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자음양영탕이 Streptozotocin(STZ)로 유발된 생쥐의 고혈당에 미치는 영향(影響)
이형호,이영수,Lee, Hyung-Ho,Lee, Young-Soo 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.3
Objectives : The aim of this study was to investigate the effect of Jaeumyangyung-tang(滋陰養榮場(JY), JA-0.65g/kg;JB-1.3g/kg) on hyperglycemic mice induced with streptozotocin(STZ). Methods : The experiment operated for 6 weeks. The rats were divided into 3 groups : diabetic group(control group), diabetic group treated with JA(0.65g/kg) for 6 weeks, and diabetic group treated with Jb(1.3g/kg) for 6 weeks. Results : In the STZ-induced diabetic group, blood glucose levels significantly increased as well as the loss of body weight. The levels of serum glucose decreased significantly (p<0.05 or p<0.01) in the JA and JB groups compared with the control. According to a tolerance test, intraperitoneal glucose was ameliorated in the JA and JB groups. The blood urea nitrogen (BUN) and creatinine levels slightly decreased. Histologic analyses of the pancreases revealed that the ${\beta}-cells$ on Langerhans' islets were destroyed by STZ, but the ${\beta}-cell$ mass was larger in the JY than in the control mice. Conclusions : These results indicate that JY can exert beneficial effects on diabetes. preservation of in vivo ${\beta}-cell$ function and regeneration of ${\beta}-cell$ dysfunction by STZ.
Caerulein으로 유발된 흰쥐의 급성 췌장염에 대한 은회반총산(銀茴蟠?散)의 효과
이형호,김인수,신민구,이영수,Lee, Hyung-Ho,Kim, In-Soo,Shin, Min-Gu,Lee, Young-Su 대한한방내과학회 2013 大韓韓方內科學會誌 Vol.34 No.3
Objectives : In this study, we aimed to investigate the effect of Eunhoebanchong-san (EBS) on caerulein-induced acute pancreatitis (AP) by detecting oxidative stress markers and performing histopathological examination. Methods : Thirty adult male Sprague-Dawley rats were divided into five groups as follows: normal (NOR), caerulein-induced (CON), caerulein+EBS (130 mg/kg, EA), caerulein+EBS (260 mg/kg, EB) and caerulein+EBS (520 mg/kg, EC) groups. Pancreatic tissues of rats from all groups were removed for apoptosis, and light, and electron microscopic examination. Blood of rats from all groups was obtained for oxidative stress markers and pathological examination. Pancreatic oxidative stress markers were evaluated by the measurements of serum amylase, and interleukin-6 (IL-6) levels were determined spectrophotometrically. Results : The ratio of pancreas/body weight increased significantly in the CON compared with the NOR, but decreased significantly in the EA, the EB, the EC groups compared with the CON. Caerulein administration resulted in a significant increase in amylase, but EBS reduced the levels of these enzymes. Interleukin-6 (IL-6) levels increased significantly in CON compared with NOR, but reduced in EA, EB, and EC group at 24 hrs. In the observations of optical microscopy and electron microscopy, the experimental groups showed significant decreases in pancreatic tissue inflammation, edema, vacuolization, necrosis compared to the control group. Altogether, this indicates EBS is potentially capable of limiting pancreatic damage produced during AP by restoring the fine structure of acinar cells and tissue. Conclusions : We concluded that EBS may have beneficial effects in the treatment of caerulein-induced AP.
습열리(濕熱痢)로 변증한 궤양성 대장염 환자의 작약탕가미방(芍藥湯加味方) 치험 2례
이형호,최기숙,임동석,유형천,이영수,최창원,김희철,서철훈,Lee, Hyung-Ho,Choi, Ki-Suk,Lim, Dong-Seok,Ryu, Hyung-Chun,Lee, Young-Soo,Choi, Chang-Won,Kim, Hee-Chul,Seo, Chul-Hoon 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.4
Ulcerative colitis, a diffuse inflammatory disease of the mucosal lining of the colon and rectum, is characterized by bloody diarrhea that waxes and wanes without apparent cause. In oriental medicine, Jakyaktang has been used to treat the disease, diagnosed as Damp-Heat dysentery. We prescribed Jakyaktang-gamibang to two patients who had suffered from ulcerative colitis diagnosed as Damp-Heat dysentery. The two patients were treated with Jakyaktang-gamibang and improved in consciousness of symptoms. We suggest that oriental medicine therapy is effective for treatment of ulcerative colitis.
이형호 ( Young Ho Lee ),박진호 ( Jin Ho Park ),김재선 ( Jae Sun Kim ),박영태 ( Young Tae Bak ),이창홍 ( Chang Hong Lee ),김철환 ( Chul Hwan Kim ),채양석 ( Yang Suk Chae ),송관규 ( Gwan Gyu Song ) 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.1
목적: 강직성 척추염 발병기전을 규명하려는 연구의 일환으로 한국인 강직성 척추염 환자에서 장 병변의 유무를 확인하여 강직성 척추염의 발병에 있어서 장 병변의 역할을 알아보고자 하였다. 방법: 강직성 척추염으로 진단받은 24명의 환자를 대상으로 하여 말단 회장부위를 포함한 대장 내시경 및 조직 검사를 시행하였다. 결과: 1) 대장 내시경상 강직성 척추염환자 24명중 Stage 1은 6명(25.0%), Stage 2는 1명(4.2%)으로 총 7명(29.2%)에서 병변이 관찰되었고 이중 5명은 약년형 만석 관절염으로 부터 발병되었으며, 병변위치는 6명(85.7%)은 말단 회장부위에, 1명(14.3%)은 대장에 위치하였다. 2) 조직소견상 Stage 0와 Stage 3는 단 1명도 없었으며 정상소견인 Stage 1은 10명(41.7%), 염증소견인 Stage 2는 14명(58.3%)이었으며, 장염증의 아형으로 급성형을 2명(8.3%), 만성형은 12명(50%)이었다. 3) 말초 관절염이 동반 안된 강직성 척추염 환자에서 급성형은 단 1명도 없었고 만성형은 6명(50%)이었으며, 말초 관절염이 동반된 환자에서는 급성형이 2명(16.7%), 만성형은 6명(50%)으로 말초 관절염이 동반된 환자에서 장병변이 더 많았다. 4) Sulfasalazine을 투여 받지 않은 환자에서 급성형은 1명도 없었고 만성형은 7명(58.3%)이었으며, sulfasalazine을 투여 받은 환자에서는 급성형이 2명(16.7%), 만성형은 5명(41.6%)으로 sulfasalazine 투여 유무에 따른 의의있는 장염증의 차이는 없었다(p=0.31). 결론: 강직성 척추염의 한국인 환자에서도 만성적인 장 병변의 발생 빈도가 외국의 보고와 일치하였으며 이는 한국인에서도 만성적인 장변변이 강직성 척추염의 발병기전에 중요한 역할을 담당할 가능성을 시사하는 소견이다. Objective: To investigate the frequency of gut inflammation in the ankylosing spondylitis and the role of gut lesion in the pathogenesis of the ankylosing spondylitis. Methods: Ileocolonoscopy and biopsy were performed in 24 patients with ankylosing spondylitis. Results: 1) Endoscopic lesions were observed in 7 patients (29.2%) of 24 patients and more often in the terminal ileum (6/7) than in the colon (1/7). Among 7 patients with endoscopic lesions, S patients were presented as juvenile chronic arthritis. 2) Histologic signs of gut inflammation were detected in 14 patients (58.3%). Actue lesions were seen in 2 patients (8.3%) and chronic lesions were seen in 12 patients (50%). 3) In 12 patients without the involvement of peripheral joints, acute lesion was not seen (0%), and chronic lesions were seen in 6 patients (50%). In 12 patients with the involvement of peripheral joints, acute lesions were seen in 2 patients (16.7%), and chronic lesions were seen in 6 patients(50%). Gut inflammations were more frequent in patients with the involvement of peripheral joints than in those without the involvement of peripheral joints. 4) In 12 patients without the administration of sulfasalazine, acute lesion was not seen(0%), and chronic lesions were seen in 7 patients (58.7%) In 12 patients with the administration of sulfasalazine, acute lesions were seen in 2 patients (16.7%), and chronic lesions were seen in 5 patients (41.6%). The frequency of gut lesions in patients without the administration of sulfasalazine was not different from that in patients with the administration of sulfasalazine(p<0.05). Conclusion: Gut inflammation was frequently found in patients with ankylosing spondylitis. Chronic gut inflammation could play a role in the pathogenesis of the ankylosing spondylitis.
이상근(Sang-Keun Lee),이동욱(Dong-Wook Lee),송현직(Hyun-Jig Song),전영주(Young-Ju Jeun),이동헌(Dong-Heon Lee),김이국(E-Guk Kim),이광식(Kwang-Sik Lee),이형호(Hyeong-Ho Lee) 한국조명·전기설비학회 1999 한국조명·전기설비학회 학술대회논문집 Vol.1999 No.-
In this paper, a plate type ozonizer has been designed and manufactured to minimize the size of ozonizer. This ozonizer have following benefits : ① convenience of shift and installation ② maximize space utility. Therefore ozone generation characteristics have been investigated by varying flow rate, supplied voltage and gap spacing of plate electrodes.