; p=0.0286 ). Conclusions: Intra-pleural route may be a candidate route of the stem cell treatment for lung diseases.
Extensively Drug-Resistant <i>Streptococcus pneumoniae</i> , South Korea, 2011–2012
Cho, Sun Young,Baek, Jin Yang,Kang, Cheol-In,Kim, So Hyun,Ha, Young Eun,Chung, Doo Ryeon,Lee, Nam Yong,Peck, Kyong Ran,Song, Jae-Hoon U.S. Department of Health and Human Services * Cen 2014 Emerging Infectious Diseases Vol.20 No.5
<P>To better understand extensively drug resistant <I>Streptococcus pneumoniae</I>, we assessed clinical and microbiological characteristics of 5 extensively drug-resistant pneumococcal isolates. We concluded that long-term care facility residents who had undergone tracheostomy might be reservoirs of these pneumococci; 13- and 23-valent pneumococcal vaccines should be considered for high-risk persons; and antimicrobial drugs should be used judiciously.</P>
Effect of file size in measuring electronic working length of teeth with open apex
Ryeon Jin,Ju-Hee Jeong,A-Ra Cho,Hyoung-Hoon Jo 조선대학교 치의학연구원 2022 Oral Biology Research (Oral Biol Res) Vol.46 No.1
This study aimed to evaluate the effect of file size in measuring the electronic working length of teeth with open apex. Twenty teeth were prepared to make the open apex models. A bur was used to cut a 2-mm apical end; the point where #10K file’s tip was reflected on the cut root surface was set to the actual root canal length (AL). A divergent open apex was prepared by retrograde apical preparation. The teeth that were covered with a gauze soaked with saline were inserted in a plastic mold, and an electronic apex locator was connected with it. In each tooth, #10, #20, #30, #40, #50, #60, #70, and #80 files were inserted into the root canal, and the electronic working length (EL) was measured at the “Apex” signal. Then, the mean difference (ΔL) between the AL and EL was evaluated for each file size. EL measurements with all file sizes were short of the apical foramen, and there was a significant difference when the file size increased from #10 to #20 and #40 to #50. Within this study’s limitations, the file size showed an impact in measuring the teeth’s EL with open apex. When the size of the apical foramen is 1.14 mm, it is more accurate to use a file of #50 size or larger when measuring the working length with an electronic apex locator.
Long-term outcomes of abdominal paraganglioma
Hye Ryeon Choi,Zeng Yap,Soon Min Choi,Sun Hyung Choi,Jin Kyong Kim,Cho Rok Lee,Jandee Lee,Jong Ju Jeong,Kee-Hyun Nam,Woong Youn Chung,Sang-Wook Kang 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.6
Purpose: Paragangliomas (PGL) are rare neuroendocrine tumors derived from chromaffin cells of the autonomic nervous system. We aim to describe our experience and the long-term outcome of abdominal PGL over the last decade. Methods: A retrospective review of patients diagnosed with PGL in our hospital between November 2005 and June 2017 was conducted. All nonabdominal PGL were excluded and the clinicopathological features and long-term outcomes of the patients were analyzed. Results: A total of 46 patients were diagnosed with abdominal PGL. The average age of diagnosis was 55.4 years and there was no sex predilection. The average tumor size was 5.85 cm and they were predominantly located in the infrarenal position (50%). The mean follow-up period was 42 months (range, 1.8–252 months). All patients with metastases had Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) of ≥4. One patient presented with synchronous metastases while 2 developed local recurrence and distant metastases. One presented with only local recurrence. One patient died 5 years after diagnosis. Conclusion: Abdominal PGL is a rare tumor with excellent long-term prognosis. Recurrence although uncommon, can occur decades after initial diagnosis. Long-term follow-up is therefore recommended for all patients with PGL, especially in patients with PASS of ≥4