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      • KCI등재후보

        보골지(補骨脂)의 Peroxynitrite 제거 기전

        장용석,민건우,정지천,Jang, Yong-Suk,Min, Gun-Woo,Jeong, Ji-Cheon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

        Objective : Peroxynitrite $(ONOO^-)$, formed from the reaction of $O_2^-$ and NO, is a cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA. It has been implicated in the aging process and age-related disease such as Alzheimer's disease, rheumatoid arthritis, cancer and atherosclerosis. The aim of this study was to investigate scavenging activities of $ONOO^-$ and its precursors. NO and $O_2^-$ and its scavenging mechanism using fluorescent probes, DCFDA, DAF-2 and DHR 123.. Methods : Psoralea corylifolia was crushed. The crushed Psoralea corylifolia was extracted 3 times, each time with 3 volumes of methyl alcohol at $60^{\circ}C$ for 24 h. The extract was filtered and evaporated under reduced pressured using a rotary evaporator to yield 16g. This was done to investigate scavenging activities of $ONOO^-$, NO, $O_2^-$ and its scavenging mechanism using fluorescent probes, DCFDA, DAF-2 and DHR 123. Results : After Psoralea corylifolia was added authentic $ONOO^-,\;{\cdot}\;O_2^-$ and NO was markedly scavenged. Also, $ONOO^-$ induced by $O_2^-$ and NO (these derived from SIN-1) was inhibited. The data showed a decrease in $ONOO^-$ mediated nitration of tyrosine through electron donation after Psoralea corylifolia was added. Data showed a dose-dependent correlation with inhibition of nitration of bovine serum albumin induced by $ONOO^-$, Furtheremore, LPS-induced ROS and RNS generation was blocked. Conclusions: These results suggest potential for use of Psoralea corylifolia as an effective $ONOO^-$ scavenger to counter the aging process and age-related diseases.

      • KCI등재

        Notes on Unrecorded Fleshy Fungi of Cordyceps in Korea

        장용석,홍순우,Jang, Yong-Suk,Hong, Soon-Woo The Korean Society of Mycology 1986 韓國菌學會誌 Vol.14 No.1

        동충하초 속에 속하는 균류로 여겨지는 40여 개체의 표본을 관찰한 결과 6종의 한국산 미기록종이 동정되었기에 보고하는 바이다. 미기록 종은 벌유충 동충하초(Cordyceps alboperitheciata), 파리 동충하초(Cordyceps discoideocapitata), 균핵 동충하초(Cordyceps intermedia), 검은 동충하초(Cordyceps nigrella), 붉은 동충하초(Cordyceps roseostromata), 딱정벌레 동충하초(Cordyceps scarabaeicola) 등이다. 여기에 인용된 표본은 서울대학교 미생물학과 표본실에 보관되어 있다. More than 40 samples of the genus Cordyceps were collected and investigated. Among them, six species were confirmed as unrecorded ones in Korea. Unrecorded species were Cordyceps alboperitheciata, Cordyceps discoideocapitata, Cordyceps intermedia, Cordyceps nigrella, Cordyceps roseostromata and Cordyceps scarabaeicola.

      • KCI등재

        간이정신진단검사를 이용한 구강작열감 환자의 심리학적 분석

        장용석,태일호,고명연,안용우,Jang, Yong-Seok,Tae, Il-Ho,Ko, Myung-Yun,Ahn, Yong-Woo 대한안면통증구강내과학회 2008 Journal of Oral Medicine and Pain Vol.33 No.1

        Personality characteristics of BMS patients were alalyzed psychologically by using the SCL-90-R. 59 BMS patient were subjected at Orofacial pain clinic, Department Of Oral Medicine, Pusan National University Hospital during the period from 2006 to 2007. The control group were subjected at dental clinic during the same period. 1. BMS patients group, Dental new patient group, Adult citizen groups were within normal range. 2. The T-scores of HOS, PHOB,PAR, PSY in BMS patient groups was significantly low. 3. The mean T-scores of male in BMS patients group shows the lowest HOS scale, the mean T-scores of female in BMS patient group shows the lowest PHOB scale. 4. The mean T-scores of female in BMS patients group show higher SOM, O-C, DEP, ANX, PSY scales. 5. As compared with the mean T-scores of acute and chronic group in BMS patients, there was no significant difference of the scales.

      • KCI등재

        3D 변형가능 형상 모델 기반 3D 얼굴 모델링

        장용석(Yong-Suk Jang),정선태(Sun-Tae Chung),김부균(Boo-Gyoun Kim),조성원(Seongwon Cho) 한국콘텐츠학회 2008 한국콘텐츠학회논문지 Vol.8 No.1

        3D 얼굴 모델링은 3D 공간에서 얼굴을 자유롭게 회전 시켜 다양한 얼굴 자세를 표현하고 조명 효과도 적절하게 모델링 할 수 있으므로, 얼굴 자세, 조명, 표정 등의 표현에 있어서 2D 얼굴 모델링에 비해 보다 정교하며 사실감이 뛰어나 얼굴 인식, 게임, 아바타 등에서 많은 요구가 존재한다. 본 논문에서는 3D 변형 가능 형상 모델에 기반을 둔 3D 얼굴 모델링 방법을 제안한다. 제안된 3D 얼굴 모델링 방법은 먼저 3D 스캐너를 통하여 획득한 3D 얼굴 스캔 데이터를 이용하여 3D 얼굴 변형 가능 형상 모델을 구축한다. 다음, 3D 얼굴 모델링을 하고자 하는 얼굴의 2D 이미지 시퀀스로부터, 해당 얼굴의 특징점들을 검출하고 이들을 매칭하여, 매칭된 특징점들로부터 인수분해 기반 SfM 기법을 이용하여 해당 특징점의 3D 버텍스 좌표 값을 구한다. 이후, 구한 3D 버텍스들을 3D 변형 가능 형상 모델에 정합하여 해당 얼굴의 3D 형상모델을 얻는다. 또한, 2D 얼굴 이미지 시퀀스들로부터 뷰 독립적인 2D 원통 좌표 텍스쳐 맵을 구하고 이를 이용하여 3D 형상 모델을 렌더링 함으로써, 최종적으로 3D 얼굴 모델을 완성한다. 제안된 3D 얼굴 모델링 방법에 의한 3D 얼굴 모델 생성 과정을 통해서, 본 논문에서 제안한 3D 얼굴 모델링 방법이 기존의 얼굴 모델링 방법들에 비해 상대적으로 빠르고 비교적 정교하게 수행됨을 볼 수 있었다. Since 3D face can be rotated freely in 3D space and illumination effects can be modeled properly, 3D face modeling is more precise and realistic in face pose, illumination, and expression than 2D face modeling. Thus, 3D modeling is necessitated much in face recognition, game, avatar, and etc. In this paper, we propose a 3D face modeling method based on 3D morphable shape modeling. The proposed 3D modeling method first constructs a 3D morphable shape model out of 3D face scan data obtained using a 3D scanner. Next, the proposed method extracts and matches feature points of the face from 2D image sequence containing a face to be modeled, and then estimates 3D vertex coordinates of the feature points using a factorization based SfM technique. Then, the proposed method obtains a 3D shape model of the face to be modeled by fitting the 3D vertices to the constructed 3D morphable shape model. Also, the proposed method makes a cylindrical texture map using 2D face image sequence. Finally, the proposed method builds a 3D face model by rendering the 3D face shape model with the cylindrical texture map. Through building processes of 3D face model by the proposed method, it is shown that the proposed method is relatively easy, fast and precise than the previous 3D face model methods.

      • NVH와 내구성능을 고려한 엔진마운팅 목표전개기법 최적 컨셉설계

        장용석(YongSok Jang),유승원(SeungWon Yoo),장홍석(HongSuk Chang),박종찬(Jong Chan Park) 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6

        Rubbers of vehicle engine mounting are attached at the engine that contributes the biggest vibrating energy. To design the engine mounting, NVH and durability performances are important, but those mostly conflict with each other. To solve this challenging task, Analytical Target Cascading optimization algorithm was used. Engine mtg. system was divided to dynamic solution and durability solution. To connect these two functional differences, rubbers’ stiffness was calculated individually from dynamic solver and FEM solver. And then the Analytical Target Cascading optimized the engine mtg. reducing the difference between them. To avoid abandonment due to late solution, Meta modeling was derived from design of experiment analysis. As a result, the optimized design became to satisfy both NVH and durability performance target.

      • KCI등재후보

        林堂遺蹟의 空間構成과 그 變化

        장용석(Jang, Yong-Suk) 한국상고사학회 2002 한국상고사학보 Vol.37 No.-

        본고는 임당유적에서 조사된 분묘, 방어시설 및 생활유적을 통하여 이들 유적들이 어떻게 공간을 구성하고 있으며, 시간의 흐름에 따라 어떠한 변화과정을 나타내는지, 그리고 공간구성이 나타내는 의미가 무엇인지를 살펴보는 것이 목적이다. 따라서 이상을 요약하면 다음과 같다. 먼저, 임당유적의 성립은 목관묘단계부터이며, 유적의 형성직후부터 경산지역을 대표하는 중심유적으로 발전하였다. 둘째, 분묘요구는 목관묘단계, 목곽묘단계, 고총고분단계로 구분하였으며, 각 단계별로 분묘군의 입지가 변화함을 확인하였다. 즉 목관묘단계는 유적의 서쪽과 중앙에서 동쪽으로, 목곽묘단계는 동쪽과 중앙에서 서쪽으로, 고총고분단계는 서쪽과 중앙에서 동쪽으로 변화하였다. 이러한 변화현상이 일률적으로 나타나는 원인은 임당유적을 형성한 집단이 아닌 하나의 집단임을 나타내는 자료로 판단된다. 셋째, 방어시설은 원삼국시대의 환호와 삼국시대의 토성으로 구분된다. 환호시설은 대규모의 토목공사인 점을 생각하면 그 자체만으로도 중심취락의 존재를 반영하고 있으며, 토성의 축조(A.D. 4C 전반~A.D. 4C 중반)는 강력한 정치체의 출현시점으로 볼 수 있으며, 이때부터 임당유적은 국읍으로 성장하기 시작하였다. 넷째, 취락시설은 F지구와 I지구에서 조사되었으며, F지구는 토성의 설치로 인하여 3C 후반에 취락의 설치가 종료된다. 취락의 설치가 종료된 후 이곳에는 토성이 축조되었다. 그리고 I지구는 계속적으로 취락지로 사용되다 6C 중반 이후에는 중심취락지구로 발전하였다. The pater is intended to know how the site make up space, how they are transformed as time goes, and what the space-construction means, through the site of life, institutions of defense, and tombs investigated in Limdang Site in Kyoungsan. The summary is as follows. 1. Limdang Site are formed from a step of wooden coffin tombs and developed into a center of site on the behalf of Kyoungsan region soon after the formation of the site. 2. The tomb-bodies are divided into wooden coffin tomb step, wood chambered tomb step, and high mound tombs step. It is confirmed that the location of tombs group are transformed according to each step. Namely, wooden coffin tombs step is form the west and the center into the east, wood chambered tombs step is form the east and the center into the west, high mound tombs step is form the west and the center into the west. It is judged that the reason this is presented unifdrmly is that the group that formed Limdang Site is not different but same. 3. An institution of defense is classified into a ditch enclosure of Proto-Three Kingdom Period and a mud wall of Three Kingdom Period. An institution of the ditch enclosure itself is a mirrow of the existence of the central-settlement in considerations of engineering public works on a large scale, the mud wall structure(A.D. 4C the first A.D. 4C mid) is considered as a point of time of appearance of a strong political system. Form this time, Limdang Site started to be developed into a main village-town. 4. the institution of settlement is investigated in F region and I region. In F region is finished the establishment of settlement in the late of 3C because of the establishment of a mud wall. And then the mud wall is builded. I region continues to be used as the settlement-region and is developed into a central settlement region after the middle of 6C.

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