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      • 선형가속기의 다엽콜리메이터 형태에 따른 치료계획 비교 평가

        임지혜,장남준,석진용,정윤주,원희수,정해윤,최병돈,Lim, Ji Hye,Chang, Nam Joon,Seok, Jin Yong,Jung, Yun Ju,Won, Hui Su,Jung, Hae Youn,Choi, Byeong Don 대한방사선치료학회 2018 대한방사선치료학회지 Vol.30 No.1

        목 적 : 임상적으로 많이 시행하는 치료부위에 고차원 치료기법 적용 시 선형가속기에 장착된 다엽콜리메이터(Multi leaf collimator, MLC)의 형태가 치료계획에 미치는 영향을 연구해 보고자 한다. 대상 및 방법 : 본원에서 척추암, 폐암 정위적체부방사선치료(Stereotactic body radiation therapy, SBRT)를 받은 환자와 전립선암, 폐암, 두경부암, 전골반암, 유방암의 용적변조회전치료(Volumetric modulated arc therapy, VMAT)를 시행한 환자들을 부위별로 10명씩 총 70명 선정하였다. Truebeam STx(Varian Medical system, Palo Alto, CA)의 high definition MLC(HD MLC)와 Vitalbeam(Varian Medical system, Palo Alto, CA)에 장착된 millenium MLC(M MLC)를 사용하였고, 치료계획은 Eclipse(Version 13.7, Varian Palo Alto USA, CA)를 이용하여 동일한 조건으로 환자마다 각각 2개씩 수립하였다. MLC의 형태에 따른 치료계획을 평가하기 위해 PTV coverage, conformity index(CI), homogeneity index(HI)를 비교하였고, 정상조직은 각 부위별로 임상에서 사용하는 평가 지표를 분석하였으며, 정상조직에서 저 선량 영역을 비교하기 위하여 $V_{30%}$을 평가하였다. 추가적으로 각 부위별로 치료표적의 길이 및 체적을 조사하였다. 결 과 : PTV coverage는 HD MLC를 적용한 폐암 SBRT에서 평균선량이 0.52 %, 척추암 SBRT에서 평균 선량과 최대선량이 각각 0.68 %, 1.13 %로 M MLC에 비해 감소하였다. CI와 HI는 척추암 SBRT 치료계획에서 HD MLC가 1.144, 1.079로 M MLC의 1.160, 1.092 보다 낮은 수치를 나타냈다(p<0.05). 결정장기의 선량 평가는 폐암 SBRT 치료계획에서 치료받는 쪽 폐의 평균선량이 HD MLC에서 1.48 %로 낮아졌다. 전립선암 VMAT은 HD MLC를 적용한 치료계획에서 방광의 $V_{30}$과 평균선량이 0.53 %, 1.42 %, 직장의 $V_{25}$와 평균선량이 0.97 %, 0.69 %로 감소하였다(p<0.05). 유방암 VMAT은 오히려 HD MLC를 사용한 치료계획에서 심장의 평균선량이 0.83 %로 높아졌다. 다른 치료부위 평가지표들은 두 MLC를 적용한 치료계획 사이에 큰 차이를 보이지 않았다(p>0.05). 결 론 : 본 연구 결과 SBRT나 전립선암 VMAT과 같이 치료표적의 길이가 짧고 크기가 작은 경우 HD MLC를 사용하는 것이 PTV coverage 및 정상조직 보호 효과 면에서 다소 이점이 있는 것으로 나타났으나, 그 외 상대적으로 길고, 큰 폐암, 두경부암, 전골반암, 유방암 VMAT에서는 MLC의 형태가 치료계획에 미치는 영향은 크지 않았다. Purpose : An aim of this study was to compare the effect of multi leaf collimator(MLC) types for high dimension radiotherapy in treatment sites used clinically. Material and Method : 70 patients with lung cancer, spine cancer, prostate cancer, whole pelvis, head and neck, breast cancer were included in this study. High definition(HD) MLC of TrueBeam STx (Varian Medical system, Palo Alto, CA) and millenium(M) MLC of VitalBeam (Varian Medical system, Palo Alto, CA) were used. Radiotherapy plans were performed for each patient under same treatment goals with Eclipse (Version 13.7, Varian Palo Alto USA, CA). To compare the indicators of the radiotherapy plans, planning target volume(PTV) coverage, conformity index(CI), homogeneity index(HI), and clinical indicators for each treatment sites in normal tissues were evaluated. To evaluate low dose distribution, $V_{30%}$ values were compared according to MLC types. Additionally, length and volume of targets for each treatment sites were investigated. Result : In stereotatictic body radiotherapy(SBRT) plan for lung, the average value of PTV coverage was reduced by 0.52 % with HD MLC. With SBRT plan using HD MLC for spine, the average value of PTV coverage decreased by 0.63 % and maximum dose decreased by 1.13 %. In the test of CI and HI, the values in SBRT plan with HD MLC for spine were 1.144, 1.079 and the values using M MLC were 1.160, 1.092 in SBRT plan for lung, The dose evaluation of critical organ was reduced by 1.48 % in the ipsilateral lung mean dose with HD MLC. In prostate cancer volumetric modulated arc therapy(VMAT) with HD MLC, the mean dose and the $V_{30}$ of bladder and the mean dose and the $V_{25}$ of rectum were reduced by 0.53 %, 1.42 %, 0.97 %, and 0.69 %, respectively (p<0.05). The average value of heart mean dose was reduced by 0.83 % in breast cancer VMAT with M MLC. Other assessment indices for treatment sites showed no significant difference between treatment plans with two types of MLC. Conclusion : Using HD MLC had a positive impact on the PTV coverage and normal tissue sparing in usually short or small targets such as lung and spine SBRT and prostate VMAT. But, there was no significant difference in targets with long and large such as lung, head and neck, and whole pelvis for VMAT.

      • KCI등재

        Human Paraoxonase 1(PON1)의 유전자 다형성에 따른 중풍환자의 습담 변증과의 상관성 연구

        임지혜,고미미,이정섭,방옥선,차민호,Lim, Ji-Hye,Ko, Mi-Mi,Lee, Jung-Sup,Bang, Ok-Sun,Cha, Min-Ho 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.4

        Objective : In the present study, we investigated genetic distribution of eight single nucleotide polymorphisms of PON1 between Dampness and Phlegm and non Dampness and Phlegm pattern identification(PI) among Korean stroke patients. Materials and Methods : One hundred forty stroke subject without Dampness and Phlegm and fifty eight stroke subjects with Dampness and Phlegm were participated in this study. After informed consents, eight single nucleotide polymorphisms(SNPs) in PON1 of each subjects were identified by DNA sequencing and primer extension method and statistical analysis was performed to determine the significant difference between Dampness and Phlegm and non Dampness and Phlegm groups. Results : Among anthropometric characteristics and blood parameters, waist circumference and total cholesterol were significantly higher in Dampness and Phlegm. Among 8 SNPs of PON1, frequency of M allele and subjects with M allele in L55M SNP were significantly higher in Dampness and Phlegm group (p=0.0032 and p=0.0053, respectively) but subjects with T allele in C-2033T SNP were lower in Dampness and Phlegm group(p=0.0302). Effect of L55M and C-2033T on Dampness and Phlegm were 3.07% and 1.75%, respectively. Conclusion : Our results suggest that L55M SNP in exon and C-2033T in promoter region of PON1 maybe affect to Dampness and Phlegm pattern identification. However, further study should be carried out to find out the detailed mechanism how L55M and C-2033T can affect Dampness and Phlegm stroke patients.

      • KCI등재

        팬을 부착한 이중외피의 이론적 검토 및 적용성에 대한 실험 연구

        임지혜(Ji Hye Lim),손장열(Jang Yeul Sohn) 대한설비공학회 2010 설비공학 논문집 Vol.22 No.9

        Double skin facade(DSF) ventilated by fans consists of a normal external and an internal envelope. In this glass layer, the installed fan replaces an air inlet for the control of air flow through the cavity. The purpose of this paper is to investigate physical theory and to analyze the applicability of fans installed in a DSF. The experiment was conducted in 2 rooms. One room has a DSF with installed fans and the other one has a typical window. The room ventilated through a DSF which fans are installed was always kept warmer than the other room, ventilated directly from the outdoors. The average increase of the supplied air temperature through the DSF ventilated by fans was 6.54℃ at 78CMH, 6.2℃ at 95CMH, and 3.7℃ at 120CMH. As a result, the DSF with installed fans was appropriate for installation in rooms. It supplies outdoor fresh air heated through a cavity and ventilates a constant air volume.

      • KCI등재후보

        지역 마케팅 홍보물에 나타난 지역 정체성 연구

        임지혜(Lim Ji-hye),윤희진(Yun Hee-jin) 한국문화산업학회 2010 문화산업연구 Vol.10 No.2

        Region began to be regarded as a target of Business management. This phenomenon is that a region considered as the product. This has provoked a new movement as the place marketing. In this study, as a regional communications strategy, I analyzed local marketing promotions for place identity, Comparingregional characteristics, I identified the relationship between it and the regional policy. Regional policies and regional promotions, if the information matches, Regional identity has been properly implemented, will be able to see. For this purpose, collected in 2009 in Incheon International Trade fair, promotions, and compare the contents of the policy areas. In terms of regional identity, local promotions and local policies did not match. Each region must try to maintain a consistent identity in the areas of policy and administration and marketing. Region began to be regarded as a target of Business management. This phenomenon is that a region considered as the product. This has provoked a new movement as the place marketing. In this study, as a regional communications strategy, I analyzed local marketing promotions for place identity, Comparingregional characteristics, I identified the relationship between it and the regional policy. Regional policies and regional promotions, if the information matches, Regional identity has been properly implemented, will be able to see. For this purpose, collected in 2009 in Incheon International Trade fair, promotions, and compare the contents of the policy areas. In terms of regional identity, local promotions and local policies did not match. Each region must try to maintain a consistent identity in the areas of policy and administration and marketing.

      • KCI등재
      • KCI등재

        풍속이 사과나무의 광합성 특성과 수액이동 및 엽손상에 미치는 영향

        임지혜 ( Ji Hye Yim ),최영민 ( Young Min Choi ),최동근 ( Dong Geun Choi ) 한국농림기상학회 2014 한국농림기상학회지 Vol.16 No.2

        This study was carried out to determine the effects of wind speed on physiological responses in ‘Fuji’ apple (Malus pumila Miller). Two levels of wind blowing (3 and 5 m·s-1) were produced by large electric fans. Photosynthetic rate was reduced by one-way wind blowing treatment at 5 m·s-1, compared to the mild wind control, and this reduction was more obvious with stronger wind and increasing duration of wind application. The reduction in photosynthesis by the wind treatments was correlated with that in the proportion of opened stomates and stomatal conductance. The one-way wind treatment at 5 m·s-1 caused a leaf browning and leaf fall, and this negative effect became more serious with increasing time of exposure to the wind treatments. The sap flux through stem increased in all wind treatments compared to the natural mild wind.

      • 사르트르의『존재와 무』에서 ‘우리들’에 관한 고찰

        임지혜(Rim Ji-Hye) 경북대학교 인문학술원 2008 동서사상 Vol.5 No.-

        사르트르는 후설에 의해 주창된 현상학적 방법을 통해 인간과 세계에 대해 이해하려 하였다. 특별히 그의 전기 저작으로 대표되는 존재와 무 에서 사르트르는 가능성을 가진 인간실재의 존재방식에 관한 연구와 더불어 그만의 독특한 타자론을 전개시키고 있다. 구체적인 타자와의 관계들 가운데, 인간은 ‘우리들’이라는 특수한 존재방식을 통하여 개인의 주체성이 살아있는 연대를 형성할 수 있다. 이렇게 형성된 ‘우리들’에 의해 언어는 그 성공의 가능성이 열리게 되며, 이러한 언어관계의 성공은 공동체 내부의 상호소통을 가능하게 한다. ‘우리들’이라는 하나의 연대적인 공동체가 힘을 발휘할 수 있게 되는 것은 바로 이러한 언어관계의 성공에 의해서인 것이다. 현재를 살아가는 우리는 이데올로기의 대립과 투쟁보다는 평화와 공존을 모색하는 시대에 살고 있다. ‘우리들’에 관한 연구는 사르트르의 타자론을 지금까지와는 다른 각도에서 새롭게 조명해 보고, 이 시대에 필요한 진정한 연대와 상호소통이 어떤 것인가에 대한 깊은 성찰을 가능하게 할 것이다. Jean Paul Sartre tried to understanding the human and the world through the phenomenological method by Edmund Husserl. Especially, in his earlier work L'etre et le neant, Sartre investigates the mode of being of human reality with possibility and develops his unique theory of others. Human, in concrete relations with others, human reality can make a solidarity where person's subjectivity is living, with unique mode of being as 'WE'. In this 'WE', language opens to possibility and, this possibility of language makes intercommunication within the community. A solidary community, ‘WE’, is displayed of it's ability by the success of the relationship of these language. Today, We are living in looking for a peace and coexistence than a opposition and conflict of ideology. My investigation of the 'we' is spotlighting newly a theory of others in Sartre, and then make us be able deeply to contemplate what are a real solidarity and intercommunication required in this time.

      • KCI등재

        사회복지전담공무원의 직무특성이 직무만족에 미치는 영향에 관한 연구: `삶의 양식`의 통제 효과를 중심으로

        임지혜 ( Ji-hye Lim ),주재현 ( Jaehyun Joo ) 서울대학교 한국행정연구소 2017 行政論叢 Vol.55 No.1

        본 연구는 사회복지전담공무원의 직무특성이 직무만족에 미치는 영향을 조사하고, 사회복지전담공무원의 `삶의 양식`이 직무특성과 직무만족의 영향관계에서 통제효과를 지니는지를 분석하는 데 목적을 두었다. 이 연구목적을 달성하기 위해 서울과 경기지역의 사회복지전담공무원을 대상으로 설문조사를 실시하였고, 계량적 분석을 통해서 다음과 같은 결과를 얻었다. 첫째, 직무특성의 하위요인 중 기술다양성과 과업정체성이 높을수록 직무만족에 부정적인 영향을 미치며, 과업중요성과 자율성이 높을수록 직무만족에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 같은 업무를 수행하는 사회복지전담공무원이라 하더라도 개인별로 서로 다른 삶의 양식을 지니는 것으로 나타났는데, 다수 사회복지전담공무원의 삶의 양식은 평등주의였고, 다음으로 개인주의가 일정 부분을 구성하고 있었으며, 소수의 계층주의와 운명주의가 존재하였다. 셋째, 삶의 양식 중에서 평등주의가 직무만족에 가장 긍정적인 영향을 미치는 것으로 나타났다. 넷째, 삶의 양식별로 직무특성이 직무만족에 미치는 영향관계에 차이가 있었다. 평등주의자들의 경우 과업중요성이 직무만족에 유의미한 영향을 미쳤으며, 개인주의자들의 경우 자율성이 직무만족에 유의미한 영향을 미쳤다. 이러한 연구결과는 사회복지전담공무원에 대한 이해의 수준을 높여주며, 그들의 직무만족 제고방안을 모색함에 있어 시사하는 바가 큰 것으로 판단된다. This study aimed to examine to what extent the job characteristics of social welfare officials would influence their job satisfaction, and to analyze whether their way of life would have a controlling effects on the relationship between job characteristics and job satisfaction. In order to achieve these purposes, this study conducted a survey of social welfare officials in Seoul and Gyeonggi Province. The results of the quantitative analysis are as follows. First, among the job characteristics of social welfare officials, `skill variety` and `task identity` showed negative effects while `task significance` and `autonomy` showed positive effects on job satisfaction. Second, the main way of life of social welfare officials was egalitarianism. Individualism appeared as the second most common type of way of life among the officials. However, hierarchy and fatalism were only minor ways of life. Third, egalitarianism most positively affected the job satisfaction of social welfare officials. Fourth, the type of way of life made a difference in the pattern of influence of job characteristics on job satisfaction. In the case of egalitarians, `task significance` showed a meaningful causal relationship with job satisfaction. However, `autonomy` showed a meaningful causal relationship with job satisfaction for individualists. These findings could contribute to the understanding of social welfare officials, and to the development of measures for enhancing their job satisfaction.

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