Involvement of a LiCl-Induced Phosphoprotein in Pigmentation of the Embryonic Zebrafish (Dania rerio)

Eun-Jung Jin(진은정),Giselle Thibaudeau 한국생명과학회 2008 생명과학회지 Vol.18 No.9

Neural crest는 신경계의 발생과정에서 생긴 특정화된 외배엽으로서 말초신경계(peripheral nervous system)의 모든 sensory cells과 fibers, 자율신경계의 대부분의 peripheral cells, unipolar spinal ganglion cell, cranial sensory ganglia, peripheral nerve의 neurolemmal sheath cells, ganglia의 capsule cells, sympathetic ganglia, chro-maffin cells, pigment cell 등이 분화한다. Fish의 경우는 melanin을 가지고 있는 melanophores, yellow pigment를 가지고 있는 xanthopores, reflecting platelets를 가지고 있는 iridophores등 3가지의 pigment-producing cell을 가지고 있다. 다양한 pigement들의 deposition, distribution에 의해 Fish와 amphibian에서 볼 수 있는 수많은 color와 pattern이 만들어지게 된다. Embryonic neural crest가 patterning을 연구하기에 아주 좋은 모델임에도 불구하고, choromatophores의 cell-signaling mechanism에 관한 연구는 거의 없는 실정이다. 본 연구에서는 melano-somes의 melanocyt로의 이동기작과 이 들의 dentiritic processe를 밝히기 밝히기 위해 phosphorylaion assay와 투과형 전자 현미경(transmission electron microscope)등을 이용한 다양한 실험들을 토대로, Lithium에 의해 유도되는 morphological alteration에 IP cell signaling pathway에 의해 조절되는 단백질의 하나인 55-kDa단백질의 인산화가 중요한 역할을 함을 밝혔다. The embryonic zebrafish (Danio rerio) is rapidly becoming an important model organism for studies of early events in vertebrate development. Neural crest-derived pigment cell precursors of the embryonic zebrafish give rise to melanophores, xanthophores, and/or iridophores. Cell-signaling mechanisms related to the development of pigmentation and pigment pattern formation remain obscure. In this study, zebrafish embryos were treated with various signaling-related molecules - LiCl (an inositol-phosphatase inhibitor), forskolin (a protein kinase-A activator), a combination of LiCl/forskolin, and LiCl/heparin (an IP₃ inhibitor) in order to identify the mechanisms involved in pigmentation. LiCl treatment resulted in ultrastructural and morphological alterations of melanophores. To identify the possible proteins responsible for this ultrastructural and morphological change, phosphorylation patterns in vitro and in vivo were analyzed. LiCl and LiCl/forskolin treatment elicited dramatic increases in the phosphorylation of a 55-kDa protein which was inhibited by heparin treatment. LiCl treatment also induced phosphorylation of a 55-kDa protein in melanophores purified from adult zebrafish. Collectively these results suggest that a LiCl-induced 55-kDa phosphoprotein plays a role in melanophore morphology and ultrastructure and ultimately effects gross pigmentation.

태권도 도복 직물의 소리 특성과 역학적 성질

진은정 ( Eun Jung Jin ),조길수 ( Gil Soo Cho ) 한국의류산업학회 2012 한국의류산업학회지 Vol.14 No.3

This study examined the sound characteristics of Taekwondo uniform fabrics to investigate the relationship between the sound parameters and the mechanical properties of the fabric as well as to provide the conditions to maximize the frictional sound of the uniform. Frictional sounds of 6 fabrics for Taekwondo uniforms were generated by the Simulator for Frictional Sound of Fabrics. The frictional speeds were controlled at low (0.62 m/s), at mid (1.21 m/s) and at high (2.25 m/s) speed, respectively, The frictional sounds were recorded using a Data Recorder and Sound Quality System subsequently, the physical sound properties such as SPL (Sound Pressure Level) and Zwicker`s psychoacoustic parameters were calculated. Mechanical properties of specimens were measured by KES-FB. The SPL, Loudness (Z) values increased while Sharpness (Z) value decreased. In the physical sound parameter, specimen E had the highest SPL value at low speed and specimen B at high speed. In case of Zwicker`s psychoacoustic parameters, the commercially available Taekwondo uniform fabrics (E, F) showed higher values of Loudness (Z), Sharpness (Z), and Roughness (Z), that indicates they can produce louder, shaper and rougher sounds than other fabrics for Taekwondo uniforms. The decisive factors that affected frictional sounds for Taekwondo uniforms were W (weight) as well as EM (elongation at maximum load) at low speed and WC(compressional energy) at high speed.

전기분해를 이용한 축산폐수의 처리

진은정(Eun Jung Jin),길대수(Dae Soo Gil),이창근(Chang Gun Lee),이병헌(Byun Hun Lee) 한국수처리학회 2000 한국수처리학회지 Vol.8 No.4

N/A This study was carried out to investigate the electrolysis treatabillity of livestock wastewater having high concentration of organic matters and nitrogen. Experiments were conducted to study any effects according to the operating conditions such as the current density, retention time and the ratio of added sea water. Possible optimum range for these operating variables are experimentally determined. In electrolysis process, removal efficiencies increased with the current density, ratio of added sea water and the length of retention time. With 0.4d㎡ electrode per 1L reaction volume, it was recommend the best conditions are 30% sea water, 5A/d㎡ current density and 4 hours of HRT. When livestock wastewater treatment applied electrolysis, removal efficiencies of COD, TP and TN lead to 90%, 86%, and 94% respectably. These results may indicated that electrolysis has an excellent nitrogen removal ability for treatment of livestock wastewater.

광합성 미세조류 Nannochloropsis oculata의 최적배양 조건

박현진 ( Hyun Jin Park ),진은정 ( Eun Jung Jin ),정태만 ( Tae Man Jung ),주현 ( Hyun Joo ),이재화 ( Jae Hwa Lee ) 한국공업화학회 2010 공업화학 Vol.21 No.6

미세조류는 전 세계 바다에 분포하고 있으며 일부 종들은 인간의 식품에 이용되어 왔다. 특히, 광합성 미세조류 Nannochloropsis oculata는 영양적 가치가 우수하여 관심을 받고 있다. 본 연구에서는 광합성 마세조류 Nannochloropsis oculata의 고농도배양을 위한 배양온도, 초기 pH, 배양액 선정, 인공해수 농도, 배지농도, CO2영향 등 최적조건을 확립하고자 하였다. 그 결과, 3%의 인공해수, 초기 pH 8.5, 배양온도 25℃가 최적 배양조건으로 판별되었다. 미세조류에 CO2를 공급하지 않았을 때에는 건조 균체량이 0.76 g/L이었지만, 5% CO2 공급 이후 1.50 g/L로 높은 성장률을 보였다. 클로로필 생합성은 미세조류 성장과 깊은 연관이 있는 것으로 판명되었다. Microalgac has been seen all over the seawater and several species are used for human food. Specially, Nannochloropsis oculata, a photosynthetic microalgae, has been focused for a vast array of valuable nutritious compounds. In order to find high mass Nannochloropsis oculata culture conditions, some of important growth factors of pH, temperature, culture media, and CO2 effect were tested. The optimal growth condition was found to be as follows: 3% artificial seawater, initial pH 8.5, and temperature 25℃. The alga mass and chlorophyll content were dramatically increased by applying 5% flue CO2 gas (150 g/L algae in a continuous CO2 flue; 0.16 g/L alga without CO2. It was shown that the chlorophyll biosynthesis was also closely associated with alga growth.

CT colonography 에서 보조 cap을 장착한 catheter의 유용성에 관한 연구

서경진(Kyeong Jin Seo),진은정(Eun Jung Jin),임승현(Seung Hyeon Lim),조영호(Yeong Ho Joh),김영남(Yeong Nam Kim) 대한CT영상기술학회 2015 대한CT영상기술학회지 Vol.17 No.1

Purpose : CT Colonography delivers an accurate diagnosis when the colon is sufficiently expanded, but causes problems in the examination by the leakage of gas when CO2 gas is injected into the anus.The catheter balloon used in the examination is possible to prevent the leakage, but it is not enough for patients with abnormal anal sphincter function causing gas leakage and increase of repeats and patients dose. Therefore, This purpose of our study was to minimize the anus gas leakage through rectal Manometry test and the use of Catheter equipped with an auxiliary cap so that our study examine whether the examination time can be shortened, number of repeats can be reduced and the patient does can be deducted. Materials and methods : For this study, We used Somatom Sensation 16 MDCT(Siemens, Erlangen, Germany) and Automatic CO2 Colon Insufflator(EZEM, New York, USA) with 20 Fr Foley Catheter(2-way standard,30 mL/cc balloon) to inject CO2 gas. The auxiliary cap was inserted at the intervals of 1.5 cm at the location of balloon of the catheter using a fill cap of a 1,000 mL dispensing bottle used by our own hospital. At the hospital from January 13 to 2014 through April 30, 2013, Among The hospital in patients scheduled toundergo surgeries for rectal & sigmoid colon cancers, 110 patients above the age of 60 who completed both Rectal Manometry test which are the objective testing of anal sphincter function and CTColonography test were chosen as the study objects. The CTC test method is a dual testing of prone and supine where testing time differences between the first and the last topogram are compared and the number of repeats is analyzed to differentiate between cases of the auxiliary cap use and non-use according to three categories of anal sphincter normality, findings of bowel obstruction and Buscopan injection. Results : When an auxiliary cap was not used and it was used, In the case of abnormal sphincters, the testing time was 4 minutes when an auxiliary cap was not used and 2.2 minutes when it was used. In the case of findings of bowel obstruction, the testing time was 6 minutes and 4 minute. In the case of absence of Buscopan, the testing time was 4.25 minutes and 2.2 minutes and shortened the testing time to 45%, 33% and 48% respectively in each category when an auxiliary cap was used and All the statistics revealed to be relevant. In the case of abnormal anal sphincter, the number of repeats was from 0.38 times to 0.2 times. In the case of finding of bowel obstruction, it was from one time to 0.44 times. In the absence of Buscopan, the number of repeats was from 0.6 times to 0.4 times. The number of repeats dropped by 47%, 56% and 33% respectively in each category when an auxiliary cap was used. Conclusions : The use of catheter equipped with an auxiliary cap in CTC examination resulted in shortening examination time and the number of repeats. This facilitated an expansion of anal sphincter not only in healthy patients but also in patients with abnormal anal sphincter and findings of bowel obstruction to improve the quality of images, reduce patient dose and failure rate of tests.Especially, it can produce great effects in patients with anorectal surgery patients who are known to lose 90% of anal function, therefore the procedure is likely to produce even better images which is highly valuable clinically when it is applied to such patients. 목적 : CT colonography는 대장이 충분히 팽창되어야 정확한 진단이 가능하지만, 항문에 CO2 gas 주입 시 gas 유출이 발생하여 검사에 지장을 준다. 검사에 사용되는 catheter balloon은 gas 유출 방지가 가능하지만 항문 괄약근 기능이 비정상인 환자에게선 gas가 유출되는 경우 많고 이에 따른 재촬영과 환자 선량 증가가 발생한다. 이에 본 연구는 Manometry 검사와 보조 cap을 장착한 catheter를 사용하여 gas 유출을 최소화하여 검사 시간 및 재촬영을 감소하여 환자 선량을 줄일 수 있는지 알아보고자 한다. 대상 및 방법 : 본 연구를 위해 Somatom Sensation 16 MDCT(Siemens, Erlangen, Germany) 장비와 CO2 gas 주입을 위한 Automatic CO2 Colon Insufflator (EZEM, New York, USA), 20 Fr Foley Catheter(30 cc balloon)를 사용하고, 보조 Cap은 본원에서 사용하는 1,000 mL 투약 병의 주입마개를 이용하여 Catheter의 balloon 부위에서 1.5 cm 정도 간격을 두고 끼워서 사용하였다. 2014년 1월 13일부터 2014년 4월 30일까지 본원에서 Rectal & Sigmoid colon cancer로 수술예정인 입원환자 중 항문 괄약근 기능의 객관적 평가가 가능한 Rectal Manometry 검사와 CT Colonography 검사를 모두 시행한 60세 이상인 환자 110명을 대상으로 하였다. CTC 검사 방법으로 Prone, Supine 두 번의 검사를 하여 처음과 마지막 Topogram의 검사시간 차이와 재 촬영횟수를 측정하여 항문 괄약근 정상 여부, bowel obstruction 여부, Buscopan 사용 여부의 3가지 항목에 따라 보조 cap 사용시와 미 사용시를 구분 지어 분석하였다. 결과: 괄약근이 비정상인 경우 보조 cap을 미 사용시와 사용시 각각 4분, 2.2분이었고, bowel obstruction이 있는 경우 각각 6분, 4분이었으며, Buscopan을 사용하지 않았을 경우는 각각 4.25분, 2.45분으로 각 항목별로 45%, 33%, 48% 모두 보조cap을 사용시에 검사 시간이 단축되었고, 통계적으로 유의한 것으로 나타났다. 재촬영 횟수는 괄약근이 비정상인 경우 보조 cap을 미 사용시와 사용시 각각 0.38회, 0.2회였고, bowel obstruction이 있는 경우 1회, 0.44회였으며, Buscopan을 사용하지 않았을 경우는 0.6회, 0.4회로 각 항목별로 47%, 56%, 33%모두 보조cap을 사용시에 재촬영 횟수가 감소 한 것으로 나타났다. 결론 : CTC 검사에서 보조 Cap을 장착한 catheter는 검사시간 단축과 재촬영을 감소시킬 수 있었다. 이는 정상인뿐만 아니라 비정상(항문 괄약근, bowel obstruction)환자 에서도 대장 팽창에 큰 도움을 주어 영상의 질 개선과 환자 선량 감소, 검사 실패 확률 감소 등을 가져왔다. 특히 항문ㆍ직장 수술환자는 일반적으로 90% 이상이 항문기능 소실이 있으므로 이들에게 적용할 때 더욱 좋은 영상을 얻을 수 있을 것이며 임상적으로 매우 유용할 것이라 생각된다.

에탄올이 신경아세포종 B103세포의 Protein Kinase C Isozyme 활성에 미치는 영향

조효정(Hyo-Jung Cho),정영진(Young-Jin Chung),진승하(Sung-Ha Jin),오우균(Woo-Kyun Oh),김상원(Sang-Won Kim),강은정(Eun-Jung Kang),박진규(Jin-kju Park) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.2

에탄올이 지속적으로 뇌 신경세포에 미치는 영향을 조사하기 위하여 흰쥐의 신경세포로부터 유래 된 B103 neuroblastoma cell을 사용하여 세포독성이 나타나지 않는 에탄올 농도(0, 50, 100, 200 mM)에서의 1, 2, 8, 18, 24시간 경과에 따라 유도되는 PKC α, γ, ε, ζ isozyme들의 양을 세포질분획과 세포막 분획으로 나누어 Western blot으로 각각 분석하였다. 100 mM의 에탄올 농도에서 분석된 PKC isozyme들 중 PKC-γ는 18시간대의 세포질에서, 그리고 PKC-ε은 8~18시간대의 세포막분획에서 각각 현저한 유도현상을 보였다. PKC-α는 200 mM의 에탄올 첨가 후 18시간과 24시간에 세포질과 세포막 분획에서 모두 대조군의 150%까지 현저한 증가를 나타낸 반면 PKC-ζ는 100, 200 mM 에탄올 농도에서 배양(18, 24시간 동안)한 세포의 세포막분획에서만 유도되었다. 그리고 50, 100, 200 mM의 에탄올 농도에서 24시간동안 배양한 세포질 분획에서 PKC-γ는 농도 의존적으로 감소하여 200 mM의 에탄올 농도에서는 대조군의 47%까지 현저한 감소를 나타내었으며, 세포내에 세포독성을 나타내지 않는 농도 특히 100~200 mM 농도범위의 에탄올을 첨가하여 24시간 동안 지속적으로 배양할 때 PKC-γ 및 ε이 관련된 신호전달체계가 억제됨을 보였다. 이는 에탄올이 PKC isozyme들의 상호간 조절을 통해 신호전달계 또는 신경전달 물질들의 변화에 영향을 줄 수 있음을 시사하며 에탄올의 중추신경계에 미치는 지속적 영향으로 나타나는 행동장애 및 뇌기능의 손상 또는 보호과정에 PKC-isozyme들이 관여할 수 있음을 시사한다. It is well known that long-term heavy ethanol intake causes alcoholic dementia, cerebellar degeneracy or Wernicke-Korsakoff syndrome and aggravates the conditions of many other neuro-psychotic disorders. Recently it is indicated that protein kinase C (PKC) plays an important role in the action of ethanol and in the neuro-adaptational mechanisms under chronic ethanol exposure. In order to investigate the effect of ethanol on PKC isoforms levels within the range of not showing any cytotoxicity, B103 neuroblastoma cell line transformed from murine central nervous system was employed and western blot analysis was carried out by using PKC isoform-specific antibodies. The changes of PKC-α, γ, ε and ζ level in the range of ethanol concentration 50~200 mM were examined at the exposure time 1, 2, 8, 18 and 24 hrs in both cytosolic and membrane fraction. A typical ethanol concentration inducing the PKC isozymes was 100 mM, and the transforming time ranges of PKC isozymes could be considered as two different parts to each PKC isoform such as initial (0~2 hrs) and prolonged (8~24 hrs) stages. PKC-γ and PKC-ε were clearly induced during the prolonged stages in cytosol at 18 hrs, and membrane fraction at 8 hrs and 18 hrs, respectively. On the other hand the PKC-α and PKC-ζ isozymes were largely induced in the prolonged stages at 18 hrs and 24 hrs, where the PKC-α isozyme was induced in both cytosol and membrane fractions at 200 mM ethanol concentration while the PKC-ζ isozyme was induced only in the membrane fractions at 100, 200 mM. At 200 mM ethanol concentration of 24 hrs incubation in the prolonged stage, the PKC-α was maximally induced by 150% of the control values whereas the PKC-γ was significantly decreased to 47% of the control values. These results suggest that 100~200 mM ethanol may modulate the signal transduction and neurotransmitter release in the central nervous system through the regulation of PKC isozymes, and the action of these isoforms may act differently each other in the cell.

우리나라의 1995-2004년도 출생코호트에서 부모의 사회계급이 영아사망률과 소아사망률에 미치는 영향

오주환,최용준,공정옥,최지숙,진은정,정성태,박세진,손미아,Oh, Ju-Hwan,Choi, Yong-Jun,Kong, Jeong-Ok,Choi, Ji-Sook,Jin, Eun-Jeong,Jung, Sung-Tae,Park, Se-Jin,Son, Mi-A 대한예방의학회 2006 예방의학회지 Vol.39 No.6

Objectives : To investigate the effect of parents' social class on infant and child mortality rates among the birth cohort, for the period of transition to and from the Koran economic crisis 1995-2004. Methods : All births reported to between 1995 and 2004 (n=5,711,337) were analyzed using a Cox regression model, to study the role of the social determinants of parents in infant and child mortality. The results were adjusted for the parents' age, education and occupation, together with mother's obstetrical history. Results. The crude death rate among those under 10 was 3.71 per 1000 births (21,217 deaths among 5,711,337 births) between 1995 and 2004. The birth cohorts from lower educated parents less than elementary school showed higher mortality rates compared with those from higher educated parents over university level (HR:3.0 (95%CI:2.8-3.7) for father and HR:3.4 (95%CI:3.3-4.5) for mother). The mother's education level showed a stronger relationship with mortality among the birth cohort than that of the fathers. The gaps in infant mortality rates by parents' social class, and educational level became wider from 1995 to 2004. In particular, the breadth of the existing gap between higher and lower parents' social class groups has dramatically widened since the economic crisis of 1998. Discussions : This study shows that social differences exist in infant and child mortality rates. Also, the gap for the infant mortality due to social class has become wider since the economic crisis of 1998.

The Effects of Wnt Signaling on Neural Crest Lineage Segregation and Specification

Jinsu Song(송진수),Eun-Jung Jin(진은정) 한국생명과학회 2009 생명과학회지 Vol.19 No.10

Neural crest는 신경계의 발생과정에서 생긴 특정화된 외배엽으로서 말초신경계(peripheral nervous system)의 모든 sensory cells과 peripheral cells, unipolar spinal ganglion cell, cranial sensory ganglia, peripheral nerve의 neurolemmal sheath cells, ganglia의 capsule cells, sympathetic ganglia, chromaffin cells, pigment cell 등의 자율신 경계의 대부분의 세포로 분화 한다. 최근pluripotetic neural crest cells의 운명이 이미 제한되어 있으며, 이러한 fate-restricted crest cells이 neural tube에서 emigration된다고 보고된바 있다. 또한 본 연구자는 Wnt와 Wnt의 antagonist가 neural crest cell의 specification이 일어나는 시기에 발현하여, neural crest cell의 segregation과 differentiation에 직접적으로 관여함을 밝혔다. 이를 보다 명확히 규명하기 위해, 본 연구에서는 neural tube에 Wnt-3a expressing cell의 grafting 혹은 dominant negative GSK construct의 electroporation을 통해 Wnt signaling을 modulation 하여 downstream mediator를 조사하였다. Wnt signaling의 stimulation은 neural crest cell의 melanoblast 로의 commitment를 유도하였으며, 이와 더불어 cadherin 7과 slug의 발현을 조절함을 확인하였다. Recent evidence has shown that many pluripotetic neural crest cells are fate-restricted and that different fate-restricted crest cells emigrate from the neural tube at different times. Jin et al. (2001) identified the expression patterns of Wnts and its antagonists at the time that neural crest cells were being specified and suggested that Wnt signaling was involved in the segregation/differentiation of neural crest cells in the trunk in vitro. In this study, we evaluated the effects of Wnt signaling in avian neural crest lineage segregation. To accomplish this, Wnt signaling was disturbed at the time of neural crest segregation and differentiation by grafting Wnt-3a expressing cells and conducting dominant negative glycogen synthase kinase (dnGSK) electroporation. Stimulation of Wnt signaling induced neural crest lineage segregation and melanoblast specification, and increased the expression levels of genes known to be involved in neural crest development such as cadherin 7 and Slug, which suggests that they are involved in Wnt-induced neural crest lineage differentiation into melanoblasts.

상황버섯 (Phellinus linteus)으로부터 항산화 및 항균 효과

김인혜(In Hae Kim),진은정(Eun Jung Jin),이재화(Jae-Hwa Lee) 한국환경성돌연변이발암원학회 2006 한국환경성돌연변이·발암원학회지 Vol.26 No.2

This study was peformed to determine the antioxidant, antimicrobial activity and antifungal of the cambodian mushroom, Phellinus linteus, in various concentrations from the mushroom extracts. It's extracts were found to cause significant free radical scavenging effects on DPPH (1,1-diphenyl-2-picrylhydrazyl). This extracts exhibited in vitro broad-spectrum antimicrobial activity of Gram-negative, Gram-positive bacteria and without antifungal activity. On the other hand, the extracts had not significant hemolytic activity against human red blood cells. These results indicate cambodian mushroom, Phellinus inteus having antioxidant and antimicrobial activity without hemolytic activity maybe useful as therapeutic agents.

스포츠웨어용 투습발수직물 소리가 심리음향학적 특성에 미치는 영향

이지현 ( Jee Hyun Lee ),이규린 ( Kyu Lin Lee ),진은정 ( Eun Jung Jin ),양윤정 ( Yoon Jung Yang ),조길수 ( Gil Soo Cho ) 한국감성과학회 2012 감성과학 Vol.15 No.2

본 연구에서는 심한 소음으로 불쾌감을 주는 스포츠웨어용 PTFE 라미네이팅 투습발수 직물 8종을 대상으로 직물 마찰음의 심리음향학적 특성을 고찰하고, 심리음향학적 특성에 영향을 미치는 직물의 기본 특성과 역학적 특성 간의 관계를 파악함으로써, 직물의 심리음향학적 마찰음을 낮출 수 있는 변인을 찾아내고자 하였다. 직물 마찰음 시뮬레이터를 이용하여 녹음한 직물의 소리에서 Zwicker의 파라미터인 심리음향학적 크기(loudness(Z)), 날카로움(sharpness(Z)), 거칠기(roughness(Z)), 그리고 변동강도(fluctuation strength(Z))를 계산한 뒤, 소리특성에 대한 사후검정 결과에 따라 시료를 덜 시끄러운 PTFE 필름 그룹과 더 시끄러운 PTFE 필름 그룹으로 나누어 마찰음의 심리음향학적 특성과 직물의 역학적 특성, 기본특성간의 관계를 고찰하였다. 심리음향학적 특성 중 loudness(Z)만이 시료의 마찰음과 유의한 관계에 있는 것으로 나타났으며, 분석 결과 직물의 기본 특성에서는 layer가 얇고 필라멘트사를 사용한 직물의 마찰음이 덜 시끄럽게 인지되는 것으로 나타났으며, 직물 마찰음의 심리음향학적 크기에 영향을 미치는 주요변수로는 layer로 것으로 나타났다. 심리음향학적 크기에 영향을 미치는 주요 역학변수로는 전단이력이 설명 변인으로 포함되었다. The objectives of this study were to investigate the psychoacoustic properties of PTFE(Poly tetra Fluoroethylene) laminated vapor permeable water repellent fabrics which are frequently used for sportswear, to examine the relationship among fabrics`` basic characteristics, mechanical properties and the psychoacoustic properties, and finally to propose the predicting model to minimize the psychoacoustic fabric sound. A total of 8 specimens`` frictional sound were recorded and Zwicker`s psychoacoustic parameters such as loudness(Z), sharpness(Z), roughness(Z), and fluctuation strength(Z) were calculated using the Sound Quality Program. Mechanical properties of specimens were measured by KES-FB system. Loudness (Z) of specimen D-1 was the highest, which means the rustling sound of the specimen D-1 was the most noisy, Statistically significant difference among film type was observed only in loudness (Z) for fabric sound, Based on ANOVA and post-hoc test, specimens were classified into less loud PTFE film group (groupⅠ) and loud PTFE film group (groupⅡ). Loudness (Z) was higher when staple yarn was used compared when filament yarn was used. According to the correlation between the mechanical properties of fabrics and loudness(Z) in groupⅠ, the shear properties, compression properties and weight showed positive correlation with loudness(Z). According to the regression equation predicting loudness(Z) of groupⅠ, the layer variable was chosen. In groupⅡ, variables explaining the loudness(Z) were yarn types and shear hysteresis(2HG5).