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위선종, 위선암에서 Bcl-2, Bcl-xL, Bax, p53 단백의 면역조직화학 발현
이동수 ( Dong Soo Lee ),강상범 ( Sang Bum Kang ),백종태 ( Jong Tae Baek ),남순우 ( Soon Woo Nam ),이강문 ( Kang Moon Lee ),안병민 ( Byung Min Ahn ),이은희 ( Eun Hee Lee ),한석원 ( Sok Won Han ),정인식 ( In Sik Chung ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Background/Aims: The aim of this study was to investigate the immunohistochemical expression of bcl-2, bcl-xL, bax, and p53 proteins according to the pathological parameters such as grade of dysplasia, histological type, depth of invasion, lymph node meta
Helicobacter pylori 제균요법 적용의 실태 분석: 단일 기관 연구
정우철 ( Woo Chul Chung ),이강문 ( Kang Moon Lee ),백창렬 ( Chang Nyol Paik ),이정록 ( Jeong Rok Lee ),정성훈 ( Sung Hoon Jung ),김진동 ( Jin Dong Kim ),한석원 ( Sok Won Han ),정인식 ( In Sik Chung ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.4
목적: 현재 H. pylori 제균치료는 소화성 궤양 환자에서만 인정을 받고, 위암이나 위염 환자를 대상으로 적용 범위를 확대 적용하는 것에는 아직 논란의 여지가 있다. 최근 들어 표준 삼제요법의 제균율이 점차 감소하는 경향을 보이며, 이는 항생제 내성의 증가 및 환자의 순응도 감소와 가장 큰 연관이 있으나, 다른 여러 요인들도 제균율에 영향을 미치는 것으로 알려져 있다. 저자들은 진료과에 따른 제균율의 차이가 있는지 알아보기 위해 진료과별 제균치료 현황과 제균율, 그리고 내시경적인 궤양에 대한 적용 빈도를 조사하였다. 대상 및 방법: 2003년 1월부터 2007년 6월까지 가톨릭대학교 성빈센트병원에서 H. pylori 제균요법을 시행했던 환자를 대상으로 소화기내과, 일반내과, 가정의학과별로 제균율의 차이를 후향 조사하였다. 대상 환자는 2,050명으로 의료영상 저장 전송 체계(PACS)를 이용하여 3명의 내시경전문의가 각각의 내시경 소견을 다시 판독하여 내시경적인 미란과 궤양을 구분하였다. 결과: 일차 삼제요법에 대한 제균율은 82.5%였고, 이차 사제요법에 대한 제균율은 71.2%였다. 일차 진료를 담당하는 가정의학과와 내과 일반에서 소화기내과에 비해 내시경적인 미란에 대해 제균요법을 시행하는 빈도가 의미 있게 높았고, 전체 제균율과 내시경적인 궤양에 대한 제균율은 유의하게 낮았다. 결론: 일차 진료과에서 적용한 H. pylori 제균요법은 미란 등 부적절한 제균대상이 많았다. 전체적인 제균율이나 내시경적인 궤양에 대한 제균율은 소화기내과가 일차 진료과에 비해 의미 있게 높았고, 이것은 여러 가지 복합적인 요인이 작용하고 있을 것이며, 그 중에서도 복약에 대한 환자의 순응도가 중요한 역할을 할 것으로 본다. Background/Aims: Eradication rates of Helicobacter pylori (H. pylori) tend to decrease over the last few years. Apart from the antibiotic resistance and patient`s compliance, various factors have an influence on the efficacy of eradication therapy. We analyzed the inter-departmental differences in the eradication therapy for H. pylori infection. Methods: Between January 2003 and June 2007, total 3,072 eradication regimens were prescribed to patients. Eradication rates according to departments-gastroenterology (GE), general internal medicine (IM) and family medicine (FM)-were analyzed retrospectively. Results: The overall eradication rate of first-line triple therapy was 82.5% and second-line quadruple therapy was 71.2%. In the department of IM and FM, the eradication therapy was applied more frequently to the patients with erosion only, not ulcer. Overall eradication rates according to the departments were 87.0% in GE, 81.1% in IM and 77.2% in FM (p=0.02 GE vs. IM and p<0.01 GE vs. FM, respectively). Eradication rate in patients with peptic ulcer was also significantly higher in GE compared with IM or FM. Conclusions: In primary clinic (IM and FM), the eradication therapy was frequently applied to erosion. The eradication rates of H. pylori in GE department were significantly higher than those of IM or FM. Inter-departmental differences of the eradication rate might be caused by patients` compliance to prescribed medication. (Korean J Gastroenterol 2009;53:221-227)
정규원(Kyu Won Chung),정환국(Whan Kook Chung),선희식(Hee Sik Sun),정인식(In Sik Chung),이흥현(Heung Hyun Lee),이만영(Man Young Lee),김용수(Yong Soo Kim),김춘추(Chun Choo Kim),김병기(Byung Kee Kim) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.2
Aplastic anemia is rare, severe complication of viral hepatitis. Over 200 cases have been reported in the literature, but only recently the virological studies have been carefully implicated. There have been reports of fatal aplastic anemia associated with type-A virus, type-B virus and non-A, non-B hepatitis. We report a 35-year-old man, who found to have severe aplastic anemia associated with fulminant hepatitis: Virological studies suggested that it was probably non-A, non-B hepatitis.
자궁경부의 원발성 Signet Ring Cell Adenocarcinoma
이정주 ( Jung Ju Lee ),차동수 ( Dong Soo Cha ),한경희 ( Kyoung Hee Han ),정인배 ( In Bai Chung ),이상영 ( Sang Young Lee ),염현식 ( Hyun Sik Youm ),이현주 ( Hyun Ju Lee ),정순희 ( Soon Hee Jung ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
Signet ring cell adenocarcinoma of the cervix is most commonly considered to be metastatic in origin. We describe one case of primary signet ring cell adenocarcinoma of the cervix occuring in 49-year-old patient. The lesion was located at the posterior lip of the cervix and about 3 cm in size. This case was parametrium thickening in pelvic examination and positive for HPV type 18. CCRT (concurrent chemoradiotherapy) was done for clinical FIGO stage ⅡB adenocarcinoma of the cervix. The patient is alive for 6month since diagnosis and disappear lesion of the cervix. A upper gastroenteroscopy, colonoscopy, cystoscopy, intravenous pyelogram, abdominal pelvic CT, PET CT, mammogram were reported negative. Therefore we concluded this case for a primary cervical origin of signet ring cell adenocarcinoma of the uterine cervix.
페닐부타존에 의해 간손상이 유발된 생쥐의 유전자 발현 분석
이은주(Eun-Ju Lee),정인해(In-Hye Jeong),김한나(Han-Na Kim),정희경(Heekyoung Chung),공구(Gu Kong),강경선(Kyung-Sun Kang),윤병일(Byung-IL Yoon),이병훈(Byeong Hoon Lee),이미옥(Mi-Ock Lee),김주한(Ju Han Kim),김형래(Hyung-Lae Kim) 한국독성학회 2006 Toxicological Research Vol.22 No.2
The KFDA (Korea Food & Drug Administration) has performed a collaborative toxicogenomics project since 2003. Its aim is to construct a toxicologenomic database of 12 hepatotoxic compounds from mice livers. Phenylbutazone which is non-steroidal anti-inflammatory drug was assigned. It was administered at low (0.0238 ㎎/㎏) and at high (0.238 ㎎/㎏) dose (5 mice per group) orally to the postnatal 6 weeks ICR mice, then the serum and liver were collected at the indicated time (6, 24 and 72 h) after administration. Serum biochemical markers for liver toxicity were measured and histopathologic studies also were carried out. The gene expression profiling was carried out by using Applied Biosystems 1700 Full Genome Expression Mouse. The 2-way ANOVA was used to find genes that reflected phenylbutazone-induced acute toxicity or dose-dependant changes. By self-organization maps (SOM), we identified groups with unique gene expression patterns, some of them are supposed to be related to phenylbutazone induced toxicity, including lipid metabolism abnormality, oxidative stress, cell death and cytoskeleton destruction.
정규원(Kyu Won Chung),선희식(Hee Sik Sun),김부성(Boo Sung Kim),정인식(In Sik Chung),이영석(Young Suk Lee),안병민(Byung Min Ahn),오수혁(Soo Hyuk Oh),유진홍(Jin Hong You),정한국(Han Kook Chung) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.1
N/A Percutaneous liver biopsies were performed in 146 patients with acute and chronic liver diseases, including neoplastic diseases. Among 146 patients, 28 patients had undergone liver biopsy under laparoscopic examination and 118 patients by blind intercostal biopsies. Ultrasonographic examination was performed before biopsy and 24 hours after biopsy. Blood pressure and pulse rate were also examined in all 146 hospitalized patients. The following results were obtained. 1) Development of intrahepatic hematoma was found by ultrasound in one case (0.6%) which the biopsy had been done under laparoscopic examination, however there were no significnt hemodynamic changes in blood pressure, hemoglobin level and pulse rate. 2) No significant hemodynamic changes noted between the prebiopsy and six hours after biopsy. 3) No other serious complications encountered in all 146 cases of liver biopsy. It is concluded that routine post-biopsy ultrasonographic examination may be unnecessary in patients undergone percutaneous liver needle biopsy if a skillful personnel and good indications were applied.
체외수정 및 배아이식술후 임신과 자연 임신된 임신부에서 임신중기 삼중표지물질 검사결과의 비교분석
이정렬(Jeong Lyol Lee),이영심(Young Sim Lee),이상학(Sang Hag Lee),최중호(Jung Ho Choi),정인배(In Bai Chung),이영진(Young Jin Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.9
N/A Objective : To compare and analysis the result of second trimester maternal serum triple marker screening test for Down syndrome and open neural tube defects in singleton pregnancies conceived by conventional in vitro fertilization- embryo transfer (IVF-ET) with that of the naturally conceived pregnancies. Methods : Maternal serum screening tests during the second trimester in 49 singleton pregnancies conceived by IVF-ET and 813 singleton pregnancies conceived naturally of whom delivery outcome was normal in each other were analyzed from April 1997 to June 2000. Results : 4 (8.2%) out of 49 cases of IVF-ET singleton pregnancies compared with 62 (7.6%) out of 813 cases of naturally conceived pregnancies had a positive results for Down syndrome or open neural tube defects. The median level of the triple markers were 1.03 0.47 multiples of the median (MoM) in IVF-ET pregnancies vs 1.05±0.39 MoM in natural pregnancies for alpha-fetoprotein (AFP), 1.11±0.64 vs 1.19±1.13 MoM for unconjugated estriol (uE3) and 1.21±0.56 vs 1.11±0.59 MoM for human chorionic gonadotropin (hCG). Conclusion : The positive rate of triple test and the median values of triple markers for Down syndrome and open neural tube defect between two groups were not different in terms of statistical significance. To provide an objective assessment of an individual patient's risk of fetal abnormality, the impact of IVF-ET on triple marker biochemistry should be studied further in larger samples and adjustments made if appropriate.