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연구논문 : 백합과 8종 식물의 항산화 활성 및 tyrosinase 억제 효과 탐색
조현우 ( Hyun Woo Cho ),정수영 ( Su Young Jung ),김지현 ( Ji Hyun Kim ),조정희 ( Jung Hee Cho ),박종철 ( Jong Chul Park ),최인영 ( In Young Choi ) 한국미용학회 2014 한국미용학회지 Vol.20 No.3
Antioxidant and antityrosinase agents are becoming increasingly important in controlling skin hyper pigmentation. The aim of this study was to investigate the antioxidant and antityrosinase activities of eight plants in Liliaceae (Liriope platyphylla, Asparaguscochinchinensis, Polygonatum odoratum var. pluriflorum Ohwi for. variegatum, Y.N. Lee, Hosta longipes, Tricyrtis dilatata, Hostaplantaginea, Hemerocallis fulva, and Convallaria keiskei.). Water or ethanol extracts of their aerial parts were performed DPPH radical scavenger assay and tyrosinase inhibition assay with L-tyrosine as a substrate. Especially, ethanol extract of Hosta longipes, Hostaplantaginea, and Hemerocallis fulva showed antioxidant and antityrosinase effects. We tested the inhibitory effects on L-DOPA oxidative activity and melanogenesis by ethanol extract of them. Hosta longipes, Hosta plantaginea, and Hemerocallis fulva inhibited the L-DOPAoxidation in dose-dependantly. Moreover, Hemerocallis fulva showed inhibitory effects of melanogenesis in α-MSH stimulated-B16F10murine melanoma cells. In the conclusion, Hemerocallis fulva ethanol extract could be used as pivotal material for the cosmetic industries with the property of antioxidation, antityrosinase and antimelanogenesis.
우주현 ( Woo Ju Hyun ),장지혜 ( Jang Ji Hye ),조정희 ( Cho Jeong Hee ) 한국간호과학회 정신간호학회(구 대한간호학회정신간호학회) 2018 정신간호학회지 Vol.27 No.2
Purpose: The aim of this study was to evaluate a ‘patient empowerment program for schizophrenia (PEPS)’ to improve problem solving ability, quality of life, and mental health literacy for hospitalized patients with schizophrenia. Methods: The study was a non-equivalent control group non-synchronized design. Study participants were recruited from a psychiatric hospital in Republic of Korea. Of 56 participants, 20 were assigned to the experimental group and 36 to the control group. Data were collected from September, 2017 to January, 2018. Data analyses included chi-squared or Fisher's exact tests, t-tests, and repeated measure ANOVA with SPSS/WIN 21.0 program. Results: After participating PEPS, the experimental group showed a significant increase in quality of life and mental health literacy compared to the control group. However, there were no significant differences in problem solving ability between the two groups. Conclusion: Findings show that patients with schizophrenia receive benefits from PEPS in terms of quality of life and mental health literacy. However, further research is necessary to develop clinical strategies to improve their problem solving abilities.
삼황세제 가미방 외용이 NC/Nga 마우스의 아토피 피부염에 대한 효과
황충연,박민철,홍석훈,주현아,조현우,정수영,조정희,Hwang, Chung-Yeon,Park, Min-Cheol,Hong, Seok-Hoon,Joo, Hyun-A,Cho, Hyun-Woo,Jung, Soo-Young,Cho, Jeong-Hee 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.1
Objectives : In this study, Samhwangsaejaegami extract was tested to prove its anti-atopic dermatitis effect on NC/Nga mice. Methods : In order to evaluate the external use effects of Samhwangsaejae extract on anti-atopic dermatitis, the expression of filaggrin, serine palmitoyltransferase(SPT), and COX-2 were analyzed. In vivo study, clinical skin severity score, IgE, IL-4, IL-5 and IL-6 level were analyzed through NC/Nga atopic mice model after 12 weeks external treatment. Results : In vitro study results showed the reduction in the expression of filaggrin, SPT, and COX-2. In vivo study results demonstrated the significant reduction in clinical skin severity score, IgE, IL-4, IL-5, IL-6 expression level. Conclusions : These results showed Samhwangsaejaegami extract can be a promising candidate for anti-atopic dermatitis treatment.
수치에 의한 부자류 식물의 아코니틴 함량의 변화에 대한 연구
문대원 ( Dae-won Mun ),김재현 ( Chae-hyun Kim ),정종길 ( Jong-gil Jeong ),조현우 ( Hyun-woo Cho ),류지훈 ( Ji-hoon Ryu ),조정희 ( Jung-hee Cho ),김대성 ( Dae-sang Kim ) 대한상한금궤의학회 2010 대한상한금궤의학회지 Vol.2 No.1
Objective : The roots of Aconitum species have been believed to cure yang depletion syndrome, kideny-yang deficiency syndrome, and obstruction of qi in the chest syndrome and have been used in traditional Korean medicine mainly for the treatment of musculoskeletal disorders. As they are the substances with toxity, they are processed by using such processing materials as childrens’ urine, Gamdutang, wet-heating. So the purpose of this study is to select most efficient method by evaluating effects of various procesing method on the contents of aconitine. Method : The contents of aconitine in the Aconitum plantswere determined by high performance liquid chromatography. Results : 1. Radix Aconiti Kusnezoffii contains twice amount of aconitine than Chun-Oh. 2. Contents of aconitine in Kyungpo-Buja, Buja-Kyungpo, childrens’ urine Buja, heuksoonpyeon are reduced by processing. 3. Content of aconitine in heuksoonpyeon is reduced the most. Conclusion : Content of aconitine in heuksoonpyeon is reduced the most.
Evaluation of Image Quality for Various Electronic Portal Imaging Devices in Radiation Therapy
손순룡(Soon Yong Son),최관우(Kwan Woo Choi),김정민(Jung Min Kim),정회원(Hoi Woun Jeong),권경태(Kyung Tae Kwon),조정희(Jeong Hee Cho),이제희(Jea Hee Lee),정재용(Jae Yong Jung),김기원(Ki Won Kim),이영아(Young Ah Lee),손진현(Jin Hyun So 대한방사선과학회(구 대한방사선기술학회) 2015 방사선기술과학 Vol.38 No.4
MV방사선 치료는 둘러싸여 있는 정상조직의 피폭선량을 최소화 하면서, target volume 내에 정확하게 선량을 전달하는데 있어 중요한 요인이다. 본 연구에서는 방사선 치료의 높은 정확성을 유지하기 위하여 megavoltage X-ray imaging (MVI)에서 edge block 을 사용한 digital radiography (DR) system 검출기의 modulation transfer function (MTF: 변조전달함수), the noise power spectrum (NPS: 잡음전력스펙트럼) and the detective quantum efficiency (DQE: 양자검출효율)를 측정하고자 한다. 우리는 텅스텐으로 구성된 19 (thickness) × 10 (length) × 1 (width) cm3 의 edge block을 사용하였으며, 다음과 같은 setting들로 pre-sampling modulation transfer function (MTF)를 계산하였다: 6-megavolt (MV) energy를 사용하고, 다양한 Radiotherapy장비인 TrueBeamTM (Varian), BEAMVIEWPLUS (Siemens), iViewGT (Elekta), ClinacR iX (Varian) 를 사용하였다. MTF결과에서 Varian TrueBeamTM flattening filter free가 MTF의 50% (mm-1)에서 0.46, 10% (mm-1) 에서 1.40로 가장 highest value를 보였다. Noise 분포는 Elekta iViewGT가 가장 낮은 분포를 보였다. DQE에서는 Elekta iViewGT가 peak DQE에서 0.0026 그리고 1 mm-1 DQE 에서 0.00014로 가장 높았다. 본 연구는 Edge method를 이용하여 MTF와 DQE산출을 재현하였으며, 현재 임상에서 사용되는 DR 시스템 측정의 높은 정확성을 유지할 수 있었으며 이러한 연구는 전통적인 QA 영상화뿐만 아니라 검출기 개발 연구에 있어서 정량적인 MTF, NPS, DQE 측정에 더욱 더 효율적으로 사용될 수 있다는 것을 알 수 있다. In megavoltage (MV) radiotherapy, delivering the dose to the target volume is important while protecting the surrounding normal tissue. The purpose of this study was to evaluate the modulation transfer function (MTF), the noise power spectrum (NPS), and the detective quantum efficiency (DQE) using an edge block in mega-voltage X-ray imaging (MVI). We used an edge block, which consists of tungsten with dimensions of 19 (thickness) × 10 (length) × 1 (width) cm3 and measured the pre-sampling MTF at 6 MV energy. Various radiation therapy (RT) devices such as TrueBeamTM (Varian), BEAMVIEWPLUS (Siemens), iViewGT (Elekta) and Clinac??iX (Varian) were used. As for MTF results, TrueBeamTM(Varian) flattening filter free(FFF) showed the highest values of 0.46 mm-1and1.40mm-1for MTF 0.5 and 0.1. In NPS, iViewGT (Elekta) showed the lowest noise distribution. In DQE, iViewGT (Elekta) showed the best efficiency at a peak DQE and 1 mm-1DQE of 0.0026 and 0.00014, respectively. This study could be used not only for traditional QA imaging but also for quantitative MTF, NPS, and DQE measurement for development of an electronic portal imaging device (EPID).
삼황세제 가미방 화장품의 아토피 피부염 환자에 대한 임상적 연구
주현아,배현진,박민철,백상철,홍석훈,양현주,조현우,정수영,조정희,황충연,Joo, Hyun-A,Bae, Hyeon-Jin,Park, Min-Cheol,Baek, Sang-Chul,Hong, Seok-Hoon,Yang, Hyun-Ju,Cho, Hyun-Woo,Jung, Soo-Young,Cho, Jeong-Hee,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.3
Objective : The purpose of this study is to investigate the effect of cosmetic cream containing Samwhangsejegamibang Extracts on Atopic dermatitis patients. Methods : A total of 51 patients who visited Wonkwang Oriental Medical Center from April 8th, 2011 to October 8th, 2011 were included in this study. In this study, the patients were treated with Samwhangsejegamibang (experimental group) and placebo group. We observed scorad index, IGA, moisture content of skin, oil content of skin, wrinkled skin and hematological examination for 4 weeks. Results : 1. Comparison of changes in Scorad Index, depending on the perspective, the experimental group showed a statistically significant decline than the placebo group. 2. Comparison of change in IGA, depending on the perspective, the experimental group showed a statistically significant decline than the placebo group. 3. Comparison of change in moisture content, oil content of skin and wrinkled skin, both the experimental group and the placebo group showed level elevation but there was no statistically significant change. 4. Comparison of change in IgE and Eosinophil, both the experimental group and the placebo group showed no statistical significance. Conclusions : Considering the above experiments, it is suggested that cosmetic cream containing Samwhangsejegamibang extracts have a positive effect on atopic dermatitis patients.