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게껍질 Chitin 및 Chitosan의 소화관내 기능성에 관한 in vitro 연구
장현주,전동원,이서래 이화여자대학교 생명과학연구소 1994 생명과학연구논문집 Vol.5 No.-
반응 조건을 달리하여 게껍질에서 chitin을 추출하고 이를 탈아세틸화하여 chitosan을 제조하였으며, 이들의 물리, 화학적 특성과 소호관내 기능성을 in vitro법으로 실시하였다. 이들 chitin질의 bulk density는 127~208㎎/㎖, 정도는 0.1% chitin의 경우 80~581 cP, 0.5% chitosan은 80~3,670 cP로 다양한 수치를 나타냈으며, chitosan의 탈아세틸화도는 81~93%로 비교적 높았다. Chitosan 제조시의 알칼리 농도와 반응 온도가 일정할 때 반응 시간이 경과할수록 탈아세틸화도는 증가하였고, 점도는 감소하는 경향을 보였다. Chitin질의 보수력은 온도 상승에 따라 약간 상승하였고, 37℃ 에서 chitosan D가 가장 높았으며, bulk density가 낮을수록 높은 보수력을 나타냈다. Glucose 흡수 억제 효과는 bulk density가 낮고 보수력이 큰 chitin질이 더 컸고 chitosan D가 가장 높은 38%를 나타냈다. Chitin질의 bile acid 흡수억제 효과는 투석 1시간 후에 15~34%를 나타냈고, pectin은 39%, cellulose는 9%를 나타냈으며 chitosan D는 3% 농도에서 34%의 가장 높은 억제 효과를 나타냈다. Chitin and chitosan samples prepard from crab's shells under different conditions were compared for their physicochemical properties and functionality in gastrointestinal tract by in vitro test. Their bulk density was in the range of 127~208 ㎎/㎖, and their viscosity was 80~581 cP in 0.1% chitin and 80~3,670 cP in 0.5% chitosan solution, showing a wide variation. The degree of deacetylation in chitosan samples as determined by IR spectral analysis was relatively high, showing 81~93%. At the same alkali concentration and reaction temperature, a longer reaction period gave an increased degree of deacetylation and lower viscosity. The water holding capacity of chitic substance became greater at higher soaking temperature; chitosan D at 37℃ showed the greatest value. Chitic substance with lower bulk density showed the higher water holding capacity. The retardation effect toward glucose absorption was higher in chitic substances of lower density and higher water holding capacity; chitosan D showed the highest value of 38%. The retardation index toward bile acid absorption after 1 hour dialysis was 15~34% in chitic substances, 39% in pectin and 9% in cellulose. The retarding effect showed the highest value of 34% in chitosan D at 3% concentration.
산전 태아사망 환자에서의 Mycoplasma hominis와 Viridans streptococcus감염 1예
김윤숙,문성택,전섭,김종수,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1
Mycoplasma hominis was isolated from a Bartholin's gland abscess 70 years ago, and ureaplasmas were isolated from the genital tract about 20 years later. Subsequently, reports incriminating mycoplasmas in the known adverse outcomes of pregnancy have been reported. Without doubt these genital mycoplasmas are able to invoke an inflammatory response and take part in the cascade of events that culminate in preterm birth. Amniotic fluid infection results in considerable pregnancy wastage in the pregnancy. In these cases Gram-positive organisms, especially group B streptococcus and Streptococcus viridans were the most common pathogens isolated. In our case, the patient has fever and vaginal discharge at 14+4 weeks gestation and two days after intrauterine fetal death was seen. The vaginal culture and sensitivity shown Mycoplasma hominis and Vihdans streptococcus. We experienced a case of Mycoplasma hominis and Viridans streptococcus infection in a patient with intrautehne fetal death and report with a brief review of literatures.
흰쥐에서 염화비닐 폭로수준에 따른 소변내 thiodiglycolic acid 농도의 변화
왕승준,차봉석,노재훈,신동천,김명수,전근재 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.4
Objectives : It is the objective of this research to identify the variation of thiodiglycolic acid(TdGA) in urine with vinyl chloride monamer(VCM) exposure levels through methylation. Methods : After rats were exposed to vinyl chloride monomer of 4 levels, 0㎎/㎥, 50㎎/㎥, 150㎎/㎥, 500㎎/㎥, respectively, of which urine was sampled in each sampling time of 0 hour, 2 hours, 4 hours, 8 hours, 16 hours, 36 hours, 48 hours. After urine had been methylated with diazomethane in the preliminary experiment and the peak of 146 m/z had been verified, the main experiment was done. Results : In the variation of TdGA with sampling times, concentration of TdGA increased rapidly in 4 hours and then decreased after 8 hours. When the variation of urinary TdGA concentration in urine according to exposure level of VGM was verified through Kruskal-Wallis statistical method at each sampling time, the significant increment with the exposure levels at 2 hours, 4 hours, 8 hours after exposure was clarified. Conclusion : TdGA concentration in urine with increment of VCM exposure level increased, especially significantly at 2 hours, 4 hours, 8 hours of sampling time.
개선된 Bridgman법으로 성장한 Bi₂Sr₂CaCu₂O_(8+δ) 單結晶의 초전도성
채건식,손인호,설정식,이수대,김영국,전동성,오재근,강성욱 경남대학교 환경문제연구소 1995 환경연구 Vol.17 No.-
The Bi₂Sr₂CaCu₂O_(8)+_(δ) single crystals are grown from the melt using a stoichiometric starting composition fer the cautions. The size and thickness of the Bi₂Sr₂CaCu₂O_(8)+_(δ) crystals depends on the cooling rate. The lower the cooling rate, the bigger and thicker the Bi₂Sr₂CaCu₂O_(8)+_(δ) crystals become. Bi₂Sr₂CaCu₂O_(8)+_(δ) X-ray diffraction(XRD) measurements of the single crystals were carried out using the radiation source of Cu Kα . In these Patterns only the (0,0,2n) diffraction appeared. The result indicated that the cleared surface of the single crystal was of the a-b face, and that the single crystal had a single phase without any undergrowth with 7K and 85K phases. In addition, although the figure is not shown, XRD patterns from (006) to (00□) were observed in the range of 2θ=0 to 60 degrees. The characterization of as-grown single crystals have been analyzed by Laue X-ray backsdattering along the c-axis and X-ray precession experiments. The result of magnetic moment vs Tc in 10 Gauss for a crystals were measurements indicated that the samples have a superconducting transition temperature of 85K.
최근 15년간 부산 및 동부 경남 지역 주요 피부 악성종양에 관한 임상적 및 통계적 고찰(1996∼2010)
하승민 ( Seung Min Ha ),고동엽 ( Dong Yeob Ko ),전수영 ( Su Young Jeon ),김기호 ( Ki Ho Kim ),송기훈 ( Ki Hoon Song ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.3
Background: The incidence of cutaneous malignant tumors, especially basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM), has continuously increased in Korea. However, there has been little research into the distribution and incidence of malignant skin tumors in the south-eastern part of Korea. Objective: The purpose of this study was to analyze recent trends in incidence and clinical patterns of cutaneous malignant tumors in Busan city and the eastern Gyeongnam Province. Methods: We reviewed 714 cases of cutaneous malignant tumors that include BCC, SCC, and MM from January 1996 to December 2010 at the Department of Dermatology in Dong-A University Hospital. Results: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 1.18% and has continuously increased from 0.63% to 1.91% over the last 15 years (1996∼2010). In particular, the average annual incidence of BCC and SCC has markedly increased from 0.35% and 0.25% to 0.94% and 0.79%, respectively. The most common cutaneous malignant tumor was BCC (48.32%), followed by SCC (41.18%) and MM (10.50%). The mean age of onset in patients who had been diagnosed with cutaneous malignant tumors was 65.07 years (males: 62.04, females: 67.87). There was a similar incidence between males and females in cutaneous malignant tumors (1:1.08). The most common site of cutaneous malignant tumors was the face (66.25%); the cheek (34.04%) was the most preferential site on the face, followed by the nose (30.23%). Conclusion: The incidence of cutaneous malignant tumors has gradually increased in Busan city and the eastern Gyeongnam Province, which was relatively higher than the incidence in other areas. It was thought to be due to the higher proportion of the elderly than in other areas of the country and skin cancer centers in our hospital. (Korean J Dermatol 2013;51(3):167∼172)
Case Report : Endometriosis in a Postmenopausal Woman on Hormonal Replacement Therapy
( Dong Su Jeon ),( Tae Hee Kim ),( Hae Hyeog Lee ),( Dong Won Byun ) 대한폐경학회 2013 대한폐경학회지 Vol.19 No.3
Endometriosis is a benign disease and an estrogen-dependent disease. Postmenopausal endometriosis is rare, because the absence of estrogenic hormone production. We report a case of endometriosis presenting in a postmenopausal woman with no history of endometriosis before hormone replacement therapy. (J Menopausal Med 2013;19:151-153)