한방치료에 따른 천식환자의 삶의 질에 대한 임상적 평가

주창엽,허태석,정희재,정승기,이형구,한동하,Ju, Chang-Yeop,Heo, Tae-Seok,Jung, Hee-Jae,Jung, Sung-Ki,Rhee, Hyung-Koo,Han, Dong-Ha 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

Objective : Asthma is a lung disorder characterized by periodic attacks of wheezing alternating with periods of relatively normal breathing. And quality of life in asthmatic patients shows a tendency to decrease. So we had a clinical study whether if oriental medical treatment could improve their quality of life or not. Methods : The 15 cases were new patients that visited at division of respiratory system, department of internal medicine in Kyunghee medical center from the 1 st of July, 2000 to the 1 st of August. All of them were diagnosed as asthma and treated by western medical therapy. We used a Quality of Life Questionnaire for adult Korean Asthmatics(QLQAKA) and evaluated the results after two times answers, at an interval of two weeks. Results : The mean of the first answer was 2.84 marks and 3.36 ones after two weeks. If there is a difference of over 0.5 points between the two, we can admit significant effect. After the asthmatic patients treated by oriental medical therapy, they gained a difference of 0.52 points, 10.4%. Conclusions : We suggest that oriental medical therapy can improve the quality of life of asthmatic patients arid we can alternate side effects of western medical therapy with oriental one. if they carry out two different treatments at the same time.

天宗穴(SI11) 자침이 자각적 호흡곤란 환자의 폐기능변화에 미치는 영향

주창엽(Chang-Yeop Ju),이재성(Jae-Sung Lee),황우석(Woo-Suck Hwang),정희재(Hee-Jae Jung),정승기(Sung-Ki Jung),이형구(Hyung-Koo Rhee) 대한한의학회 2002 대한한의학회지 Vol.23 No.3

소청룡탕치료 기관지천식환자의 혈액내 호산구수와 혈청IgE 및 T림프구아형의 변화

정희재,주창엽,이재성,이경기,이형구,정승기,황우석,Jung, Hee-Jae,Ju, Chang-Yeop,Lee, Jae-Sung,Lee, Kyung-Ki,Rhee, Hyung-Koo,Jung, Sung-Ki,Hwang, Woo-Suck 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Background : Nowadays asthma is considered to be an inflamatory disease characterized by airborne hyper-responsiveness and pulmonary eosinophilia. Objective : We aimed to identify the effects of Sochongryongtang on blood eosinophil, serum IgE and T lympocyte subpopulation in asthmatic patients. Material and Methods : The subjects consisted of fifteen patients with asthma who had been treated with Sochongryongtang for two weeks from February 2001 through June 2001. Sochongryongtang is herbal decoction which has been used for the traditional therapeutic agent of asthma. Results : The blood eosinophil and serum IgE in a normal controlled group. However, the T lympocyte subpopulation in asthmatic patients was not significantly different from the T lympocyte subpopulation in a normal group. The patients were treated with Sochongryongtang for two weeks. No significant difference in the blood eosinophil, serum IgE and T Iympocyte in the sub population. After treatment with Sochongryongtang for two weeks, FEV 1 increased significantly over 0.5 points out of total scores. Conclusion : This study shows that Sochongryongtang has effects on improvement of pulmonary function and quality of life in asthmatic patients. However, the patients who were treated with Sochongryongtang for two weeks showed no significant difference in the blood eosinophil, serum IgE and T lympocyte subpopulation. Further long-term studies must be made on a large number of asthmatic patients.

흉막삼출액을 동반한 폐렴의 치험 1례

한동하,주창엽,허태석,정희재,정승기,이형구 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

The patient was diagnosed as pneumonia through several tests alike simple chest X-ray, sputum culture and CRP, with stroke. He got a little pleural effusion at right lung field, as parapneumonic pleural effusion. He was suffering from fever, productive cough, pleuritic pain, additionally right side weakness due to stroke. We performed oriental medical treatments like herbal medicine and acupuncture therapy without useing western antibiotics and antifebrile medicine. Through those treatments we could get very good results. The herb medicine used at this case was mainly Yuanpae-tang(完肺湯) and Chungpaehualmyung-tang(淸肺活命湯), mainly. From the results, we could find out that the oriental medical treatments were very effective to reduce inflammatory fever and to care pneumonia with pleural effusion. So in order to prevent antibiotics abuse, we have to make more researches into pneumonia and try to find out more effective oriental medical therapies for infectious diseases.

청상보하탕(淸上補下湯)의 기관지천식환자에 대한 스테로이드 절약효과

최준용,이재성,주창엽,정희재,이형구,정승기,황우석,Choi Jun-Yong,Lee Jae-Sung,Ju Chang-Yeop,Jung Hee-Jae,Rhee Hyung-Koo,Jung Sung-Ki,Hwang Woo-Suck 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1

Background : In recent years, the glucocorticoid hormone has become a fundamental medication for asthma. However, a long period of hormone administration will result. in general. side effects on many body parts as well as hormone dependence, which has become a serious problem for western physicians. Objectives : We aimed to identify the clinical effects of Cheongsanghoha-tang and the steroid sparing effects of Cheongsanghoha-tang on. Materials and Methods : A subject group consists of 36 asthmatics who had been treated with Cheongsanghoha-tang for four weeks. Cheongsanghoha-tang is a herbal decoction, which has been used of the traditional therapeutic agent of asthma. PFT, QLQAKA, blood eosinophil, serum IgE, Serum IL-4. IL-5, IFN-${\gamma}$ were checked before and 4weeks after the treatment. Results : The only FVC% in ICSG among asthmatic patients was increased significantly compared to NICSG. Treatment of Cheongsanghoha-tang for four weeks resulted in significant increase in QLQAKA. The NICSG treated with Cheongsangboha-tang for four weeks were no significant difference in the blood eosinophil, serum IgE, IL-4 and IL-5. The PFT and QLQAKA in NICSG were increased significantly after 4 weeks treatment. But the serum IFN-${\gamma}$ in NICSG was decreased significantly after 4 weeks treatment. Discontinuation of treatment with inhaled corticosteroid in ICSG resulted in insignificant changes in PFT, the blood eosinophil, the serum IgE, IL-4, IL-5 and IFN-${\gamma}$ and significant increase in QLQAKA. As a result. 8 of 13 cases were cured with hormones completely and the rest of ICSG reduced the dose of ICS. Conclusions : This study shows that Cheongsanghoha-tang has the effects on the improvement of pulmonary function and cures asthmatic patients. These findings demonstrate that Cheongsanghoha-tang has the steroid sparing effect. Some satisfactory therapeutic results have been obtained in treating hormone-dependent asthma by Cheongsanghoha-tang. However. the concept and mechanism of hormone-dependent asthma have not been fully defined yet, and the standard for judging therapeutic effects have not been established. Obviously further researches concerning all these are still necessary.

행인(杏仁)이 천식관련 chemokine 분비와 호산구 chemotaxis에 미치는 영향

정희재,정승기,이형구,주창엽,Jung, Hee-Jae,Jung, Sung-Ki,Rhee, Hyung-Koo,Ju, Chang-Yeop 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.1

Objective: Eosinophils are typically characterized by a bilobar nucleus with highly condensed chromatin and cytoplasm containing two major types of granules, specific and primary granules, and lipid bodies. The role of inflammation in asthma and other allergic diseases of the airways is widely appreciated, and airway inflammation is now included as a defining feature of asthma. The importance of the presence of eosinophils in the airways of patients with fetal asthma has long been recognized, but the mechanism by which these cells are recruited and retained in the lungs are only now being elucidated. Eotaxin is a potent and specific eosinophil chemoattractant that is mobilized in the respiratory epithelium after allergic stimulation. Methods : Water extracts of Armeniacae Amarum Semen(AAS) and pulmonary epithelial cell lines A549(alveolar typeII epithelial cells) and human eosinophils were used. Cytotoxic effects of AAS and MIS assay were estimated, as well as the effects of AAS on chemokines from prestimulated A549 cells by sandwich ELISA and RI-PCR. Chemotaxis assay was conducted on prestimulated eosinophils treated with AAS. Results : In this study it is demonstrated that $TGF-{\alpha}$, IL-4 and $IL-1{\beta}$ induced the accumulation of chemokine mRNAs in the alveolar epithelial cell lines A549 in dose-dependent manner. Eotaxin and IL-8 were inhibited by AAS in dose-dependent manner(p<0.05). Eosinophil migration was inhibited at high concentrations of AAS(p<0.05). Conculusions : These findings are indicative of suppression of eotaxin and IL-8, and suggest that this is accomplished through AAS treatment. This raises the possibility that AAS is of therapeutic value in diseases such as asthma.

소청용탕이 기관지천식 환자의 혈청 IL-4, IL-5, $IFN-{\gamma}$변화에 미치는 영향

정승기,허태석,황우석,주창엽,김영우,정희재 대한한의학회 2002 대한한의학회지 Vol.23 No.2

Background : Asthma is considered to be an inflammatory disease characterized by airway hyperresponsiveness and pulmonary eosinophilia. Production of cytokines by bronchial epithelial cells may contribute to the local accumulation of inflammatory cells in patients with bronchial asthma. In many recent studies molecular biological methods have been used to investigate the role of cytokines in pathogenesis and new therapeutic targets of asthma. Objective : We aimed to identify the effects of Sochongryong-tang on Serum IL-4, IL-5, $IFN-{\gamma}$ in asthmatic patients. Material and Methods: The subjects consisted of 15 patients with asthma who had been treated with Sochongryong-tang for two weeks from February 2001 through June 2001. Sochongryong-tang is an herbal decoction which has traditionally been used as a therapeutic agent for asthma. Results : The serum IL-4 in asthmatic patients was increased significantly compared to the serum IL-4 in the normal control group. However, the serum IL-5, $IFN-{\gamma}$ in asthmatic patients showed no significant difference from the serum IL-5, $IFN-{\gamma}$ in the normal control group. The patients were treated with Sochongryong-tang for two weeks with no significant difference in the serum IL-4, IL-5, and $IFN-{\gamma}$. Conclusion : This study shows that the serum IL-4 may be a new therapeutic target of asthma. Further long-term studies must be made in a larger number of asthmatic patients.

알레르기 질환 및 한방치료에 대한 일반인의 인식 조사

허태석,한동하,정희재,정승기,이형구,주창엽,Heo, Tae-Seok,Han, Dong-Ha,Jung, Hee-Jae,Jung, Sung-Ki,Rhee, Hyung-Koo,Ju, Chang-Yeop 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

Objective : This research was carried out to find out the general understanding of allergic diseases, the frequencies of allergic diseases and the attitude toward their oriental medical treatment(OMT) among common people. Methods : A total of 360 visitors at The 2nd International Exhibition on Oriental Medicine in 2000, participated in this research. We performed this survey with 22 items on the questionnaire. Results : Respondents knew the. fact that the allergic diseases were hereditary and could be affected by the living environment. 41.8% of the respondents had a past history of allergic diseases. Among the people who had allergic diseases, 63.5% had allergic rhinitis, which was the largest portion. Among them, 52.9% had a familial history. 81.5% of respondents with allergic diseases received western medical treatment for their allergies, 16.3% received both western and oriental medical treatment and 2.2% received OMT only. Among those who were treated for allergic disease, 62.0% were unsatisfied with the low effect of the treatment. To the point of excellence of OMT, 69.7%, which was the largest portion of respondents, believed that OMT could improve their constitutions. The problem with OMT was the high price of herbal medicine and this was the problem most frequently stated, by 51.4% of respondents. There was a positive attitude towards the effect of OMT, and respondents had a preference to receive OMT in the future(p<0.01). Conclusions : These days, it is a fact that the OMT for allergic diseases has a lower proportion to that of western treatment In order to increase the role of OMT, we think, oriental medical doctors need to develop an explanatory model of improving $people^{\circ}{\phi}s$ constitutions and should lower the cost of herbal medicine.

淸上補下湯의 기관지천식환자에 대한 스테로이드 절약 효과

황우석,이형구,정승기,최준용,이재성,주창엽,정희재 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.1

육미지황탕합사백산(六味地黃湯合瀉白散)과 상백피(桑白皮)가 인간 기관지상피세포의 IL-6, IL-8, GM-CSF mRNA level에 미치는 영향

황우석,허태석,정희재,정승기,이형구,주창엽,Hwang, Woo-Suck,Heo, Tae-Seok,Jung, Hee-Jae,Jung, Sung-Ki,Rhee, Hyung-Koo,Ju, Chang-Yeop 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.3

Objectives: We aimed to identify the dose-dependent inhibitory effects of Yukmijihwang-tang-Hap-Sabaek-san(YMHSB) and Root cortex of Morus alba L.(RCM) on the mRNA expression of Interieukin(IL)-6, IL-S, granulocyte macrophage colony stimulating factor(GM-CSF) involved in the asthma model. Methods: In this study BEAS-2B cell lines, human epithelial cells, were used. These cells were stimulated by tumor necrosis $factor(TNF)-{\alpha},\;IL-1{\beta}$ and histamine for artificial inflammatory expression. ${\beta}-actin$ messenger RNA(mRNA) was used for the internal standard. After each 24 hours of the YMHSB and RCM treatment, total cellular RNAs were collected by treating RNA zol directly on the living cells. Then the transcriptional activities of IL-6, 8 and GM-CSF were measured by RT-PCR with electrophoresis. Results: In the YMHSB study, the mRNA expression of GM-CSF and IL-8 is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. In the RCM study, the mRNA expression of GM-CSF and IL-S is significantly inhibited compared to that of control group. But the mRNA expression of IL-6 is not significantly inhibited. Conclusions: This study shows that YMHSB and RCM have dose-dependent inhibitory effects on the mRNA expression of IL-S and GMCSF in human epithelial cells. So these herbal medicines may inhibit the inflammatory process of asthma. Advanced studies are required to investigate the mechanisms of inhibition by herbal medicine in the asthma model.