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( Hyung Jun Park ),( Seiwon Lee ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background Exposure to particulate matter (PM) is a key public health issue, but effective intervention has not yet been established. A systematic literature review and meta-analysis has been conducted to assess the relationship between the use of air filters, one of the most-studied interventions, and respiratory outcomes in patients with chronic respiratory disease. Methods We systemically reviewed intervention studies on PM using Pubmed, EMBASE, and Cochrane databases up to September 2019. Studies that included data on PM concentration changes and respiratory symptoms or lung function in patients with respiratory diseases were eligible for inclusion. Effect estimates were quantified separately using the random-effects model. Results Seven studies were included in our study. Air filter use reduced indoor PM2.5 by 11.45 μg/m3 (95% confidence interval [CI]: 6.88-16.01μg/m3). Air filter use improved predicted forced expiratory volume in one second (FEV1) by 3.60% (95% CI: 0.29- 6.90%). Air filter use was not associated with a significant change in respiratory symptoms (odds ratio: 0.82; 95% CI: 0.62-1.08). Conclusion The findings from this systematic review suggest that a role for air filter with respect to reduced indoor PM and increased lung function. Further studies in high density PM regions may provide additional information on this role.
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( You Sun Kim ),( Ji Young Kim ),( Ryeon Jin Cho ),( Seiwon Lee ),( Sang Do Lee ),( Yeon Mok Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Because it is expensive and low effect of adipose derived stem cells (ASCs) to induce regeneration of emphysematous lung in mice model, we applied new approach that artifi cial nanovesicles made by serial extrusion were injected into emphysematous mice lung. Methods: Artificial nanovesicles were produced by the breakdown of ASCs passing through a serial extrusion with fi lters (10, 5 and 1 μm). To induce emphysema, C57BL/6 mice were intratracheally injected with 0.4U of porcine pancreas elastase. 0.5 and 1.5 μg of artifi cial nanovesicles were intratacheally injected at 7 day after elastase injection and lung collected at 14 day after elastase injection. Lung regeneration was measured by mean linear intercept using (MLI) from lung histology stained by H&E.Results: We observed that artifi cial nanovesicles were nanometer-sized (30 - 200 nm) on NanoSight analysis and simultaneously expressed extracellular vesicles` and ASCs` marker protein. 1 x 10 of ASCs produced 1.5 μg of Nanovesicles based on protein amount. Emphysematous lungs (MLI: 106 μm ± 11 μm, n=8) were slightly regenerated by systemic injected 1 x 10^5of ASCs (MLI: 87 μm ± 15 μm, n=5, p = 0.03). Regeneration in lung from elastase induced emphysema mice were improved in 0.5 (MLI: 82 μm ± 8 μm, n=9, p < 0.001) and 1.5 μg (MLI: 81 μm ± 13 μm, n=3, p = 0.04) of artifi cial nanovesicles injected mice compared with ASC injected mice. Conclusions: Artifi cial nanovesicles from ASCs were more effective even with less amount of cells compared with ASCs only. Therefore, artifi cial nanovesicles may be new therapeutic candidate to regenerate emphysematous lung.
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( Ryeon Jin Cho ),( You Sun Kim ),( Ji Young Kim ),( Seiwon Lee ),( Sang Do Lee ),( Yeon Mok Oh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Stem cell treatments via intra-venous route were reported to restore emphysema in mice model. In these mice model, a serious adverse event, sudden death was recognized immediately after the infusion of stem cells. So we tried a different route of stem cell infusion via intra-pleural route and evaluated the effect of adipose-derived stem cells via intra-pleural infusion in elastase-induced emphysema mice. Methods: Mouse emphysema model was developed in C57BL/6 mice with the intra- tracheal injection of elastase(0.4 units/mice). 1x10<sup>5</sup> of ASCs were infused via intra-pleural route at 1week after elastase injection in C57BL/6 mice. Histological analysis of lung tissue was performed with the measurement of mean linear intercept (MLI) at 1week after ASCs intra-pleural infusion. Results: Elastase induced emphysema in these mice model (mean standard deviation of MLI: 122μm ± 17 μm, n=4 for elastase-injected mice, n=4 vs. 57μm ± 1 μm, n=2 for control mice, n=2 ) We observed the restoration of alveolar destruction by the infusion of adipose-derived stem cells via intra-pleural route in elastase-induced emphysema mice (MLI for ASCs-treated mice via intra-pleural route, 89μm ± 4 μm, n=4 vs. only elastase-injected mice 122μm ± 17 μm, n=4; p=0.0286 ). Conclusions: Intra-pleural route may be a candidate route of the stem cell treatment for lung diseases.
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