암의 다발성 뼈 전이의 방사성동위원소 치료

최상규,Choi, Sang Gyu 한국호스피스완화의료학회 2014 한국호스피스.완화의료학회지 Vol.17 No.4

암의 다발성 뼈 전이는 폐암, 유방암, 전립선암, 신장암 등 다양한 암에서 흔히 관찰된다. 뼈 전이는 뼈에 발생한 이차적인 암으로 통증, 골절, 그리고 체중을 지지하는 뼈의 불안정성을 유발할 수 있어 신체활동과 삶의 질을 저하시킨다. 뼈 전이 치료 시 병리조직소견, 환자의 전신 상태, 침범 부위, 그리고 환자의 신경학적 소견등 다양한 요인을 고려하여 진통제, 수술, 항암화학요법 그리고 방사선 치료 등을 시행하게 된다. 외부 방사선 치료는 전통적으로 국소 뼈 전이로 인한 통증의 치료에 이용되어왔지만 특히 유방암이나 전립선암의 다발성 골형성 뼈 전이의 경우 $^{89}Sr$, $^{186}Re$, $^{188}Re$, $^{153}Sm$ and $^{117m}Sn$ 등의 방사성동위원소를 이용한 치료가 시행되고 있는데, 약제 투여의 간편함, 낮은 부작용, 방사능 피폭위험에서의 안전성, 높은 치료 반응 등 다양한 장점을 가진 치료로 임상에서의 유용성이 점차 증가되고 있다. Multiple bone metastases are common manifestation of many malignant tumors such as lung cancer, breast cancer, prostate cancer and renal cell carcinoma. Bone metastasis is secondary cancer in the bone, and it can lead to bone pain, fracture, and instability of the weight bearing bones, all of which may profoundly reduce physical activity and life quality. Treatment for bone metastasis is determined by multiple factors including pathology, performance status, involved site, and neurologic status. Treatment strategies for bone metastasis are analgesics, surgery, chemotherapy and radiotherapy. External beam radiotherapy has traditionally been an effective palliative treatment for localized painful bone metastasis. However, in some cases such as multiple bone metastases, especially osteoblastic bone metastasis originated from breast or prostate cancer, the radiopharmaceutical therapy using $^{89}Sr$, $^{186}Re$, $^{188}Re$, $^{153}Sm$ and $^{117m}Sn$ are also useful treatment option because of administrative simplicity (injection), few side effects, low risk of radiation exposure and high response rate. This article offers a concise explanation of the radiopharmaceutical therapy for multiple bone metastases.

III기 비소세포성 폐암의 방사선치료 성적

최상규,오도훈,배훈식,Choi, Sang-Gyu,Oh, Do-Hoon,Bae, Hoon-Sik 대한방사선종양학회 1995 Radiation Oncology Journal Vol.13 No.4

목적 : III기 비소세포성 폐암으로 근치적 방사선치료를 받은 환자의 생존율과 예후인자를 알아보기 위하여 본 연구를 시행하였다. 방법 : 1991년 1월부터 1993년 12월까지 비소세포성 폐암으로 강동성심병원 치료방사선과에서 45 Gy 이상의 근치적 방사선치료를 시행 받았던 35명의 환자에 대한 치료 결과를 후향적으로 분석하였다. 병기별 환자의 분포는 IIIA 15 명, IIIB 20 명이었다. 방사선 치료는 6 MV X-선을 이용하여 일일선량 1.8 Gy-2 Gy씩 주 5 회 조사하여 48.4-66.6 Gy (중앙값 61.2 Gy)까지 치료하였다. 9명의 환자에서 유도화학요법, 1명의 환자에서 동시화학요법이 시행되었고 대부분이 FIP(5-FU, ifosfamide, cisplatin) 복합화학요법을 시행받았다. 결과 : 전체 환자의 중앙생존기간은 6개월이었으며 1년 생존율은 23.3%, 2년 생존율은 6.7%이었고 병기에 따른 중앙생존기간은 IIIA 8개월, IIIB 5.5개월 이었다. 항암화학요법을 시행한 10명의 중앙생존기간은 11개월, 1년 생존율은 60%이었고 방사선 단독 치료의 경우는 중앙 생존기간이 5개월, 1년 생존율이 9%로 통계학적으로 유의한 차이가 있었다 (p=0.03). 생존율에 영향을 미치는 예후 인자는 총 방사선량, 치료 1개월 후의 반응, 치료후의 전신상태이었으며 연령, 성별, 치료전 전신상태, 체중 감소의 유무, 원발병소의 위치, 병리조직학적 분류, 림프절 병기 등은 생존율에 영향을 주지 않았다. 결론 : III기 비소세포성 폐암 환자에서 전통적인 방사선치료로는 장기 생존을 기대하기 어려우며 항암화학요법, 수술을 병합하는 다원적 치료 또는 변형분할조사 등의 보다 적극적인 치료가 필요할 것으로 생각된다. Purpose : To evaluate the survival and prognostic factors in patients with stage III non-small cell lung cancer treated with curative radiotherapy alone or combined with chemotherapy Materials and Methods : A retrospective analysis was undertaken of 35 patients who had locally advanced non-small-cell lung cancer and treated with curative radiotherapy in Department of Therapeutic Radiology, Kangdong Sacred Heart Hospital, from January 1991 through December 1993. According to AJCC staging, 15 patients were stage IIIA, and 20 were stage IIIB. Radiotherapy was delivered with 1 8-2 Gy per fraction/day. 5 days per week using 6 MV X-ray, to a total dose ranging from 48.8 Gy to 66.6 Gy (median, 61.2 Gy) in 4 to 9 weeks. Ten patients received neoadjuvant or concurrent chemotherapy with FIP (5-FU, ifosfamide, and cisplatin) or FP (5-FU and cisplatin) Results : For all Patients, median survival was 6 months. 1-year and 2-year survival rates were 23.3% and 6.7%, respectively The median survival was 8 months in stage IIIA and 5.5 months in stage IIIB. In patients treated with radiation therapy alone, median survival was 5 months and 1-year survival rate was 9%. In patients who received chemotherapy, median survival was 11 months and 1-year survival rate was 60%. The difference of survival between these two groups was statistically significant (p=0.03). Total radiation dose, degree of response, and Post-treatment ECOG score were also significantly associated with survival. But it was not affected by age, sex, pretreatment ECOG score, presence or absence of weight loss, tumor location. pathologic type, N stage, and degree of response to treatment. Conclusion : Conventional radiotherapy alone is unlikely to achieve long term survival in patients with stage III NSCLC. Radiotherapy with altered fractionation schedule or multimodality treatment combined with surgery and/or chemotherapy should be considered if feasible.

관 유동과 Blasius 유동에서 가장 불안정한 교란에 관하여

최상규,정명균,Choi, Sang-Kyu,Chung, Myung-Kyoon 대한기계학회 2003 大韓機械學會論文集B Vol.27 No.6

The pseudospectral method for stability analysis was used to find the most influential disturbance mode for transition of plane channel flows and Blasius flow at their critical Reynolds numbers. A number of various oblique disturbance waves were investigated for their pseudospectra and resolvent norm contours in each flow, and an exhaustive search method was employed to find the disturbing waves to which the flows become most unstable. In plane Poiseuille flow an oblique disturbance with a wavelength of 3.59h (where h is the half channel width) at an angle $28.7^{\circ}$ was found to be the most influential for the flow transition to turbulence, and in plane Couette flow it is an oblique wave with a wavelength of 3.49h at an angle of $19.4^{\circ}$. But in Blasius flow it was found that the most influential mode is a normal wave with a wavelength of $3.44{\delta}_{999}$. These results imply that the most influential disturbance mode is closely related to the fundamental acoustic wave with a certain shear sheltering in the respective flow geometry.

차세대 군용전원용 500W급 마이크로 터빈 발전기 시스템 설계

최상규,최범석,한용식,우병철,송인혁,민성기,임진식,Choi, Sang-Kyu,Choi, Bum-Suk,Han, Yong-Shik,Woo, Byung-Chul,Song, In-Hyuck,Min, Seong-Ki,Lim, Jin-Sik 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.6

Recent developments of small-size unmanned or manned mobile systems such as autonomous robots, exoskeleton or armored suits, micro air vehicles, and unmanned armored vehicles require long-lasting independent power sources of high energy and power density to support the systems' operation for up to 72 hours in the fields. Chemical batteries such as Ni-MH, Li-Ion, the current primary power sources for mobile devices, however, are not capable of providing enough power and energy density for the next generation high power mobile machines. For this reason, KIMM along with KERI and KIMS has been carrying out a 500W MTG development project under the DAPA's "Next generation military power source R&D program" since 2009. In this paper, a design process for a 500W MTG system currently being developed at KIMM is briefly described and the technical issues related to its development are addressed.

노인의 스트레스 요인과 대처방안에 영향을 미치는 요인

최상규,남철현,이순자,김기열,박금화,이응창,Choi, Sang-Gyu,Nam, Chul-Hyun,Lee, Soon-Ja,Kim, Gi-Yeol,Park, Geum-Hwa,Lee, Uung-Chang 대한예방한의학회 2006 대한예방한의학회지 Vol.10 No.1

This study was conducted to analyze factors influencing old people's stress and coping with it. The subjects of this study were 1186 people who lived in 6 cities. The data were collected from September, 2003 to March, 2003. The result of this study can be summarized as follow. 1. 14.3% of the respondents was in good health, while 30.6% of them was not in good health. 11.0% of them had good eyesight and 22.2% had a good sense of hearing. 12.0% of them had good teeth. 2. The level of coping with stress was 59.9 points on the basis 100 points. The level of coping with it actively was highest, while the level of coping with it passively was lowest. 3. Factors which influenced old people's stress were job health condition, leisure activity, smoking, hearing ability, and regular exercise. 4. Factors which affected coping with stress were gender, having meals regularly, smoking, job, vigor, preference of foods, and average pocket money per month. As shown in the above results, the level of old people's stress factors and coping with it were significantly low in the groups of low education level, having less pocket money, living alone, being in bad health, having weak eyesight, having bad sense of hearing, having bad teeth, low satisfaction level with leisure, and having no health behavior. Therefore, the method of decreasing stress factors and coping with it should be developed. The government and related organizations must make great efforts to improve old people's quality of life and increase healthy life expectancy.

평행 Poiseuille, 평행 Couette, Blasius Flow의 준안정 해석

최상규,정명균,Choi, Snag-Kyu,Chung, Myung-Kyoon 대한기계학회 2003 大韓機械學會論文集B Vol.27 No.3

We investigate the spectra and the pseudospectra in plane Poiseuille flow, plane Couette flow and Blasius flow. At subcritical Reynolds number, the spectra are lied strictly inside the stable complex half-plane, but the pseudospectra are lied in the unstable half-plane, reflecting the large linear transient growth that certain perturbations may excite. It means that the smooth flows may become to turbulent even though all the eigenmodes decay monotonically. We found that pseudospectra is one reason that causes subcritical transition in plane Poiseuille flow and plane Couette flow and bypass transition in Blasius flow.

재활용 산화철 및 알루미늄 분말을 활용한 철도레일 이음용 테르밋 분말 개발

최상규,박성상,백응률,Choi, Sang-Kyu,Park, Sung-Sang,Baek, Eung-Ryul 대한용접접합학회 2012 대한용접·접합학회지 Vol.30 No.5

Nowadays in Republic of Korea, whole amount of the thermite welding powder for rail joinning is dependent on import. However the demand of the thermite welding powder would be enlarge because some constructing high-speed train and city metro projects are currently in progress. In addition this is the main reason why we should develop the thermite welding powder, domestically. This study is focused on utilizing the recyclable materials like Al powders from cans and iron oxide scales from wire rods as the main components of the thermite welding powder. By minimizing Al content in weld zone by controlling the mixing ratio of the Al powder in the thermite welding powder, the excessive dissolution of the Si and Mn components came from the Al powders could be controled. The tensile strength of welding zone in welded rail was 740 MPa, with that the developed thermite welding powder.

회전축 계의 진동응답을 이용한 불균형 질량 탐지

최상규(Sangkyu Choi),박정호(Jungho Park),이우식(Usik Lee) 한국철도학회 2013 한국철도학회 학술발표대회논문집 Vol.2013 No.11

Micro Electrical Impedance Tomography에서 Multi-cross electrode 을 이용한 영상복원

최상규(Sangkyu Choi),박인규(Park Ingyu),장대훈(Jang Daehoon),서보인(Servo In),이은주(Eunjoo Lee) 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.06

Nonfunctional Parathyroid Carcinoma

최상규(Sang Gyu Choi) 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.2

부갑상선암은 매우 드문 내분비악성 종양으로 부갑상선기능 항진증의 0.5∼4%를 차지하며 흔히 고칼슘 혈증과부갑상선호르몬의 증가를 보인다. 비기능성 부갑상선암은 부갑상선기능 항진증으로 나타나는 증상이 없으며 병리조직학적 진단기준이 분명하지 않아 늦게 진단이 되는 질환이다. 근치적 절제술이 가장 표준적인 치료이지만 수술후 국소재발이 흔하기 때문에 불완전 절제가 시행되었거나 미세 잔류 종양이 있는 경우 외부 방사선치료를 시행하여 국소 조절률 향상을 얻을 수 있다고 보고되고 있다. 저자는 부갑상선에 발생한 비기능성 악성종양으로 근치적절제술 후 외부 방사선치료를 시행한 1예를 경험하였기에 문헌 고찰과 함께 이를 보고하고자 한다. Parathyroid carcinoma is a rare endocrine malignancy accounting for 0.5% to 4.0% of all cases of hyperparathyroidism and commonly present as hypercalcemia and parathyroid hormone (PTH) elevation. Nonfunctional parathyroid carcinoma does not show symptoms of hyperparathyroidism and only showed a vague indication of being pathologic, even when detected late. The optimal treatment is en bloc resection of the cancer, but frequent local recurrence after surgery has been reported. Adjuvant local treatment such as radiotherapy may improve the likelihood local control in cases with incompletely resected or microscopic residual tumor. The results of this study point to a case of nonfunctional parathyroid carcinoma treated by external beam radiotherapy after en-bloc resection of cancer.