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Pituitary Macroincidentaloma - 증례보고 -
조성진,심재준,장재칠,김범태,신원한,최순관,변박장,Cho, Sung Jin,Shim, Jae Joon,Chang, Jae Chil,Kim, Bum Tae,Shin, Won Han,Choi, Soon Kwan,Byun, Bark Jang 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.8
With improvements in diagnostic imaging techniques for the brain, pituitary tumors without neurological signs or symptoms have occasionally been found. To evaluate therapeutic strategy for incidentally found pituitary tumors ("pituitary incidentaloma"), we analyzed the result of magnetic resonance imaging findings and of ophthalmological and endocrinological studies in 3 cases with follow up. Incidentally found functioning tumors were excluded. All of 3 cases is greater than 10mm in tumor size("pituitary macroincidentaloma"). The follow-up period was 49 months, 16 months and 6 months(mean, 25.3 months) in each case. There was no evidence of tumor enlargement, endocrinological problems and visual field defect during follow-up period. Patients with pituitary incidentalomas usually follow a benign course and neurosurgical intervention is not initially required in the management even those greater than 10mm in diameter. Observation over time may be good approach to the patient with a pituitary macroincidentaloma to avoid the unnecessary risk for surgery in a patients with a stable mass.
기후 변화의 생태계 영향에 대한 ABMS 연구 : 빙하감소와 북극곰의 모의실험을 바탕으로
조성진(Sung-jin Cho),나유경(Yu-Gyung Na),이준영(Joon-young Lee),조창현(Chang-Hyeon Joh) 대한지리학회 2011 대한지리학회지 Vol.46 No.3
최근 기후 변화에 따른 생태계의 변화에 대한 연구가 활발히 이루어지고 있다. 본 연구는 생태계 연구에 새로운 연구방법으로서 행위자 기반 모델(ABMS)을 소개하고, 사례연구를 통해 이 분야에 대한 활용 가능성을 제안하고자 한다. ABMS의 활용 가능성을 제안 · 평가하기 위하여, 기후 변화로 인한 빙하의 감소와 그에 따른 북극곰의 멸종 위기에 대해서 에이전트기반의 모형을 수립하고 모의실험을 실행하였다. 연구 결과는 중요 변수 간 상호작용에 신뢰할 만한 일관성을 발견할 수 있었다. 이러한 연구 결과는 제안한 빙하-북극곰 모델이 환경 변화에 따른 북극곰 멸종 시기 예측에 기여할 것을 기대할 수 있게 한다. 이에 따라, ABMS는 생태계의 다양한 변화 과정의 분석 일반에 적용이 가능할 것을 기대할 수 있다. It has actively advanced to study the impact of climate change on ecosystem. This study addresses ABMS (Agent Based Modeling and Simulation) as a methodology of ecosystem research. ABMS would suggest the possibility of practical use in this sector. This study would investigate how the melting speed of glacier in the arctic influences the extinction period of polar bears. The Polar Bears and Glacier Model in this study is expected to contribute to accurate prediction of the polar bear’s extinction period. The suggested ABMS could also be applied to the study of various factors of ecosystem in general.
지렁이 중장에서 발현되는 Endo-$\beta$-1,4-glucanase의 동정 및 특성에 관한 연구
이명식,조성진,탁은식,허소영,이종애,박범준,조현주,신주옥,박순철,Lee Myung Sik,Cho Sung Jin,Tak Eun Sik,Hur So Young,Lee Jong Ae,Park Bum Joon,Cho Hyun Ju,Shin Chuog,Park Soon Cheol 한국토양동물학회 2003 한국토양동물학회지 Vol.8 No.1,2
지렁이 (Eisenia andrei)의 중장에서 내생의 endoglucanase 유전자의 전체 염기 서열을 동정하였다. ORF의 길이는 1,371 bp이며, 456개의 아미노산으로 번역된다. NCBI에 등록된 가재와 흰개미의 cellulase 및 endo-$\beta$-1, 4-glucanase와 50-51%의 유사성을 보이며, 활성 부위가 잘 보존되어 있었다. 계통수 분석에서는 다른 동물 분류군에서 밝혀진 GHF9 그룹의 cellulase와 근연관계가 없음이 확인되었다. Endogeneous endoglucanase (EC 3.2.1.4) cDNA was cloned from a representative species (Eisenia anderi) of the earthworm family Lumbricidae. Endoglucanase from the midgut of the earthworm is composed of 456 amino acids and belongs to glycosyl hydrolase family 9 (GHF9), sharing high homologies (50-51 %) with those of selected termite and crayfish. This endoglucanase consists of three consensus catalytic domains found in most microbial cellulases. A phylogenetic tree was constructed using the amino acid squence data matched through the BLASTX program and showed that GHF9 families could be divided into four groups of arthropoda, bacteria, plant and annelida.
두경부 편평 세포암의 원발 병소와 전이 경부 림프절에서 Matrix Metalloproteinase-9와 Basic Fibroblast Growth Factor의 발현
노영수(Young Soo Rho),황준식(Joon Sik Hwang),김진(Jin Kim),김진환(Jin Hwan Kim),조성진(Sung Jin Cho),신형식(Hyung Sik Shin) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.1
Objectives: Cancer lethality is usually the result of local invasion and metastasis of neoplastic cell from the primary tumor. Because of their ability to degrade extracellular matrix components, matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) have been implicated in the breakdown of basement membrane and underlying stroma, thereby facilitating tumor growth and invasion. It has been well established that MMPs and bFGF expression correlate with cervical lymph node metastasis, but studies on expression in the metastatic cervical lymph node itself are not enough. We have analyzed matrix metalloproteinases (MMPs) and basic fibroblast growth factor (bFGF) in squamous cell carcinoma of the head and neck and metastatic cervical lymph node, and evaluated their relationship and clinicophathologic significance. Material and Methods: 20 cases of squamous cell carcinoma of the head and neck were entered on the study of immunohistochemical stains for MMP-9 and bFGF in the obtained tissue from primary tumor and metastatic cervical lymph node. We analyzed the relationship between MMP-9, bFGF expression of the primary tumor and metastatic node with age, sex, T-stage, N-stage, histologic grade, pathologic stage and disease free survival. Results: Expression of MMP-9 and bFGF in cancer cell and metastatic lymph node was higher than that in normal cell and lymph node. According to histologic differentiation, expression of MMP-9 of the metastatic cervical lymph node was higher than primary tumor. Considering to other clinicopathologic factor, no statistical significance was seen in MMP-9 and bFGF. Conclusion: We found that expression of MMP-9 is higher in the metastatic lymph node than primary tumor in the poorly differentiated squamous cell carcinoma. But we don't find out the statistical significance in relation between bFGF and clinical factors. So we guess that some different mechanism of MMP-9 and bFGF in Head & Neck squamous cell carcinoma exist. Further studies will be necessary to establish their pathogenesis in the Head and Neck cancer.
신재국(Jae Kook Shin),김학준(Hag Joon Kim),임병도(Byeong Do Lim),정의식(Eu Sik Jung),박창서(Chang Sue Park),조성진(Sung Jin Cho) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
Aplasic anemia is an extremely rare disease characterized by hypocellular bone marrow with fatty infiltration and peripheral blood pancytopenia. For over half of patients, no cause can be determined and the causal relation between aplastic anemia and pregnancy is not yet clear. Aplastic anemia in pregnancy is difficult to the obstetrician managing it because the risk of bleeding and infections are high and mortality in aplastic anemia associated with pregnancy is more than 20%. However, with improved treatment modalities and close clinical collaboration of hematologist and obstetrician, aplastic anemia complicated in pregnancy is becoming more frequent with favorable outcome. We experienced a case of aplastic anemia initially detected during pregnancy who was managed with intensive hematological support leading to delivery a healthy infant vaginally. We report this case with a brief review of the literature.
고민석(Min Seok Koh),임병도(Byung Do Lim),김학준(Hag Joon Kim),이혁우(Hyuk Woo Lee),정의식(Eui Sik Jung),조성진(Sung Jin Cho),노호상(Ho Sang Roh),김상현(Sang Hyeon Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8
N/A Objective : This study investigated changes of voice and hearing in premenopausal and postmenopausal woman Methods : We studied forty postmenopausal and forty premenopausal women. Each women was asked to describe their subjective vocal symptoms and phonate a vowel /a/ sound for 3 seconds. The phonated sound in each case was recorded and analysed by the computerized speech lab (LSL 4300B, KAY Elemetrics Corp. USA). We also conducted audiometric pure-tone threshold testing on the same group. Statistical analysis of voice and hearing parameters was done by paired T test Results : Jitter in menopausal group was significantly increased compared with premenopausal group, but other voice parameters showed no significant differences. There were no significant changes of vocal parameters between menopausal patients with or without vocal symptoms. And there were no significant changes of hearing parameters, either Conclusion : The change of voice parameters was objectively identified in menopausal women, and so therapist of menopausal symptoms must take the voice changes into consideration.