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오인준,이미영,이용복,신상철,Oh, In-Joon,Lee, Mi-Young,Lee, Yong-Bok,Shin, Sang-Chul 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.3
Ibuprofen, a nonsteroidal antiinflammatory, analgesic and antipyretic drug, has several limitations in clinical application because of low solubility in water and gastrointestinal irritation. Effect of ibuprofen/$2-Hydroxypropyl-{\beta}-cyclodextrin\;(HP{\beta}CD)$ inclusion compound on release of suppository was investigated. Complex formation was confirmed by $^{1}H-\;and\;^{13}C-NMR$ spectroscopy. The release of ibuprofen from suppository base in vitro was significantly increased by the complexation with $HP{\beta}CD$. The release of ibuprofen from hydrophilic base was faster than that from hydrophobic base. In vivo studies, the release rate of ibuprofen from suppository was accelerated after rectal administration in complex form. This results suggested that ibuprofen/$HP{\beta}CD$ complex can be practically used for suppository to have faster effect of ibuprofen with reduced side effect.
유제화에 의한 경구용 항암제인 테가푸르의 장관 임파수송
이용복,남권호,장우익,오인준,고익배,Lee, Yong-Bok,Nam, Kweon-Ho,Chang, Woo-Ik,Oh, In-Joon,Koh, Ik-Bae 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.1
W/O and O/W emulsions of tegafur (50 mg/5 ml/kg) were orally administered to rats to compare with their mesenteric lymphatic delivery effects. And also in order to demonstrate the lymph targeting associated to the oral route, it was deemed necessary to investigate the fate of solution after oral administration as a control. Lymph and plasma samples were periodically taken from each subject of mesenteric lymphatic duct cannulated rats. Then, lymph and plasma levels of tegafur and its active metabolite, 5-FU, were simultaneously observed. Also pharmacokinetic parameters were compared with each others. On the other hand, most previous studies of lymphatic transport have not addressed the question of whether an increase in mesenteric or thoracic lymph transport by the manipulation of a suspected variable was due to a selective delivery to the intestinal lymphatics or an overall increase availability. Therefore, based on a physiologically based pharmacokinetic model which represents the characteristics of lymphatic systems, we are also going to determine the contributions of mesenteric lymph transport versus thoracic lymph transport of tegafur reported in reference(13). In comparison with tegafur solution, AUC and mean residence time of plasma tegafur were significantly increased in W/O emulsion but significantly decreased in O/W emulsion. Lymph flow rates were similar in both solution and W/O emulsion but half in O/W emulsion. AUC of tegafur in mesenteric lymph and in plasma for W/O emulsion were 3.7 times and 2.9 times more than those for O/W emulsion, respectively. And AUC of 5-FU in thoracic lymph for W/O emulsion was 3.7 times more than that for O/W emulsion. These results suggested that lymphatic delivery or tegafur by W/O emulsion was more effective than that by on emulsion due to its differences or formation ability of chylomicrons.
난용성 약물의 용출 증가(제4보) -재결정법에 의한 푸로세미드의 미세화-
고익배,신상철,오인준,Koh, Ik-Bae,Shin, Sang-Chul,Oh, In-Joon 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.2
The size of furosemide was reduced by the recrystallization method in order to increase the dissolution rate of the drug. Surfactants or hydrophilic polymers were used to suppress the aggregation in the crystal formation-growth process of microparticles by dispersing action. Dissolution rate of microparticles increased remarkably due to the size reduction of microparticle. The particle size decreased with increasing the concentration of the drug and the dispersing agents, i.e., surfactants or hydrophilic polymers. No polymorphic transition occurred during the microcrystallization process, but the habit of crystal formation was altered in the case of anionic surfactant.
에어탈 정 ( 아세클로페낙 100mg ) 에 대한 세니탈 정의 생물학적 동등성
김수진(Soo Jin Kim),오인준(In Joon Oh),박행순(Haeng Soon Park),서세민(Se Min Seo),서순팔(Soon Pal Suh),이용복(Yong Sok Lee) 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.4
Bioequivalence of two aceclofenac tablets, the Airtal^(TM) (Daewoong Pharmaceutical Co., Ltd.) and the Senital^(TM) (Hana Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20∼29 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100 ㎎ of aceclofenac was orally administered, blood was taken at predetermined time intervals and the concentration of aceclofenac in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_t) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_t between two tablets were 3.69%, 2.44% and 0.51%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_t were 87.85%, 98.70% and more than 99%, respectively. Detectable differences (Δ) and confidence intervals were all less than ±20%. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Senital^(TM) tablet is bioequivalent to Airtal^(TM) tablet.