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- 저자 : 황승덕(Seung Deok Hwang) (검색결과 2 건)
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간경변증 환자의 말초혈액단핵구에서 중합효소연쇄반응법을 이용한 Cytomegalovirus DNA 의 검출
문종호(Jong Ho Moon),유창범(Chang Beom Ryu),박철호(Cheol Ho Park),류권호(Kwon Ho Ryu),박찬욱(Chan Wook Park),이준성(Joon Sung Lee),이문성(Moon Sung Lee),조성원(Sung Won Cho),황승덕(Seung Deok Hwang),심찬섭(Chan Sup Shim),이희발(Hi Ba 대한내과학회 1995 대한내과학회지 Vol.49 No.6
N/A Objectives: Human cytomegalovirus(CMV) infections are common and usually asymptomatic, but fatal infections occur frequently in immunocompromised patients. In Korea, CMV infection is common and patients with liver cirrhosis are frequently in a condition of immunosuppression, may predispose to the frequent occurrence of CMV infections. The purpose of this study was to investigate the prevalence of CMV infection in patients with liver cirrhosis and to evaluate the relationship between the status of C3:IV infection and liver function. Methods, The subjects of this study were 36patients with liver cirrhosis, 4patients with non A, non B, non C(NANRNC) hepatitis, and 13normal controls. IgG and IgKI antibodies to CMV were measured using a microparticle enzyme immunoassay(MEIA). Specimens of urine were cultured for CMV using shell vial culture method. Peripheral blood mononuclear cells(PBMC) were investigated for the presence of CMV-DNA using PCR. Rusults: In CMU antibody test, IgM and IgG antibodies were detected in 7(19.4%) of 36patients with liver cirrhosis, IgG antibody was detected in the other 29patients and all control subjects. In shell vial culture, CMV was cultured in 1(2.8%) of 36patients with liver cirrhosis(IgM and IgG positive). CMV DNA was detected by PCR in 19(52.8%) of 36patients with liver cirrhosis, but 1(7.7%) of 13 control subjects (p<0.05). CMV DNA was detected in 6(85.7%) of 7cirrhotic patients with IgM and IgG antibodies positive, 13(44.8%) of 29cirrhotic patients with IgG antibody positive. CMV DNA positive cirrhotic patients show 5(26.3%) in Child A, 6(31.6%) in Child H, 8(42.1%) in Child C. CMV DNA negative cirrhotic patients show 4(23.5%) in Child A, 12(70.6%) in Child B, 1(5.9%) in Child C(p<0.05). CMV DY:A positive cirrhotic patients showed the tendency of more frequent detection of HBsAg and HBeAg than CMU DNA negative cirrhotic patients(p<0.05). Conclusion: These results suggest that CMV infection is common in cirrhotic patients and the CMV DNA positive patients with liver cirrhosis have more impairment of liver function than the CMV DNA negative patients with liver cirrhosis.
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HBeAg 양성인 만성 HBV 보유자에서 HBV Core Promoter 변이의 임상적 의의
김성일,조주영,이준성,김진오,이문성,황성규,김연수,심찬섭,조영덕,이희발,홍수진,문종호,황승덕 대한소화기학회 1997 대한소화기학회지 Vol.30 No.6
Background/Aims: Transcriptions of precore and pregenomic mRNAs of hepatitis B virus(HBV) are under the control of fee core promoter. Therefore, mutations in this promoter region might change the activity of liver diseases through altered transcriptional level of either mRNA. In chronic HBV carriers, mutations of the promoter are repoited to be frequent in HBV carriers with anti-HBe rather than those with HBeAg. The present study was carried out to identify the .difference in patterns of the mutations according to the severity of the liver diseases, and to investigate whether the presence of the mutant might affect the seroconversion from HBeAg to anti-HBe. Methods: DNA sequences of the core promoter region were determined in various chronic HBV carriers with HBeAg, including five cases of asymptomatic carrier(ASC, 21 clones), eight with chronic hepatitis (CH, 50 clones) and two with liver cirrhosis died of liver failure due to spontaneous exacerbation(LC-SE, 13 clones). Results: Core promoter mutations were found in 3 cases of ASC (11 clones), all of CH(48 clones) and LC-SE(13 clones). 1762(A→T) and 1764(G→A) mutations were found in all of CH(40 clones) and LC-SE(13 clones), whereas they were not detected in any case of ASC. These mutants were isolated as a dominant strain in the five cases of CH irrespective of natural or interferon-induced seroconversion from HBeAg to anti-HBe. Compared with the patterns of mutations encountered in the cases of CH, similar patterns of mutation were found in the cases of LC-SE. Conclusions: 1762(A→T) and 1764(G→A) mutation was most frequent in chronic hepatitis and liver cirrhosis. Taken together, it is likely that the presence of the mutants has little effect on the difference of disease severity or seroconversion from HBeAg to anti-HBe in chronic hepatitis and liver cirrhosis.
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