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      • KCI등재

        Streptococcus mutans에 대한 생강과 천연추출물의 광역학 항균효과

        황혜림,강시묵,이은송,김백일 대한치과의사협회 2019 대한치과의사협회지 Vol.57 No.10

        mutans (S.mutans ), which is known to cause dental caries, in order to confirm whether these extracts could perform as photosensitizers for the effects of photodynamic therapy (PDT). Methods: This study used the strain of streptococcus mutans ATCC 25175 distributed by the Korean Collection for Type Cultures of the Korea Research Institute of Bioscience & Biotechnology. Commercial edible curcuma, ginger and finger root were used as the natural extracts for the use of photosensitizer. To extract organic solvent, 3 g of each powder was mixed in 30 ㎖ of dimethyl sulfoxide (DMSO, VWR, Germany) before extraction. 1.8 ㎖ of the photosensitizer solution, manufactured in the concentrations of 5, 0.5, and 0.05 ㎎/㎖, was mixed with 0.2 ㎖ of the S. mutans culture medium that had been cultured for 2 days. To induce the photodynamic reaction, Qraycam (AIOBIO, Seoul, Korea) equipped with 405 ㎚ LED was used to expose light for 5 minutes to irradiate 59 ㎻ energy for 300 seconds. Results: Compared with the case with no light, a higher photodynamic therapeutic effect was confirmed with 0.05㎎/㎖ curcuma powder extract, the concentration of 0.5 ㎎/㎖ and LED light of 405 ㎚ wavelength (p=0.000, p=0.003). 0.05 ㎎/㎖ of curcuma powder extract and the concentration of 0.5 ㎎/ ㎖ showed 100% antibacterial effect when exposed to light, whereas the concentration of 5 ㎎/㎖ showed 11.95% antibacterial effect. When exposed to light, 0.05 ㎎/㎖ of ginger powder extract showed an antibacterial effect which didn't statistically decrease. The concentrations of 0.5 ㎎/㎖ and 5 ㎎/㎖ did not show any antibacterial effects. As a result of examining any photodynamic therapeutic effects of finger root powder extract on S. mutans , no statistically significant effect was found. Conclusion: The curcuma powder extract is expected to perform as a photosensitizer. Even though belonging to the same ginger family, ginger powder and finger root powder seem difficult to perform as photosensitizer.

      • 정책교란으로서 비즈니스 혁신규제 : 우버에서 에어비앤비까지

        황혜림 서울대학교 기술과법센터 2019 Law & technology Vol.15 No.6

        “우버화”라는 용어는 비단 우버(Uber) 뿐만 아니라 에어비앤비(Airbnb) 등 과 같은 공유경제 산업이 활성화됨에 따라 운수업계, 숙박업계 등 기존 산업계와의 충돌로부터 빚어지는 현상을 의미한다. 혁신을 주도하는 새로운 기술 또는 비즈니스 모델(또는 둘 다)은 기존 산업을 지배하는 규제 구조와 관련된 문제를 제기하며, 기술혁신은 기존 규제 체계와 잘 맞지 않거나 긴장관계에 놓이게 된다. 이러한 갈등의 조정을 위해 각국이 “전통적인 규제방식”을 어떻게 변경시킬 것인지 관심이 모아지고 있다. 비즈니스 혁신에 의해 촉발되는 정책 교란에는 네 종류가 있다. 교묘한 회피, 면제 및 공백, 해결책이 그것이다. 예를 들어 에어비앤비는, 법적으로 차별을 두는 호스트에 의한 ‘면제’ 와 구역제, 호텔세 및 기타 규제 제도와 관련된 일련의 ‘교묘한 회피’ 정책 교란을 야기했다. 이와 같은 정책 교란에 대한 규제 기관의 정책 대응 방법에는 차단, 프리패스, 구체제, 신체제 및 신뢰이익의 보상이 있다. 에어비앤비와 우버택시의 국내 도입에 따른 법적 공백이 발생한 것과 관련해, 규제 대응 방법으로써 ‘구체제’ 또는 ‘신체제’ 이론을 적용하여 관련 국내법의 개정과 새로운 법률의 도입을 고려해 볼 수 있다. The term “Uber” refers to a phenomenon resulting from conflicts with existing transportation and lodging industries as the representative shared economy industry such as Airbnb and Uber is revitalized. A new technology or business model (or both) that drives innovation raises issues related to regulatory structures governing existing industries, and technological innovation is not well suited or strained with existing regulatory frameworks. Attention is being paid to how countries will change their “traditional regulatory methods” to reconcile these conflicts. There are four types of policy disruptions triggered by business innovation; End-run, Exemption and Gap, Solution. Airbnb, for example, has created an ‘Exemption’ policy disruption through hosts legally discriminating and a set of End-run disruptions involving zoning, hotel tax and other regulatory regimes. The regulatory agencies’ policy response to this policy disruption includes Block, Free Pass, OldReg, NewReg, Reliance Interest compensation. Regarding the legal Gap caused by the introduction of Airbnb and UberTaxi in Korea, the application of the “OldReg” or “NewReg”theory as a means of regulatory response could be considered to revise relevant domestic laws and introduce new acts.

      • KCI등재

        당뇨에 이환된 알코올 의존 환자의 신경인지기능 이상

        황혜림,민정아,권 민,천영훈,박재우,채숙희,김대진 대한신경정신의학회 2012 신경정신의학 Vol.51 No.5

        ObjectivesZZDiabetes and alcohol dependence are considered as independent risk factors for cognitive impairment. This research was to investigate whether cognitive functions in diabetic alcohol dependent patients were more impaired than non-diabetic alcohol dependent patients. MethodsZZA cross-sectional study was conducted in alcohol dependence patients (n=138). Patients with alcohol dependence diagnosed by Diagnostic and Statistical Manual of Mental Disorder, 4th edition, Text Revision underwent a 75 g oral glucose tolerance test, to classify to diabetics group and non-diabetics group. In addition to demographic and clinical characteristics, cognitive functions assessed using the Korean-Mini Mental Status Examination (K-MMSE), word list memory test, and word fluency test, word list recall test from Korean version of the consortium to establish a registry for Alzheimer’s disease, and block design test, digit span test, and digit symbol test from Korean-Wechsler Adult Intellogence Scale were compared between the two groups. ResultsZZThere was no significant difference in demographic and other clinical characteristics between the non-diabetic and diabetic alcoholic patients. Compared to non-diabetic alcoholic patients, diabetic alcoholic patients were more impaired on language of K-MMSE (p=0.028) and digit symbol test (p=0.044). ConclusionZZThese findings suggest the more severe impairment of selective cognitive functions in diabetic alcoholic patients than non-diabetic alcoholic patients. Future replication of these findings in a large population is necessary

      • KCI등재후보

        The relationship between hypertension and sleep duration: an analysis of the fifth Korea National Health and Nutrition Examination Survey (KNHANES V-3)

        황혜림,이정규,이상엽,차광수,최정현,정동욱,이유현,조영혜,탁영진,김윤진 대한고혈압학회 2015 Clinical Hypertension Vol.21 No.7

        Introduction: Hypertension is a significant risk factor for cardiovascular disease (CVD). The majority of patients, however, cannot easily maintain a healthy blood pressure. Therefore, lifestyle modifications are important and may include getting enough sleep. The purpose of this study was to determine the relationship between sleep duration and hypertension, as defined by the Joint National Committee (JNC) 7 and JNC 8 guidelines. Methods: We used the data from 6,365 individuals aged ≥ 18 years based on national data from a representative sample of the 5th Korea National Health and Nutrition Examination Survey V-3 in 2012. The participants were divided into three categories: JNC 7, JNC 8, and newly excluded only. The duration of sleep was classified as less than 5, 6, 7, 8, or more than 9 hours. Results: Compared with the appropriate sleep duration of 7 hours, with a sleep duration of less than 5 hours, the recommended pharmacological treatment of hypertension rate increased 1.908-fold (95% CI = 1.483-2.456) according to the JNC 8 guidelines and 1.864-fold (95% CI = 1.446-2.403) according to the JNC 7 guidelines. However, there was no statistical difference with the other sleep categories. Discussion: The recommended hypertension treatment rate increased significantly in the less than 5 hours sleep group according to the JNC 8 guidelines. To manage hypertension effectively, it may be useful to maintain a lifestyle of sleeping more than 6 hours.

      • KCI등재후보

        The Effect of Oral Health Belief Influence on the Preventive Oral Health Behaviors in College Students

        황혜림,조영식 대한예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.3

        Objective: The purpose of this study was to investigate the effects of oral health belief on the personal oral health practice and preventive dental care in college students. Methods: The total 319 individuals completed a self-reported questionnaire on oral health belief such as importance, seriousness,benefits and barriers, modifying factors and oral health behaviors. Results: 1. The Female students showed a higher level of seriousness, importance, benefits (p<0.05), and the respondents who were older than 21 years showed a higher level of seriousness (p<0.05). 2. The group who didn't experience oral health educations showed a higher level of barriers scores (p<0.05) and the group who perceived showed a lower level of perceived oral health status (p<0.05). 3. 'Perceived oral health status' effects on seriousness according to gender, age, oral health education and perceived oral health status (B=0.174, p<0.05). The factor effecting importance were age (B=−0.044) and perceived oral health status (B=0.074). The perceived oral health status effected on perceived barriers (B=0.191). 4. Using multiple regression analysis and logistic regression analysis, the study showed that importance (B=0.076, p<0.05) and barriers (B=0.098, p<0.05) affected on tooth brushing practice and importance (B=0.434,OR=1.543, p<0.05) and oral health education (B=0.795, OR=2.214, p<0.05) affected on regular scaling. Conclusion: Factors affecting oral health behaviors were 'importance', 'barriers' in oral health belief and the oral health education experienece in cue to action.

      • KCI등재

        Second Language Acquisition of Pseudo-VP-Ellipsis and Gapping in Korean

        황혜림 서울대학교 언어교육원 2023 語學硏究 Vol.59 No.3

        Previous research shows that constructions involving missing material can pose a challenge in second language (L2) acquisition. Using Korean Pseudo-Verb-Phrase-Ellipsis and Gapping, this study examines whether L2 learners whose first language (L1) is Chinese manage to develop implicit knowledge of the two constructions' grammaticality in a conjunct clause and ungrammaticality in an adjunct clause. In the acceptability judgment task, our L2 learners as a group did not show target-like performance, but their judgment patterns revealed a proficiency effect, such that L2 learners with higher proficiency displayed target-like knowledge of the (un)grammaticality of Pseudo-Verb-Phrase-Ellipsis and Gapping is Korean, despite the absence of available sources of linguistic data (e.g., L1 transfer, negative evidence, explicit instructions). This study is significant in expanding the current body of research through its findings that support (higher-proficiency) L2 learners can acquire a complex structure that poses a challenge to them.

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