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저출력 레이저 조사가 PC12 신경 세포 증식과 분화에 미치는 영향
주형욱,이성재,현정근,김병희,박원범,이창호,권범선 대한재활의학회 2005 Annals of Rehabilitation Medicine Vol.29 No.4
Objective: We examined the effect of low power laser irradiation (LPLI) on the proliferation and differentiation of PC12 nerve cells. Method: After seeding 4×105 PC12 nerve cells each in the 24 well-culture dishes, we cultured them for 6 days with RPMI1640 media. LPLI (650 nm, 5 mW, 5 sec) was applied for 1 day, 2 days and 3 days (1, 2 and 3-day-LPLI groups) consecutively. For the degree of proliferation of PC12 nerve cells, we compared the total cell number at 6th day after LPLI by MTT cell proliferation assay. For the degree of differentiation, we compared the length of neurite out- growth and the expression of RT97 at 6th day after adding nerve growth factor on each group. Results: The total cell numbers were increased significantly after LPLI, but those increments were not significant among 1, 2, and 3-day-LPLI groups. The numbers of the differentiated PC12 nerve cells and the expressions of RT97 were diminished serially according to the number of days of LPLI. Conclusion: We conclude that LPLI increased the proliferation and decreased the differentiation of PC12 nerve cells. We could suggest that single or short-term use of LPLI on the injured nerve should be helpful for enhancing the neural regeneration in vivo.
A Case of Alveolar Soft Part Sarcoma of the Pleura
주형욱,서광원,제갈양진,안종준,이영직,김영민,옥철호,나승원 대한의학회 2013 Journal of Korean medical science Vol.28 No.2
Alveolar soft part sarcoma (ASPS) is a rare malignant soft-tissue neoplasm of unknown histogenesis. The two main sites of occurrence are the lower extremities in adults and the head and neck in children. We report the first case of pleural ASPS occurring in a 58-yr-old man who presented with progressive dyspnea. A computed tomographic scan of the thorax revealed a large enhancing pleural mass with pleural effusion in the left hemithorax. Wide excision of the pleural mass was performed. Histologically, the tumor consisted of organoid nests of large polygonal cells, the cytoplasm of which had eosinophilic and D-PAS positive granules. Immunohistochemical staining showed that the tumor cell nuclei were positive for transcription factor 3 (TFE3). The pleural ASPS with multiple bone metastases recurred 1 yr after surgery and the patient died of acute pulmonary embolism 1.5 yr after diagnosis.
지역사회획득 천공성 충수염의 세균학, 항생제 감수성, 경험적 항생 제에 대한 연구
주형욱,이현성,김재희,전재완,김규열,정윤성,전재범 대한감염학회 2012 Infection and Chemotherapy Vol.44 No.6
Background: The aim of this study was to study bacteriology and antibiotic susceptibility in patients with community-acquired perforated appendicitis over a five-year-period. Materials and Methods: We conducted a retrospective review of the records of adult patients (age ≥18 years) who were diagnosed as having perforated appendicitis at Ulsan University Hospital between January 2007 and December 2011. Patients who had healthcare-associated or hospital-acquired appendicitis were excluded. Intraoperative specimens submitted to the microbiology laboratory were obtained either by aspiration of pus into a syringe or by use of a swab. Anaerobic bacterial cultures were not performed. Results: Among 216 adult patients with perforated appendicitis, we analyzed 163culture-positive cases. The overall mortality rate of patients was 0.6% (1/163). Escherichia coli was the most common pathogen (93/163, 57.0%), followed by Streptococcus spp. (45/163, 27.6%), Pseudomonas aeroginosa (13/163, 7.9%),and Enterococcus spp. (17/163, 10.4%). The susceptibility of E. coli to quinolones (ciprofloxacin or levofloxacin) was 74.1%. The susceptibility of E. coli to amoxicillin/clavulanate, cefoxitin, ceftriaxone, piperacillin/tazobactam, and carbapenem reached 75%, 86%, 90%, 98%, and 100%, respectively. Isolated E. coli , including ESBL producing organism and P. aeroginosa, were highly susceptible to piperacillin/tazobactam. Empirical antibiotics used most commonly were a combination of third generation cephalosporin and metronidazole. Conclusion: E. coli was the most common pathogen of community-acquired perforated appendicitis, and resistance to quinolone was greater than 25%. We cannot recommend quinolones for use as empirical therapy for treatment of perforated appendicitis.
주형욱,신영민,황정원,서광원,안종준,나승원 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Catecholamine-induced cardiomyopathy rarely occurs after local epinephrine application. Takotsubo cardiomyopathy (TC) or stress-induced cardiomyopathy is believed to be secondary to a catecholamine surge that is brought on by intense psychological or physical stress. Inverted TC caused by iatrogenic excessive epinephrine administration has recently been reported, thus supporting the role of catecholamine in the pathophysiology of TC. There is no report of inverted TC with ventricular fibrillation after a usual dose of intrabronchial epinephrine administration during bronchoscopy. We present a case of intrabronchial epinephrine-induced inverted TC with ventricular fibrillation in a 31-year-old man with no previous history of cardiac disease.
주형욱 ( Hyung-wook Joo ),백영민 ( Young Min Baek ) 한국PR학회 2016 PR연구 Vol.20 No.3
This study examines how the effect of company-cause fit (i.e., the congruence between a company``s core business and a cause pursued in its cause-related advertisement) on customers`` attitudes towards the advertisement and the company is mediated through customers`` attributions, and whether a CSR (corporate social responsibility) reputation influences the mediation effect. To achieve the research purposes, 30-seconds TV advertisement was prepared for experimental stimulus and measured how respondents differently report their assumed attributions and attitudes towards the advertisement and the company which they were exposed to. Results show that the direct and indirect effects of the company-cause fit on customers`` attitude were moderated by a company``s CSR reputation. Specifically, while the company-cause fit promotes customers`` advertisement attitude via their attributions under the positive CSR reputation, such mediation effect is not detected under the neutral CSR reputation. Also the direct effect of company-cause fit on customers`` company attitude is observed under the neutral CSR reputation, but not under the positive CSR reputation. This study``s implications are two-fold. Theoretically, our results provides PR researchers the reasons why the company-cause fit``s influences on customers`` attitudes varies across studies by focusing on both mediation and moderation process. Practically, this study gives PR practitioners general guidelines how they plan optimal fit of the cause-related advertisement and how the advertisement should be packaged and delivered to their targeted customers.
허브 염용액으로 마리네이드 한 고등어의 이화학적 특성 및 관능 평가
주형욱(Hyoung Woog Ju) 한국조리학회 2011 한국조리학회지 Vol.17 No.3
This study focuses on the qualitative characteristics of mackerel marinated with herb extracts. By differentiating the amounts of garlic, ginger and basil, the optimal amount of each ingredient to be added has been found. According to the result of the experiment, the highest level of preference has been shown for the combination of 3% of garlic, 3% of ginger and 2% of basil, generating the optimal amounts to be added. Since the pH change shown by the mackerel marinated by adding the optimal combination of 3% of garlic, 3% of ginger and 2% of basil is included in the range of pH 6.2-6.4, which is the initial point of decomposition for red-fleshed fish, it can be considered to be appropriate for the qualitative characteristics of the product. According to the differences test, GA3 has shown the lowest level of strength, making it soft. Also, GA3 has shown the highest level of elasticity together with the characteristic of being moist. As a result, it can be said that garlic is better than ginger and basil. According to the preference test, GA3 has shown the highest level of preference in terms of appearance, flavor, texture, taste and overall preference. By considering the above results of the experiment, GA3 (3% of garlic) can be regarded as the optimal amount to be added.