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경부와 성문하부에 발생한 Rosai-Dorfman Disease
조휴채,이성수,최현석,이준규 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.11
Rosai-Dorfman disease is a systemic disease and its etiology is not wel understood. It is very rare but established disease. We of bilateral neck mas. Subglottic mas was also detected by flexible laryngoscopy. Lymph node excision and laryngeal micro-surgery were performed. The histopathologic findings demonstrated proliferative large histiocytes with clear cytoplasm and rounded nuclei, and lymphagocytosis (emperiopolesis), which were the features of Rosai-Dorfman disease. Rosai-Dorfman di-(Korean J Otorhinolaryn -gol-Head Neck Surg 207 ;50 :1062-4)
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윤태미,서경선,조휴채,이준규 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.6
Nasopharyngeal actinomycosis is a rare clinical disease. To our knowledge, only a few other cases of nasopharyngeal actinomycosis have been reported previously, following a nasal trauma or surgical manipulation. We report a case of actinomycosis presenting nasopharyngeal mass without prior mucosal trauma. Our patient had endonasal endoscopic excision of the infected tissue and was treated with 4 weeks of oral antibiotics therapy without any evidence of recurrence. We recommend including actinomycosis in the differential diagnosis of a nasopharyngeal mass. (Korean J Otolaryngol 2006;49:663-5)
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어지럼을 주소로 응급실로 내원한 1,060예의 임상적 고찰
김각,홍용성,조휴채,조형호,장철호,조용범 대한이비인후과학회 2009 대한이비인후과학회지 두경부외과학 Vol.52 No.4
Background and Objectives:Dizziness is an illusion of environmental movement due to various causes. It is difficult to confirm the diagnosis of dizziness according to history and physical examination in restricted situation such as emergency room. The aim of this study is to find another clue for diagnosis in patients of dizziness who visited emergency room. Subjects and Method:Author retrospectively reviewed the charts of 1,060 patients of dizziness who visited emergency room at Chonnam University Hospital from July 2004 to June 2005 and accumulated the various information such as final diagnosis, clinical feature, physical examination, present illness and past history etc. Results:Average age of patients was 57. The most frequently consulted department for evaluation of dizziness was the department of otolaryngology, head and neck surgery (>29.8%). Benign paroxysmal positional vertigo (BPPV) was the most frequent final diagnosis (14.4%) in all patients. But, cerebrovascular disease was the more frequent cause for dizziness in male and old age group. Whirling type dizziness was frequent in BPPV (36.8%) and spontaneous nystagmus was detected frequently in peripheral type vertigo such as vestibular neuritis (65.1%). Average age of central vertigo patients was 61.4 and other vertigo patients was 55. Patients of central vertigo visited the emergency room more frequently in the months of Dec, Jan, Feb and patient of other vertigo visited more frequently in June, July, Aug. Conclusion:Various specialized departments should be involved in effective and exact diagnosis of dizziness. The organized questionnaire in addition to prevalence, incidence and characteristics of dizziness may be used in finding another clue for diagnosis and managing dizzy patients helpfully.
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인간 유양돌기 골수 유래 간엽줄기세포의 획득 및 신경세포로의 분화
조형호,정한성,장수정,박종성,조휴채,장철호,조용범 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.5
Reports of neural differentiation of mesenchymal stem cells suggest the possibility that these cells may serve as a source for stem cell-based regenerative medicine to treat neurological disorders. The purpose of this study was to generate neural cells by differentiation of bone marrow-derived mesenchymal stem cells that isolated from human mastoid process. Materials and Method:Human mesenchymal stem cells (hMSCs) isolated from human mastoid process bone marrow during mastoidectomy for chronic otitis media surgery were characterized using fluorescence-activated cell sorter. Induction of neural differentiation from hMSCs was performed using mitogenic factors (basic fibroblast growth factor, epidermal growth factor, forskolin, isobutylmethylxanthine), and the characterization of differentiated hMSCs was performed using immunohistochemistry, RT-PCR and whole cell patch clamp technique. Results:hMSCs from bone marrow of mastoid process were isolated and cultured. Differentiated cells from hMSCs expressed mRNA transcripts for neuron specific markers, TUJ1 and neurofilament proteins (NF-L, NF-M) as determined by RT-PCR, and neuron specific markers, suhc as NeuN, TUJ1, microtubule- associated protein-2 (MAP2) and glial fibrillary acidic protein by immunohistochemistry. These cells showed voltagedependent sodium currents that was blocked by tetrodotoxin. Conclusion:hMSCs, which were isolated from human mastoid process bone marrow, were one of the good sources for stem cell-based regenerative medicine to treat neurological disorders. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:422-8)
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악설골근 하부까지 연장된 이악하부 표피양 낭종의 구강내 적출 1례
이준규(Joon Kyoo Lee),조휴채(Hyu Chae Cho),윤태미(Tae Mi Yoon),임상철(Sang Chul Lim) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.2
Epidermoid cysts located in floor of mouth can be easily removed intraorally. The cysts inferior to mylohyoid muscle have been excised transcervically. However, an intraoral removal of a cyst extended inferior to mylohyoid muscle has not been reported yet. A 20-year-old female visited to the hospital with a cystic mass in submental region. Neck computed tomography revealed a 6.0×4.3cm sized circumscribed cystic mass in midline of sub-mental area. The cyst lied external to the genioglossal and geniohyoid muscle, extending inferior to mylohyoid muscle. The mass was removed successfully by intraoral approach. It was performed under the exposure by the division of genioglossal and geniohyoid muscle, traction of the cystic wall after aspiration of the cyst, and digital compression externally.
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