주요우울장애자의 성별에 따른 뇌 회백질 밀도 차이

전하정,음영지,정이내,손진훈 한국감성과학회 2016 추계학술대회 Vol.2016 No.-

Terra 및 Aqua MODIS 위성자료를 활용한 동남아시아의 AOD 특징 분석

전하정,이나현,구자호,박상서 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.10

Role of Postoperative Radiation Therapyin the Management of Cervical Cancer

전하정,이명자 대한방사선종양학회 2004 Radiation Oncology Journal Vol.22 No.4

전두엽 EEG 알파파의 비대칭성과 정서 지각

전하정,오형석,엄진섭,박지은,손진훈 한국감성과학회 2016 춘계학술대회 Vol.2016 No.-

간외 담도계암에서 방사선치료의 역할

전하정,이명자 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.2

The purpose of this study is to evaluate the effectiveness and tolerance of external beam radiotherapy for carcinoma of the extrahepatic biliary system(EHBS) including gallbladder (GB) and extrahepatic bile ducts (EHBD) and to define the role of radiotherapy for theses tumors. We retrospectively analyzed the records of 64 patients with carcinoma of the EHBS treated with external beam radiotherapy at our institution between April, 1986 and July, 1999. Thity four patients had GB cancers and remaining 30 patients did EHBD cancers. Of those 34 GB cancers, 3 had Stage Ⅱ, 18 did Stage Ⅲ and 13 did Stage Ⅳ disease, respectively. Male to female ratio was 16 to 18. Twenty two patients underwent radical surgery with cuartive intent and 12 patients did biopsy and bypass surgery alone. All of these patients except for 5 patients were treated with 4500 cGy or higher doses postoperatively. Follow up periods ranged from 11 to 92 months. Of those 20 EHBD cancers, one had Stage Ⅰ, 3 did StageⅡ, 15 did StageⅢ and 11 did Stage Ⅳ disease, respectively. Male to fecale ratio was 24 to 6. Twenty four patients underwent Whipple's procedure or resection and drainage with curative aim and remaing 6 patients did bypass surgery alone. Postoperatively 24 patients were irradiated with 4500 cGy or higher doses and 6 patients with 3180 to 4140 cGy. Follow up periods ranged from 8 to 62 months. Overall median survival time of patients with GB cancer was 12 months. Median survival time for patients with Stage Ⅲ and Ⅳ disease were 14 months and 5 months, respectively. Corresponding two year survival rates were 31% and 17%, respectively. Those who underwent surgery with curative intent showed significantly better survival at 12 months than those who underwent bypass surgery alone(65% vs 14%). None of the patients died of treatment related complications. Median survival time for entire group of 30 patients with EHBD cancers was 10 months. Median survival time for 15 Stage Ⅲ disease and 11 Stage Ⅳ disease were 10 and 7 months, respectively. Survival rates at 9 month for patients treated with radical surgery and bypass alone were 63% and 0%, respectively. Postoperative external beam radiotherapy for carcinoma of the extrahepatic biliary system is well tolerated and might improve survival of patients, especially those with resectable lesions with microscopic or gross residual disease after surgery.

External Beam Radiotherapy for Primary Spinal Cord Tumors

전하정,Chun, Ha-Chung The Korean Society for Radiation Oncology 1989 Radiation Oncology Journal Vol.7 No.2

1969년부터 1983년까지 버지니아 의대부속병원에서 방사선 치료를 받은 34예의 원발성 척수암중, 조직검사 또는 아절제술을 시행한 후 수술후 방사선 요법으로 치료받은 32예 (Astrocytoma 16, ependymoma 16)에 대한 치료실적을 보고하고자 한다. 29예에서는 $45\~55Gy$를 5내지 6주간에 조사 받았으며 나머지 3예에서는 40Gy이하의 선량을 조사받았다. 50Gy 이상 조사된 6예는 모두 척수가 조사야에 포함되었다. 본 연구의 최저 추적 기간은 5년이었다. 방사선 치료 실패 후 재수술로 치료된 3예를 포함하여, 모든 예에서 생존율은 5년과 10년에서 각각 $73\%\;와\;50\%$이었다. 각각의 투병생존율은 $60\%\;와\;32\%$이었다. 45Gy 이상의 선량을 받은 29예에서는 5년 무병생존이 $63\%$이었다. 13예에서 치료실패를 경험했으며 치료실패는 조사야에서만 관찰되었다. Ependymoma가 astrocytoma보다 통계적으로 유의하게 무병생존율이 높았다 $(45\%\;:\; 89\%(p<0.05))$, 원발부위에 있어 경추가 포함된 예에서 그렇지 않은 예보다 생존율이 저하되었다. 원발부위의 cauda equina포함여부는 예후에 영향이 없었다. 최고 20년간 추적결과 방사선 치료에 의한 신경성 합병증은 관찰되지 않았다. 본 연구는 원발성 척수암의 치료에 있어서 방사선 치료가 안전하고 효과적임을 확인하였다. Of 34 evaluated patients with primary spinal cord tumors, 32 were irradiated at our institution between 1969 and 1983. The results are reported of 32 patients, 16 with ependymoma and 16 with astrocytoma, who were treated with post-operative external beam radiotherapy following biopsy or subtotal resection Twenty-nine patients received $45\~55Gy$ megavoltage beam irradiation in $5\~6$ weeks and the remaining three patients received less than 40Gy. Spinal cord was in the irradiated field for six patients who received more than 50Gy. The minimum follow-up was five years. Five and ten year acturaial survival rates for entire group of patients were $73\%(22/30)\;and\;50\%(8/16)$, including three patients who were salvaged by surgery after radiation failures. Corresponding five and ten year relapse free survival rates were $60\%(18/30)\;and\;32\%(6/19)$, respectively. Of the 29 patients who recived more than 45Gy, relapse free survival at five years was $63\%(17/27)$. Treatment failed in 13 patients and all of those failures were in the irradiated portal. Patients with ependymomas have significantly better relapse free survival than those with astrocytomas, $80\%\;vs.\;40\%$ (p<0.05). There was significant difference in survival between patients with tumors involving the cervical spine and those with tumors in the other loactions, $45\%$ vs. $89\%(p<0.05)$. There was no significant differnece in survival between patients with cauda equina tumors and those with tumors at spinal cord, $100\%\;vs.\;68\%(p>0.05)$. No radiotherapy related neurological deficit was noted with a maximum 20 year follow-up. This study confirms that external beam radiotherapy is a safe and effective treatment modality for primary spinal cord tumors.

폴리그라 비교질문검사의 타당성: fMRI 연구

전하정,음영지,손진훈,엄진섭 한국감성과학회 2018 감성과학 Vol.21 No.2

The logical assumption of the comparison question test (CQT) is that the guilty person pays more attention to the relevant questions than to the comparison questions, and that the innocent person pays more attention to the comparison questions than to the relevant questions. The purpose of this study was to verify the logic of the comparison question test using functional magnetic resonance imaging (fMRI). The participants were tested for brain responses during a mock crime and performed the CQT under guilty and innocent conditions. After brain imaging, we evaluated the psychological burden of responding to the relevant questions and comparison questions. In the guilty conditions, the degree of burden was higher for the relevant questions than the comparison questions, and there was no significant difference in the innocent conditions. The fMRI results showed that, in the guilty conditions, greater activation was observed in the right superior temporal gyrus and right inferior frontal gyrus when relevant questions were presented relative to comparison questions. Based on these findings, the logical assumption of the CQT was discussed. 비교질문 검사의 논리 가정은 유죄인 조사상자는 비교질문보다 련질문에 주의를 더 기울이고 무죄인 조사상 자는 련질문보다 비교질문에 주의를 더 기울인다는 것이다. 본 연구는 기능자기공명상(fMRI)을 이용하여 비교질 문검사의 논리 타당성을 검증하다. 이를 하여 실험참여자에게 모의 범죄를 수행하도록 한 후 유죄조건과 무죄조건 에서 비교질문검사를 실시하면서 뇌 반응을 측정하다. 뇌 상을 촬한 후에는 련질문과 비교질문에 ‘아니오’라고 응답하는 것이 얼마나 심리으로 부담되는지를 평가하도록 하다. 행동 반응 결과, 유죄조건에서 비교질문보다 련질 문에 ‘아니오’라고 응답하는 것이 더 부담이 되는 것으로 나타났고 무죄조건에서는 두 질문 유형 간에 유의한 차이가 나타나지 않았다. 뇌 반응 결과, 유죄조건에서는 비교질문에 비해 련질문이 제시되었을 때 우측 상측두회와 우측 하두회에서 더 큰 활성화가 찰되었다. 그러나 무죄조건 분석 결과 질문유형에 따른 뇌 역 활성화 차이는 없는 것으로 나타났다. 이러한 결과에 근거하여 유죄조건과 무죄조건에 한 비교질문검사의 논리 가정을 논의하다.

유방암의 방사선치료

全河禎 대한의학협회 1992 대한의학협회지 Vol.35 No.4

External Beam Radiotherapy in the Management of Low Grade Astrocytoma of the Brain

전하정 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.1

Purpose: This study was designed to evaluate the effectiveness of postoperative radiotherapy for patients with low-grade astrocytomas and to define an optimal radiotherapeutic regimen and prognostic factors. Materials and Methods: A total of 69 patients with low-grade astrocytomas underwent surgery and postoperative radiotherapy immediately following surgery at our institution between October 1989 and September 2006. The median patient age was 36 years. Forty-one patients were 40 years or younger and 28 patients were 41 years or older. Fourteen patients underwent a biopsy alone and the remaining 55 patients underwent a subtotal resection. Thirty-nine patients had a Karnofsky performance status of less than 80% and 30 patients had a Karnofsky performance status greater than 80%. Two patients were treated with whole brain irradiation followed by a coned down boost field to the localized area. The remaining 67 patients were treated with a localized field with an appropriate margin. Most of the patients received a dose of 50∼55 Gy and majority of the patients were treated with a dose of 54 Gy. Results: The overall 5-year and 7-year survival rates for all of the 69 patients were 49% and 44%, respectively. Corresponding disease free survival rates were 45% and 40%, respectively. Patients who underwent a subtotal resection showed better survival than patients who underwent a biopsy alone. The overall 5-year survival rates for patients who underwent a subtotal resection and patients who underwent a biopsy alone were 57% and 38%, respectively (p<0.05). Forty-one patients who were 40 years or younger showed a better overall 5-year survival rate as compared with 28 patients who were 41 years or older (56% versus 40%, p<0.05). The overall 5-year survival rates for 30 patients with a Karnofsky performance status greater than 80% and 39 patients with a Karnofsky performance status less than 80% were 51% and 47%, respectively. This finding was not statistically significant. Although one patient was not able to complete the treatment because of neurological deterioration, there were no significant treatment related toxicities. Conclusion: Postoperative radiotherapy following surgery is a safe and effective treatment for patients with low-grade astrocytomas. The extent of surgery and age were noted as significant prognostic factors in this study. However, further effective treatment might be necessary in the future to improve long-term survival rates.

Results of Radiation Therapy for Squamous Cell Carcinoma of the Esophagus

전하정,이명자 대한방사선종양학회 2009 Radiation Oncology Journal Vol.27 No.1

Purpose: This study was designed to evaluate the effectiveness and prognostic factors for patients treated with postoperative radiation therapy following surgery or with radiation therapy alone for squamous cell carcinoma of the esophagus. Materials and Methods: We retrospectively analyzed 132 esophageal cancer patients treated with postoperative radiation therapy following surgery or patients who were treated with radiation therapy alone at our institution from 1989 to 2006. Thirty-five patients had stage II disease, 88 patients had stage III disease and nine patients had stage IV disease. Tumors were located at the upper esophagus in 18 patients, the mid esophagus in 81 patients and the distal esophagus in 33 patients. Sixty patients were treated with radiation therapy alone and 72 patients were treated with postoperative radiation therapy following surgery. Eight patients received a dose less than 40 Gy and 78 patients received a dose of 40 to 50 Gy. The remaining 46 patients received a dose of 50 to 60 Gy. The majority of patients who underwent postoperative radiation therapy received a dose of 45 Gy. Results: Actuarial survival rates for all of the patients at two years and five years were 24% and 5%, respectively. The median survival time was 11 months. Survival rates for patients who underwent postoperative RT at two years and five years were 29% and 8%, respectively. The corresponding survival rates for patients who received radiation alone were 18% and 2%, respectively. Survival rates at two years and five years were 43% and 15% for stage II disease, 22% and 2% for stage III disease and 0% and 0% for stage IV disease, respectively; these findings were statistically significant. Two-year survival rates for patients with upper, middle and distal esophageal cancer were 19, 29% and 22%, respectively. Although there was a trend of slightly better survival for middle esophageal tumors, this finding was not statistically significant. Complete response to radiation was achieved in 13 patients (22%) and partial response to radiation was achieved in 40 patients (67%) who received radiation alone. No response to radiation was noted in seven patients (12%). A statistically significant difference in survival rates was seen between patients that had a complete response and patients that had a partial response. Two-year survival rates for patients that had a complete response versus patients that had a partial response were 31% and 17%, respectively. There were no survivors for patients with no response as determined at two-year follow-up. Conclusion: We conclude that radiation therapy is an effective treatment for esophageal cancer. Stage and response to radiation therapy were noted to be prognostic factors. A more effective treatment modality is needed to improve long term survival because of the relatively dismal prognosis for this tumor