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한국형 출혈열 환자에서 병기에 따른 혈중 Atrial Natriuretic Polypeptide 농도의 변화
박정의(Jeong Euy Park),송치욱(Chi Wook Song),송관규(Gwan Gyu Song),표회정(Heui Jung Pyo),박승철(Seung Chull Park),이창홍(Chang Hong Lee),김대원(Dae Won Kim),이갑노(Kap Ro Lee),양영선(Yung Sun Yang),황흥곤(Heung Kon Hwang),문정식(Jung 대한내과학회 1987 대한내과학회지 Vol.33 No.6
N/A The plasma atrial naturiuretic polypeptide (ANP) was repeatedly measured in each clinical phases in 20 patients (20.8±7.2yr) with Korean Hemorrhagic Fever (KHF). The study purpose was to see whether there is any relationship between the clinical course of KHF and the changes of plasma level of ANP. In three patients the plasma ANP could be repeatedly measured from the early oliguric to diruetic phases. In these three patients the plasma level of renin activity and aldosterone were very high in the early oliguric phase. Then the plasma renin activity and aldosterone level decreased steeply in remarkable degree to near normal level while the patient is still in oliguric phase and stayed at this level during the diuretic phase. The plasma ANP level was low (30-80pg/ml) in the early oliguric phase. Then with the sudden remarkable decrease of plasma renin activity and aldosterone the plasma ANP increased rapidly to high level (230-280pg/ml), then was decreased to near normal level (90-190pg/ml) making a narrow peaked plasma ANP concentration curve, and then the level stayed at near normal level during the diuretic phase. Around the time when the plasma renin activity and aldosterone concentrations were decreased to their low level and the plasma ANP was increased to it's peak level the oliguric phase was changed to the diuretic phase. The changes of plasma cortisol level followed the pattern of changes of plasma renin and aldosterone. It is possible that the increase of plasma ANP level might have had some role in the initiation of diuretic phase in these patients. It is not certain whether these changes are the unique changes seen only in patients with KHF or the changes seen also in patients with acute renal failure of other causes.
이창홍(Chang Hong Lee),박영태(Young Tae Bak),김진호(Jin Ho Kim),김재선(Jae Seon Kim),변관수(Kwan Soo byun),권소영(So Young Kwon),목영재(Young Jae Mok),지종대(Jong Dae Ji),김준석(Jun Suk Kim),채양석(Yang Seok Chae) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A In spite of the application of an aggressive surgical approach and the detection of disease in an early stage, the 5-year survival rate of patients with acllvanced gastric cancer is still low. It is well known that the survival of the disease is closely related to TNM classification. But it is not sufficient enough to identify poor prognostic subgroups. Recently substantial evidence suggests that tumor angiogenesis in several types of cancer can be an independent prognostic predicto,. In this study we investigated how tumor angiogenesis in gastric cancer correlated with stage, grade of cell differentiation and survival. We highlighted the vessel by staining their endothelial cells immunocytochemicailly for factor VIII and counted thern in the most dense areas of neovascularization in 46 surgical specimens of advanced gastric cancer. The mean counts in patients with stage I, II and III were 19+- 7.31+-11 and 43+-30 respectively. But microvessel counts did not correlated significantly with grade of cell diifferentiation and survival. In conclusion, the number of microvessels per 200X fielid of light microscope in the areas of the rnost intensive neovasrularization in an advanced gastric cancer may be one predictor that reflects prognosis but needs further study whether it could be an independent prognostic predictor or not.