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신장 ; 대장용종에서 ILK (Integrin-Linked kinase)와 beta-catenin의 발현
채현석 ( Hiun Suk Chae ),김진수 ( Jin Soo Kim ),손혜숙 ( Hye Sook Sohn ),노상영 ( Sang Young Rho ),김형근 ( Hyung Keun Kim ),조영석 ( Young Suk Cho ),이보인 ( Bo In Lee ),강진형 ( Jin Hyung Kang ),최규용 ( Kyu Yong Choi ),맹이소 ( 대한내과학회 2009 대한내과학회지 Vol.77 No.3
목적: ILK와 beta-catenin을 통한 세포전달은 여러 악성 질환의 시작과 진행에 있어서 중요하다. ILK는 beta-catenin의 전사를 조절하며 암세포에서 세포 이동 및 침습에 관여한다. 최근에 대장암과 전구 단계인 샘종에서 ILK와 beta-catenin이 발현한다는 연구가 있었다. 이에 저자들은 대장용종에서 육안적 및 병리학적 소견의 차이에 따른 ILK와 beta-catenin의 발현을 알아보았다. 방법: 비악성 질환으로 수술한 6명의 정상 대장 조직(6)과 대장용종절제술로 획득한 용종을 모양에 따라 유경성 용종(Ip, 16), 무경성 용종(Is, 22) 및 측방 발육형 종양(laterally spreading tumor LST, 24)으로 나누었다. 또한 현미경적 소견에 따라 관샘종(TA, 47)과 과형성 용종(HP, 15)으로 나누고 관샘종은 이형성의 정도에 따라 나누었다. 이들 조직에서 ILK와 beta-catenin의 발현을 면역화학염색법으로 비교하였다. 결과: 용종의 육안적 모양에 따라 Ip, Is, LST에서 ILK, beta-catenin의 발현의 차이는 통계적으로 차이가 없었다(p>0.05). 조직학적으로 ILK, beta-catenin의 발현은 과형성 용종보다 관상 샘종에서 발현이 증가하였다(p<0.05). 관상 샘종에서는 이형성의 정도가 심할수록 ILK와 beta-catenin의 발현이 높았다(p<0.05). 전체 용종에서 ILK의 발현이 높은 용종의 경우에 beta-catenin의 발현이 높은 경우가 많았다(p<0.01). 결론: 대장용종에서 ILK와 beta-catenin의 발현은 대장용종의 모양에 따른 차이가 없었고, 샘종이 과형성 용종보다 발현이 증가되었고 샘종의 이형성이 심할수록 발현율이 높았다. Background/Aims: Signaling pathways via integrin-linked kinase (ILK) and β-catenin are important in the initiation and progression of various malignant diseases. ILK modulates the transcription of β-catenin and is implicated in cell migration and invasiveness. Recently, premalignant colon polyps were found to express ILK and β-catenin. Therefore, we investigated the expression of ILK and β-catenin in colon polyps according to the gross morphology and pathologic type. Methods: Based on morphology, colon polyps (62) were classified as being a pedunculated polyp (Ip, 16), sessile polyp (Is, 22), or laterally spreading tumor (LST, 24). The colon polyps were classified pathologically as tubular adenomas (TAs, 47) and hyperplastic polyps (HPs, 15). The expression levels of ILK and β-catenin in colon polyps and normal colon (6) were evaluated with immunohistochemistry. Results: In normal colon, ILK was not expressed, and β-catenin stained in the cell membrane only. Based on the gross morphology of the colon polyps, no significant difference was seen in the expression of ILK and β-catenin (p>0.05). The expression of both ILK and β-catenin in TAs was greater than that in HPs (p<0.01): the greater the dysplasia in TAs, the more both ILK and β-catenin were expressed (p<0.05). The grade of expression of ILK was correlated with that of β-catenin in colon polyps (p<0.01). Conclusions: The expression of ILK and β-catenin did not differ according to the morphology of colon polyps, but was expressed more in TAs than in HPs, especially in severe dysplasia. (Korean J Med 77:315-320, 2009)
동물행동 및 복지 : 건조감귤박 및 소맥피를 급여한 말의 성장과 육질에 미치는 영향
채현석 ( Hyun Seok Chae ),김남영 ( Nam Young Kim ),조인철 ( In Chul Cho ),조상래 ( Sang Rae Cho ),조원모 ( Won Mo Cho ),박용상 ( Yong Sang Park ),오신애 ( Shin Ae Oh ),장애라 ( Aera Jang ),성필남 ( Pil Nam Seong ),고문석 ( Moon Su 한국동물자원과학회(구 한국축산학회) 2013 한국축산학회지 Vol.55 No.3
본 연구는 제주지역에서 많이 생산되는 동산부산물인 건조감귤박을 활용하여 말 사료로서의 이용성을 구명하고 사육이 완료된 말을 도축하여 육질 특성을 구명하기 위해 실시되었다. 급여한 농산부산물은 소맥피만 급여한 처리구와 건조팰렛감귤박(20%)에 소맥피(80%)를 흔합한 처리구로 구분하여 수행하였으며 농산부산물 급여는 1일 2회 체중의 1.5%를 기준으로 급여시켰고 물과 건초는 자유 급식시켰다. 일당증체량의 변화는 소맥피급여구와 소맥피+건조 감귤박처리구에서 유사한 경향을 나타내었고 사료요구율은 소맥피+건조감귤박처리구가 소맥치 단독 처리구보다 더 낮은 값을 나타내었다. 말고기의 도체율은 소매피+건조감귤박처리구가 소맥피처 리구 보다 더 낮은 값을 나타내었다. 그러나 육량등급은 소맥피+건조감귤박처리구가 더 우수하게 나타났다. 육색에서 명도(L*)은 소맥피처리구보다 소맥피+건조감귤박처리구에서 더 밝은 값을 나타내었으나 황색도(b*)는 오히려 더 낮은 값을 나타내었다. 말고기의 물리적 변화에서 전단력은 소맥피처리구보다 소맥피+건조감귤박처리구가 더 낮은 값을 나타내면서 보수력과 가열감량도 함께 증가하였다. 일반성분에서 지방은 소맥피처리구보다 소맥피+건조감귤박처리구가 더 낮은 값을 나타내었고 다른 성분은 비슷하였다. 무기물은 소맥피+건조감귤박처리구가 Ca, K, Mg, Cu, Mn이 소맥피처리구 보다 더 많은 것으로 나타났으나 유의적인 차이는 없었다(p<0.05). 아미노산에서는 소맥피+건조감귤박처리구가 methionine, glutamic acid, glycine이 소맥피처리구보다 약간씩 증가하였다. 지방산은 소맥피+건조감귤박처리구가 stearic acid, oleic acid, eicosenoic acid, arachidonic acid 함량이 증가하는 경향을 나타내었다. 결과적으로 농산부산 물로써 소맥피의 일부를 건조감귤박으로 대치하여도 비육사료로 손색이 없는 것으로 사료된다. This study was conducted to elucidate the characteristics of equine meat traits and to evaluate the utilization of dried-citrus pulp abundantly produced in Jeju Island as feed ingredient in the diet of finished meat horses. Treatment groups consisted of wheat bran (A) and the dried-pellet mixture of citrus pulp (20%) and wheat bran (80%) (B). Feeding of agricultural by-products were 2 times in a day at the level of 1.5% of body weights. Water and dried-grass forage was not restricted. The average daily gain was similar in both groups. Feed conversion of treatment B showed lower level than that of A. Carcass rate of B was relatively lower than that of A, but meat yield grade of B was higher than that of A. For meat color traits, L* of B was lighter than that of A, and b* of group B was lower than that of group A. From the analysis of physical characteristics of equine meats, shearing force had decreased in the treatment B but the levels of drip loss and water holding cavity had increased in the treatment B compared to A. The level of crude fat is lower in the treatment B than the treatment A. For the mineral contents, the treatment B showed higher levels of Ca, K, Mg, Cu and Mn than that of A. For the fatty acid contents, the treatment B showed increased levels of stearic acid, oleic acid, eicosenoic acid, and arachidonic acid compared to A. Consequently, these results suggested that dried-citrus pulp might be utilized as replacement material for equine forage. Please rewrite the whole abstract and should include all required information. Before resubmission, please check it again from a native colleague in your group.
구연 / 제 2 회의장 / 위장관 39 : 흰쥐의 대장에서 Dimethylhydrazine 에 의해 유발된 aberrant crypt foci 의 부위와 시간에 따른 변화
채현석(Hiun Suk Chae),오수혁(Soo Hyun Oh),이봉수(Bong Soo Lee),한석원(S . W . Han),이창돈(Chang Don Lee),최규용(K . Y . Choi),정인식(I . S . Chung),선희식(H . S . Sun),맹이소(Lee so Maeng),이은정(Een Jung Lee) 대한소화기학회 1999 대한소화기학회 추계학술대회 Vol.1999 No.-
Helicobacter pylori에 감염된 십이지장궤양과 비궤양성 소화불량에서 ABO 혈액형과 HLA의 연관
채현석(Hiun Suk Chae),김태규(Tai Gyu Kim),한훈(Hoon Han),김성수(Sung Soo Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.5
N/A Background/Aims: It has been known that genetic factors, for example, blood group, non-secretor and HLA system, are associated with duodenal ulcer and that Helicobacter pylori infection is the major cause of peptic ulcer. However, Helicobacter pylori is also found in non-ulcer dyspepsia and asyrnptomatic patients without ulcer formation. But, it is still not known regarding what kind of genetic factors have an effect on ulcer formation at the time of Helicobacter pylori infection. This study was performed to make clear wbich genetic factors are re1ated with duodenal ulcers among Koreans, and what kind of genetic factors could influence on the ulcer formation in the patients with Helicobacter pylori infection according to ABO blood groups and HLA antigen.'.. Methods: The duodenal ulcer patients (36), non-ulcer dyspepsia (19) and norraal healthy controls (103) were included in this study. Helicobacter pylori infection was detected with phenol red spray method in vivo which was confirmed with Warthin-Starry silver stain. HLA antigen expression (HLA-A,B) of peripheral blood T lymphocytes was studied with microlymphocytotoxicity teclmique. Results: Tbe frequency of HLA-A 33 was higher in duodenal ulcer patients (l4/36, 38.9%) compared with the control group (21/103, 20.4%). On the contrary, no difference in HLA-B has been shown between duodenal ulcer patients and controls. Among patients with Helicobacter pylori infection, blood group 0 was significant1y more frequent in patients with duodenal ulcers (21/36, 58.3%) than in non-ulcer dyspepsia (5/19, 26.3%). In patients with HLA-A 33, blood group 0 was significantly more frequent in duodenal ulcer patients (7/)4, 50%) than in non-ulcer dyspepsia patients (0/7, 0%). Conclusions: In Helicobacter pylori-infected patients, HLA-A 33 is related with duodenal ulcers and the patients with both blood group 0 and HI.A-A 33 are more likely to have duodeual ulcers than those with HLA-A 33 and without blood groop O. (Korean J Gastrnenterol 1996; 28:623 - 631)
예건 ( 予乾 ) 저장온도 및 첨가농도를 달리한 개미산 ( Formic acid ) 이 사일리지 품질에 미치는 영향
채현석 ( H . S . Chae,H . H . Theune ) 한국축산학회 1979 한국축산학회지 Vol.21 No.5
The effect of formic acid on the fermentation was investigated in a 3 - factor experiment, in which the degree of prewilting, the storage temperature, and the amount of applied acid were considered. The material was obtained from are autumn cut, of young plant which is difficult to ensilage(DM 27.69, 44.0%). For experimental reasons the amount of acid applied 0.0, 0.25, 0.5 and 1.0% of green matters.