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Hypoxia-Induced Endothelial Progenitor Cell Function Is Blunted in Angiotensinogen Knockout Mice
최진화,Minh-Phuong Nguyen,Dongjin Lee,오구택,이유미 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.6
Angiotensinogen (AGT), the precursor of angiotensin I, is known to be involved in tumor angiogenesis and associated with the pathogenesis of coronary atherosclerosis. This study was undertaken to determine the role played by AGT in endothelial progenitor cells (EPCs) in tumor progression and metastasis. It was found that the number of EPC colonies formed by AGT heterozygous knockout (AGT+/-) cells was less than that formed by wild-type (WT) cells, and that the migration and tube formation abilities of AGT+/- EPCs were significantly lower than those of WT EPCs. In addition, the gene expressions of vascular endothelial growth factor (VEGF), Flk1, angiopoietin (Ang)-1, Ang-2, Tie-2, stromal derived factor (SDF)-1, C-X-C chemokine receptor type 4 (CXCR4), and of endothelial nitric oxide synthase (eNOS) were suppressed in AGT+/- EPCs. Furthermore, the expressions of hypoxia-inducible factor (HIF)-1α and -2α were downregulated in AGT+/- early EPCs under hypoxic conditions, suggesting a blunting of response to hypoxia. Moreover, the activation of Akt/eNOS signaling pathways induced by VEGF, epithelial growth factor (EGF), or SDF-1α were suppressed in AGT+/- EPCs. In AGT+/- mice, the incorporation of EPCs into the tumor vasculature was significantly reduced, and lung tumor growth and melanoma metastasis were attenuated. In conclusion, AGT is required for hypoxia-induced vasculogenesis.
G-code 패킷 컨트롤을 통한 웹 기반 금형 가공 공정관리
최진화,백세진,이정원,전병철,조명우 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-
This paper is proposed web-based mold manufacturing process management system for the effective manufacturing processing management. Developed system is G-code analysis to include manufacturing information and organize according to cutting level, tool species, and tool path, etc. It is able to insert OMM(On Machine Measurement)-code in the organized G-code. And this system is developed to control remote-place manufacturing process management system by web-based Sever / Client system. So this is able to control remote-place system monitoring and mold manufacturing process management.
최진화,김성민,최진환,안경순,심영보,손진희,최선길 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.6
A case of multiple intradural schwannomas of the cauda equina is reported without evidence of any other manifestations of neurofibromatosis. The patient had symptoms of cauda equina compression. Following a diagnosis of multiple intradural tumors of the cauda equina, based on lumbar spine MRI with contrast enhancement, the tumors at the L1 body, L3 body, L3- L4 intervertebral space level were removed completely, innolving two rootlets. After the operation, the patient is asymptomatic apart from left S3 dermatome hypesthesia.
최진화,Ji Sook Kim,So Yoon Ahn,장윤실,박원순,Se In Sung 대한신생아학회 2018 Neonatal medicine Vol.25 No.4
Purpose: The aim of this study is to examine the tolerability and effect of early highdose amino acid administration in extremely low birth weight infants (ELBWIs). Methods: This retrospective cohort study included ELBWI (birth weight <1,000 g, n=142). Biochemical, nutritional, and neurodevelopmental data were compared between infants who received conventional low amino acid (LAA; 1.5 g/kg/day) and those who received high amino acid (HAA; 3 g/kg/day) within the first 48 hours after birth. Neurodevelopmental data included weight, height, and head circumference at discharge, 12 to 14 and 18 to 24 months of corrected age and the Korean Bayley Scale of Infant Development II (K-BSID-II) score at 18 to 24 months of corrected age. Results: The HAA group demonstrated higher peak plasma albumin (3.0±0.4 vs. 3.2± 0.5, P<0.05) and lower serum creatinine (1.7±0.9 vs. 1.4±0.8, P<0.05) during the first 14 days than the LAA group. Full enteral feeding was achieved significantly earlier in infants in the HAA group than in infants in the LAA group (46.2±23.0 days vs. 34.3±21 days, P<0.01). There was no difference between the two groups in the z score changes in all growth indicators from birth to discharge and at 12 to 14 and 18 to 24 months of corrected age, as well as in the K-BSID-II score at 18 to 24 months of corrected age. Conclusion: Aggressive administration of amino acids during the first 2 days of life in ELBWI was well tolerated and correlated with earlier full enteral feeding, but did not improve growth and neurodevelopment.