두시하태독법의 Th2 분화 조절을 통한 알레르기 비염 완화 효과

최준용,안상현,김기봉,Choi, Jun-yong,Ahn, Sang-hyun,Kim, Ki-bong 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.4

Objectives: This study investigated the effects of Douchi Hataedock on Th2-skewed conditions to control allergic rhinitis. Methods: NC/Nga mice were divided into three groups: 10 mice were assigned to the control group (CTRL; no treatment), 10 mice to allergic rhinitis-induced (ARE) without treatment group, and 10 mice to the allergic rhinitis-induced (FGT) after Douchi Hataedock treatment group. The 3-week-old mice of the FGT group were given one 10 mg/kg dose of Douchi Hataedock extract and resensitized to allergic antigens at weeks four, five, and six. Allergic rhinitis was induced primarily in mice nasal cavities for five days after one week of final sensitization. The second induction used the same method one week after the first induction was completed. After one week, the nasal mucosal tissues of each group were observed. Immunohistochemical staining for IL-4, STAT6, CD40, $Fc{\varepsilon}RI$, substance P, MMP-9, $NF-{\kappa}B$ p65, p-IkB, and iNOS in the nasal mucosa was also performed. Results: The FGT group had less respiratory epithelial damage and less mucin secretion in goblet cells than the ARE group and showed a 62% decrease in IL-4, 85% decrease in STAT6, 71% decrease in CD40, 69% decrease in $Fc{\varepsilon}RI$, 43% decrease in substance P, 49% decrease in MMP-9, 43% decrease in NF-kB p65, 38% decrease in p-IkB, and 73% decrease in iNOS compared to the ARE group. Conclusions: Douchi Hataedock lessens inflammation in epithelial and goblet cells and reduces inflammatory mediator secretion in a mouse allergic rhinitis model.

동과자 에탄올 추출물이 비알코올성 지방간 세포 모델에 미치는 효과

최준용,김소연,권민정,김균하,주명수,한창우,Choi, Jun-Young,Kim, So-Yeon,Kwun, Min-Jung,Kim, Kyun-Ha,Joo, Myung-Soo,Han, Chang-Woo 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.4

Objectives : In this study, we investigated the effect and the underlying mechanism of ethanol extract of Benincasa seeds on a cellular model of non-alcoholic fatty liver disease (NAFLD) established by treating HepG2 cells with palmitate. Methods : We evaluated ethanol extract of Benincasa seeds (EEBS) for its hepatic lipid-lowering potential in fatty acid overloaded HepG2 cells. After incubation in palmitate containing media with or without EEBS, intracellular neutral lipid accumulations were quantified by Nile red staining. We also investigated the effect of EEBS on lipogenesis and ${\beta}$-oxidation. $LXR{\alpha}$-dependent SREBP-1c activation, expression of lipogenic genes, and expression of ${\beta}$-oxidation related genes were determined with or without pretreatment of EEBS. Results : EEBS significantly attenuated palmitate-induced intracellular neutral lipid accumulation in HepG2 cells. EEBS suppressed fatty acid synthesis by inhibiting $LXR{\alpha}$-dependent SREBP-1c activation. EEBS also repressed SREBP-1c mediated induction of lipogenic genes, including ACC, FAS, and SCD-1. However, EEBS had no effect on ${\beta}$-oxidation related CPT-1 and $PPAR{\alpha}$ gene expression. Conclusions : Our results suggest that EEBS has an efficacy to decrease hepatic lipid accumulation, and this effect was mediated by inhibiting the $LXR{\alpha}$-SREBP-1c pathway that leads to expression of lipogenic genes and hepatic steatosis. Therefore, the Benincasa seeds may have a potential clinical application for treatment of this chronic liver disease.

두경부암 방사선치료 시 선량 균일도 향상을 위한 Thermoplastic 구강 보상체의 개발

최준용,원영진,박지연,김종원,문봉기,윤형근,문수호,전종병,서태석,Choi, Joon-Yong,Won, Young-Jin,Park, Ji-Yeon,Kim, Jong-Won,Moon, Bong-Ki,Yoon, Hyong-Geun,Moon, Soo-Ho,Jeon, Jong-Byeong,Suh, Tae-Suk 한국의학물리학회 2012 의학물리 Vol.23 No.4

두경부암 방사선치료 시 공동 경계면 및 주변 치료 부위의 선량 균일도 향상을 위하여 조직 등가의 thermoplastic 구강 보상체를 개발하였다. Thermoplastic의 유용성 평가를 위해, 기존에 사용해 오던 치과용 인상재료인 paraffin, alginate, 그리고 putty로 제작한 각 구강 보상체의 물성 및 선량 분포 향상도를 비교하였다. 물성 평가에는 강도 평가(압축 실험, 낙하 실험)와 자연변형도(시간에 따른 체적 변화) 평가를 수행하였으며, 개발한 선량 검증용 팬톰에 삽입한 유리선량계와 Gafchromic EBT2 필름을 이용하여 표면선량, 공동 경계면 선량 및 빔 측면도를 측정하여 전달 선량을 평가하였다. 두 달간 각 구강 보상체의 자연변형도 평가하였을 때, alginate는 수분증발로 최대 80% 체적 변화를 보였으나, thermoplastic을 포함한 나머지 조직 등가 물질은 체적 변화가 3% 미만으로 나타났다. 강도 평가 중 5회 반복한 1.5 m 높이의 자유 낙하실험에서 paraffin은 충격에 의하여 파손이 발생되었으나, thermoplastic은 낙하에 의한 파손이 발생되지 않았으며, 압축 강도 실험에서도 paraffin에 비하여 8배 이상의 높은 힘에서도 파손되지 않았다. 유리선량계를 이용한 선량 검증 결과, 1문 조사 시 조직등가[약 80 HU (Hounsfield Unit)]의 thermoplastic은 동일한 처방 선량 전달 시 약 1,000 HU 이상의 값을 나타내는 putty에 비해 4% 낮은 출력계수(monitor unit) 전달로 약 4.9%의 낮은 표면 선량을 전달하였다. 또한 빔 입사 방향을 기준으로 할 때, 구강 통과 후 경계면의 빔 측면도에서 선량 균일도 평가를 위해 측정한 조사영역 편평도는 air, thermoplastic, putty에서 각각 11.41, 3.98, 4.30으로 나타났다. Thermoplastic 구강 보상체는 조직 등가 물질로 기존에 사용해오던 구강 보상체에 비하여 강도가 높고 물질 변형 확률이 적으며, 구강을 포함을 경계면 및 주변 부위에 균일한 선량 분포를 형성할 수 있으므로 균일한 처방 선량 전달 및 피부 선량 감소가 가능하다. Aquaplast Thermoplastic (AT) is a tissue-equivalent oral compensator that has been developed to improve dose uniformity at the common boundary and around the treated area during radiotherapy in patients with head and neck cancer. In order to assess the usefulness of AT, the degree of improvement in dose distribution and physical properties were compared to those of oral compensators made using paraffin, alginate, and putty, which are materials conventionally used in dental imprinting. To assess the physical properties, strength evaluations (compression and drop evaluations) and natural deformation evaluations (volume change over time) were performed; a Gafchromic EBT2 film and a glass dosimeter inserted into a developed phantom for dose verification were used to measure the common boundary dose and the beam profile to assess the dose delivery. When the natural deformation of the oral compensators was assessed over a two-month period, alginate exhibited a maximum of 80% change in volume from moisture evaporation, while the remaining tissue-equivalent properties, including those of AT, showed a change in volume that was less than 3%. In a free-fall test at a height of 1.5 m (repeated 5 times as a strength evaluation), paraffin was easily damaged by the impact, but AT exhibited no damage from the fall. In compressive strength testing, AT was not destroyed even at 8 times the force needed for paraffin. In dose verification using a glass dosimeter, the results showed that in a single test, the tissue-equivalent (about 80 Hounsfield Units [HU]) AT delivered about 4.9% lower surface dose in terms of delivery of an output coefficient (monitor unit), which was 4% lower than putty and exhibited a value of about 1,000 HU or higher during a dose delivery of the same formulation. In addition, when the incident direction of the beam was used as a reference, the uniformity of the dose, as assessed from the beam profile at the boundary after passing through the oral compensators, was 11.41, 3.98, and 4.30 for air, AT, and putty, respectively. The AT oral compensator had a higher strength and lower probability of material transformation than the oral compensators conventionally used as a tissue-equivalent material, and a uniform dose distribution was successfully formed at the boundary and surrounding area including the mouth. It was also possible to deliver a uniformly formulated dose and reduce the skin dose delivery.

휴대용 폐기능 검사기의 재현성과 기대치에 관한 연구

최준용,정희재,이건영,정승연,황준호,이형구,정승기,Choi, Jun-Yong,Jung, Hee-Jae,Lee, Kun-Young,Jeong, Seung-Yeon,Hwang, Joon-Ho,Rhee, Hyung-Koo,Jung, Sung-Ki 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.3

Objectives : The object of this study was to evaluate repeatability of portable spirometry and to determine an appropriate equation for predicted value. Materials and Methods : The subjects were 76 men and 45 women recruited from among Kyunghee University oriental medical students. Portable spirometry was performed via the procedure recommended in ATS guidelines. Repeatability of spirometry was checked against ATS repeatability standards and NHLEP QC grade. Percentage of predicted value of non-smokers was calculated through a Caucasian population-based regression equation(by Morris et al.) and Korean population based regression equation(by Kim et al.). These were compared. Result : 91.7% of subjects matched repeatability standards of ATS and 95% of subjects got interpretable NHLEP QC grades of A, B, and C. Mean percentage of predicted value by Morris et al. were as follows: Mean of FVC% was 90.86, FEV1% was 96.66, FEV1/FVC% was 107.48. Mean percentage of predicted value by Kim et al. were as follows. Mean FVC% was 92.38, FEV1% was 89.77, FEV1/FVC% was 96.95. Conclusions : Results of this study show that more than 90% of subjects meet repeatability criteria. This supports a role for the portable spirometer as a primary oriental medical office tool. Further, results are a verify that they Korean population-based predicted value equation is a more appropriate standard than the Caucasian population-based one, but a still more accurate standard is needed for the Korean adult population.

청상보하탕(淸上補下湯)의 기관지천식환자에 대한 스테로이드 절약효과

최준용,이재성,주창엽,정희재,이형구,정승기,황우석,Choi Jun-Yong,Lee Jae-Sung,Ju Chang-Yeop,Jung Hee-Jae,Rhee Hyung-Koo,Jung Sung-Ki,Hwang Woo-Suck 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1

Background : In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result. in general. side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians. Objectives : We aimed to identify the clinical effects of Cheongsanghoha-tang and the steroid sparing effects of Cheongsanghoha-tang on. Materials and Methods : A subject group consists of 36 asthmatics who had been treated with Cheongsanghoha-tang for four weeks. Cheongsanghoha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4. IL-5, IFN-${\gamma}$ were checked before and 4weeks after the treatment. Results : The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsanghoha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN-${\gamma}$ in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN-${\gamma}$ and significant increase in QLQAKA. As a result. 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS. Conclusions : This study shows that Cheongsanghoha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsanghoha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsanghoha-tang. However. the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary.

HIV 감염 예방의 최신 지견

최준용 ( Jun Yong Choi ) 대한내과학회 2016 대한내과학회지 Vol.90 No.6

There are many evidence-based methods to prevent human immunodeficiency virus (HIV) transmission. This review describes recent updates on the prevention of HIV infection via sexual contact, mother-to-child transmission, and occupational exposure. The use of antiretroviral therapy to prevent HIV has been a major accomplishment. Successful strategies for preventing the sexual transmission of HIV include the implementation of treatment for prevention, pre-exposure prophylaxis, and microbicides. Mother-to-child HIV transmission can be minimized by screening and administering pre-, intra-, and postpartum prophylaxis. Adherence to universal precautions and post-exposure prophylaxis are effective preventive measures for occupational exposure. The implementation of prevention strategies based on scientific evidence should decrease the spread of this epidemic. (Korean J Med 2016;90:474-480)

자하거(紫河車) 약침의 기관지 천식 치료 가능성에 대한 소고(小考)

최준용 ( Jun Young Choi ),오달석 ( Dal Seok Oh ),정희재 ( Hee Jae Jung ),최선미 ( Sun Mi Choi ),정승기 ( Sung Ki Jung ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.2

Objectives: The aim of this study was to find out some rationales for using Hominis placental extract(HPE) pharmaco-acupuncture on asthmatic patients, and to suggest an appropriate clinical research of HPE pharmaco-acupuncture on asthma. Methods: Articles regarding immunologic experiments about HPE and clinical reports about HPE-contained pharmaco-acupuncture on asthmatic patients were reviewed by on-line and off-line searching. Results and Conclusions: HPE is suggested to have several pharmacological effects on allergic diseases including asthma as well as autoimmune diseases. There are some observational studies of HPE-contained pharmaco-acupuncture on asthmatic patients. However, the designs of these studies are not sufficient to investigate the exact effect of HPE pharmaco-acupuncture on asthma. To investigate HPE pharmaco- acupuncture as a novel asthma therapy, it will be needed to perform further experiments about HPE`s pharmacological mechanism on asthma and to try further advanced clinical researches such as well-designed randomized controlled trial of HPE pharmaco-acupuncture.

전화회선을 이용한 음성 DB 수집에 관한 연구

최준용(Jun-Yong Choi),박순영(Soon-Young Park),방만원(Man-Won Bang),이용주(Yong-Joo Lee) 한국통신학회 1992 한국통신학회 학술대회논문집 Vol.1992 No.7

서울시 젠트리피케이션 단계별 택시 이용 패턴 분석

최준용(Choi, Junyong),곽민철(Kwak, Minchul),데이비드리(David Lee),박민주(Park, Minju) 한국생태환경건축학회 2020 한국생태환경건축학회 학술발표대회 논문집 Vol.20 No.1

다 개체 로봇의 협업기법에 관한 연구

최준용(Jun-Yong Choi),김동환(Dong Hwan Kim),이귀형(Gui Hyung Lee) 대한기계학회 2010 大韓機械學會論文集A Vol.34 No.8

이 연구에서는 다 개체 로봇에 의해 하나의 로봇을 자율적으로 포획하는 협업제어에 관한 연구를 제안한다. 제안된 방안은 각 로봇에 대한 작업역할을 지정하는 역할 분류기, 단일 로봇의 행동 선택기 그리고 복잡한 상황을 대처하는 협업관리기로 구성되어 있다. 이 연구에서는 주변의 다개체 로봇의 다양한 행동을 통하여 단위 로봇을 특정지역으로 몰아가는 결과를 시뮬레이션을 통하여 그 적절성을 검증하였다. In this study, we proposed duty executions to confine a robot in a specific place with multiple robots. The proposed method involved the use of a role classifier for assigning labor roles, behavior selector for each robot, and a collaboration manager for handling complex situations. Further, we verified the validity of the proposed method by performing simulations to confine a robot in the specific location by using multiple robots.