자살시도 환자의 혈소판내 세로토닌 농도와 심리학적 특성에 관한 연구

정희연,권영준,박인준,홍세용,최의정,진혁희,Jeong, Hee Yeon,Kwon, Young Joon,Park, In Joon,Hong, Se Yong,Choi, Eui Jung,Jin, Hyuk-Hee 대한생물정신의학회 1999 생물정신의학 Vol.6 No.1

자살 시도군 21명, 우울증 환자군 14명, 그리고 정상 대조군 10명을 대상으로 혈소판내 세로토닌의 농도, 반 구조화된 설문조사, 다면적 인성검사, HAM-D, 충동성 검사를 시행하여 비교한 결과는 다음과 같았으며, 자살 시도군의 자살방법은 대부분 농약 중독이었다. 1) 자살 시도자의 남녀 비는 차이가 없었다. 2) 혈소판내의 세로토닌의 농도는 자살 시도군, 우울증 환자군 및 정상 대조군간에 차이가 없었다. 3) 다면적 인성검사 결과는 자살 시도군의 경우 D, Hs, Pt 척도가 높았으며, 우울증 환자군의 경우 D, Pa, Si 척도가 높았다. 4) HAM-D 점수는 우울증 환자군과 자살 시도군 모두에서 높았으며, 특히 우울증 환자군의 경우 더 의미 있게 높았다. 5) 충동성 검사 결과는 자살 시도군이 우울증 환자군에 비하여 무계획 충동성, 운동 충동성이 의미 있게 높았다. Objectives : Significant progress has been made in understanding psychosocial, psychological, and environmental factors associated with suicide. However it is only recently that attention has been paid to the understanding of the neurobiology of suicide. The aim of this study was to examine the relationship between platelet serotonin level and suicidal behavior and psychological features of the suicidal attempters. Methods : After a suicidal attempt platelet serotonin level was measured from 21 patients and compared it with those from depression patients and normal controls. Also MMPI, HAM-D, Barratt impulsiveness scale(BIS) were done to evaluate their psychological features. Results : 1) There was no significant difference in sex ratio of the suicidal attempters. 2) There was no significant difference in platelet serotonin levels among three groups. 3) The analysis of MMPI revealed that the scores of D, Hs, Pt in clinical scales were significantly higher in suicide patients and scores of D, Pa, Si were in depression patients. 4) The HAM-D score was significantly higher in depression and suicide patients, especially in depression patients. 5) The analysis of Barratt impulsiveness scale revealed that the scores of nonplanning, motor and cognitive impulsiveness scale were significantly higher in suicide patients. Conclusions : There was no significant difference in platelet serotonin levels among three groups. However the analysis of psychological features revealed significant differences. Therefore we concluded that psychological examinations are benefit to evaluate the suicidal tendency.

Haloperidol로 치료한 Tourette 장애에서 발생한 항정신병약물-퇴행 증후군 1례

정희연,조현주,권영준,박인준,진혁희,Jeong, Hee-Yeon,Cho, Hyun-Ju,Kwon, Young-Joon,Park, In-Joon,Jin, Hyuk-Hee 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

Authors report a case of separation anxiety disorder, which developed as a side effect during haloperidol treatment of Tourette syndrome(TS). In this case, 14 years old boy developed attention deficit symptoms during his infancy. At 4th grade of primary school, he developed vocal tic, motor tic, and coprolalia. With 5mg/day of haloperidol treatment his symptoms of TS were subsided. During the treatment, he developed features of separation anxiety disorder, including dependence, pleading, clinging, and sadness. Symptoms of attention deficit and separation anxiety disorder were improved by 25mg/day of imipramine treatment. During haloperidol treatment of TS, careful observation may be needed whether separation anxiety disorder-like symptom develops.

산조인이 백서 뇌에 미치는 영향 - 세로토닌, 수면시간, 수면뇌파, 자동운동을 중심으로 -

정희연,권영준,박인준,권준택,한병훈,이성필,Jeong, Hee-Yeon,Kwon, Young-Joon,Park, In-Joon,Kwon, Joon-Taek,Han, Byung-Hoon,Lee, Sung-Pil 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

Objects : Sanjoin, the seeds of Zizyphus vulgaris var. spinosus has been used as the most important hypnotic agent in chinese medicine to treat insomnia. This research was performed in order to examine the effect of betulinic acid and sanjoinine-A which are components of Sanjoin. Method : Sleeping time, sleep recordings of EEG, EMG, serum serotonin level, and locomotor activity were measured in rats which received betulinic acid and sanjoinine-A as sleep induction material extracted from Sanjoin. Results : 1) Groups received betulinic acid, sanjoinine-A, and lorazepam showed increased sleep time than control group with saline. 2) Groups with betulinic acid, sanjoinine-A, lorazepam and saline recorded ${\beta}$-wave in sleep recordings of EEG. In EMG, there was no significant difference among all groups. 3) No significant difference in serum serotonin level among all groups was found. 4) In autonomic activity testing, groups of betulinic acid, sanjoinine-A, and lorazepam showed significantly more decreased in activity than saline group. In comparison of groups of betulinic acid and sanjoinine-A with a group of lorazepam, there was no significant difference. Conclusion : These results suggest that betulinic acid and sanjoinine-A have the sedative effect like lorazepam rather than sleep effect.

주정의존 환자에서 가족력 유무에 따른 ${\beta}$-endorphine의 반응

정희연,박인준,권영준,Jeong, Hee-Yeon,Park, In-Joon,Kwon, Young-Joon 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

주정의존에 기여하는 여러 원인 중의 하나로 알려진 ${\beta}$-endorphin의 작용에 대해 알아보기 위해서 가족력 유무에 따라 남자 주정의존 환자 48명의 기본 혈중 alcohol 농도, ${\beta}$-endorphin 농도, cortisol 농도 및 혈당과 알코올 투여 후 각각의 농도를 측정하여 다음의 결과를 얻었다. 1) 가족력이 있는 주정의존 환자군과 가족력이 없는 환자군과의 비율은 약 2 : 1이었다. 2) 입원 당시의 나이는 가족력이 있는 주정의존 환자군이 가족력이 없는 환자군의 나이보다 적었다. 3) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 알코올의 농도변화는 세 군간에 차이가 없었다. 4) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 ${\beta}$-endorphin의 농도변화는 세 군간에 차이가 없었다. 5) 가족력이 있는 환자군과 없는 환자군, 그리고 정상대조군에서 알코올 투여 후 혈중 cortisol의 농도변화는 세 군간에 차이가 없었다. 6) 가족력이 있는 환자군과 없는 환자군에서 알코올 투여 후 혈당변화는 양 군간에 차이가 없었다. Objectives : To evaluate the relation of familial history of alcoholism and plasma level of ${\beta}$-endorphin, ethanol, ${\beta}$-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls. Methods : Subjects are divided into two groups by family history of alcoholism. Blood samples were obtained before and after 0.75mg/kg of ethanol consumption at 7th admission day. Results : 1) The ratio of family history positive to negative of the patient group was 2 to 1. 2) The age at admission of positive family history group was younger than negative group. 3) There was no significant difference in change of plasma ethanol level among three groups. 4) There was no significant difference in change of plasma ${\beta}$-endorphin level among three groups. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level between two patient groups.

주정의존 환자에서 초발연령에 따른 ${\beta}$-Endorphin의 반응

정희연,박인준,김진만,진혁희,Jeong, Hee-Yeon,Park, In-Joon,Kim, In-Man,Jin, Hyuk-Hee 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

정상대조군 29명 및 남자 주정의존 환자 48명을 발병연령에 따라 분류하여 입원 7일 후 오전 9시에 알코올 0.75gm/kg을 투여하기 전후의 혈중 ${\beta}$-endorphin농도, alcohol농도, cortisol농도, 그리고 혈당을 측정하여 비교한 결과는 다음과 같다. 1) 25세 이전과 25세 이후에 발병한 환자군의 비율은 약 2 : 3이었다. 2) 25세 이전과 25세 이후에 발병한 두 환자군간에 입원 당시의 연령은 차이가 없었다. 3) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 알코올의 농도변화는 세 군간에 차이가 없었다. 4) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 ${\beta}$-endorphin의 농도변화는 세 군간에 차이가 없었다. 5) 25세 이전과 25세 이후에 발병한 두 환자군과 정상대조군에서 알코올 투여 후 혈중 cortisol의 농도변화는 세 군간에 차이가 없었다. 6) 25세 이전과 25세 이후에 발병한 두 환자군에서 알코올 투여 후 혈당변화는 양군간에 차이가 없었다. Objectives : To evaluate the relation of onset-age and plasma level of ${\beta}$-endorphin, Ethanol, ${\beta}$-endorphin, cortisol and blood glucose were compared in 48 male alcoholics and 29 normal controls Methods : Alcoholics are divided into two groups by onset-age of alcoholism. Blood samples were obtained before and after 0.75gm/kg of ethanol consumption at the 7th admission day. Results : 1) The ratio of onset-age before 25 years to after 25 years of the patient group was 2 to 3. 2) There was no significant difference in age at admission between two patient groups. 3) There was no significant difference in change of plasma ethanol levels among three groups. 4) There was no significant difference in change of plasma ${\beta}$-endorphin levels among three groups. 5) There was no significant difference in change of plasma cortisol level among three groups. 6) There was no significant difference in change of fasting blood sugar level among two patient groups.

정신분열병 환자에 있어서 가족력과 임상유형(Type I, Type II)에 따른 안구추적운동의 차이

정희연,임두원,권영준,주경수,서미경,김동수,Jeong, Hee Yeon,Rheem, Doo Won,Kwon, Young Joon,Joo, Gyung Soo,Seo, Mi Kyoung,Kim, Dong Soo 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

Smooth pursuit eye movement, one of the reliable biological markers of schizophrenia, is not always abnormal in schizophrenic patients. Therefore the authors studied it in schizophrenic patients and normal controls and compared the results according to the presence or abscence of family history of psychosis and types (type I and type II). The results are as follows: 1) In the 18 normal control group (8 mole, 10 female), there was no sex difference in the responses of smooth pursuit eye movement. 2) In th 44 schizophrenic group (28 male, 16 female), there also was no sex difference in the responses of smooth pursuit eye movement. 3) In comparison of 44 schizophrenic group to 18 normal control group, there was significantly increased abnormal response in smooth pursuit eye movement in schizophrenic group (P < 0.005). 4) In schizophrenic group, there was no difference in the responses of smooth pursuit eye movement between type I and type II schizophrenia. 5) The presence or abscence of family history of psychosis made no difference in the responses of smooth pursuit eye movement in schizophrenic group. 6) Subdivision of type I or type II in each case of presence or abscence of family history made no difference in the responses of smooth pursuit eye movement in schizophrenic group.

눈깜박임을 주소로 내원한 아동에서의 틱 장애

정희연 ( Hee Yeon Jung ),정선주 ( Sun Ju Chung ),황정민 ( Jeong Min Hwang ) 대한안과학회 2002 대한안과학회지 Vol.43 No.2

전신진동자극훈련을 병행한 PNF 결합패턴 훈련이 뇌졸중환자의 근력, 균형 및 보행에 미치는 효과

최광용,정희연,맹관철,Choi, Kwang-Yong,Jeong, Hee-Yeon,Maeng, Gwan-Cheol 대한고유수용성신경근촉진법학회 2017 PNF and Movement Vol.15 No.2

Purpose: The purpose of this study was to prove the effects of the PNF patterns combined with whole-body vibration (PWBV) training on muscle strength, balance, walking speed, and endurance in stroke patients. Methods: Sixteen subjects were randomly assigned to the PWBV group (n=8) and the whole-body vibration (WBV) group (n=8). The PWBV group performed PNF pattern exercises using sprinter combined with WBV, while the WBV group performed using squatting for 30 minutes. Both groups performed therapeutic interventions five days per week over a period of four weeks. The manual muscle test, timed up and go test (TUG), 10-meter walk test (10MWT), and six-minute walk test (6MWT) were used to assess the muscle strength, balance, and gait of the participants. The SPSS Ver. 19.0 statistical program was used for data processing. Statistical analysis included a pared t-test to compare the pre- and post-intervention, and an independent t-test was used to compare groups. The significance level was set as 0.05. Results: The PWBV group and WBV group showed significant improvements in the TUG, 10MWT, and 6MWT (P<0.05). Significant differences between the PWBV and WBV groups were found (P<0.05). Conclusion: The PWBV improved muscle strength, balance, gait speed, and endurance in stroke patients. Thus, PWBV may be suggested as a therapeutic intervention in patients with stroke hemiplegia.

정신분열병과 양극성 장애의 P300 비교

박인준,정희연,권영준,Park, In-Joon,Jeong, Hee-Yeon,Kwon, Young-Joon 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

정신분열병 환자 16명(남자 12명, 여자4명), 양극성 장애 환자 15명(남자 7명, 여자 8명), 정상 대조군 16명(남자 8명, 여자 8명)을 대상으로 유발 전위검사 P300을 시행하여 얻은 결과는 다음과 같다. 1) 정신분열병 환자군의 Cz, Pz, T3에서의 P300 전위값은 정상 대조군에 비하여 유의하게 낮았다. 2) 정신분열병 환자군의 T3에서의 P300 전위값은 T4에 비하여 유의하게 낮았다. 3) 정신분열병 환자군의 T3에서의 P300 전위값은 양극성 장애 환자군에 비하여 유의하게 낮았다. 4) 정신분열병 환자군의 T3에서의 P300 잠복기는 T4에 비하여 유의하게 지연되어 있었다. 5) 정신분열병 환자군의 T3에서의 P300 잠복기는 양극성 장애 환자군에 비하여 유의하게 지연되어 있었다. 이상의 결과들을 종합해 보면 유발 전위검사 P300을 시행하여 얻은 검사 결과 정신분열병 환자군은 좌측 측두엽 기능 부전, 특히 좌측 상측두회의 기능 부전을 보였으나 양극성 장애 환자군은 정상 대조군과 마찬가지로 좌측 상측두회의 기능 부전을 보이지 않아 두 장애의 정신생리학적 발병 원인은 서로 차이가 있으며, 특히 정신분열병의 정신생리학적 발병 원인은 특히 좌측 상측두회의 기능 부전과 관련있음을 의미하는 것으로 생각된다. Objective : Asymmetries in evoked potential P300 topography of schizophrenia and bipolar disorder are still controversial. The purpose of this study was to examine the difference in P300 topography between schizophrenia and bipolar disorder. Method : P300 was recorded from 16 schizophrenic, 15 bipolar manic, and 16 control subjects. All were right-handed. Subjects silently counted target stimuli(2.0kHz) among trains of standard stimuli(1.0kHz). Averages were constructed from brain responses to target stimuli. Results : 1) Schizophrenics displayed significantly smaller peak amplitude of P300 over Cz, Pz, T3 than controls. 2) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than bipolar manics. 3) Schizophrenics displayed significantly smaller peak amplitude of P300 over T3 than their T4. 4) Schizophrenics displayed significantly delayed latency of P300 over T3 than bipolar manics. 5) Schizophrenics displayed significantly delayed latency of P300 over T3 than their T4. Conclusions : Left-sided P300 abnormality, especially left superior temporal gyrus, in schizophrenics relative to bipolar manics and controls suggests that psychophysiological cause of schizophrenia and bipolar disorder is different and P300 asymmetry is specific to the psychophysiological cause of schizophrenia.

정신분열증 환자에서 Cimetidine에 의한 Prolactin 분비 반응 - 양성 및 음성 아형 남자 환자에서 -

진혁희,권영준,정희연,한선호,Jin, Hyuk Hee,Kwon, Young Joon,Jeong, Hee Yeon,Han, Sun Ho 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

Objects : There is considerable interest in the role of serotonin(5-HT) in the pathophysiology of schizophrenia. Cimetidine, $H_2$ antagonist, produces transient increase in serum prolactin(PRL) levels by indirect serotonergic mechanism in man following intravenous administration. Therefore the authors investigated the effects of cimetidine on serum PRL levels of male unmedicated schizophrenics. Method : Baseline serum prolactin level and psychopathology were measured at 9:00 AM. in the two groups(12 positive schizophrenics, 7 negative schizophrenics) and $T_{30}$ levels were measured 30 minutes after intravenous injection of cimetidine (ie, 9:30 AM) Results: 1) Baseline prolactin levels were not different in the three groups. 2) Prolactin levels of 30 minutes after intravenous injection of cimetidine($T_{30}$) compared with baseline prolactin levels were increased all in the three groups. 3) Degrees of interval change from baseline to $T_{30}$ were significantly different between normal control and negative schizophrenics(p<0.05). Conclusion : The prolactin response to cimetidine was significantly blunted in negative male schizophrenics than normal control. These data are consistent with the hypothesis of an abnormality of serotonergic activity, including down-regulation $5-HT_2$ receptors, in male negative schizophrenics. 최근에 정신분열증의 병태생리에 세로토닌계에 대한 관심이 고조되고 있고 cimetidine이 간접적인 세로토닌계 자극으로 PRL 분비 반응을 유발한다 하여 본 연구에서는 양성 및 음성 증상 척도 (PANSS)에 의하여 양성 및 음성 아형으로 정신분열증 환자군을 구분, 정상대조군과 두 아형들간의 PRL 기저지와 cimetidine 유발성 PRL $T_{30}$치를 측정하여 정신분열증의 아형에 따른 seretonin과의 상관 관계를 규명하고자 연구가 시도되었다. 대상은 DSM-N(APA 1994)의 진단 기준을 만족시키는 입원 당시 7일 이상 항정신병약물을 복용하지 않은 남자 정신분열증 환자 19명으로 하였고, PANSS에 의해 양성 아형 (12명) 및 음성 아형 (7명) 환자군으로 나누어 오전 9시에 PRL 기저치 측정과 함께 cimetidine(5mg/kg) 정액 점주 30분 후인 9시 30분에 cimetidine에 의한 PRL $T_{30}$치를 측정하여 다음과 같은 결과를 얻었다. 1) PRL 기저치는 세 군에서 차이가 없었다. 2) 기저와 $T_{30}$간에 PRL치의 변화는 세 군에서 증가했음을 보여주었다. 3) 기저와 $T_{30}$간에 PRL치 증가량에 대한 상대적인 비교에서 정상대조군과 양성 아형 환자군 간, 양성 아형 환자군과 음성 아형 환자군 간에는 차이가 없었으나 정상대조군과 음성 아형 환자군 간에서 상호 유의한 차이가 있었다(p<0.05). 상기 연구 결과들은 정상대조군에서 보다 음성 아형 환자군에서 cimetidine에 의한 PRL반응이 둔감하게 나타난 것을 보여준다 하겠다. 이러한 결과들은 정상대조군에서는 나타나지 않지만 남자 음성 아형 정신분열증 환자군에서 $5-HT_2$ 수용체 하향 조절을 포함하는 세로토닌계 활성 이상 소견이 나타날 수 있다는 가설(Meltzer등 1993) 들과 일치한다 하겠다.