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박상서 한국융합보안학회 2007 융합보안 논문지 Vol.7 No.3
정보보안의 중요성에 관한 인식이 증가함에 따라 다양한 보안대책이 조직에 도입되고 있다. 하지만 대부분의 경우 이들 보안대책은 전략적으로 운영되지 않고 있다. 따라서 본 논문은 조직에서의 정보보안 전략은 무엇인가에 대해 개념적으로 연구한다. 이를 위하여 다양한 문헌에서 정보보안 전략이 어떻게 소개되었으며, 어떠한 전략이 제시되어 왔는지 연구한다. 본 논문은 조직의 정보보안에 있어서의 전략 자체에 초점을 맞추어, 개념을 정립하고, 지금까지 제시되어 온 다양한 전략을 식별하여 체계적으로 분류하였다는데 의의가 있다. As the importance of information security increases, organizations are employing various security countermeasures into their information systems. However, they are not being adapted based on a strategic framework. Therefore this paper researches on the concept of the strategy in organizational information This paper studies literatures to find out how information security strategies have been discussed and what types of them have been until now. This paper contributes to the formation of concept of strategy and classification of them by focusing on strategies them-selves in organizational information security.
박상서,김창주,김성현,김태운,이삼준 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.S2
Purpose: Wnt pathway is closely related to neurodevelopmental process associated with cognitive function. After administration of valproic acid to the pregnant mice, the effect of swimming exercise of pregnant mice on the memory, neuronal production, and apoptosis of pups was studied in relation with Wnt/β-catenin signaling pathway. Methods: On day 12 of pregnancy, mice were injected subcutaneously with 400-mg/kg valproic acid. The pregnant mice in the control with swimming exercise group and in the valproic acid injection with swimming exercise group were allowed for swimming for 30 minutes one time per a day, repeated 5 days per a week, during 3 weeks. Step-through avoidance task and Morris water maze task for memory function, immunohistochemistry for 5-bromo-2’-deoxyuridine (BrdU)-positive cells and western blot for brain-derived neurotrophic factor (BDNF), Wnt, β-catenin, Bcl-2 related X protein (Bax), B-cell lymphoma 2 (Bcl-2), cleaved caspase-3 were carried out. Results: Maternal swimming exercise during pregnancy improved memory function, increased BDNF expression, and neuronal proliferation in the valproic acid injected pups. Maternal swimming exercise during pregnancy suppressed Wnt expression and phosphorylation of β-catenin in the valproic acid injected pups. Maternal swimming exercise inhibited Bax and cleaved caspase-3 expression and increased Bcl-2 expression in the valproic acid injected pups. Conclusions: Maternal swimming exercise during pregnancy improved memory function by increasing cell proliferation and inhibiting apoptosis through Wnt/β-catenin signaling cascade activation in the valproic acid injected pups. Maternal swimming exercise during pregnancy may have a protective effect on factors that induce autism in the fetus.
박상서,박혜상,정형모,곽효범,노미현,허준원,유수지,김태운 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.S1
Purpose: Chemotherapy is associated with the side effects including damage to the mitochondrial DNA. Doxorubicin (DOX) serves as a chemotherapeutic agent for the patients with breast cancer or prostate cancer. DOX causes muscle weakness and fatigue. We investigated the effects of treadmill exercise on DOX-induced apoptosis and mitochondrial dysfunction in relation to central fatigue. For this study, we used the rat model of DOX-induced muscle damage. Methods: DOX (2 mg/kg) was intraperitoneally injected 1 time per week for 4 weeks. Treadmill running continued 5 days per week for 4 weeks. Muscle strength and fatigue index in the gastrocnemius were measured. Immunohistochemistry for the expressions of tryptophan hydroxylase (TPH) and 5-hydroxytryptamine (5-HT) in the dorsal raphe was conducted. We used western blot analysis for the expressions of Bax, Bcl-2, and caspases-3 in the gastrocnemius. Mitochondrial function in the gastrocnemius was also evaluated. Results: DOX treatment decreased muscle strength with increase of fatigue index in the gastrocnemius. Mitochondria function was deteriorated and apoptosis in the gastrocnemius was enhanced by DOX treatment. Expressions of TPH and 5-HT in the dorsal raphe were increased by DOX treatment. Treadmill exercise attenuated DOX-induced muscle fatigue and impairment of mitochondria function. Apoptosis in the gastrocnemius was inhibited and over-expression of TPH and 5-HT was suppressed by treadmill exercise. Conclusions: Apoptosis was enhanced and mitochondria function was deteriorated by DOX treatment, resulting in muscle weakness and central fatigue. Treadmill exercise suppressed apoptosis and prevented deterioration of mitochondria function in muscle, resulting in alleviation of muscle weakness and central fatigue during DOX therapy.