Detection of Individuals Restoring Fertility by DNA Fragment Converted into STS (sequence tagged site) in Red pepper

Lee,Jang-Soo,Lee,Keun-Hyang,Kim,Yeo-Song,Kang,Kwon-Kyoo,Nou,Ill-Sup,Hirata,Yutaka 한국자원식물학회 2004 Plant Resources Vol.7 No.2

Co-segregation of male fertility with DNA markers selected by RAPD analysis as being potentially linked to the restorer gene (Rf) for Cytoplasmic male sterility (CMS) was analyzed using segregating F2 population. One RAPD marker directly linked to the Rf locus was identified. Amplification of OPT-02/570 using the STS primers generated a monomorphic band of each fertile plants randomly selected F2 progenies. From these results, this specific marker would be strongly linked to be restoring gene. The use of STS marker is effective in overcoming the reliability of the RAPD phenotype and improving their utility for MAS, co-dominant STS markers are especially very useful.

Benzyl nitrate의 合成에 관한 硏究

李正根,張香東 건국대학교 1970 學術誌 Vol.11 No.1

Benzyl nitroate has been synthesized by the use of silver nitrate in acetonitrile and benzye chloride in carbone tetrachoride. But, it was synthesized by the use of Mercurous nitrate in the same method as above. And, it was also, synthesized by the some method in tetrahydrofuran and Dioxane The products are confirmed with agreement of I. R standard chart thrdugh the infrared specroscopy.

미술치료가 경도정신지체 학생의 부적응 행동에 미치는 효과

이근매,김향지,조진식 한국정신지체아교육학회 2003 지적장애연구 Vol.5 No.-

연구는 경도정신지체 중학생의 부적응 행동을 개선하여 일상생활의 적응력을 높일 수 있도록 하기위해 미술치료를 실시하여 그 효과를 살펴보고자 한다. 연구의 구체적 목적은 다음과 같다. 첫째, 미술치료가 경도정신지체학생의 부적응 행동에 미치는 효과를 알아본다. 둘째, 회기별 진행과정에서 경도정신지체 학생의 부적응행동 변화 에 미치는 효과를 살펴본다. 연구의 결론은 다음과 같다. 첫째, 다양한 미술치료 프로그램을 실시했을 때 경도정신지체 학생의 부적응 행동이 감소되었다. 둘째, 미술치료 초기에는 연구자의 지시에 잘 따르지 못했고 동료와 잘 어울리지 못했지만, 회기가 진행 될수록 연구자와의 상호작용도 증가되었고 동료관계도 개선되었다. 따라서 미술치료 프로그램은 일선 교육현장에서 정신지체아동의 부적응행동을 긍정적으로 개선하는데 유용하게 활용 될 수 있을 것으로 본다. This research sought to conduct art therapy to mild mentally retarded students in middle school to correct their maladjustment behavior and enhance their adaptability to the routine life. The specific objectives of the research are as follows. First, the research determines the effect of art therapy on the maladjustment behavior of mild mentally retarded students. Second, the research determines the effect on the change in maladjustment behavior of the mentally retarded students in the process of treatment by session. The conclusion of the research is as follows. First, when various art therapy programs were offered, the maladjustment behavior of less serious mentally retarded students lessened. Second, the students could not follow appropriately the researcher's instruction and befriend each other during the initial phase of the art therapy, but with sessions continuing, students increased their interaction with the researcher, and improved relations with their peers. Hence, art therapy programs are considered to be useful in improving the maladjustment behavior of mentally retarded children on the education field.

數學敎科에서 프리젠테이션을 活用한 授業方法이 學習態度에 미치는 影響

이규재,신향근 順天大學校 師範大學 附屬 科學敎育硏究所 1998 科學과 敎育 Vol.6 No.-

It is thought that the pleasant and interesting class would change students' learning attitude positively and increase learning effects. So we are trying to introduce the application of computers to the class to be used in various ways and to be effective in arousing the learning motivation of students. The purpose of this research is to look for the teaching method which can cause students' interest in learning and help students to have an affirmative attitude toward their learning. After carrying out both the presentation program using computer and the traditional, explanatory class alternately, we conducted a comparative analysis on the students' learning attitudes and examined the students' responses on the 'presentation' class. The result of the research was that the 'presentation' class was more affirmative in arousing the motivation of the students than the traditional, explanatory teaching method. We also came to the conclusion that the 'presentation' class was more affirmative in establishing a positive learning attitude than the traditional, explanatory class.

위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

순천대학교 사범대학 발전 및 특성화 방안 연구

신란식,신향근,이화자 순천대학교 1996 大學發展硏究論文集 Vol.2 No.-

The purpose of this study was to present development plans and to draw up measures to specialize the College of Education (COE) as a teacher training institute after analyzing the problems with which COE in confronted. The plans and measures are primarily to aim attracting many students with better qualities and to assist them to have teaching jobs under the current system of Examination for Teacher Appointment. This study involved multiple data sources obtained from literature review questinnaire survey, and personal contact with the faculty of COE, Questions in the questionnaire were addressed to ask the faculty´s opinions on a curriculum, a school system in university, a practicum for teacher training, a middle and a high school attached to COE, establishing an in-service teacher training institute in COE, and other measures related to the specialization of COE. The findings of the study indicated that the following suggestions should be realized if COE is to be developed and specialized ; 1. A special selection procedure should be applied to attract students with high qualities, 2. Education for the teaching of subject matters should be reinforced and a new curriculum be developed to meet the needs of COE, 3. Appropriate measures should be devised to carry out substantial teacher training for student teachers, 4. A curriculum committe should be formed and asked to work for the management of the curriculum suitable for the specialization of COE, 5. A multi-major or a minor system should be introduced across the student´s specialization fields, 6. A department needed in COE can be established as a major area under the school system in university, 7. The establishment of a middle and a high school attached to COE should be proposed to the Ministry of Education, 8. An educational research center should be established to investigate into issue related to pro-service and in-service education continually, 9. An institute for in-service teacher training and a community education center should be established to render services to the local community, and 10. A second building of COE should be constructed to be equipped with sufficient educational facilities.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.