Comparison of Anisotropic Analytic Algorithm Plan and Acuros XB Plan for Lung Stereotactic Ablative Radiotherapy Using Flattening Filter-Free Beams

정진범,엄근용,김인아,김재성,이정우,홍세미,김연래,박병문,강상원,서태석,Chung, Jin-Beom,Eom, Keun-Yong,Kim, In-Ah,Kim, Jae-Sung,Lee, Jeong-Woo,Hong, Semie,Kim, Yon-Lae,Park, Byung-Moon,Kang, Sang-Won,Suh, Tae-Suk Korean Society of Medical Physics 2014 의학물리 Vol.25 No.4

이 연구는 비편평화여과기(flattening filter-free, FFF) 빔을 이용한 폐 정위절제방사선치료(stereotactic ablative radiotherapy, SABR)에 대하여 서로 다른 선량계산 알고리즘의 선량적 효과를 조사하였다. SABR를 받은 10명의 폐암 환자를 대상으로하여 평가하였다. 모든 치료계획은 Eclipse 치료계획시스템의 Acuros XB (AXB) 알고리즘을 이용하여 수립되었다. 다른 선량계산 알고리즘과 비교를 위하여, 추가적으로 anisotropic analytic algorithm (AAA) 알고리즘을 적용한 치료계획을 재 수립하였다. 두 알고리즘 평가를 위해서, 치료표적과 손상위험장기의 선량체적히스토그램(dose-volume histogrim, DVH)를 분석하였다. 그리고 기술적 인자로써 계산시간과 총 MU 값을 평가하였다. DVH 비교분석을 통해, PTV의 최대선량은 AXB이 AAA 보다 5.2% 높았으며 최소선량은 4.4% 낮게 나타났다. PTV의 $V_{105%}$에서 7.06%까지 큰 차이를 나타났다. 폐의 최대선량은 AXB 치료계획에서 약간 크게 나타났다. 동측성 폐에 5, 10과 20 Gy 선량이 조사되는 체적은 AAA 보다 AXB에서 더 크게 나타났으나 대측성 폐에 대해서는 거의 비슷하게 나타났다. 척수와 심장에서 최대선량의 차이도 크지 않았다. 계산시간의 경우, AXB가 AAA보다 13.7% 정도 소요시간이 적었고 MU 값은 AXB에서 3.47% 더 많았다. 이 연구의 결과들은 회전조절치료 기법을 포함하여 FFF 빔이 적용된 폐 SABR 치료계획에서 AXB 알고리즘은 선량계산의 정확성과 계산시간의 감소의 장점을 제공할 수 있을 것이다. This study investigated the dosimetric effects of different dose calculation algorithm for lung stereotactic ablative radiotherapy (SABR) using flattening filter-free (FFF) beams. A total of 10 patients with lung cancer who were treated with SABR were evaluated. All treatment plans were created using an Acuros XB (AXB) of an Eclipse treatment planning system. An additional plans for comparison of different alagorithm recalcuated with anisotropic analytic algorithm (AAA) algorithm. To address both algorithms, the cumulative dose-volume histogram (DVH) was analyzed for the planning target volume (PTV) and organs at risk (OARs). Technical parameters, such as the computation times and total monitor units (MUs), were also evaluated. A comparison analysis of DVHs from these plans revealed the PTV for AXB estimated a higher maximum dose (5.2%) and lower minimum dose (4.2%) than that of the AAA. The highest dose difference observed 7.06% for the PTV $V_{105%}$. The maximum dose to the lung was also slightly larger in the AXB plans. The percentate volumes of the ipsilateral lung ($V_5$, $V_{10}$, $V_{20}$) receiving 5, 10, and 20 Gy were also larger in AXB plans than for AAA plans. However, these parameters were comparable between both AAA and AXB plans for the contralateral lung. The differences of the maximum dose for the spinal cord and heart were also small. The computation time of AXB plans was 13.7% shorter than that of AAA plans. The average MUs were 3.47% larger for AXB plans than for AAA plans. The results of this study suggest that AXB algorithm can provide advantages such as accurate dose calculations and reduced computation time in lung SABR plan using FFF beams, especially for volumetric modulated arc therapy technique.

20대 성인 여성의 드롭치에 따른 체형 분류 및 브래지어 컵 사이즈 변화 연구

정진아 ( Jin Ah Jeong ),최혜선 ( Hei Sun Choi ),최정욱 ( Jeong Wook Choi ) 한국의류학회 2014 한국의류학회지 Vol.38 No.6

The study provides baseline data on developing ready-to-wear clothes for adult females in their twenties who have finished shaping their bodies and have realized an ideal shape. We analyzed the data from females aged from 20 to 29 in “The 5thSize Korea Survey” and “The 6thSize Korea Survey”, and sorted body shapes into several types according to drop values before analyzing and comparing the characteristics among groups. We also referred to the change by year in the size of upper inner wear. To classify body shapes, three drop values were assigned for bust girth - waist girth, hip girth - waist girth, hip girth - bustgirth; through cluster analysis all data were classified into three body types. Type 1 is more like normal body shapes with small drop values at the bust girth - waist girth and well-build lower body. Type 2 is Xshaped body shaped like a fiddle with big drop values at all parts. Type 3 is Y-shaped body with a big dropvalue at the bust girth - waist girth and well-build upper body. Type 2, X-shaped body, has the majority of distribution in every year, which proved to be the most idealistic body shape. There was a change in the brassiere cup size. Korean ladies in their twenties have larger breasts. The body shapes of Korean females in their twenties are increasingly like those of westerners. Bust girth is a very critical element to set measurements and design patterns for upper wear; consequently, a change in the size of breasts should be considered.

MOSFET 선량계 특성분석을 위한 팬톰 개발 및 특성 비교

정진범,이정우,김연래,이두현,최경식,김재성,김인아,홍세미,서태석,Chung, Jin-Beom,Lee, Jeong-Woo,Kim, Yon-Lae,Lee, Doo-Hyun,Choi, Kyoung-Sik,Kim, Jae-Sung,Kim, In-Ah,Hong, Se-Mie,Suh, Tae-Suk 한국의학물리학회 2007 의학물리 Vol.18 No.1

본 연구는 MOSFET (Metal Oxide Semiconductors Fleid Effect Transistors) 선량계의 교정과 특성분석을 위해서, 자체 팬톰을 개발하고 이 팬톰을 적용하여 표준감도와 고감도 두 종류의 MOSFET선량계의 특성을 비교 평가하는 것이다. 본 연구에서 개발한 팬톰은 직경 10cm의 반구형 모양인 팬톰과 1cm 두께 $30{\times}30cm^2$의 평판형의 팬톰으로 아크릴로 제작되었다. 평판형 팬톰은 MOSFET 선량계의 교정과 선량재현성, 선량직선성, 선량률 의존성을 측정하는데 사용하였으며 반구형 팬톰은 빔 입사각도 및 선량계 방향에 대한 MOSFET 선량계 특성을 분석하기 위해서 사용하였다. 모든 측정과정은 선형가속기(CL21EX, Varian, USA)의 6 MV 광자선, SSD 100cm, 조사면 $10{\times}10 cm^2$에서 수행하였다 선량계 교정과 선량재현성 평가에 사용된 5개의 표준감도와 고감도 MOSFET 선량계에 각각 200 cGy로 5번 반복 조사하여 $1.09{\pm}0.01{\sim}1.12{\pm}0.02,\;2.81{\pm}0.03{\sim}2.85{\pm}0.04mV/cGy$. 범위의 평균 교정계수가 결정되었고 선론쌔현성은 두 선량계 모두 2%이내로 거의 동일하였다. $5{\sim}600\;cGy$ 범위에서의 선량직선성은 두 MOSFET 선량계 모두 결정계수 $R^2=0.997$, 0.999인 좋은 선량직선성을 나타내었다. 200 cGy로 $100{\sim}600\;MU/min$ 범위의 선량률 의존성도 1%이내로 두 선량계가 동일하게 나타났다. 그러나 빔 입사각도와 선량계 방향의 의존성 평가에서, 표준감도와 고감도 MOSFET선량계는 평균적으로 빔 입사각도에 대해 13%, 10%의 변동폭과 ${\pm}4.4%$와 ${\pm}2.1%$의 표준편차가 있었으며, 선량계 방향에 대해 5%, 2%의 변동폭, ${\pm}2.1%$와 ${\pm}1.5%$의 표준편차로 두 선량계 간 현저한 차이를 나타났다 그러므로 여러 방향의 치료빔을 사용하는 방사선 치료의 선량검증을 위해서는 빔 입사각도와 선량계 방향의 의존성이 적은 고감도 MOSFET 선량계를 사용하는 것이 표준감도 WOSFET 선량계를 사용하는 것보다는 더 정확한 선량검증을 수행할 수 있을 것으로 사료된다. This study is to develope a phantom for MOSFET (Metal Oxide Semiconductors Field Effect Transistors) dosimetry and compare the dosimetric properties of standard MOSFET and microMOSFET with the phantom. In this study, the developed phantom have two shape: one is the shape of semi-sphere with 10cm diameters and the other one is the flat slab of $30{\times}30cm$with 1 cm thickness. The slab phantom was used for calibration and characterization measurements of reproducibility, linearity and dose rate dependency. The semi-sphere phantom was used for angular and directional dependence on the types of MOSFETs. The measurements were conducted under $10{\times}10cm^2$ fields at 100cm SSD with 6MV photon of Clinac (21EX, Varian, USA). For calibration and reproducibility, five standard MOSFETS and microMOSFETs were repeatedly Irradiated by 200cGy five times. The average calibration factor was a range of $1.09{\pm}0.01{\sim}1.12{\pm}0.02mV/cGy$ for standard MOSFETS and $2.81{\pm}0.03{\sim}2.85{\pm}0.04 mV/cGy$ for microMOSFETs. The response of reproducibility in the two types of MOSFETS was found to be maximum 2% variation. Dose linearity was evaluated In the range of 5 to 600 cGy and showed good linear response with $R^2$ value of 0.997 and 0.999. The dose rate dependence of standard MOSFET and microMOSFET was within 1% for 200 cGy from 100 to 500MU/min. For linearity, reproducibility and calibration factor, two types of MOSFETS showed similar results. On the other hand, the standard MOSFET and microMOSFET were found to be remarkable difference in angular and directional dependence. The measured angular dependence of standard MOSFET and microMOSFET was also found to be the variation of 13%, 10% and standard deviation of ${\pm}4.4%,\;{\pm}2.1%$. The directional dependence was found to be the variation of 5%, 2% and standard deviation of ${\pm}2.1%,\;{\pm}1.5%$. Therefore, dose verification of radiation therapy used multidirectional X-ray beam treatments allows for better the use of microMOSFET which has a reduced angular and directional dependence than that of standard MOSFET.

거꾸로 교실을 적용한 과학수업이 초등학생의 과학 학습 동기 및 학업성취도에 미치는 영향

정진아 ( Jin Ah Jeong ),배진호 ( Jin Ho Bae ),소금현 ( Keum Hyun So ) 한국생물교육학회 2015 생물교육 Vol.43 No.4

This study was conducted to examine the effect of elementary science class with Flipped learning on scientific learning motivation and academic achievement of elementary students. Two fifth grade classes were divided into experimental group and comparative group to treat the experimental group with elementary science class using Flipped learning. General class according to teacher manual was implemented for the comparison group. Elementary science class applying flipped learning was conducted for 12 sessions throughout the experimental period of 9 weeks. The results of this study were as follows. First, elementary science class with flipped learning was effective in improving scientific learning motivation. Second, elementary science class with flipped learning had significant effect on improvement of academic achievement.

직강화 하천구간과 자연형 하천복원구간의 식물상 및 출현빈도 비교 -불광천을 사례로-

정진아 ( Jin Ah Jeong ),김혜주 ( Hyea Ju Kim ),이은희 ( Eun Heui Lee ) 한국환경생태학회 2004 한국환경생태학회지 Vol.18 No.1

백서 심근에서 plasmid 벡터를 이용한 유전자 전달 및 VEGF 유전자 발현의 특성

정진옥 ( Jin Ok Jeong ),박선진 ( Sun Jin Park ),허정은 ( Jeong Eun Huh ),정은아 ( Eun Ah Jung ),오주현 ( Ju Hyeon Oh ),권현철 ( Hyeon Cheol Gwon ),이영주 ( Young Joo Lee ),김선영 ( Sun Young Kim ),박정의 ( Jeong Euy Park ),이원로 대한내과학회 2001 대한내과학회지 Vol.60 No.1

N/A Background : The purpose of this study was to compare gene expression among newly designed eukaryotic expression vectors, and to characterize the pattern of vascular endothelial growth factor(VEGF) expression using the most potent plasmids DNA vector. Methods : After exposure of a beating rat heart (Sprague-Dawley, 250-300g), 5 different types of plasmid DNA was injected directly into the myocardium. Reporter protein was analyzed by ELISA in the extracted heart. Results : The vector harboring cytomegalovirus (CMV) promoter and enhancer induced the strongest expression of reporter gene (chloramphenicol acetyl transferase; CAT) compared to those of pC3.1, pEF1a, RSV, pActin in the rat heart via direct injection of plasmid DNA into the apex (p<0.001). Using pCN-CAT, gene expression showed a dose-dependent response over a range of 0.3-10 ㎍. CAT expression could be detected up to 30 days after 10 ㎍ of pCN-CAT injection with the maximal expression on day 5. In X-gal staining of injected pCN-lacZ gene, β-galactosidase was found only around the needle track in the apex. The expressed hVEGF121 had biologic activity with vascular permeability assay (Miles assay) in guinea pigs. After injection of pCN-hVEGF121 into the apex of the rat heart, the expression of VEGF protein was dose-dependent over the range of 25 and 500 ㎍. VEGF expression was detected up to 14 days with its peak on day 2 after injection of 250 ㎍ of pCN-hVEGF121. When plasmid was injected into the apex of the rat heart, the expression of VEGF in the heart showed concentration gradient from the apex to the base. However, the expression of CAT was detected only in the apex. Conclusion : Plasmids vector with hCMV IE promoter/enhancer will provide clear advantages over other previously developed plasmids and the information regarding the behaviors of VEGF expression may be useful in angiogenic gene therapy of the heart.(Korean J Med 60:3-15, 2001)

정맥 주사 주입과 관련된 데이터 관리시스템 설계에 관한 연구

정진형(Jin-Hyoung Jeong),김정아(Jeong-Ah Kim),조요한(Yoe-Han Cho),김승훈(Seung-Hun Kim),이상식(Sang-Sik Lee) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.1

보문 : 국내 남성용 스킨스쿠버복 생산실태 및 소비자 만족도

최진희 ( Jin Hee Choi ),정진아 ( Jin Ah Jeong ) 韓國衣類學會 2009 한국의류학회지 Vol.33 No.11

The Effect of Caregiving Stress on Depression among Korean Married Adult Children of Korea

김윤정,정진아,가현수,Kim, Yun-Jeong,Chung, Jin-Ah,Ka, Hyun-Su The Society of Digital Policy and Management 2014 디지털융복합연구 Vol.12 No.10

본 연구의 목적은 노부모를 부양하는 성인자녀의 부양스트레스가 우울감에 미치는 영향을 파악하는데 있다. 이를 위해 2014년 1월 2월 충남의 H 대학의 대학원생을 조사원으로 활용하여 노부모부양에 책임이 있는 기혼의 성인자녀를 대상으로 편의표집을 하였으며, 350부를 배포하여 최종적으로 307명의 자료를 분석에 사용하였다. 성인자녀의 부양스트레스의 신뢰도는 .94, 우울감의 신뢰도는 .92로 높은 것으로 나타났다. 연구결과, 첫째, 노부모 부양 성인의 우울감은 평균 2.56점, 부양스트레스는 평균 2.53점으로 보통수준이하로 낮았다. 둘째, 기혼 성인자녀의 부양스트레스는 여성인 경우, 50대 이상, 농촌에 거주, 경제수준이 낮은 경우 더 높았다. 우울감은 배우자가 없는 경우, 경제수준이 낮은 경우 더 높았다. 셋째, 기혼 성인자녀의 경제수준이 낮을수록, 부양 스트레스가 높을수록 우울감이 높은 것으로 나타났다. The purpose of this study is to examine the relationship between caregivng stress and depression of the caregiver. The data was collected through by a survey on to married adults who are responsible for the care of old parents. The survey(by purposive sampling) was conducted over the course of for the three months duration from Jan. to Feb. 2014. A total of Finally, 307 copies of the questionnaire retrieved were used for analysis. First, in the case of women, those in their 50s or over, and in the all both gender cases, those who live in rural area, and those who perceive their economic levels as 'low' tend to have higher caregivng stress than other kinds of groups. Second, those who do not have spouses, and those who perceive their economic levels as 'low' tend to have higher depression than other kinds of groups, and those who hold the whole responsibility of caring old parents had a severe high depression. Third, it was found that the greater higher the caregivng stress of caregivers get, the more serious higher their stresses become get.

탈미네랄화된 골분/PLGA 지지체에서 늑연골 세포의 부착과 성장에 미치는 영향

조선아(Sun Ah Cho),송정은(Jeong Eun Song),김경희(Kyoung Hee Kim),고현아(Hyun Ah Ko),이동원(Dong Won Lee),권순용(Soon Yong Kwon),정진화(Jin Wha),김길선(Gil Gilson Khang) 한국고분자학회 2013 폴리머 Vol.37 No.5

늑연골세포는 초기 증식능력이 관절연골세포보다 우수하며, 또한 세포 채취에 용이하다는 장점이 있어, 관절연골의 대안으로 사용된다. FDA의 승인을 받은 합성고분자인 폴리락산-글리콜산 공중합체(PLGA)는 조직공학적 생체재료로 사용되고 있으나, 세포 부착률이 낮고, 염증반응을 야기시킨다고 보고되고 있다. 본 연구에서는 세포의 증식에 영향을 주며 염증반응이 감소된다고 보고된 탈미네랄골분(DBP)을 이용하여, 함량별 DBP/PLGA를 제조한 뒤,세포를 파종하여 연구를 실시하였다. 세포의 부착 및 증식률을 측정하기 위하여 세포 파종한 후 MTT와 SEM 분석을 수행하였으며, DBP가 세포외 기질 형성에 미치는 영향을 확인하고자 글리코스아미노글라이칸(sGAG)과 콜라겐함량을 측정하였다. 생체 내·외 환경에서 세포의 부착과 증식에 미치는 영향을 관찰하기 위해 연구를 진행하여,PLGA 지지체보다 DBP/PLGA 지지체가 세포의 성장과 증식에 영향을 주는 것을 확인하였으며, DBP의 함량이 증가할수록 효과가 좋은 것으로 나타났다. It has been widely accepted that costal cartilage cells (CCs) have more excellent initial proliferation capacity than articular cartilage cells as well as the easiness for isolation and collection. This study demonstrated that CCs might be one of the substitutes for articular cartilage cells by tissue engineered cartilage. Poly(lactic-co-glycolic acid) (PLGA)has been extensively tested and used as scaffold material but it was limited by the low attachment of cells and the induction of inflammatory cells. Base on previous our studies, we confirmed demineralized bone particle (DBP) had the power of the reduction of inflammatory reaction and the stimulation proliferation of cells. We fabricated PLGA scaffold loaded with 10, 20, 40 and 80 wt% DBP and then tested the possibility of the regeneration of cartilage using CCs. Assays of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and scanning electron microscope (SEM) carried out to evaluate the attachment and proliferation of CCs in DBP/PLGA scaffolds. Glycosaminoglycan (sGAG) and collagen contents assay were conducted to confirm the effects of DBP on formation of extracellular matrix. This study demonstrated that DBP/PLGA scaffolds showed significant positive effects on cell growth and proliferation due to the vitality of DBP as well as the possibility of the application of CCs for tissue engineered cartilage.