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Development of HA-PCL Nanoparticles Loaded with Upconversion Dye for Transdermal Delivery
최혜은,정우엽,김기수 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
In phototherapy, there are problems with biomedical applications when visible light is irradiated on the skin owing to low penetration into tissue. For these reasons, we developed polycaprolactone grafted hyaluronic acid nanoparticles (HA-PCL NPs) for transdermal delivery of up conversion (UC) dye which can convert light with low energy into high energy as light source with large penetration depth. The successful preparation of HA-PCL NPs containing UC dyes were confirmed by DLS and TEM, and stability was identified by the UV-Vis spectroscopy. In addition, the penetration test of NPs for 24 hours on porcine skin confirmed successful permeation by measuring variation of blue light intensity. Based on these results, our HA-PCL NPs are appropriated for transdermal delivery of UC dye and can resolve the limitation of low penetration due to short wavelengths for effective phototherapy and showed the potential as a phototherapy platform for treatment of various skin disease.
The Nipponophone Company and Record Consumption in Colonial Korea
최혜은 고려대학교 한국사연구소 2015 International Journal of Korean History Vol.20 No.1
This paper is a history of the Korean record industry in the 1910s and 20s,focusing on the record company Nihon Chikuonki Shokai (Nitchiku hereafter). Asthe first record company in the Japanese empire and the only one which operated aKorean branch until the middle of the 1920s, Nitchiku provides a gateway forunderstanding the formative period of the Korean record industry. In this paper, Ipay special attention to the fact that Nitchiku was a foreign-funded and foreignmanagedcompany and explore how it was able to take root in its markets bystudying the company뭩 localization strategies, which I call 밿mage politics.?Ichallenge the common perception that Nitchiku was an independent company andthereby demonstrate that it had special connections with major record companiesin Europe and the U.S. even before its transition to Nippon Columbia. I also arguethat consumers targeted by Nitchiku in the Korean market were not limited toKoreans, but also included multicultural groups residing in colonial Korea,especially Japanese. Such a business approach helped expose Korean recordconsumers to the global sound culture of the era, mediated through records. Indoing so, I hope to illuminate how colonial Korea was intricately interconnectedand interdependent with Japan in the circumstances engendered by Japaneseimperialism as well as the capitalism of the era.
차세대 이동통신 시스템에서 L2 지연 감소를 통한 빠른 핸드오프
최혜은,김남기,윤현수,Choi Hye-Eun,Kim Namgi,Yoon Hyunsoo 한국정보처리학회 2004 정보처리학회논문지 C : 정보통신,정보보안 Vol.11 No.7
이동 통신 시스템에서 핸드오프는 패킷 손실, 전송 지연, 지터 등을 유발하여 사용자의 서비스 품질을 저하시킨다. 더욱이 차세대 이동 통신 시스템으로 주목받고 있는 OFDM(Orthogonal Frequency Division Multiplexing) 시스템에서는 OFDM 특성 상 하드 핸드오프를 수행해야 하고, 높은 용량의 마이크로 셀과 빠른 속도의 단말로 인해 핸드오프 주기가 잦아진다. 따라서 핸드오프 시 유발되는 서비스 품질은 3세대 이후의 이동 통신 시스템의 성능을 결정짓는데 매우 중요한 요소가 된다고 볼 수 있다. 그러므로, 이를 위해 핸드오프 시 QoS를 보장해 줄 수 있는 알고리즘에 대한 연구가 절실히 필요하다. 지금까지 차세대 이동 통신 시스템을 위한 기존 연구들은 IP 계층에서 L3 핸드오프 지연이나 L3 패킷 손실을 줄이는데 만 주력해 왔다. 즉 MAC 계층과 같은 2계층의 핸드오프 지연을 줄이기보다는 3계층에서 보상하는 방식으로 핸드오프지연을 줄여 온 것이다. 하지만 여전히 존재하는 L2 지연은 실시간 트래픽과 같은 지연 민감 서비스 등에서 QoS를 크게 저하시키게 된다. 따라서 본 논문에서는 L2 핸드오프 지연을 최소화할 수 있는 끊김 없는 핸드오프 알고리즘을 제안한다. It is generally known that handoff delay degrades the QoS by packet drop, packet delay and jitter. Moreover. handoff highly effects on QoS in beyond 3G system because not only micro cells for achieving high capacity and fast moving nodes induce the frequent handoff but also hard handoff must be carried out in OFDM system. Therefore, study on a handoff algorithm for guaranteeing QoS is required. Related works on handoff for beyond 3G system mainly focused on reducing the L3 handoff delay or packet loss. That is, these schemes try to compensate L2 delay rather directly eliminate it. However, remained 1.2 delay degrades QoS, especially delay-sensitive realtime traffic. Therefore, we proposed the seamless handoff algorithmwhich can minimize the L2 handoff delay.
최혜은,박태언,김기수 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
Among the visible light, short wavelength like green light can be widely used in photomedicine due to high energy. However, there are limitations when short wavelength light is irradiated because of low penetration into tissue and cell damages. The limitations can be improved by loading the UC dye can covert low frequency into higher frequency on hyaluronic acid-based nanoparticles. The successful preparation of HA-PCL/UC NPs was confirmed by DLS and TEM, and stability was confirmed by UV-visible spectroscopy. By UC analysis, NPs steady emitted green light, and further analysis in porcine skin tissue dispersant showed the applicability of our NPs in real skin tissue. Based on these results, our HA-based NPs are appropriated for transdermal delivery of UC dye and can complement the barriers of short wavelength with low penetration for effective phototherapy in the skin.
유료노인복지시설 거주노인의 일상생활수행정도와 만족도에 관한 연구
최혜은,안옥희,정연강 중앙대학교 의과대학 간호학과 간호과학연구소 2002 중앙간호논문집 Vol.6 No.2
This dissertation is on perceiving ADL(ADL : Activities of Daily Living), IADL(IADL : Instrumental Activities of Daily Living) and satisfaction of the residents paid Welfare facilities. It also seeks the elderly to use paid Welfare facilities a better life by analyzing the influence on ADL, IADL and satisfaction. Data for this present study was collected via questionnaires randomly distributed to residents of paid Welfare facilities from 1 June to 30 June, 2002. Questionnaires were issued to 200 people and 108 were returned. The data was analyzed by frequency, percentage, t-test, ANOVA, factor analysis, correlation coefficients analysis. The results are as follows : First, For the ADL, score of step climbing was comparatively lower than that of other activities. The ADL showed significant differences according to religion. Second, For the IADL, using public transportation and bank facilities were comparatively difficult. Ability of IADL was generally lower than that of ADL. The IADL showed significant differences according to the existence of relatives. Third, Th general satisfaction facility service condition showed significant differences according to sex, education, disease, the existence of a grandson and granddaughter. Forth, Average score of the life satisfaction was 41.09. The life satisfaction showed significant differences according to marital status and the existence of relatives. According to results of correlation analysis between score of life satisfaction and ADL, IADL, facility service condition showed correlation. In summary it is important to improve the ADL, IADL status and facility service condition, life satisfaction among the elderly in paid Welfare facilities. To do this government, related groups, related professionals have to develop policies and concrete programs for the benefit of the elderly.