신경성 염증질환에서 지질 신호전달물질인 lactosylceramide의 역할

이윤선, 유재명, 최경미, 이용문, 홍진태, 윤여표, 유환수 충북대학교 약품자원개발연구소 2007 약학논문집 Vol.22 No.-

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Ayres의 감각통합중재 중심원리에 따른 치료사의 치료수행도 조사

홍은경,김경미,장문영 대한감각통합치료학회 2011 대한감각통합치료학회지 Vol.9 No.1

목적 : 본 연구에서는 자기-평가 방법을 이용하여 Ayres의 감각통합중재 중심 원리를 바탕으로 한 치료사의 치료적 수행 정도를 알아보고자 하였다. 연구방법 : 연구기간은 2010년 5월부터 6월까지이었고, 연구대상은 감각통합중재를 하고 있는 치료사 66명이었 다. 자기 기입식 설문지를 이용하여 Ayres의 감각통합중재 중심원리에 따라 치료를 수행하는 정도를 자기-평가 하도록 하였다. 설문지는 감각의 기회제공, 적절한 도전의 과제 제공, 활동을 선택할 기회 제공 등 Ayres의 감각통 합중재 중심 원리에 대한 10가지 항목으로 구성하였다. 총 66부의 수거된 설문지는 기술통계를 이용하여 분석하 였고, T 값을 통해 퍼센타일을 알아보았다. 결과 : 모든 치료사들은 Ayres의 감각통합중재 중심 원리의 10가지를 모두 고려하여 치료하는 것으로 나타났다. 10가지 Ayres의 감각통합중재 중심 원리 중 자기 조직화 가이드 중심 원리를 제외하고 90%이상에서 종종, 자주, 항상 고려하여 치료하고 있었다. 감각의 기회제공, 적절한 과제제공, 활동 선택 기회제공, 아동의 성공을 최대화, 신체적 안전성 보장, 치료적 존중의 감정 조성은 T 값 50점 이상을 나타냈다. 자기 조직화 가이드, 적절한 각성 유 지, 놀이 환경의 조성, 아동이 치료실 정리에 참여는 T 값 50점 이하를 나타냈다. 결론 : 지속적인 Ayres의 감각통합중재 중심 원리에 따른 치료사의 자기 수행에 대한 평가를 통해 치료의 질을 점 검하고 높이는 것이 필요하다. Purpose : In this study, we tried to know that how the occupational therapists applied the core principles of Ayres's sensory integration(ASI) intervention for clients by using the method of self-assessment. Methods : The study period was from May 2010 to June 2010. The subjects were therapists who use a sensory integration intervention. We letted them to do self-assessment about degree of performing the treatment according to the core principles of ASI by using a questionnaire. Total 66 questionnaires were collected. SPSS for Windows version 15.0 was statistically analyzed. Results : There wasn't anybody without considering the 10 core principles of ASI interventions for children. Therapist's answer(more than 90%) was sometimes, often, always except for the guide self-organization in the 10 core principles of ASI intervention. On the basis of total average score of raw score of 10 core principles of ASI intervention, provide sensory opportunities, provide just-right challenges, collaborate on activity choice, maximize child's success, ensure physical safety, and foster therapeutic alliance showed more than 50 points(T value). The guide self-organization, support optimal arousal, create play context, and arrange room to engage child showed less than 50 points T value. Conclusion : The most effective interventions for sensory integration is the treatment based on the core principles of ASI intervention. According to core principle of ASI intervention, checking the quality of care and increasing the quality of care is needed through performing self-assessment.

호알칼리성 Bacillus sp. No. 4의 Cyclodextrin Glycosyltransferase에 의한 Glycosyl Sucrose의 생산과 저충치성 당으로서의 응용

손천배,유미경,김명희,문숙경 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

Action of a cyclodextrin glycosyltransferase (CGTase) produce from alkalophilic Bacillus sp. No. 4 was studied in a solution containing starch and sucrose to prepare glycosyl sucrose syrup with good sweetness and antidecaying properties of teeth. In the initial stage of the reaction the CGTase produced cyclodextrin, however, the cyclodextrin disappeared and glycosyl sucrose was formed with the lapse of reaction time. The best proportion of sucrose to starch for prodution of glycosyl sucrose was about 1 : 1. The optimum pH and temperature of the coupling reaction was pH 6.0 and 60℃, respectively. Main composition of glycosyl sucrose syrup prepared with 20% starch and 20% sucrose was sucrose 18%, glucosyl sucrose (G_2F) 15.3% and amltosyl sucorse (G_3F) 11.3%. And glucose, maltose and maltotriose were produced very little. Smaller amounts of acid and insoluble glucan were formed in the syrup by Streptococcus mtans OMZ176 than in the sucrose. Therefore, the prepared glycosyl sucrose sucrose syrup is expected to prevent teeth from decaying.

效率的인 都市成長管理를 위한 開發制限區域 接境地域의 管理方案

金瑛,趙宰英,文美景 경상대학교 생산기술연구소 2000 生産技術硏究所論文集 Vol.16 No.-

For classification of the border areas, this study attempts a discriminant analysis using two kinds of main characteristics: land-use variables and land-price variables; consequen1ty the management strategy of the border areas is subdivided into 4 functional types according to hit ratio. The results of this study can be summarized as follows. (1) A-type area requires management strategy connected to town's function because it is similar to high-density-town. (2) B-type area resulted from not only a restrictive land-use control but also in need of environmental preservation under development pressure. Accordingly the management of this type of area requires especially residential participation. (3) Since C-type area is in close connection to the suburbs of towns, the management of this area demands both conservation and development through environmentally affection and sustainable management strategy. (4) The management of D-type area is closely related to that of Green Belt area because it is given more developmental pressure with town expanding in consideration of land-use and land-price. And since this area is used for woodland or farmland, it is necessary to prevent from sprawling development and conserve environment.

Brief Screening for Four Mental Illnesses of the Elderly in Community Mental Health Services: the BS4MI-Elderly

Yun Kyeong Seon,Moon Bong-Goon,Park Miae,Kim Seong-Ju,Shin Yunmi,Cho Sun Mi,Noh Jai Sung,Lim Ki-Young,Chung Young-Ki,Son Sang Joon,Roh Hyun Woong,Hong Chang Hyung 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.5

Objective Early detection and proper management of mental illness can help to prevent severe deterioration. However, with limited financial and human resources of community mental health services, it is not practical to carry out all conventional screening tools simultaneously. In this study, we aimed to develop and validate a brief but comprehensive screening questionnaire for four common mental illnesses of the elderly. Methods The brief screening for four mental illnesses of elderly (BS4MI-elderly) is a 14-item binary response questionnaire that covers dementia, depressive disorder, sleep disorder, and hwa-byung. To test validity, we compared conventional scale scores for three groups of participants classified using the BS4MI-elderly. The sensitivity, specificity, predictive value of positive test, likelihood ratio of positive test and internal consistency of the BS4MI-elderly were assessed. Finally, a correlation analysis between the BS4MI-elderly and general mental health scales was conducted. Results A total of 254 participants aged over 65 years were recruited. The BS4MI-elderly showed moderate to high sensitivity for the test that distinguishes the normal group from the risk and disorder groups (dementia: 0.61, depressive disorder: 0.88, sleep disorder: 0.85, hwa-byung: 0.94) and high specificity for the test that distinguishes the disorder group from the normal and risk groups (dementia: 0.91, depressive disorder: 0.93, hwa-byung: 0.84, sleep disorder: 0.84). The BS4MI-elderly also exhibited good internal consistency and significant correlations with general mental health scales. Conclusion The BS4MI-elderly, a brief but comprehensive screening tool, could be a useful instrument for screening the elderly in community mental health services.

Assessment of Parenting Attitudes by Children and Adolescents with Migraine

Kyeong Mi Lee(Kyeong Mi Lee),Min Suk Koh(Min Suk Koh),Ho-chan Lim(Ho-chan Lim),Soorack Ryu(Soorack Ryu),Yong Joo Kim(Yong Joo Kim),Jin-Hwa Moon(Jin-Hwa Moon) 대한소아신경학회 2022 대한소아신경학회지 Vol.30 No.4

Purpose: We aimed to investigate the parenting attitudes reported by patients and their relationships with the characteristics of headaches in children and adolescents with migraine. Methods: We conducted a retrospective review of medical records of children and adolescents with migrainous headaches (n=115; 59.1% female; mean age, 11.89±2.00 years). Children evaluated parental attitudes using the Parenting Attitude Test-Youth (PAT-Y), which comprises eight subscales and four newly devised secondary subscales. Headache severity was calculated by the visual analog scale (VAS), monthly frequency (MF), and VAS×MF/4 (VF). The scores of PAT-Y subscales and the correlations between PAT-Y scores and headache severity were analyzed by age group and sex. Scores for children’s depression inventory, childhood behavior checklists, and an attention deficit hyperactivity disorder scale were also analyzed. Results: In the elementary school age group, VAS was weakly negatively correlated with the “achievement press” (r=-0.28, P<0.05) and “high expectation” (r=-0.25, P<0.05) attitudes, and VF was weakly negatively correlated with “achievement press” (r=-0.32, P<0.05), “punishment” (r=-0.27, P<0.05), and “high expectation” (r=-0.29, P<0.05). In the middle-school age group, MF and VF were moderately positively correlated with the “achievement press” attitude (r=0.48, P<0.01 and r=0.48, P<0.01, respectively), VF was weakly positively correlated with the “neglectful” attitude(r=0.31, P<0.05), and MF was weakly positively correlated with scores for depression (r=0.29, P<0.05) and internalized problems (r=0.31, P<0.05). Conclusion: Parenting attitudes perceived by children and adolescents with migrainous headaches varied by age, and some parenting attitudes were related to headache severity. Education on age-appropriate parenting attitudes may help cope with migrainous headaches.

Inverse Relationship between Adipocyte Differentiation and Ceramide Level in 3T3-L1 Cells

Choi, Kyeong-Mi,Lee, Youn-Sun,Choi, Mi-Hwa,Sin, Dong-Mi,Lee, Seunghyun,Ji, So-Young,Lee, Mi Kyeong,Lee, Yong-Moon,Yun, Yeo-Pyo,Hong, Jin-Tae,Yoo, Hwan-Soo Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.6

<P>Adipocyte differentiation has been a target in anti-obesity strategies and is known to be closely related to lipid metabolism. Ceramide, a major sphingolipid metabolite, has been implicated in differentiation. In this study, we investigated whether ceramide biosynthesis is related to adipogenesis in 3T3-L1 cells. Preadipocytes can be differentiated synchronously by a mixture of adipogenic inducers including 3-isobutyl-1-methylxanthine, dexamethasone and insulin. The number of lipid droplets and the triglyceride content, which are differentiation biomarkers, gradually increased during adipogenesis. Interestingly, ceramide and sphingosine contents in the differentiated cells were decreased compared to those in preadipocytes. When the preadipocytes were treated with an 3-isobutyl-1-methylxanthine- or dexamethasone- or insulin-deficient mixture of inducers, the cellular ceramide levels were significantly increased compared with those in cells treated with the complete set of inducers. When preadipocytes were treated with 0, 0.1 or 1 μg/ml insulin along with 3-isobutyl-1-methylxanthine and dexamethasone, the ceramide levels were decreased and the triglyceride content was increased in a concentration-dependent manner. When the cells were treated with epigallocatechin gallate, an adipocyte differentiation inhibitor, during adipogenesis, the ceramide levels of adipocytes were increased and the fat content was decreased. In conclusion, our findings demonstrate that cellular ceramide levels are inversely correlated with adipocyte differentiation.</P>

Inhibitory Activities of Anthraquinones from Rubia akane on Phosphatase Regenerating Liver-3

Moon, Mi-Kyeong,Han, Young-Min,Lee, Yu-Jin,Lee, Lan-Hee,Yang, Jae-Heon,Kwon, Byoung-Mog,Kim, Dae-Keun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.11

The methanolic extract of the roots of Rubia akane (Rubiaceae) was found to show inhibitory activity on phosphatase of regenerating liver-3 (PRL-3). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone compounds, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-${\alpha}$-rhamnosyl($1{\rightarrow}2$)-${\beta}$-glucoside and 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, as inhibitors on PRL-3. These compounds inhibited PRL-3 in a dose-dependent manner with $IC_{50}$ values of 5.2 and 1.3 ${\mu}g$/mL, respectively.

Case Report : Six-month Outcomes of Mobile Phone Application-based Self-management in a Patient with Type 2 Diabetes

( Mi Kyeong Hong ),( Young Yun Cho ),( Mi Yong Rha ),( Jae Hyeon Kim ),( Moon Kyu Lee ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.3

We report the case in order to examine the effect of a mobile application program (“Diabetes & Nutrition”) developed in 2011- 2012 for self-management in patients with type 2 diabetes and to recommend important considerations when the mobile application program is developed. A 46-year-old man was newly diagnosed with type 2 diabetes in 2013 and had no complications. The height of the patient was 168 cm and the body weight was 75.6 kg. Nutrition education was conducted according to a medical prescription, and follow-up nutrition education was conducted after 3 and 6 months. After nutrition education, the patient was engaged in self-management using “Diabetes & Nutrition” program during 3 months. At 3 months, the body weight had decreased by 4.4 kg (from 75.6 to 71.2 kg), waist circumference by 5 cm (from 88 to 83 cm) and HbA1c level from 7.9% to 6.1%. Also at 3 months, the medication was reduced from from the dose of 850 mg to the dose of 500 mg metformin per twice a day. Since then, the patient did not continue to use the “Diabetes & Nutrition” because the level of blood glucose had stabilized, and the patient felt inconvenient and annoying to use the program. At 6 months, no significant change in the body weight and body composition was observed in comparison with those at 3 months. The present case demonstrates that the early use of “Diabetes & Nutrition” could be helpful for self-management of glycemic control in patients with type 2 diabetes. Developing self-management mobile application programs in the future will require strategies of how to promote continuous use of application program and self-management of type 2 diabetes.

[P8-268] Effect of Mori Cortex Radicis on High Fat Diet Induced Obesity in Mice

Mi Kyeong Moon,Ji Yun Ahn,Suna Kim,Tae Wan Kim,Tae Youl Ha 한국식품영양과학회 2009 한국식품영양과학회 학술대회발표집 Vol.2009 No.11