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궤양성 대장염의 Antineutrophil Cytoplasmic Antibody ( ANCA ) 발현율
한상원(Sang Won Hang),오수혁(Soo Hyuk Oh),정현(Hyun Jung),양영상(Young Sang Yang),채현석(Hyun Seok Chae),이봉수(Bong Soo Lee),서정민(Jung Min Suh),김재광(Jae Kwang Kim),백남종(Nam Jong Baeg),최규용(Kyu Yong Choi),정인식(In Sik Jung) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.3
N/A Antineutrophil cytoplasmic antibodies (ANCA) are autoantibodies against various antigens present in the cytoplasmic primary granules of neutrophils detected by standard indirect immunofluorescent technique fixing the neutrophil with alcohol. There are two types of ANCA characterized by immunoreactivity, perinuclear type AACA(P-ANCA) and cytoplasmic type ANCA(C-ANCA). ANCA was demonstrated in the sera of patients with inflammatory bowel disease. We have evaluated the reactivity against human neutrophils of sera from 44 patients with ulcerative colitis, 4 Crohns disease, 3 tuberculous colitis, 2 Behqets disease, 10 simple co- litis and 25 healthy controls. 26/44 (59.1%) sera from patients with ulcerative colitis con- tained ANCA compared with 2/4 (50.0%) from Crohns disease, 1/2 (50.0%) from Behqets disease and 2/25 (8%) from control sera. All ten from patients with simple colitis and all three sera from tuberculous colitis were negative. The presence or titer of ANCA was not cor- related with activity of treatment of ulcerative colitis. The predominant pattern of ANCA was cytoplasmic (30/31) and only one serum gave a perinucleatr pattern. In conclusion, ANCA occurred more commonly in ulcerative colitis than tuberculous colitis or simple colitis.(Korean J Gastroenterol 1994;26: 451 457)
구연 / 제 2 회의장 / 위장관 39 : 흰쥐의 대장에서 Dimethylhydrazine 에 의해 유발된 aberrant crypt foci 의 부위와 시간에 따른 변화
채현석(Hiun Suk Chae),오수혁(Soo Hyun Oh),이봉수(Bong Soo Lee),한석원(S . W . Han),이창돈(Chang Don Lee),최규용(K . Y . Choi),정인식(I . S . Chung),선희식(H . S . Sun),맹이소(Lee so Maeng),이은정(Een Jung Lee) 대한소화기학회 1999 대한소화기학회 추계학술대회 Vol.1999 No.-
민준기(Jun Ki Min),정우철(Woo Chul Jung),백기현(Gi Hyun Baek),김양리(Yang Ree Kim),오수혁(Soo Hyuk Oh),강문원(Moon Won kang),정인식(In Sik Chung),양우진(Woo Jin Yang),김성훈(Sung Hun Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4
N/A Objectives: Tsutsugamushi disease is an acute, febrile illness of humans that is caused by Rickettsia tsutsugamushi. Hypoalbuminemia was reported in some cases of tsutsugamushi disease, but its frequcncy and etiology were not clarified. Therefore we prospectively evaluated fourteen cases of Tsutsugamushi disease patients to idendify intestinal protein loss as a cause of hypoalbuminemia and to assess the value of 99mTc-HSA abdominal scintigraphy for detecting intestinal protein loss. Methods: From November 1994 to December 1994, in fourteen patients with tsutsugamushi disease, serum albumin level and fecal a-1-antitrysin excretion were measured at admission. Anterior abdominal images were obtained at 2, 4, and 24hours after intravenous injection of 30 mCi of Tc-Human serum albumin. Results: 1) The age distribution was mainly in the forties, and fifties. Geographically, 10 cases in the northern part of Kyung-Ki Do and 4 cases in Seoul were occurred. 2) Laboratory findings showed hypoalbuminemia in 5 cases(35.7%), elevated AST and ALT in 11 cases (78.6%), prolonged prothrombin time in 1 cases (7.1%), and proteinuria(30mg/dl) in 9 cases(64.3%). 3) Fecal a-1-antitrypsin concentration was measured in 10 cases of 14 patients with tsutsugamushi disease, of which 8 cases revealed abnormally elevated concentration of fecal a-l-antitrypsin(2.6mg/g dry weight). 4) 99mTc-HSA scintigraphy was positive in 11 of 1478.696) patients with tsutsugamushi disease. 5) In patients with positive 99mTc-HSA scintigraphy, protein loss sites were small bowel(6/11, 54.5%), descending colon(3/14, 27.3%), ascending colon(2/11, 18.1%). Conclusion: Intestinal protein loss was idendified in some patients with tsutsugamushi disease by the measurement of fecal a-1-antitrpysin concentration. 99mTc-HSA scintigraphy is easy and readily available study for detecting intestinal protein loss sites. The comparison of the severity of intestinal protein loss before and after treatment is recommended in patients with tsutsugarnushi disease who have abnormal intestinal protein loss.
쯔쯔가무시병 환자에서 질환의 중증도의 표지자로서의 저알부민혈증의 임상적 의의
김영옥(Young Ok Kim),전희경(Hee Kyung Jeon),조석구(Seok Goo Cho),윤선애(Sun Ae Yoon),손현식(Hyun Sik Son),오수혁(Soo Hyuk Oh),채현석(Hyun Suk Chae),김관형(Kwan Hyoung Kim),채장성(Jang Seong Chae),이창돈(Chang Don Lee),이봉수(Bong Soo 대한내과학회 2000 대한내과학회지 Vol.59 No.5
N/A Background : Although hypoalbuminemia is common in patients with tsutsugamushi disease, acute rickettsial infectious disease, its impact on the severity of disease is not reported. Therefore, we studied the role of hypoalbumiemia as a marker of the severity of disease in patients with tsutsugamushi disease. Methods : We retrospectively reviewed clinical data of 95 patients with tsutsugamushi disease who were admitted between January 1994 and December 1999 at Uijongbu St. Mary's hospital. We compared clinical and laboratory findings, complications, and mortality between hypoalbuminemic group (serum albumin < 3.0 g/dL) and control (serum albumin ≥ 3.0 g/dL). Results : Of the total 95 patients, 50 patients (52.6%) had hypoalbuminemia. In hypoalbuminemic group, the incidence of hypotension was higher (20.0% vs 2.2%, p=0.006) and the duration of admission was longer (12.0±4.5 vs 8.8±2.7 days, p<0.001), compared to control. The degree of thrombocytopenia in hypoalbuminemic group was severer than that in control (84,000±46,000 vs 138,000±75,000/mm3, p<0.001). Hypoalbuminemic group showed higher incidence of interstitial pneumonia (64.0 vs 13.3%, p<0.001), hypoxia (40.0 vs 6.6%, p<0.001), metabolic acidosis (12.0 vs 0%, p=0.018), and acute renal failure (18.0 vs 4,4%, p=0.038), compared to control. Four patients who had hypoalbuminemia died due to septic shock and multiorgan failure. Conclusion : This study shows that hypoalbuminemia could be used as a marker of the severity of disease in patients with tsutsugamushi disease.(Korean J Med 59:516-521, 2000)
최상욱,양진모,조성원,이창돈,장재순,이성희,김성수,오수혁,채현석,박석희,송화헌 대한소화기학회 1998 대한소화기학회지 Vol.32 No.1
A 56-year-old man who, one year ago, had received left lateral segmentectomy of the liver secondary to ruptured hepatocellular carcinoma, was admitted with hemoperitoneum. The abdominal CT scan revealed several nodules in the intraperitoneal cavity with no definite tumor recurrence on the liver. The celiac angiography revealed no definite tumor staining on the liver, but showed a large amount of leakage of dye from hypervascular mass on the peritoneum supplied from gastroduodenal artery. The bleeding was successfully controlled with transarterial chemoembolization on that bleeding vessel. After a second transarterial chemoembolization, he was discharged in improved condition. Thereafter, two sessions of transarterial chemoembolization were performed on that metastatic tumor, and he has been in healthy condition until now.