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장희종,정재일,김명찬,조동휘,조동식,이상훈,김시우,차성철,조유진,석윤철,기승석,강행지 대한소화기내시경학회 2005 Clinical Endoscopy Vol.31 No.6
Enteritis cystica profunda (ECP) is characterized by mucin-filled cystic spaces that are partially lined by non-neoplastic columnar epithelium, and these are found in the wall of the small bowel. This is a very rare disease compared to cystica profunda involving the stomach or colon. The cause of ECP is still unclear. Most ECP is related to or it may accompany other intestinal diseases. We encountered one case of ECP of the duodenal bulb that presented as polyp, and this was not related to adenocarcinoma or any other intestinal diseases like Crohn's disease or ulcerative colitis. Endoscopic polypectomy was done and the ECP was later confirmed through histological evaluation. 심재성 낭종성 장염(enteritis cystica profunda, ECP)은 매우 드문 질환으로 성숙된 선상피가 점막하층까지 침윤하여 낭종을 형성하며 대부분 동반질환이 있는 것으로 알려졌다. 저자들은 고혈압 외에 특별한 질병 없이 건강히 지내던 환자에서 우연히 발견된, 십이지장 구부에 용종 형태로 발병한 ECP 1예를 경험하였기에 보고하는 바이다.
Osteoma of Paranasal Sinuses with a Report of Ten Cases
장희종,이봉재,김재호,이광선 대한비과학회 1995 Journal of rhinology Vol.2 No.1
The osteoma of the paranasal sinus is a relatively rare but most common disease among the benign neoplasms in the paranasal sinus. It frequently occurs in relatively young men, and the frontal sinus is known to be the most common site of involvement and then the ethmoid, maxillary, and sphenoid sinus in the order of frequency. The authors experienced 10 cases of osteoma of the paranasal sinuses ; frontal sinus in 3 cases, ethmoid sinus in 4 cases, and maxillary sinus in 3 cases, during the period of recent 6 years. We retrospectively reviewed the medical records, X-ray films and pathological specimens of 10 patients with osteoma in the paranasal sinuses. The age range of patients was between twenties and fifties and the male to female ratio was 7:3. Only two patients complained osteoma-specific symptoms such as frontal headache or exophthalmos, but the other eight cases were incidentally detected on CT films which were taken preoperatively for the operation of chronic sinusitis. One case of frontal sinus osteoma was managed via unilateral osteoplastic frontal sinus operation and another case of osteoma involving orbit and ethmoid sinus was operated via external ethmoidectomy approach with reconstruction of the medial orbital wall using remodeled middle turbinate. The other eight osteomas were removed during the endoscopic sinus operations or Caldwell-Luc’s operations for the treatment of chronic sinusitis. All the patients have been doing well postoperatively without any complications.
기니픽의 전정기관 감각유모세포에 대한 Aminoglycoside의 영향
장희종,이광선 울산대학교 의과대학 1995 울산의대학술지 Vol.4 No.2
Experimental studies about the effects of various ototoxic drugs were performed by many authors, and among them antibiotic aminoglycoside-related ototoxicity has been widely studied. The histopathology of aminoglycoside ototoxicity has been relatively well described, but still many aspects are remained to be revealed and especially domestic studies are very insufficient. The authors applied small amount of gentamicin(GM) and streptomycin(SM) to the guinea pig through the fenestration of lateral semicircular canal, and sacrificed the animals at 4th and 8th weeks postoperatively. The authors performed in vivo fixation with 1% osmium tetroxide and post-fixation with modified Karnovsky's fixative. The three semicircular canals were obtained by microdissection. The cristae ampullares were embedded in the Immunobed kit and cut with the thickness of 2㎛ by Reichert-Jung Supercut. The mid-portions of each crista ampullaris were collected and stained with Hematoxylin and Eosin. The mounted slides were analyzed under light microscope with the image analyzer system. The results are as follow ; The distribution of sensory hair cells, especially type I cells showed a tendency to decrease in general, and was statistically significantly reduced in GM 8-week group. The areas of the epithelial layer and sensory cells also showed a tendency to decrease, but not so much extent as the decrease of cell numbers. The distribution and area of supporting cells didn't show a big difference between each group, but showed a statistically significant reduction in GM 8-week group. In conclusion, the crista ampullaris resulted in the loss of sensory hair and degenerative cell changes after aminoglycoside application. The numbers of hair cell had a decreasing tendency generally. The result of supporting cell reduction in one group should be further discussed. These results are thought to be a useful data for the study of vestibular pathophysiology induced by ototoxic drugs.
정재일,장희종,이상훈,조동식,김시우,차성철,조유진,석윤철,구진회,강행지 대한소화기내시경학회 2006 Clinical Endoscopy Vol.33 No.4
Duodenal abscess is a rarely reported disease throughout the entire world. Duodenal abscesses are developed mostly from the complication of duodenal ulcer perforation, and only small percentage of duodenal abscesses are the result of cholecysto-duodenal fistula which was made by gall bladder perforation. We report a 84-year-old male patient who presented to the emergency department with severe anorexia and generalized weakness for 2 weeks. The upper gastrointestinal endoscopy done and revealed a protruding mass at the lesser curvature of the duodenal bulb. As soon as the mass was punched with a biopsy forceps, a large amount of abscess began to pour out into the intestinal lumen. Abdominal CT scan demonstrated the presence of an air-fluid level the in gall bladder and also abscess in the porta hepatitis which was located between the gall bladder and the duodenum. Because the patient refused any surgical intervention, we treated him conservatively with intravenous antibiotics. Patient's symptom of anorexia was slowly resolved, and patient was discharged 10 days later. (Korean J Gastrointest Endosc 2006;33:235-238) 십이지장 농양은 십이지장 궤양의 천공으로 발생하거나 담낭염으로 인한 간 문맥 주위 농양의 십이지장과의 누공형성으로 파급되어 발생하는 것으로 알려져 있으며 전 세계적으로도 드문 질환이다. 일반적인 급성 궤양성 천공이나 담낭염과 다른 비 특이적 증상및 방사선 소견을 보이는 경우가 많아 진단이 늦어지기도 하며 치료는 배농술을 포함한 수술적 처치를 주로 시행한다. 저자 등은 심한 전신쇠약과 식욕부진을 주소로 내원한 환자에게서 담낭염으로 인하여 발생한 것으로 추정되는 간 문맥 주위 농양에서 파급된 속발성 십이지장 구부 농양을 상부 위장관 내시경 검사를 통해 확인하고 수술 치료를 할수 없는 상황에서 내시경 배액술 및 항생제 정주를 통해서 임상경과의 호전을 경험하였기에 보고하는 바이다.