구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)

최성훈,이경민,이봉효,임성철,정태영,서정철,Choi, Sung-Hun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한침구의학회 2007 Korean Journal of Acupuncture Vol.24 No.2

Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.

경도인지 장애 평가 및 분석 시스템

최성훈,주문일,양영애,김희철,Choi, Sung-Hoon,Joo, Moon-Il,Yang, Yeong-Ae,Kim, Hee-Cheol 한국정보통신학회 2016 한국정보통신학회논문지 Vol.20 No.11

최근 인구 고령화가 급속히 진행되면서 치매인구가 빠른 속도로 증가하고 있다. 치매는 완벽한 치료법이 없기 때문에 경도인지 장애 평가를 통해 조기 발견하여 예방 훈련하는 것이 중요하다. 기존의 경도인지 장애 평가는 수기형태로 이루어지며, 피검자와 검사자의 1:1 대면 평가가 원칙이다. 이는 검사자의 피로도 증가와 이로 인한 평가오류의 가능성을 증가시킨다. 또한 도출된 데이터도 수기 형태이기에 다양한 방식으로 분석 및 활용하기에는 한계가 있다. 따라서 기존 방식의 제한점을 극복 수 있는 시스템화가 가능한 어플리케이션을 활용하여 평가하고, 그 결과를 저장 및 분석할 수 있는 시스템 개발이 필요하다. 본 논문은 경도인지 장애를 평가할 수 있는 피검자와 검사자용 어플리케이션과 평가 데이터를 저장 및 분석할 수 있는 시스템을 개발하고자 한다. As the aging society is accelerated, the population with dementia grows significantly faster. Because there is no complete cure of dementia, it is of great importance to detect the disease at a very early stage and prevent its fast aggravation through evaluation of MCI(Mild Cognitive Impairment) which happens before dementia. The current assessment of MCI conducts only in the form of hand-written data and by 1:1 face to face communication between the subjects and the examiners. Due to this, both examiners' fatigue rate and evaluation error rate increase. Further, there are some limitations in utilizing and analyzing data collected. Against the problems, therefore, there is a need to develop a computerized system by which MCI is assessed, and the results are saved and analyzed. This paper presents the development of such a system enabling MCI evaluation, its related data collection and analysis.

역률보상 고효율 PWM 단상 정류기의 설계

최성훈,김인동,노의철,Choi, Seong-Hun,Kim, In-Dong,Nho, Eui-Cheol 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.3

본 논문에서는 기존의 역율 보상회로에 비해 성능이 좋은 역율 보상 고효율 PWM 단상 정류기를 제안하였다. 제안한 정류기의 설계를 용이하게 하기위한 설계 가이드라인을 상세히 제시하였으며, 제안한 정류기의 특성을 실험으로 증명하였다. 제안한 정류기는 주 전류가 흐르는 선로 구성에서 2개의 주스위치만 존재하므로 도통손을 상당히 감소 시켰으며, 또한 단일 ZVT 회로를 통해 스위칭 손실을 감소시켰다. 제안한 정류기는 부스트 컨버터형의 같은 IGBT 모듈을 사용하므로 주 회로 구성도 간단할 뿐만 아니라, 주 스위치와 보조스위치의 게이트 전원을 제어전원과 공유할 수 있어 단일 제어전원으로 전체 시스템을 제어하므로 시스템의 크기를 보다 콤팩트하게 할 수 있는 특성을 지니고 있다. The parer proposes a power factor correction high efficiency PWM single-phase rectifier. Its good characteristics such as simple PWM control, low switch stress, and low VAR rating of commutation circuits make the proposed rectifier very suitable for various unidirectional power applications. In addition, the proposed rectifier consists of three boost-converter-type IGBT modules with the switching devices located at the bottom leg of the rectifier scheme, which also enables the use of the same power supply in both control and gate driver, thus resulting in simple control and power circuit structure. The detailed principle of operation and experimental results are also included. In particular, the design guide line is also suggested to make the circuit design of the proposed rectifier easy and fast.

피질하 혈관성치매의 진단, 치료 및 예방 : 1례 보고와 함께

최성훈,구세광,전우현,백경민,한창현,전원경,이영준,Choi, Seong-Hun,Ku, Sae-Kwang,Cheon, Woo-Hyun,Baek, Kyung-Min,Han, Chang-Hyun,Kyung, Jeon-Won,Lee, Young-Joon 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.3

Vascular dementia(VaD) is currently considered to be the second most common type of dementia. VaD is not a single diagnostic entity, but a heterogeneous syndrome which encompasses several clinicopathological forms of dementia resulting from cerebrovascular diseases. A common form of VaD is subcortical VaD which is characterized by lacunar infarcts and deep white matter changes, leading to a progressive decline in memory and cognitive function. The neuropsychological and cognitive profiles of subcortical VaD have been reported relatively homogeneous. At present, subcortical vascular dementia is regarded as the most important subtype of VaD with getting the attention of vascular dementia. The aims of this study are to discuss the concept of subcortical VaD and its importance focusing on diagnosis, prevention and treatment with a case report.

Halcyon^TM 선형가속기 6MV-FFF 에너지의 표재 선량에 대한 고찰: Phantom Study

최성훈,엄기천,유순미,박제완,송흥권,윤인하,Choi, Seong Hoon,Um, Ki Cheon,Yoo, Soon Mi,Park, Je Wan,Song, Heung Kwon,Yoon, In Ha 대한방사선치료학회 2020 대한방사선치료학회지 Vol.32 No.-

목 적: 본 연구는 HalcyonTM과 TrueBeamTM에서 사용하는 6MV-FFF(Flattening Filter Free) 에너지를 이용하여 전산화치료계획시스템(Treatment Planning System, TPS)에서 계산된 선량과 광자극형광선량계(Optically Stimulated Luminescence Dosimeter, OSLD)로 측정된 표재 선량(Superficial dose)을 비교하고자 한다. 재료 및 방법: 팬텀연구를 위해 인체모형 팬텀(Human Phantom)의 CT 영상을 이용하여 치료계획시스템에서 성문암(Glottic cancer)과 유사한 치료계획용적(Planning Target Volume, PTV)과 두경부위의 등 중심점(Iso-center) 위치에 측정을 위한 Point(M), Point(R), Point(L)의 구조물을 설정하고 체표윤곽(Body contour)에 5mm Bolus를 적용하였다. 그 후 전산화치료계획은 HalcyonTM과 TrueBeamTM의 6MV-FFF 에너지를 이용하여 정적(Static) 세기변조방사선치료(Intensity Modulated Radiation Therapy, IMRT)와 용적변조회전치료(Volumetric Modulated Arc Therapy, VMAT)계획을 각각 수립하였다. 전산화치료계획과 동일하게 재현하기 위해 OSLD를 등 중심점에 위치시키고 5mm Bolus를 적용하여 선량 전달 후 오차율을 비교하였다. 결 과: 인체모형 팬텀을 사용한 실험 결과 HalcyonTM의 전산화치료계획시스템에서의 점 선량과 OSLD를 이용한 선량 측정의 오차율의 절댓값의 평균은 VMAT, IMRT 각각 1.7±1.2%, 4.0±2.8%로 확인되었으며, TrueBeamTM의 오차율의 절댓값의 평균은 VMAT, IMRT 각각 2.4±0.4%, 8.6±1.8%로 확인되었다. 결 론: 실험결과 HalcyonTM을 기준으로 TrueBeamTM에서 VMAT과 IMRT 각각 2.4배, 3.6배 더 큰 오차가 발생하는 것을 확인할 수 있었다. 따라서 본 연구의 결과를 토대로 표재 선량에 대한 정확한 선량평가가 이루어져야 하는 경우, TrueBeamTM보다 HalcyonTM에서 정확한 선량 평가가 이루어질 수 있을 것으로 사료된다. Purpose: The aims of this study were to compare the superficial dose with Optically Stimulated Luminescence Dosimeter(OSLD) measurement and Treatment Planning System(TPS) calculation for 6MV-Flattening Filter Free(FFF) energy using HalcyonTM and TrueBeamTM. Materials and methods: Phantom study was performed using the CT images of human phantom. In the treatment planning system, the Planning Target Volume(PTV) was contoured which is similar to Glottic cancer. Furthermore, Point(M), Point(R), and Point(L) were contoured at the iso-center of head and neck region and 5mm bolus was applied to the body contour. Each treatment plans using 6MV-FFF energy from HalcyonTM and TrueBeamTM with static Intensity Modulated Radiation Therapy(IMRT) and Volumetric Modulated Arc Therapy(VMAT) were established with eclipse. To reproduce the same position as the TPS, OSLDs were placed at the iso-center point and 5mm bolus was applied to compare the error rate after the dose delivery. Result: The results of the study using human phantom are as follows. In case of HalcyonTM, the mean absolute error rates of the point dose using the treatment planning system and the dose measured by OSLD were 1.7%±1.2% for VMAT and 4.0±2.8% for IMRT. Also TrueBeamTM was identified as 2.4±0.4% and 8.6±1.8% respectively for VMAT and IMRT. Conclusion: Through the results of this study, TrueBeamTM confirmed that the average error rate was 2.4 times higher for VMAT and 3.6 times higher for IMRT than HalcyonTM. Therefore, based on the results of this study, If we need a more accurate dose assessment for the superficial dose, It is expected that using HalcyonTM would be better than TrueBeamTM.

제강.연주 공장 설계와 운영을 위한 시뮬레이터

최성훈,Choi, Seong-Hoon 한국시뮬레이션학회 2011 한국시뮬레이션학회 논문지 Vol.20 No.2

치열한 경쟁과 원자재 가격 급등은 시행착오를 최소화 하면서 제철소를 최적으로 설계하여 운영할 것을 한층 더 강력하게 요구하고 있다. 컴퓨터 시뮬레이션은 이 요구에 부합되는 방법론을 제공할 수 있다. 본 논문의 목적은 제강 연주 공장의 설계와 운영을 지원하기 위한 시뮬레이터를 제안하는 것이다. 본 연구에서 제안하는 시뮬레이터는 유지보수와 확장에 용이하도록 널리 알려진 Arena로 개발되었으며 사용의 편의성을 위하여 엑셀 기반으로 입출력 인터페이스를 설계하였다. 또한 운반 대차와 천정 크레인으로 구성되는 복잡한 운반 모듈을 포함하여 모델의 정확도를 높였다. 시뮬레이터는 생산량 분석과 물류 분석을 통하여 제강 연주 공장 설계안의 적정성을 평가하는데 유용하게 사용될 수 있다. 그리고 다양한 상황별로 최적의 제품 조합을 도출하는데 적용될 수 있으며, 공정별 설비별로 작업을 배정하는 조업 운영 패턴을 평가하고 정확도를 향상시키는 도구로써 활용이 가능하다. Stiff competition and skyrocketing prices of raw materials are increasingly demanding the optimal design and operation of iron and steel mills minimizing trial and error. Computer simulation can provide the methodology in accordance with requirements. The purpose of this paper is to suggest a simulator for the design and operation of the steelmaking and continuous casting mill. The simulator was developed using Arena, popular simulation software and input and output interface based on MS Excel. It allows easy access for the maintenance and extension of the model. One of distinct features of the proposed simulator is the inclusion of complex transportation modules composed of transfer cars and overhead cranes. The simulator can be used for evaluating various alternative designs of a projected mill via throughput analysis and material flow analysis. Also, one can utilize it effectively to search for the best product mix suitable for many types of situations. It could be an invaluable tool evaluating the performance of operation patterns and improving the accuracy.

태백산(太白山) 광화대(鑛化帶) 중부지역(中部地域) 페그마타이트에 대한 지화학적(地化學的) 연구(硏究)

최성훈,지정만,Choi, Sung-Hoon,Chi, Jeong-Mahn 대한자원환경지질학회 1990 자원환경지질 Vol.23 No.1

This study has been carried out on the Pegmatites, Naedeogri Granites, Nonggeori Granites and Metasedimentary rocks in the middle area of Taebaeksan region to investigate the geochemical properties and possibility of productivity. Pegmatites are characterized by metamorphosed anatectic pegmatite and differentiated magmatic pegmatite, and are mixed type of rare-element pegmatite and mica-bearing pegmatite by the classification of Ginsburg(1979). The petrological type of the igneous rocks is thought to be calcalkali, subalkaline and peralumious. According to chemical variations against D. I., differentiation trends from Naedeogri and Nonggeori Granites through non-mineralized pegmatites to mineralized pegmatites are supposed. From the relationship between oxided and $SiO_2$, pegmatites and Nonggeori Granite have shown similar tendencies and bulk composition of pegmatites and similar to metasedimentary rocks near the intrusives. By judging the correlations of trace elements, it is elucidated that pegmatites adjacent to Naedeogri and Nonggeori Granites have been originated in magma differentiation from these granites and the others have been differentiated by remelting or partial melting from metasedimentary rocks. $Sp_5$, $Sp_8$, and $Sp_9$ pegmatites are considered as productive rocks, and $Sp_4$, $Sp_6$, $Sp_7$, $Sp_{10}$, $Sp_{11}$, and $Sp_{12}$ pegmatites and granites are supposed to have a weak productivity, in terms of element ratios related with Sn mineralizations. Tourmalines in productive pegmatites are formed under the circumstance of Li-poor granitoids and associated with pegmatites, and the others are seemed to be originated in metapelites and metapsammites which are not coexisting with an Al-saturating phase. Three types of chemical zoning are noticed in tourmalines: (1) apparently homogeneous compositional patterns, (2) a continuous core-to-rim zoning and, (3) a discontinuous core-to-rim zoning. From results of EPMA of tourmalines, Al, Mg and Ca increase closer to rim, while Fe decreases.

Osteonecrosis 수술 후 족과부동통(足?部疼痛) 후유증 치험 1례

최성훈,김경운,이윤경,이경민,임성철,정태영,서정철,Choi, Sung-Hun,Kim, Kyung-Un,Lee, Yoon-Kyoung,Lee, Kyung-Min,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.1

Objective : The clinic study or report about Oriental Medical treatment about osteonecrosis is very insufficient. Therefore, we report a case about a sequela of operation of talus osteonecrosis treated by Oriental Medical treatments. Methods : The patient was managed by bee venom and Carthami Flos Herbal-Acupuncture, Sa-am and body acupucture, moxibustion, physical theraphy and herbal medicine. We evaluated the patient through Visual Analogue Scale(VAS). Results : After 25 days of treatment, the patient showed that clinical symptoms was decreased and VAS changed from 10 to 2. Conclusion : In this case, Oriental Medical treatments for a sequela of operation of talus osteonecrosis was effective. But further studies are required to confirm the effect of these methods.

헬름홀쯔 적분 방정식에 기반을 둔 구조물의 음향방사 및 구조/음향 연성 수치해석

최성훈,Choi, Sung-Hoon 한국음향학회 2008 韓國音響學會誌 Vol.27 No.8

An alternative formulation of the Helmholtz integral equation derived to express the pressure field explicitly in terms of the velocity vector of a radiating surface is used to solve acoustic radiation and fluid/structure interaction problems. This formulation, derived for arbitrary sources, is similar in form to the Rayleigh's formula for planar sources. Because the surface pressure field is expressed explicitly as a surface integral of the surface velocity, which can be implemented numerically using standard Gaussian quadratures, there is no need to use BEM to solve a set of simultaneous equations for the surface pressure at the discretized nodes. Furthermore the non-uniqueness problem inherent in methods based on Helmholtz integral equation is avoided. Validation of this formulation is demonstrated for some simple geometries. 본 논문에서는 헬름홀쯔 적분 방정식에서 유도된 식을 이용하여 구조물의 표면 압력을 구조진동 성분에 대한 단순한 적분형태로 표현하여 음향방사 및 구조/음향 연성 문제를 수치적으로 푸는 방법에 대하여 다룬다. 이 식은 임의의 형상에 대하여 유도된 식으로 Rayleigh 식과 유사한 형태를 갖는다. 이 식을 이용하면 표면 압력을 구조물의 속도에 대한 단순 적분 형태로 나타낼 수 있기 때문에 경계요소법과 같이 연립방정식에 대한 행렬식을 풀 필요가 없다. 또한 헬름홀쯔 적분 방정식에 기반을 둔 다른 방법 들이 가지는 해의 유일성 문제도 갖지 않는 장점이 있다. 본 논문에서는 구형 셀에 대하여 수치해와 정해를 비교하여 제안한 방법의 타당성을 검증하였다.

혈관성치매에 대한 한.양방 치료약물의 처방 사례연구

최성훈,전우현,백경민,한창현,전원경,감철우,이영준,Choi, Seong-Hun,Cheon, Woo-Hyun,Baek, Kyung-Min,Han, Chang-Hyun,Jeon, Won-Kyung,Gam, Cheol-Ou,Lee, Young-Joon 대한예방한의학회 2011 대한예방한의학회지 Vol.15 No.3

Objectives : Vascular dementia is the second common cause of dementia after Alzheimer's disease. It assumed that the ratio of prescription drugs on vascular dementia are quite different from each hospital in Western medicine or Oriental medicine, respectively. The aim of this research is to collect and analyze the ratio of prescription drugs on vascular dementia in Western medicine or Oriental medicine in university hospitals. Methods : We collected and analyzed the data related to prescriptions on vascular dementia in the department of neurology in three university hospitals(A, B, C) and in the department of internal medicine in two Oriental medicine hospitals(Daegu Haany Oriental Hospital, Dong Eui Oriental Hospital). Results : In the department of neurology in A university hospital, donepezil(69.1%), memantine(14.0%), rivastigmine(12.3%), galantamine(4.5%) were prescribed in order. In B university hospital, galantamine(57.8%) donepezil(33.3%), rivastigmine(6.7%), donepezil with memantine(4.4%) were prescribed. In C university hospital, donepezil(62.0%), rivastigmine(25.0%), galantamine(7.0%) memantine(6.0%) were prescribed. The average frequencies of prescribed medication in the department of neurology in A, B, C university hospitals were donepezil(54.8%), galantamine(23.1%), rivastigmine(14.7%), memantine(7.4%). In Oriental medicine hospitals, various prescriptions have been used for vascular dementia. Among them, Ansincheongnoetang (安神淸腦湯) and Gamijihangeumja(加味地黃飮子) were often prescribed in Daegu Haany Oriental Hospital, and Bojungikgitang(補中益氣湯) in Dong Eui Oriental Hospital, too. Conclusions : Cholinesterase inhibitors such as donepezil, galantamine, rivastigmine and NMDA receptor inhibitor like memantine have been used as a drug of choice for vascular dementia in all surveyed university hospitals. In oriental hospitals, various prescriptions have been used for vascular dementia.